Aliases for IRAK2 Gene
External Ids for IRAK2 Gene
Previous GeneCards Identifiers for IRAK2 Gene
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]
GeneCards Summary for IRAK2 Gene
IRAK2 (Interleukin 1 Receptor Associated Kinase 2) is a Protein Coding gene. Diseases associated with IRAK2 include Lymphocytic Colitis. Among its related pathways are Bacterial infections in CF airways and IL-1 signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is IRAK1.
UniProtKB/Swiss-Prot for IRAK2 Gene
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
The IRAKs (Interleukin-1 receptor-associated kinases) are serine-threonine kinases, EC 22.214.171.124, that are essential regulators of IL-1R and TLR-mediated signaling. Four IRAK isoforms have been identified to date, IRAK1, IRAK2, IRAK3 (IRAK-M) and IRAK4.