Aliases for ITGA6 Gene
External Ids for ITGA6 Gene
Previous GeneCards Identifiers for ITGA6 Gene
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
GeneCards Summary for ITGA6 Gene
ITGA6 (Integrin, Alpha 6) is a Protein Coding gene. Diseases associated with ITGA6 include itga6-related epidermolysis bullosa with pyloric atresia and epidermolysis bullosa with pyloric atresia. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include protein complex binding and laminin binding. An important paralog of this gene is ITGA8.
UniProtKB/Swiss-Prot for ITGA6 Gene
Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.