Aliases for ITGA6 Gene
External Ids for ITGA6 Gene
Previous GeneCards Identifiers for ITGA6 Gene
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
GeneCards Summary for ITGA6 Gene
ITGA6 (Integrin Subunit Alpha 6) is a Protein Coding gene. Diseases associated with ITGA6 include Epidermolysis Bullosa, Junctional, With Pyloric Stenosis and Itga6-Related Epidermolysis Bullosa With Pyloric Atresia. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and Hematopoietic cell lineage. GO annotations related to this gene include protein complex binding and laminin binding. An important paralog of this gene is ITGA7.
UniProtKB/Swiss-Prot for ITGA6 Gene
Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).