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Aliases for ITGA6 Gene

Aliases for ITGA6 Gene

  • Integrin, Alpha 6 2 3
  • CD49 Antigen-Like Family Member F 3 4
  • VLA-6 3 4
  • Integrin Alpha-6 3
  • Integrin Alpha6B 3
  • CD49f Antigen 4
  • ITGA6B 3
  • CD49f 3

External Ids for ITGA6 Gene

Summaries for ITGA6 Gene

Entrez Gene Summary for ITGA6 Gene

  • The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGA6 Gene

ITGA6 (Integrin, Alpha 6) is a Protein Coding gene. Diseases associated with ITGA6 include duodenal atresia and itga6-related epidermolysis bullosa with pyloric atresia. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include integrin binding. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA6 Gene

  • Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.

Gene Wiki entry for ITGA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA6 Gene

Genomics for ITGA6 Gene

Genomic Location for ITGA6 Gene

Start:
172,427,354 bp from pter
End:
172,506,453 bp from pter
Size:
79,100 bases
Orientation:
Plus strand

Genomic View for ITGA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA6 Gene

Regulatory Elements for ITGA6 Gene

Proteins for ITGA6 Gene

  • Protein details for ITGA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23229-ITA6_HUMAN
    Recommended name:
    Integrin alpha-6
    Protein Accession:
    P23229
    Secondary Accessions:
    • B2RMU9
    • B4DG69
    • B4DKB8
    • C4AM96
    • G5E9H1
    • Q08443
    • Q0MRC7
    • Q14646
    • Q16508
    • Q53RX7
    • Q59HB7
    • Q86VL6
    • Q9UCT1
    • Q9UN03

    Protein attributes for ITGA6 Gene

    Size:
    1130 amino acids
    Molecular mass:
    126606 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21.
    SequenceCaution:
    • Sequence=BAG57680.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ITGA6 Gene

neXtProt entry for ITGA6 Gene

Proteomics data for ITGA6 Gene at MOPED

Post-translational modifications for ITGA6 Gene

  • In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro.
  • Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on Ser-1103 of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand
  • Palmitoylation by DHHC3 enhances stability and cell surface expression.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn78, Asn223, Asn323, Asn409, Asn770, Asn787, Asn930, Asn966, and Asn997

Other Protein References for ITGA6 Gene

No data available for DME Specific Peptides for ITGA6 Gene

Domains for ITGA6 Gene

Gene Families for ITGA6 Gene

HGNC:
  • CD :CD molecules
  • ITG :Integrins

UniProtKB/Swiss-Prot:

ITA6_HUMAN
Family:
  • Belongs to the integrin alpha chain family.:
    • P23229
Similarity:
  • Contains 7 FG-GAP repeats.:
    • P23229
genes like me logo Genes that share domains with ITGA6: view

Function for ITGA6 Gene

Molecular function for ITGA6 Gene

GENATLAS Biochemistry: integrin,alpha 6 cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,component of VLA-6 receptor and of hemidesmosomes,mediating cell-extracellular matrix interactions also involved in the fertilization of ova and embryonic development,dimerizing with ITGB1 (laminin receptor) or ITGB4 (component of hemidesmosome)
UniProtKB/Swiss-Prot Function: Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.

Gene Ontology (GO) - Molecular Function for ITGA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 21880726
GO:0032403 protein complex binding --
GO:0043236 laminin binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ITGA6: view
genes like me logo Genes that share phenotypes with ITGA6: view

Animal Models for ITGA6 Gene

MGI Knock Outs for ITGA6:

miRNA for ITGA6 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITGA6 Gene

Localization for ITGA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA6 Gene

Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGA6 Gene COMPARTMENTS Subcellular localization image for ITGA6 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
cytosol 2
peroxisome 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ITGA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005913 cell-cell adherens junction IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0008305 integrin complex --
genes like me logo Genes that share ontologies with ITGA6: view

Pathways for ITGA6 Gene

genes like me logo Genes that share pathways with ITGA6: view

Gene Ontology (GO) - Biological Process for ITGA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007044 cell-substrate junction assembly TAS 9185503
GO:0007160 cell-matrix adhesion IEA --
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007596 blood coagulation TAS --
GO:0010668 ectodermal cell differentiation IEP 23154389
genes like me logo Genes that share ontologies with ITGA6: view

Compounds for ITGA6 Gene

(18) Novoseek inferred chemical compound relationships for ITGA6 Gene

Compound -log(P) Hits PubMed IDs
kalinin 76.2 3
sikvav 63 2
matrigel 57.5 5
yigsr 54.2 1
hpvs 25.6 1
genes like me logo Genes that share compounds with ITGA6: view

Transcripts for ITGA6 Gene

Unigene Clusters for ITGA6 Gene

Integrin, alpha 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21a ·
SP1: - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:

ExUns: 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b
SP1: -
SP2: - - -
SP3: -
SP4: -
SP5:
SP6:

Relevant External Links for ITGA6 Gene

GeneLoc Exon Structure for
ITGA6
ECgene alternative splicing isoforms for
ITGA6

Expression for ITGA6 Gene

mRNA expression in normal human tissues for ITGA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGA6 Gene

This gene is overexpressed in Nerve - Tibial (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGA6 Gene

SOURCE GeneReport for Unigene cluster for ITGA6 Gene Hs.133397

mRNA Expression by UniProt/SwissProt for ITGA6 Gene

P23229-ITA6_HUMAN
Tissue specificity: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).
genes like me logo Genes that share expressions with ITGA6: view

Orthologs for ITGA6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGA6 36
  • 99.57 (n)
  • 99.73 (a)
ITGA6 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGA6 36
  • 89.45 (n)
  • 91.81 (a)
ITGA6 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA6 36
  • 89.61 (n)
  • 92.85 (a)
ITGA6 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itga6 36
  • 86.77 (n)
  • 93.13 (a)
Itga6 16
Itga6 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITGA6 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA6 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itga6 36
  • 85.69 (n)
  • 91.15 (a)
chicken
(Gallus gallus)
Aves ITGA6 36
  • 72.59 (n)
  • 72.36 (a)
ITGA6 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGA6 37
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia INTA6 36
tropical clawed frog
(Silurana tropicalis)
Amphibia itga6 36
  • 66.27 (n)
  • 66.45 (a)
Str.11842 36
zebrafish
(Danio rerio)
Actinopterygii itga6a 36
  • 63.58 (n)
  • 64.43 (a)
itga6a 37
  • 63 (a)
OneToMany
itga6b 37
  • 57 (a)
OneToMany
itga6l 37
  • 46 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000307 36
  • 42.84 (n)
  • 35.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta mew 36
  • 44.71 (n)
  • 34.85 (a)
mew 37
  • 27 (a)
OneToMany
mew 38
  • 29 (a)
scb 38
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea ina-1 36
  • 46.52 (n)
  • 33.3 (a)
ina-1 37
  • 26 (a)
OneToMany
ina-1 38
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
ManyToMany
CSA.6547 37
  • 33 (a)
ManyToMany
Species with no ortholog for ITGA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGA6 Gene

ENSEMBL:
Gene Tree for ITGA6 (if available)
TreeFam:
Gene Tree for ITGA6 (if available)

Paralogs for ITGA6 Gene

Selected SIMAP similar genes for ITGA6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ITGA6: view

Variants for ITGA6 Gene

Sequence variations from dbSNP and Humsavar for ITGA6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs17664 -- 172,504,503(+) CCTTT(A/G)TTTTT utr-variant-3-prime
rs1076594 -- 172,461,708(+) TTGGC(A/G)TTTAA intron-variant
rs1076595 -- 172,461,891(+) CTAGA(C/T)TAGGA intron-variant
rs1076596 -- 172,462,521(-) ACATG(C/T)GGCGG intron-variant
rs1076597 -- 172,462,545(-) TTGCA(A/G)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA6 Gene

Variant ID Type Subtype PubMed ID
nsv875414 CNV Gain 21882294
esv2677918 CNV Deletion 23128226
esv269531 CNV Insertion 20981092
esv272846 CNV Insertion 20981092

Relevant External Links for ITGA6 Gene

HapMap Linkage Disequilibrium report
ITGA6
Human Gene Mutation Database (HGMD)
ITGA6

Disorders for ITGA6 Gene

(1) OMIM Diseases for ITGA6 Gene (147556)

UniProtKB/Swiss-Prot

ITA6_HUMAN
  • Epidermolysis bullosa letalis, with pyloric atresia (EB-PA) [MIM:226730]: An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for ITGA6 Gene

(51) Novoseek inferred disease relationships for ITGA6 Gene

Disease -log(P) Hits PubMed IDs
pyloric atresia 88.4 7
epidermolysis bullosa junctional 82.9 6
eb-pa 81.3 2
lethal junctional epidermolysis bullosa 73.1 1
pemphigoid bullous 71.3 16

Relevant External Links for ITGA6

GeneTests
ITGA6
GeneReviews
ITGA6
Genetic Association Database (GAD)
ITGA6
Human Genome Epidemiology (HuGE) Navigator
ITGA6
genes like me logo Genes that share disorders with ITGA6: view

Publications for ITGA6 Gene

  1. Integrin alpha6 cleavage: a novel modification to modulate cell migration. (PMID: 17303120) Pawar S.C. … Cress A.E. (Exp. Cell Res. 2007) 3 4 23
  2. Identification of an epitope within human integrin alpha 6 subunit for the binding of autoantibody and its role in basement membrane separation in oral pemphigoid. (PMID: 16424229) Rashid K.A. … Ahmed A.R. (J. Immunol. 2006) 3 23
  3. Interleukin-1alpha enhances the aggressive behavior of pancreatic cancer cells by regulating the alpha6beta1-integrin and urokinase plasminogen activator receptor expression. (PMID: 16504015) Sawai H. … Manabe T. (BMC Cell Biol. 2006) 3 23
  4. Keratinocyte-secreted laminin 5 can function as a transient receptor for human papillomaviruses by binding virions and transferring them to adjacent cells. (PMID: 16940506) Culp T.D. … Christensen N.D. (J. Virol. 2006) 3 23
  5. The nonintegrin laminin binding protein (p67 LBP) is expressed on a subset of activated human T lymphocytes and, together with the integrin very late activation antigen-6, mediates avid cellular adherence to laminin. (PMID: 10477615) Canfield S.M. … Khakoo A.Y. (J. Immunol. 1999) 3 23

Products for ITGA6 Gene

  • Addgene plasmids for ITGA6

Sources for ITGA6 Gene

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