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Aliases for INSRR Gene

Aliases for INSRR Gene

  • Insulin Receptor-Related Receptor 2 3
  • IRR 3 4 6
  • IR-Related Receptor 3 4
  • EC 2.7.10.1 4 63
  • Insulin Receptor-Related Protein 3
  • EC 2.7.10 63

External Ids for INSRR Gene

Summaries for INSRR Gene

GeneCards Summary for INSRR Gene

INSRR (Insulin Receptor-Related Receptor) is a Protein Coding gene. Diseases associated with INSRR include neurofibrosarcoma. Among its related pathways are GPCR Pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include transmembrane receptor protein tyrosine kinase activity and insulin receptor substrate binding. An important paralog of this gene is ALK.

UniProtKB/Swiss-Prot for INSRR Gene

  • Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.

Gene Wiki entry for INSRR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSRR Gene

Genomics for INSRR Gene

Genomic Location for INSRR Gene

Start:
156,840,063 bp from pter
End:
156,859,018 bp from pter
Size:
18,956 bases
Orientation:
Minus strand

Genomic View for INSRR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INSRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSRR Gene

Regulatory Elements for INSRR Gene

Transcription factor binding sites by QIAGEN in the INSRR gene promoter:

Proteins for INSRR Gene

  • Protein details for INSRR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14616-INSRR_HUMAN
    Recommended name:
    Insulin receptor-related protein
    Protein Accession:
    P14616
    Secondary Accessions:
    • O60724
    • Q5VZS3

    Protein attributes for INSRR Gene

    Size:
    1297 amino acids
    Molecular mass:
    143720 Da
    Quaternary structure:
    • Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain

neXtProt entry for INSRR Gene

Proteomics data for INSRR Gene at MOPED

Post-translational modifications for INSRR Gene

  • Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn47, Asn311, Asn411, Asn492, Asn528, Asn616, Asn634, Asn756, Asn885, and Asn898

Other Protein References for INSRR Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for INSRR Gene

Gene Families for INSRR Gene

Suggested Antigen Peptide Sequences for INSRR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14616

UniProtKB/Swiss-Prot:

INSRR_HUMAN
Domain:
  • The extracellular domain is required for sensing alterations in external pH:
    • P14616
  • Contains 3 fibronectin type-III domains.:
    • P14616
  • Contains 1 protein kinase domain.:
    • P14616
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.:
    • P14616
genes like me logo Genes that share domains with INSRR: view

Function for INSRR Gene

Molecular function for INSRR Gene

GENATLAS Biochemistry: insulin receptor,related receptor,expressed in subsets of neuron,renal distal tubules,enterochromaffin-like cells of the fundic stomach and in the islets of pancreas,mutated in a region,involved in the susceptibility to type II non insulin dependent diabetes
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.

Enzyme Numbers (IUBMB) for INSRR Gene

Gene Ontology (GO) - Molecular Function for INSRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004714 transmembrane receptor protein tyrosine kinase activity NAS 10226785
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with INSRR: view
genes like me logo Genes that share phenotypes with INSRR: view

Animal Models for INSRR Gene

MGI Knock Outs for INSRR:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for INSRR Gene

Localization for INSRR Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSRR Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INSRR Gene COMPARTMENTS Subcellular localization image for INSRR gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for INSRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane NAS 10226785
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with INSRR: view

Pathways for INSRR Gene

genes like me logo Genes that share pathways with INSRR: view

Pathways by source for INSRR Gene

1 R&D Systems pathway for INSRR Gene
2 KEGG pathways for INSRR Gene

Gene Ontology (GO) - Biological Process for INSRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS 10226785
GO:0018108 peptidyl-tyrosine phosphorylation NAS 10226785
GO:0030238 male sex determination IEA --
GO:0031532 actin cytoskeleton reorganization IDA 21641549
genes like me logo Genes that share ontologies with INSRR: view

Compounds for INSRR Gene

(2) HMDB Compounds for INSRR Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(3) Novoseek inferred chemical compound relationships for INSRR Gene

Compound -log(P) Hits PubMed IDs
phosphotyrosine 60.1 2
tyrosine 53.1 14
glucose 20.8 2
genes like me logo Genes that share compounds with INSRR: view

Transcripts for INSRR Gene

mRNA/cDNA for INSRR Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INSRR Gene

Insulin receptor-related receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INSRR Gene

No ASD Table

Relevant External Links for INSRR Gene

GeneLoc Exon Structure for
INSRR
ECgene alternative splicing isoforms for
INSRR

Expression for INSRR Gene

mRNA expression in normal human tissues for INSRR Gene

mRNA differential expression in normal tissues according to GTEx for INSRR Gene

This gene is overexpressed in Kidney - Cortex (10.4), Testis (6.3), and Stomach (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INSRR Gene

SOURCE GeneReport for Unigene cluster for INSRR Gene Hs.248138

genes like me logo Genes that share expressions with INSRR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for INSRR Gene

Orthologs for INSRR Gene

This gene was present in the common ancestor of animals.

Orthologs for INSRR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INSRR 35
  • 99.59 (n)
  • 99.46 (a)
INSRR 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INSRR 35
  • 90.26 (n)
  • 93.45 (a)
INSRR 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INSRR 35
  • 89.35 (n)
  • 92.9 (a)
INSRR 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Insrr 35
  • 85.43 (n)
  • 89.13 (a)
Insrr 16
Insrr 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INSRR 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Insrr 35
  • 85.48 (n)
  • 89.21 (a)
chicken
(Gallus gallus)
Aves INSRR 36
  • 70 (a)
OneToOne
LOC100857811 35
  • 74.69 (n)
  • 74.56 (a)
lizard
(Anolis carolinensis)
Reptilia INSRR 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68585 35
tropical clawed frog
(Silurana tropicalis)
Amphibia insrr 35
  • 65.69 (n)
  • 67.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3837 36
  • 27 (a)
OneToMany
CG10702 37
  • 26 (a)
CG3837 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea daf-2 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for INSRR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for INSRR Gene

ENSEMBL:
Gene Tree for INSRR (if available)
TreeFam:
Gene Tree for INSRR (if available)

Paralogs for INSRR Gene

Paralogs for INSRR Gene

Selected SIMAP similar genes for INSRR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INSRR: view

Variants for INSRR Gene

Sequence variations from dbSNP and Humsavar for INSRR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_041434 -
VAR_041435 -
VAR_041436 -
VAR_041437 -
VAR_041438 A lung adenocarcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for INSRR Gene

Variant ID Type Subtype PubMed ID
nsv831648 CNV Loss 17160897
nsv831659 CNV Loss 17160897

Relevant External Links for INSRR Gene

HapMap Linkage Disequilibrium report
INSRR
Human Gene Mutation Database (HGMD)
INSRR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSRR Gene

Disorders for INSRR Gene

(1) MalaCards Diseases for INSRR Gene

Search for INSRR Gene in MalaCards »

(1) University of Copenhagen DISEASES for INSRR Gene

(1) Novoseek inferred disease relationships for INSRR Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3

Relevant External Links for INSRR

Genetic Association Database (GAD)
INSRR
Human Genome Epidemiology (HuGE) Navigator
INSRR
genes like me logo Genes that share disorders with INSRR: view

No data available for UniProtKB/Swiss-Prot for INSRR Gene

Publications for INSRR Gene

  1. Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor. (PMID: 10226785) Haenze J. … Kiess W. (Horm. Metab. Res. 1999) 3 4 23
  2. Localization of the insulin receptor-related receptor gene to human chromosome 1. (PMID: 2249481) Shier P. … Watt V.M. (Cytogenet. Cell Genet. 1990) 2 3 23
  3. Primary structure of a putative receptor for a ligand of the insulin family. (PMID: 2768234) Shier P. … Watt V.M. (J. Biol. Chem. 1989) 2 3 4
  4. Polymorphism screening of the insulin receptor-related receptor gene (INSRR) on 1q in Pima Indians. (PMID: 11513557) Wolford J.K. … Prochazka M. (Mol. Cell. Probes 2001) 23 48
  5. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y. … Boer J.M. (J. Lipid Res. 2008) 3 48

Products for INSRR Gene

  • Addgene plasmids for INSRR

Sources for INSRR Gene

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