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Aliases for INSL4 Gene

Aliases for INSL4 Gene

  • Insulin-Like 4 (Placenta) 2 3
  • Insulin-Like Peptide 4 3 4
  • EPIL 3 4
  • Early Placenta Insulin-Like Peptide (EPIL) 3
  • Early Placenta Insulin-Like Peptide 3

External Ids for INSL4 Gene

Previous GeneCards Identifiers for INSL4 Gene

  • GC09P005385
  • GC09P005212
  • GC09P005221
  • GC09P005266

Summaries for INSL4 Gene

Entrez Gene Summary for INSL4 Gene

  • INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. [provided by RefSeq, Jul 2008]

GeneCards Summary for INSL4 Gene

INSL4 (Insulin-Like 4 (Placenta)) is a Protein Coding gene. Diseases associated with INSL4 include placenta accreta. GO annotations related to this gene include receptor binding and insulin-like growth factor receptor binding.

UniProtKB/Swiss-Prot for INSL4 Gene

  • May play an important role in trophoblast development and in the regulation of bone formation

Gene Wiki entry for INSL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSL4 Gene

Genomics for INSL4 Gene

Regulatory Elements for INSL4 Gene

Genomic Location for INSL4 Gene

5,231,419 bp from pter
5,235,304 bp from pter
3,886 bases
Plus strand

Genomic View for INSL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INSL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSL4 Gene

Proteins for INSL4 Gene

  • Protein details for INSL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Early placenta insulin-like peptide
    Protein Accession:
    Secondary Accessions:
    • A8K678
    • Q5W127

    Protein attributes for INSL4 Gene

    139 amino acids
    Molecular mass:
    15445 Da
    Quaternary structure:
    No Data Available

neXtProt entry for INSL4 Gene

Proteomics data for INSL4 Gene at MOPED

Post-translational modifications for INSL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INSL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INSL4 Gene

Domains for INSL4 Gene

Protein Domains for INSL4 Gene


Suggested Antigen Peptide Sequences for INSL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q14641
  • Belongs to the insulin family.
genes like me logo Genes that share domains with INSL4: view

No data available for Gene Families for INSL4 Gene

Function for INSL4 Gene

Molecular function for INSL4 Gene

GENATLAS Biochemistry: insulin-like 4,growth factor expressed in placenta and uterus
UniProtKB/Swiss-Prot Function: May play an important role in trophoblast development and in the regulation of bone formation

Gene Ontology (GO) - Molecular Function for INSL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8702754
GO:0005159 insulin-like growth factor receptor binding TAS 8666396
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with INSL4: view

miRNA for INSL4 Gene

miRTarBase miRNAs that target INSL4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for INSL4 Gene

Localization for INSL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSL4 Gene


Subcellular locations from

Jensen Localization Image for INSL4 Gene COMPARTMENTS Subcellular localization image for INSL4 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for INSL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space TAS 8702754
genes like me logo Genes that share ontologies with INSL4: view

Pathways for INSL4 Gene

SuperPathways for INSL4 Gene

No Data Available

Interacting Proteins for INSL4 Gene

Gene Ontology (GO) - Biological Process for INSL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8702754
GO:0007267 cell-cell signaling TAS 8702754
GO:0007275 multicellular organismal development TAS 8702754
GO:0007565 female pregnancy TAS 8702754
GO:0008283 cell proliferation TAS 8702754
genes like me logo Genes that share ontologies with INSL4: view

No data available for Pathways by source for INSL4 Gene

Compounds for INSL4 Gene

(1) Novoseek inferred chemical compound relationships for INSL4 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 0 1
genes like me logo Genes that share compounds with INSL4: view

Transcripts for INSL4 Gene

mRNA/cDNA for INSL4 Gene

(47) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INSL4 Gene

Insulin-like 4 (placenta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INSL4 Gene

No ASD Table

Relevant External Links for INSL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INSL4 Gene

mRNA expression in normal human tissues for INSL4 Gene

SOURCE GeneReport for Unigene cluster for INSL4 Gene Hs.418506

mRNA Expression by UniProt/SwissProt for INSL4 Gene

Tissue specificity: Expressed in placenta, uterus and in fetal perichondrium. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells.
genes like me logo Genes that share expressions with INSL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for INSL4 Gene

Orthologs for INSL4 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for INSL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia INSL4 35
  • 98.56 (n)
  • 97.84 (a)
INSL4 36
  • 98 (a)
Species with no ortholog for INSL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INSL4 Gene

Gene Tree for INSL4 (if available)
Gene Tree for INSL4 (if available)

Paralogs for INSL4 Gene Pseudogenes for INSL4 Gene

genes like me logo Genes that share paralogs with INSL4: view

No data available for Paralogs for INSL4 Gene

Variants for INSL4 Gene

Sequence variations from dbSNP and Humsavar for INSL4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs12720 -- 5,231,712(+) GGACG(A/T)CCCAA synonymous-codon, reference
rs1128593 -- 5,234,202(+) taccc(C/T)gattt downstream-variant-500B
rs1555476 -- 5,233,054(+) ATTTC(C/T)ATTTA intron-variant
rs1803824 -- 5,231,511(+) GGAGA(G/T)TTCAG utr-variant-5-prime
rs2093446 -- 5,230,371(+) TCCTG(C/G)GGGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for INSL4 Gene

Variant ID Type Subtype PubMed ID
nsv892136 CNV Gain 21882294
nsv527495 CNV Gain 19592680
nsv466100 CNV Gain 19166990
dgv8017n71 CNV Loss 21882294
nsv892141 CNV Gain 21882294
nsv831495 CNV Loss 17160897
nsv525777 CNV Loss 19592680
nsv892144 CNV Gain 21882294
nsv892145 CNV Gain 21882294

Relevant External Links for INSL4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSL4 Gene

Disorders for INSL4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for INSL4 Gene including...

Search for INSL4 Gene in MalaCards »

(4) Novoseek inferred disease relationships for INSL4 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 5.13 7
metastasis 0.842 2
tumors 0 3
cancer 0 3

Relevant External Links for INSL4

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with INSL4: view

No data available for UniProtKB/Swiss-Prot for INSL4 Gene

Publications for INSL4 Gene

  1. Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta. (PMID: 8666396) Chassin D. … Bellet D. (Genomics 1995) 2 3 4 23
  2. Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. (PMID: 12414911) Janneau J.-L. … Bellet D. (J. Clin. Endocrinol. Metab. 2002) 3 4 23
  3. Identification of pro-EPIL and EPIL peptides translated from insulin- like 4 (INSL4) mRNA in human placenta. (PMID: 9284764) Bellet D. … Bidart J.-M. (J. Clin. Endocrinol. Metab. 1997) 3 4 23
  4. The INSL4 gene maps close to WI-5527 at 9p24.1-->p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome. (PMID: 9730618) Veitia R. … McElreavey K. (Cytogenet. Cell Genet. 1998) 2 3 23
  5. Insulin-like 4 (INSL4) gene expression in human embryonic and trophoblastic tissues. (PMID: 9740319) Laurent A. … Vidaud M. (Mol. Reprod. Dev. 1998) 3 4 23

Products for INSL4 Gene

Sources for INSL4 Gene

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