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Aliases for INSL3 Gene

Aliases for INSL3 Gene

  • Insulin Like 3 2 3 5
  • Insulin-Like 3 (Leydig Cell) 2 3
  • Leydig Insulin-Like Peptide 3 4
  • Relaxin-Like Factor 2 4
  • Prepro-INSL3 2 3
  • Ley-I-L 3 4
  • RLNL 3 4
  • RLF 3 4
  • Leydig Insulin -Like Hormone 3
  • Relaxin-Like Factor B 3
  • Insulin-Like 3 3

External Ids for INSL3 Gene

Previous HGNC Symbols for INSL3 Gene

  • RLNL

Previous GeneCards Identifiers for INSL3 Gene

  • GC19M018421
  • GC19M018319
  • GC19M017772
  • GC19M017928
  • GC19M017492

Summaries for INSL3 Gene

Entrez Gene Summary for INSL3 Gene

  • This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

GeneCards Summary for INSL3 Gene

INSL3 (Insulin Like 3) is a Protein Coding gene. Diseases associated with INSL3 include Cryptorchidism and Testicular Cancer. Among its related pathways are G alpha (s) signalling events and Signaling by GPCR. GO annotations related to this gene include receptor binding and protease binding.

UniProtKB/Swiss-Prot for INSL3 Gene

  • Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

Gene Wiki entry for INSL3 Gene

Additional gene information for INSL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSL3 Gene

Genomics for INSL3 Gene

Regulatory Elements for INSL3 Gene

Enhancers for INSL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H017764 1.5 Ensembl ENCODE dbSUPER 11.5 +55.7 55736 3 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF2 GTF3C2 SLC30A9 GLIS2 MVB12A ENSG00000268030 B3GNT3 UNC13A MAP1S GTPBP3 INSL3 HAUS8 PLVAP ENSG00000268938
GH19H017762 1.4 Ensembl ENCODE dbSUPER 11.8 +58.9 58864 1 HDAC1 YBX3 HDGF PKNOX1 BMI1 RFX5 ZNF366 RCOR1 FOS SP3 MAP1S B3GNT3 INSL3 PLVAP NXNL1 F2RL3 GC19M017755 GC19P019904
GH19H017845 1.3 FANTOM5 ENCODE 12.7 -27.3 -27302 6 HDGF PKNOX1 SIN3A ARID4B DMAP1 SLC30A9 GTF3C2 ZNF143 ZNF207 RUNX3 UPF1 ENSG00000268030 FCHO1 JAK3 B3GNT3 INSL3 MVB12A GTPBP3 UNC13A HAUS8
GH19H017841 1.2 ENCODE dbSUPER 13.3 -20.7 -20741 2 HDGF PKNOX1 ATF1 SIN3A ZNF2 ZNF143 KLF7 ATF7 SP3 REST INSL3 RAB3A JAK3 GC19M017837
GH19H017775 1.2 Ensembl ENCODE 11.7 +45.2 45220 1 HDAC1 HDGF PKNOX1 TBL1XR1 RB1 YBX1 BATF THRB RAD21 GATA2 FCHO1 UNC13A RPL18A INSL3 SNORA68 GC19M017755 B3GNT3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INSL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for INSL3 Gene

Chromosome:
19
Start:
17,816,512 bp from pter
End:
17,821,574 bp from pter
Size:
5,063 bases
Orientation:
Minus strand

Genomic View for INSL3 Gene

Genes around INSL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INSL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSL3 Gene

Proteins for INSL3 Gene

  • Protein details for INSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51460-INSL3_HUMAN
    Recommended name:
    Insulin-like 3
    Protein Accession:
    P51460
    Secondary Accessions:
    • B4DZ72
    • G3XAG0
    • Q3KPI5
    • Q3KPI6
    • Q6YNB5
    • Q9UEA2
    • Q9UPH6

    Protein attributes for INSL3 Gene

    Size:
    131 amino acids
    Molecular mass:
    14502 Da
    Quaternary structure:
    • Heterodimer of a B chain and an A chain linked by two disulfide bonds.
    SequenceCaution:
    • Sequence=CAA52017.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INSL3 Gene

    Alternative splice isoforms for INSL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INSL3 Gene

Post-translational modifications for INSL3 Gene

No Post-translational modifications

Other Protein References for INSL3 Gene

Antibody Products

  • Abcam antibodies for INSL3

No data available for DME Specific Peptides for INSL3 Gene

Domains & Families for INSL3 Gene

Gene Families for INSL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted secreted proteins

Protein Domains for INSL3 Gene

Suggested Antigen Peptide Sequences for INSL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51460

UniProtKB/Swiss-Prot:

INSL3_HUMAN :
  • Belongs to the insulin family.
Family:
  • Belongs to the insulin family.
genes like me logo Genes that share domains with INSL3: view

Function for INSL3 Gene

Molecular function for INSL3 Gene

GENATLAS Biochemistry:
Leydig insulin-like protein 3,member of the insulin-like superfamily
UniProtKB/Swiss-Prot Function:
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

Gene Ontology (GO) - Molecular Function for INSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 20082125
GO:0005102 receptor binding TAS 8020942
GO:0005158 insulin receptor binding TAS 8253799
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with INSL3: view
genes like me logo Genes that share phenotypes with INSL3: view

Human Phenotype Ontology for INSL3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for INSL3 Gene

MGI Knock Outs for INSL3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INSL3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for INSL3 Gene

Localization for INSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INSL3 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for INSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with INSL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for INSL3 Gene

Pathways & Interactions for INSL3 Gene

genes like me logo Genes that share pathways with INSL3: view

Gene Ontology (GO) - Biological Process for INSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 8253799
GO:0007283 spermatogenesis TAS 8253799
GO:0010634 positive regulation of epithelial cell migration IDA 23539510
GO:0090303 positive regulation of wound healing IDA 23539510
genes like me logo Genes that share ontologies with INSL3: view

No data available for SIGNOR curated interactions for INSL3 Gene

Drugs & Compounds for INSL3 Gene

(8) Drugs for INSL3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for INSL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INSL3: view

Transcripts for INSL3 Gene

Unigene Clusters for INSL3 Gene

Insulin-like 3 (Leydig cell):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INSL3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for INSL3 Gene

No ASD Table

Relevant External Links for INSL3 Gene

GeneLoc Exon Structure for
INSL3
ECgene alternative splicing isoforms for
INSL3

Expression for INSL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INSL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INSL3 Gene

This gene is overexpressed in Testis (x40.1) and Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for INSL3 Gene

This gene is overexpressed in Pancreatic juice (52.1) and Fetal ovary (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for INSL3 Gene



Protein tissue co-expression partners for INSL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INSL3 Gene:

INSL3

SOURCE GeneReport for Unigene cluster for INSL3 Gene:

Hs.37062

mRNA Expression by UniProt/SwissProt for INSL3 Gene:

P51460-INSL3_HUMAN
Tissue specificity: Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast.

Evidence on tissue expression from TISSUES for INSL3 Gene

  • Nervous system(4.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for INSL3 Gene

Germ Layers:
  • mesoderm
Systems:
  • reproductive
  • urinary
Organs:
Abdomen:
  • kidney
Pelvis:
  • testicle
  • ureter
genes like me logo Genes that share expression patterns with INSL3: view

Primer Products

Orthologs for INSL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for INSL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INSL3 33 34
  • 98.47 (n)
dog
(Canis familiaris)
Mammalia INSL3 33 34
  • 79.44 (n)
cow
(Bos Taurus)
Mammalia INSL3 33 34
  • 77.61 (n)
rat
(Rattus norvegicus)
Mammalia Insl3 33
  • 68.31 (n)
mouse
(Mus musculus)
Mammalia Insl3 33 16 34
  • 68.08 (n)
oppossum
(Monodelphis domestica)
Mammalia INSL3 34
  • 24 (a)
OneToOne
Species where no ortholog for INSL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INSL3 Gene

ENSEMBL:
Gene Tree for INSL3 (if available)
TreeFam:
Gene Tree for INSL3 (if available)

Paralogs for INSL3 Gene

No data available for Paralogs for INSL3 Gene

Variants for INSL3 Gene

Sequence variations from dbSNP and Humsavar for INSL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs104894697 Pathogenic, Cryptorchidism (CRYPTO) [MIM:219050] 17,816,972(-) GCAGC(C/G/T)CCTGC reference, missense
rs104894698 Pathogenic, Cryptorchidism (CRYPTO) [MIM:219050] 17,816,946(-) ATCAC(C/T)GCCAC reference, synonymous-codon, missense
rs121912555 Pathogenic, Cryptorchidism (CRYPTO) [MIM:219050] 17,816,920(-) ACCAA(C/G)CCTGC reference, missense
rs121912556 Pathogenic 17,816,945(-) TCACC(A/G)CCACC reference, missense
rs398122886 Pathogenic 17,817,033(-) AGAGA(C/T)GACAT reference, synonymous-codon, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for INSL3 Gene

Variant ID Type Subtype PubMed ID
dgv50n68 CNV loss 17160897

Variation tolerance for INSL3 Gene

Gene Damage Index Score: 0.38; 8.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INSL3 Gene

Human Gene Mutation Database (HGMD)
INSL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSL3 Gene

Disorders for INSL3 Gene

MalaCards: The human disease database

(12) MalaCards diseases for INSL3 Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cryptorchidism
  • cryptorchism
testicular cancer
  • childhood neoplasm of the testis
testicular disease
  • disorder of testis
anorchia
  • absence of testes
infertility
- elite association - COSMIC cancer census association via MalaCards
Search INSL3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

INSL3_HUMAN
  • Cryptorchidism (CRYPTO) [MIM:219050]: One of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. {ECO:0000269 PubMed:11095425, ECO:0000269 PubMed:11746019, ECO:0000269 PubMed:12601553}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for INSL3

Genetic Association Database (GAD)
INSL3
Human Genome Epidemiology (HuGE) Navigator
INSL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INSL3
genes like me logo Genes that share disorders with INSL3: view

No data available for Genatlas for INSL3 Gene

Publications for INSL3 Gene

  1. Different insulin-like 3 (INSL3) gene mutations not associated with human cryptorchidism. (PMID: 11383919) Marin P … Foresta C (Journal of endocrinological investigation 2001) 3 4 22 45 60
  2. Ala/Thr60 variant of the Leydig insulin-like hormone is not associated with cryptorchidism in the Japanese population. (PMID: 11380919) Takahashi I … Takada G (Pediatrics international : official journal of the Japan Pediatric Society 2001) 3 4 22 45 60
  3. Genetic analysis of the INSL3 gene in patients with maldescent of the testis. (PMID: 11182749) Lim HN … Hughes IA (European journal of endocrinology 2001) 3 4 22 45 60
  4. Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism. (PMID: 11095425) Tomboc M … Witchel SF (The Journal of clinical endocrinology and metabolism 2000) 3 4 22 45 60
  5. Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY I-L) and chromosomal localization of the human gene (INSL3). (PMID: 8020942) Burkhardt E … Engel W (Genomics 1994) 2 3 4 22 60

Products for INSL3 Gene

Sources for INSL3 Gene

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