Aliases for INSL3 Gene
External Ids for INSL3 Gene
Previous HGNC Symbols for INSL3 Gene
Previous GeneCards Identifiers for INSL3 Gene
This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
GeneCards Summary for INSL3 Gene
INSL3 (Insulin Like 3) is a Protein Coding gene. Diseases associated with INSL3 include Cryptorchidism, Unilateral Or Bilateral and Testicular Cancer. Among its related pathways are Peptide ligand-binding receptors and Relaxin signaling pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and protease binding.
UniProtKB/Swiss-Prot for INSL3 Gene
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.