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Aliases for INSL3 Gene

Aliases for INSL3 Gene

  • Insulin Like 3 2 3 5
  • Insulin-Like 3 (Leydig Cell) 2 3
  • Leydig Insulin-Like Peptide 3 4
  • Relaxin-Like Factor 2 4
  • Prepro-INSL3 2 3
  • Ley-I-L 3 4
  • RLNL 3 4
  • RLF 3 4
  • Leydig Insulin -Like Hormone 3
  • Relaxin-Like Factor B 3

External Ids for INSL3 Gene

Previous HGNC Symbols for INSL3 Gene

  • RLNL

Previous GeneCards Identifiers for INSL3 Gene

  • GC19M018421
  • GC19M018319
  • GC19M017772
  • GC19M017928
  • GC19M017492

Summaries for INSL3 Gene

Entrez Gene Summary for INSL3 Gene

  • This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

GeneCards Summary for INSL3 Gene

INSL3 (Insulin Like 3) is a Protein Coding gene. Diseases associated with INSL3 include Cryptorchidism and Testicular Disease. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include receptor binding and protease binding.

UniProtKB/Swiss-Prot for INSL3 Gene

  • Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

Gene Wiki entry for INSL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSL3 Gene

Genomics for INSL3 Gene

Regulatory Elements for INSL3 Gene

Enhancers for INSL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around INSL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for INSL3 Gene

17,816,512 bp from pter
17,821,574 bp from pter
5,063 bases
Minus strand

Genomic View for INSL3 Gene

Genes around INSL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INSL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSL3 Gene

Proteins for INSL3 Gene

  • Protein details for INSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin-like 3
    Protein Accession:
    Secondary Accessions:
    • B4DZ72
    • G3XAG0
    • Q3KPI5
    • Q3KPI6
    • Q6YNB5
    • Q9UEA2
    • Q9UPH6

    Protein attributes for INSL3 Gene

    131 amino acids
    Molecular mass:
    14502 Da
    Quaternary structure:
    • Heterodimer of a B chain and an A chain linked by two disulfide bonds.
    • Sequence=CAA52017.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INSL3 Gene

    Alternative splice isoforms for INSL3 Gene


neXtProt entry for INSL3 Gene

Proteomics data for INSL3 Gene at MOPED

Post-translational modifications for INSL3 Gene

No Post-translational modifications

Other Protein References for INSL3 Gene

Antibody Products

  • Abcam antibodies for INSL3

No data available for DME Specific Peptides for INSL3 Gene

Domains & Families for INSL3 Gene

Gene Families for INSL3 Gene

Protein Domains for INSL3 Gene


Suggested Antigen Peptide Sequences for INSL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the insulin family.
  • Belongs to the insulin family.
genes like me logo Genes that share domains with INSL3: view

Function for INSL3 Gene

Molecular function for INSL3 Gene

GENATLAS Biochemistry:
Leydig insulin-like protein 3,member of the insulin-like superfamily
UniProtKB/Swiss-Prot Function:
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
genes like me logo Genes that share phenotypes with INSL3: view

Human Phenotype Ontology for INSL3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for INSL3 Gene

MGI Knock Outs for INSL3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for INSL3 Gene

Localization for INSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSL3 Gene


Subcellular locations from

Jensen Localization Image for INSL3 Gene COMPARTMENTS Subcellular localization image for INSL3 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for INSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with INSL3: view

Pathways & Interactions for INSL3 Gene

genes like me logo Genes that share pathways with INSL3: view

Interacting Proteins for INSL3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000321724 P51460-INSL3_HUMAN for INSL3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for INSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001556 oocyte maturation IEA --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
GO:0007283 spermatogenesis TAS 8253799
GO:0008284 positive regulation of cell proliferation IEA --
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with INSL3: view

No data available for SIGNOR curated interactions for INSL3 Gene

Drugs & Compounds for INSL3 Gene

(8) Drugs for INSL3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for INSL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INSL3: view

Transcripts for INSL3 Gene

Unigene Clusters for INSL3 Gene

Insulin-like 3 (Leydig cell):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INSL3 Gene

No ASD Table

Relevant External Links for INSL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INSL3 Gene

mRNA expression in normal human tissues for INSL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INSL3 Gene

This gene is overexpressed in Testis (x40.1) and Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for INSL3 Gene

This gene is overexpressed in Pancreatic juice (52.1) and Fetal ovary (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INSL3 Gene

SOURCE GeneReport for Unigene cluster for INSL3 Gene Hs.37062

mRNA Expression by UniProt/SwissProt for INSL3 Gene

Tissue specificity: Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast.
genes like me logo Genes that share expression patterns with INSL3: view

Protein tissue co-expression partners for INSL3 Gene

- Elite partner

Primer Products

Orthologs for INSL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for INSL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia INSL3 35
  • 77.61 (n)
  • 70.23 (a)
INSL3 36
  • 41 (a)
(Canis familiaris)
Mammalia INSL3 35
  • 79.44 (n)
  • 72.9 (a)
INSL3 36
  • 63 (a)
(Mus musculus)
Mammalia Insl3 35
  • 68.08 (n)
  • 62.71 (a)
Insl3 16
Insl3 36
  • 30 (a)
(Pan troglodytes)
Mammalia INSL3 35
  • 98.47 (n)
  • 97.71 (a)
INSL3 36
  • 55 (a)
(Rattus norvegicus)
Mammalia Insl3 35
  • 68.31 (n)
  • 60.66 (a)
(Monodelphis domestica)
Mammalia INSL3 36
  • 24 (a)
Species with no ortholog for INSL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INSL3 Gene

Gene Tree for INSL3 (if available)
Gene Tree for INSL3 (if available)

Paralogs for INSL3 Gene

No data available for Paralogs for INSL3 Gene

Variants for INSL3 Gene

Sequence variations from dbSNP and Humsavar for INSL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs186828508 - 17,821,436(+) TGGGC(C/G)CGGGG reference, missense
VAR_013232 -
VAR_013233 -
rs6523 - 17,821,329(-) CTGCG(A/G)CCGGA reference, missense
rs104894697 Cryptorchidism (CRYPTO) 17,816,972(-) GCAGC(C/T)CCTGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for INSL3 Gene

Variant ID Type Subtype PubMed ID
dgv50n68 CNV Loss 17160897
nsv911209 CNV Loss 21882294
dgv3764n71 CNV Loss 21882294
nsv911214 CNV Loss 21882294
nsv911219 CNV Loss 21882294
nsv911220 CNV Loss 21882294
nsv911221 CNV Loss 21882294
dgv3766n71 CNV Loss 21882294

Variation tolerance for INSL3 Gene

Gene Damage Index Score: 0.38; 8.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INSL3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSL3 Gene

Disorders for INSL3 Gene

MalaCards: The human disease database

(12) MalaCards diseases for INSL3 Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • cryptorchism
testicular disease
  • disorder of testis
testicular cancer
  • childhood neoplasm of the testis
sertoli-leydig cell tumor
  • sertoli-leydig cell tumors
- elite association - COSMIC cancer census association via MalaCards
Search INSL3 in MalaCards View complete list of genes associated with diseases


  • Cryptorchidism (CRYPTO) [MIM:219050]: One of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. {ECO:0000269 PubMed:11095425, ECO:0000269 PubMed:11746019, ECO:0000269 PubMed:12601553}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for INSL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with INSL3: view

No data available for Genatlas for INSL3 Gene

Publications for INSL3 Gene

  1. Ala/Thr60 variant of the Leydig insulin-like hormone is not associated with cryptorchidism in the Japanese population. (PMID: 11380919) Takahashi I. … Takada G. (Pediatr. Int. 2001) 3 4 23 48 67
  2. Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY I-L) and chromosomal localization of the human gene (INSL3). (PMID: 8020942) Burkhardt E. … Engel W. (Genomics 1994) 2 3 23
  3. Effect of helix-promoting strategies on the biological activity of novel analogues of the B-chain of INSL3. (PMID: 19067106) Shabanpoor F. … Wade J.D. (Amino Acids 2010) 3 23
  4. INSL3 has tumor-promoting activity in thyroid cancer. (PMID: 19950223) Hombach-Klonisch S. … Klonisch T. (Int. J. Cancer 2010) 3 23
  5. In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme. (PMID: 20082125) Zhang W.J. … Guo Z.Y. (Protein J. 2010) 3 23

Products for INSL3 Gene

Sources for INSL3 Gene