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Aliases for AQP7 Gene

Aliases for AQP7 Gene

  • Aquaporin 7 2 3
  • Aquaglyceroporin-7 3 4
  • Aquaporin Adipose 3 4
  • AQP7L 3 4
  • AQP-7 3 4
  • AQPap 3 4
  • AQP9 3 4
  • Aquaporin-7-Like 4
  • GLYCQTL 3

External Ids for AQP7 Gene

Previous HGNC Symbols for AQP7 Gene

  • AQP7L

Previous GeneCards Identifiers for AQP7 Gene

  • GC09M033697
  • GC09M033554
  • GC09M033374
  • GC09M033341

Summaries for AQP7 Gene

Entrez Gene Summary for AQP7 Gene

  • Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in sperm function. [provided by RefSeq, Jul 2008]

GeneCards Summary for AQP7 Gene

AQP7 (Aquaporin 7) is a Protein Coding gene. Diseases associated with AQP7 include chronic closed-angle glaucoma and meniere's disease. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and glycerol channel activity. An important paralog of this gene is AQP10.

UniProtKB/Swiss-Prot for AQP7 Gene

  • Forms a channel for water and glycerol

Tocris Summary for AQP7 Gene

  • Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.

Gene Wiki entry for AQP7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AQP7 Gene

Genomics for AQP7 Gene

Regulatory Elements for AQP7 Gene

Genomic Location for AQP7 Gene

Chromosome:
9
Start:
33,383,179 bp from pter
End:
33,402,682 bp from pter
Size:
19,504 bases
Orientation:
Minus strand

Genomic View for AQP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AQP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AQP7 Gene

Proteins for AQP7 Gene

  • Protein details for AQP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14520-AQP7_HUMAN
    Recommended name:
    Aquaporin-7
    Protein Accession:
    O14520
    Secondary Accessions:
    • Q08E94
    • Q5T5L9
    • Q8NHM3

    Protein attributes for AQP7 Gene

    Size:
    342 amino acids
    Molecular mass:
    37232 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AQP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AQP7 Gene

Proteomics data for AQP7 Gene at MOPED

Post-translational modifications for AQP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for AQP7 Gene

Domains & Families for AQP7 Gene

Gene Families for AQP7 Gene

HGNC:
IUPHAR :

Protein Domains for AQP7 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O14520

UniProtKB/Swiss-Prot:

AQP7_HUMAN :
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA)
  • Belongs to the MIP/aquaporin (TC 1.A.8) family.
Domain:
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA)
Family:
  • Belongs to the MIP/aquaporin (TC 1.A.8) family.
genes like me logo Genes that share domains with AQP7: view

Function for AQP7 Gene

Molecular function for AQP7 Gene

GENATLAS Biochemistry:
aquaporin 7,water channel forming integral protein,MIP family,expressed in the testis,putatively involved in the formation of late spermatids,also expressed in kidney
UniProtKB/Swiss-Prot Function:
Forms a channel for water and glycerol

Gene Ontology (GO) - Molecular Function for AQP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015204 urea transmembrane transporter activity IBA --
GO:0015250 water channel activity TAS 9405233
GO:0015254 glycerol channel activity EXP --
genes like me logo Genes that share ontologies with AQP7: view
genes like me logo Genes that share phenotypes with AQP7: view

Animal Models for AQP7 Gene

MGI Knock Outs for AQP7:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AQP7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AQP7 Gene

Localization for AQP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AQP7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AQP7 Gene COMPARTMENTS Subcellular localization image for AQP7 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AQP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell --
GO:0005737 cytoplasm IDA 18718702
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9405233
GO:0005911 cell-cell junction IDA 18718702
genes like me logo Genes that share ontologies with AQP7: view

Pathways & Interactions for AQP7 Gene

genes like me logo Genes that share pathways with AQP7: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for AQP7 Gene

Gene Ontology (GO) - Biological Process for AQP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 9405233
GO:0006810 transport --
GO:0006833 water transport TAS --
GO:0007588 excretion TAS 9405233
GO:0009992 cellular water homeostasis IBA --
genes like me logo Genes that share ontologies with AQP7: view

No data available for SIGNOR curated interactions for AQP7 Gene

Drugs & Compounds for AQP7 Gene

(3) Drugs for AQP7 Gene - From: IUPHAR, DGIdb, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Forskolin Experimental Pharma 0
Glycerol Experimental Pharma 176
Hg<sup>2+</sup> Pharma Inhibitor 0
genes like me logo Genes that share compounds with AQP7: view

Transcripts for AQP7 Gene

Unigene Clusters for AQP7 Gene

Aquaporin 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AQP7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AQP7 Gene

No ASD Table

Relevant External Links for AQP7 Gene

GeneLoc Exon Structure for
AQP7
ECgene alternative splicing isoforms for
AQP7

Expression for AQP7 Gene

mRNA expression in normal human tissues for AQP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AQP7 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x12.2), Adipose - Subcutaneous (x9.0), Heart - Left Ventricle (x7.5), and Breast - Mammary Tissue (x6.1).

Protein differential expression in normal tissues from HIPED for AQP7 Gene

This gene is overexpressed in Testis (23.3), Fetal ovary (10.8), Urine (9.6), Heart (8.6), Fetal gut (6.9), and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AQP7 Gene



SOURCE GeneReport for Unigene cluster for AQP7 Gene Hs.455323

genes like me logo Genes that share expression patterns with AQP7: view

Protein tissue co-expression partners for AQP7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AQP7 Gene

Orthologs for AQP7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AQP7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AQP7 35
  • 78.05 (n)
  • 71.34 (a)
AQP7 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AQP7 35
  • 80.65 (n)
  • 73.61 (a)
AQP7 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aqp7 35
  • 78.45 (n)
  • 76.33 (a)
Aqp7 16
Aqp7 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aqp7 35
  • 79.29 (n)
  • 76.89 (a)
oppossum
(Monodelphis domestica)
Mammalia AQP7 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AQP7 36
  • 40 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AQP7 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves AQP7 35
  • 63.29 (n)
  • 59.14 (a)
AQP7 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia aqp7 35
  • 57.76 (n)
  • 54.15 (a)
zebrafish
(Danio rerio)
Actinopterygii aqp7 35
  • 59.81 (n)
  • 55.24 (a)
aqp7 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M02F4.8 37
  • 36 (a)
Y69E1A.7 37
  • 38 (a)
aqp-1 36
  • 30 (a)
ManyToMany
aqp-2 36
  • 36 (a)
ManyToMany
aqp-3 36
  • 25 (a)
ManyToMany
aqp-7 36
  • 31 (a)
ManyToMany
aqp-8 36
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 17 (a)
OneToMany
Species with no ortholog for AQP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AQP7 Gene

ENSEMBL:
Gene Tree for AQP7 (if available)
TreeFam:
Gene Tree for AQP7 (if available)

Paralogs for AQP7 Gene

Paralogs for AQP7 Gene

Pseudogenes.org Pseudogenes for AQP7 Gene

genes like me logo Genes that share paralogs with AQP7: view

Variants for AQP7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for AQP7 Gene

O14520-AQP7_HUMAN
Genetic variations in AQP7 are responsible for changes in glycerol release during exercise and define the glycerol quantitative trait locus (GLYCQTL) [MIM:614411]

Sequence variations from dbSNP and Humsavar for AQP7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3569 -- 33,385,167(+) ACAGA(A/G)TCCTC synonymous-codon, reference, missense
rs13434 -- 33,384,979(-) CATCC(A/C)TTCCC utr-variant-3-prime
rs138917677 -- 33,396,225(+) CTGAG(A/G)TCGGG intron-variant, upstream-variant-2KB
rs138745598 -- 33,387,087(+) AGGCC(A/G)AATAC reference, synonymous-codon, utr-variant-5-prime
rs138333398 -- 33,397,836(+) GGAAG(C/T)CTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AQP7 Gene

Variant ID Type Subtype PubMed ID
nsv8439 CNV Loss 18304495
nsv482129 CNV Gain 20164927

Variation tolerance for AQP7 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AQP7 Gene

HapMap Linkage Disequilibrium report
AQP7
Human Gene Mutation Database (HGMD)
AQP7

Disorders for AQP7 Gene

MalaCards: The human disease database

(4) MalaCards diseases for AQP7 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
chronic closed-angle glaucoma
  • anatomical narrow angle glaucoma
meniere's disease
  • meniere disease
diabetes insipidus, nephrogenic
  • nephrogenic diabetes insipidus
obesity
  • obesity, association with
- elite association
Search AQP7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AQP7

Genetic Association Database (GAD)
AQP7
Human Genome Epidemiology (HuGE) Navigator
AQP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AQP7
genes like me logo Genes that share disorders with AQP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AQP7 Gene

Publications for AQP7 Gene

  1. AQP1 mediates water transport in the carotid body. (PMID: 20049482) MuA+oz-Cabello A.M. … EchevarrA-a M. (Pflugers Arch. 2010) 23 67
  2. Insulin-mediated regulation of decidual protein induced by progesterone (DEPP) in adipose tissue and liver. (PMID: 19937567) Kuroda Y. … Shimomura I. (Horm. Metab. Res. 2010) 23 67
  3. Aquaporins as potential drug targets for Meniere's disease and its related diseases. (PMID: 19096777) Takeda T. … Taguchi D. (Handb Exp Pharmacol 2009) 23 67
  4. Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity: relationship with glucose abnormalities. (PMID: 19615702) Miranda M. … Vendrell J. (Metab. Clin. Exp. 2009) 23 67
  5. Role of aquaporin-7 and aquaporin-9 in glycerol metabolism; involvement in obesity. (PMID: 19096781) Maeda N. … Funahashi T. (Handb Exp Pharmacol 2009) 23 67

Products for AQP7 Gene

Sources for AQP7 Gene

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