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Aliases for INHBB Gene

Aliases for INHBB Gene

  • Inhibin, Beta B 2 3
  • Inhibin, Beta B (Activin AB Beta Polypeptide) 2
  • Activin Beta-B Chain 4

External Ids for INHBB Gene

Previous GeneCards Identifiers for INHBB Gene

  • GC02P118308
  • GC02P119023
  • GC02P121009
  • GC02P121198
  • GC02P120819
  • GC02P113427

Summaries for INHBB Gene

Entrez Gene Summary for INHBB Gene

  • The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq, Jul 2008]

GeneCards Summary for INHBB Gene

INHBB (Inhibin, Beta B) is a Protein Coding gene. Diseases associated with INHBB include varicocele and ectopic pregnancy. Among its related pathways are Signaling by GPCR and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is INHBE.

UniProtKB/Swiss-Prot for INHBB Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHBB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INHBB Gene

Genomics for INHBB Gene

Regulatory Elements for INHBB Gene

Genomic Location for INHBB Gene

Start:
120,346,143 bp from pter
End:
120,351,808 bp from pter
Size:
5,666 bases
Orientation:
Plus strand

Genomic View for INHBB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INHBB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHBB Gene

Proteins for INHBB Gene

  • Protein details for INHBB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09529-INHBB_HUMAN
    Recommended name:
    Inhibin beta B chain
    Protein Accession:
    P09529
    Secondary Accessions:
    • Q53T31
    • Q8N1D3

    Protein attributes for INHBB Gene

    Size:
    407 amino acids
    Molecular mass:
    45122 Da
    Quaternary structure:
    • Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.

neXtProt entry for INHBB Gene

Proteomics data for INHBB Gene at MOPED

Post-translational modifications for INHBB Gene

  • Glycosylation at Asn93
  • Modification sites at PhosphoSitePlus

Other Protein References for INHBB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for INHBB Gene

Domains for INHBB Gene

Gene Families for INHBB Gene

HGNC:

Suggested Antigen Peptide Sequences for INHBB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09529

UniProtKB/Swiss-Prot:

INHBB_HUMAN :
  • P09529
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with INHBB: view

Function for INHBB Gene

Molecular function for INHBB Gene

GENATLAS Biochemistry: inhibin,beta B subunit,dimerizing with INHBA,homodimerizing to form activin B,heterodimerizing with INHBA or INHA to form activin AB or inhibitin B,respectively
UniProtKB/Swiss-Prot Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins

LifeMap Function Summary for INHBB Gene

Gene Ontology (GO) - Molecular Function for INHBB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 3122219
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005179 hormone activity TAS 3122219
GO:0005515 protein binding IPI 12697670
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with INHBB: view
genes like me logo Genes that share phenotypes with INHBB: view

Animal Models for INHBB Gene

MGI Knock Outs for INHBB:

miRNA for INHBB Gene

miRTarBase miRNAs that target INHBB

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for INHBB Gene

Localization for INHBB Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHBB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INHBB Gene COMPARTMENTS Subcellular localization image for INHBB gene
Compartment Confidence
extracellular 5
cytosol 1
golgi apparatus 1
lysosome 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for INHBB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 3122219
GO:0005615 extracellular space IBA --
GO:0048471 perinuclear region of cytoplasm IDA 16650820
genes like me logo Genes that share ontologies with INHBB: view

Pathways for INHBB Gene

genes like me logo Genes that share pathways with INHBB: view

Pathways by source for INHBB Gene

1 Sino Biological pathway for INHBB Gene
1 BioSystems pathway for INHBB Gene
1 GeneGo (Thomson Reuters) pathway for INHBB Gene

Gene Ontology (GO) - Biological Process for INHBB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development NAS 12790766
GO:0006952 defense response TAS 3122219
GO:0009267 cellular response to starvation ISS --
GO:0009612 response to mechanical stimulus IDA 10320815
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA --
genes like me logo Genes that share ontologies with INHBB: view

Compounds for INHBB Gene

(1) Novoseek inferred chemical compound relationships for INHBB Gene

Compound -log(P) Hits PubMed IDs
gnrh 11.8 1
genes like me logo Genes that share compounds with INHBB: view

Transcripts for INHBB Gene

mRNA/cDNA for INHBB Gene

(46) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INHBB Gene

Inhibin, beta B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INHBB Gene

No ASD Table

Relevant External Links for INHBB Gene

GeneLoc Exon Structure for
INHBB
ECgene alternative splicing isoforms for
INHBB

Expression for INHBB Gene

mRNA expression in normal human tissues for INHBB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INHBB Gene

This gene is overexpressed in Adipose - Subcutaneous (6.8), Breast - Mammary Tissue (4.7), and Adipose - Visceral (Omentum) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for INHBB Gene

SOURCE GeneReport for Unigene cluster for INHBB Gene Hs.1735

genes like me logo Genes that share expressions with INHBB: view

No data available for mRNA Expression by UniProt/SwissProt for INHBB Gene

Orthologs for INHBB Gene

This gene was present in the common ancestor of animals.

Orthologs for INHBB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INHBB 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INHBB 35
  • 90.91 (n)
  • 94.84 (a)
INHBB 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INHBB 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inhbb 35
  • 90.34 (n)
  • 97.3 (a)
Inhbb 16
Inhbb 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INHBB 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inhbb 35
  • 90.99 (n)
  • 97.54 (a)
chicken
(Gallus gallus)
Aves INHBB 35
  • 79.44 (n)
  • 89.58 (a)
INHBB 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INHBB 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1090 35
zebrafish
(Danio rerio)
Actinopterygii inhbb 35
  • 70.53 (n)
  • 72.88 (a)
inhbb 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Actbeta 36
  • 12 (a)
OneToMany
activin-bgr 37
  • 30 (a)
Species with no ortholog for INHBB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INHBB Gene

ENSEMBL:
Gene Tree for INHBB (if available)
TreeFam:
Gene Tree for INHBB (if available)

Paralogs for INHBB Gene

Paralogs for INHBB Gene

Selected SIMAP similar genes for INHBB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INHBB: view

Variants for INHBB Gene

Sequence variations from dbSNP and Humsavar for INHBB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs4328642 -- 120,349,274(+) GGCCA(C/T)GGTGA reference, synonymous-codon
rs5833831 -- 120,348,678(+) AAAAA(-/A)GCCCT intron-variant
rs7566379 -- 120,349,030(+) GCAGA(C/G)AGTGT intron-variant
rs7568413 -- 120,352,036(+) GTTTA(C/T)CCTGC downstream-variant-500B
rs7578624 -- 120,344,903(+) AGGTA(C/G)GGACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for INHBB Gene

Variant ID Type Subtype PubMed ID
nsv829640 CNV Loss 20364138
nsv874969 CNV Loss 21882294
nsv874970 CNV Loss 21882294
nsv829641 CNV Gain 20364138

Relevant External Links for INHBB Gene

HapMap Linkage Disequilibrium report
INHBB
Human Gene Mutation Database (HGMD)
INHBB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INHBB Gene

Disorders for INHBB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for INHBB Gene including...

Search for INHBB Gene in MalaCards »

(2) Novoseek inferred disease relationships for INHBB Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2
cancer 0 1

Relevant External Links for INHBB

Genetic Association Database (GAD)
INHBB
Human Genome Epidemiology (HuGE) Navigator
INHBB
genes like me logo Genes that share disorders with INHBB: view

No data available for UniProtKB/Swiss-Prot for INHBB Gene

Publications for INHBB Gene

  1. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue M.P. … McGlynn K.A. (Cancer Res. 2008) 3 23 48
  2. The expression of inhibin beta B is high in human adipocytes, reduced by weight loss, and correlates to factors implicated in metabolic disease. (PMID: 16650820) SjAPholm K. … Carlsson L.M. (Biochem. Biophys. Res. Commun. 2006) 3 23
  3. Development of a new antibody to the human inhibin/activin betaB subunit and its application to improved inhibin B ELISAs. (PMID: 17991484) Ludlow H. … Groome N.P. (J. Immunol. Methods 2008) 3 23
  4. Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis. (PMID: 11344232) Salmenkivi K. … Liu J. (J. Clin. Endocrinol. Metab. 2001) 3 23
  5. Inhibin: definition and nomenclature, including related substances. (PMID: 3345731) Burger H.G. … Igarashi M. (Endocrinology 1988) 2 3

Products for INHBB Gene

Sources for INHBB Gene

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