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Aliases for INHBB Gene

Aliases for INHBB Gene

  • Inhibin Beta B Subunit 2 3 5
  • Inhibin, Beta B (Activin AB Beta Polypeptide) 2
  • Activin Beta-B Chain 4
  • Inhibin, Beta B 2

External Ids for INHBB Gene

Previous GeneCards Identifiers for INHBB Gene

  • GC02P118308
  • GC02P119023
  • GC02P121009
  • GC02P121198
  • GC02P120819
  • GC02P113427

Summaries for INHBB Gene

Entrez Gene Summary for INHBB Gene

  • This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016]

GeneCards Summary for INHBB Gene

INHBB (Inhibin Beta B Subunit) is a Protein Coding gene. Diseases associated with INHBB include Eclampsia and Pre-Eclampsia. Among its related pathways are TGF-beta signaling pathway (KEGG) and Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is INHBA.

UniProtKB/Swiss-Prot for INHBB Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene Wiki entry for INHBB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INHBB Gene

Genomics for INHBB Gene

Regulatory Elements for INHBB Gene

Enhancers for INHBB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G120565 0.9 ENCODE dbSUPER 11.2 +220.5 220506 1.8 SOX5 SOX13 CTCF HMG20A ATF2 RARA TCF7 KDM1A SMAD4 HNRNPL INHBB GLI2 GC02M120575 ENSG00000232140
GH02G120396 1.3 FANTOM5 ENCODE 5 +52.9 52915 5.7 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ZBTB7B SLC30A9 FOS INHBB GC02M120397 GC02M120375
GH02G120343 0.9 ENCODE 0.7 -2.6 -2564 0.2 ELF3 RB1 ARID4B THRB ZNF48 RAD21 RARA GLIS2 ZNF143 EGR2 INHBB LOC105373989
GH02G120372 0.8 ENCODE 0.3 +27.6 27579 1.7 HDGF ARNT YBX1 PLRG1 ZBTB40 TCF12 ZNF207 ZNF114 ZNF662 SP1 MTCO3P43 GC02M120375 INHBB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INHBB on UCSC Golden Path with GeneCards custom track

Promoters for INHBB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000122466 -443 601 ZNF263 RNF2 SUZ12 CHD1 ZMYM3 CBX2 ZBTB8A RBBP5 E2F1 BCL6

Genomic Location for INHBB Gene

Chromosome:
2
Start:
120,346,143 bp from pter
End:
120,351,808 bp from pter
Size:
5,666 bases
Orientation:
Plus strand

Genomic View for INHBB Gene

Genes around INHBB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INHBB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INHBB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHBB Gene

Proteins for INHBB Gene

  • Protein details for INHBB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09529-INHBB_HUMAN
    Recommended name:
    Inhibin beta B chain
    Protein Accession:
    P09529
    Secondary Accessions:
    • Q53T31
    • Q8N1D3

    Protein attributes for INHBB Gene

    Size:
    407 amino acids
    Molecular mass:
    45122 Da
    Quaternary structure:
    • Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.

neXtProt entry for INHBB Gene

Post-translational modifications for INHBB Gene

  • Glycosylation at isoforms=93
  • Modification sites at PhosphoSitePlus

Other Protein References for INHBB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for INHBB Gene

Domains & Families for INHBB Gene

Gene Families for INHBB Gene

Suggested Antigen Peptide Sequences for INHBB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09529

UniProtKB/Swiss-Prot:

INHBB_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with INHBB: view

Function for INHBB Gene

Molecular function for INHBB Gene

GENATLAS Biochemistry:
inhibin,beta B subunit,dimerizing with INHBA,homodimerizing to form activin B,heterodimerizing with INHBA or INHA to form activin AB or inhibitin B,respectively
UniProtKB/Swiss-Prot Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene Ontology (GO) - Molecular Function for INHBB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 3122219
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005179 hormone activity TAS 3122219
GO:0005515 protein binding IPI 2575216
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with INHBB: view
genes like me logo Genes that share phenotypes with INHBB: view

Animal Models for INHBB Gene

MGI Knock Outs for INHBB:

Animal Model Products

CRISPR Products

miRNA for INHBB Gene

miRTarBase miRNAs that target INHBB

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INHBB Gene

Localization for INHBB Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHBB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INHBB gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for INHBB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 3122219
GO:0005615 extracellular space IBA,IEA --
GO:0048471 perinuclear region of cytoplasm IDA 16650820
GO:0071944 cell periphery IEA --
genes like me logo Genes that share ontologies with INHBB: view

Pathways & Interactions for INHBB Gene

genes like me logo Genes that share pathways with INHBB: view

Gene Ontology (GO) - Biological Process for INHBB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development NAS 12790766
GO:0006952 defense response TAS 3122219
GO:0009267 cellular response to starvation IEA,ISS --
GO:0009612 response to mechanical stimulus IDA 10320815
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA --
genes like me logo Genes that share ontologies with INHBB: view

No data available for SIGNOR curated interactions for INHBB Gene

Drugs & Compounds for INHBB Gene

(1) Additional Compounds for INHBB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INHBB: view

Transcripts for INHBB Gene

mRNA/cDNA for INHBB Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INHBB Gene

Inhibin, beta B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INHBB Gene

No ASD Table

Relevant External Links for INHBB Gene

GeneLoc Exon Structure for
INHBB
ECgene alternative splicing isoforms for
INHBB

Expression for INHBB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INHBB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INHBB Gene

This gene is overexpressed in Adipose - Subcutaneous (x6.8), Breast - Mammary Tissue (x4.7), and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for INHBB Gene

This gene is overexpressed in Rectum (15.7), Prostate (14.9), Testis (14.8), Lung (10.8), and Urinary Bladder (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for INHBB Gene



Protein tissue co-expression partners for INHBB Gene

NURSA nuclear receptor signaling pathways regulating expression of INHBB Gene:

INHBB

SOURCE GeneReport for Unigene cluster for INHBB Gene:

Hs.1735

Evidence on tissue expression from TISSUES for INHBB Gene

  • Nervous system(4.5)
  • Stomach(3.2)
  • Heart(2.7)
  • Kidney(2.5)
  • Intestine(2.4)
  • Muscle(2.4)
  • Liver(2)
genes like me logo Genes that share expression patterns with INHBB: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INHBB Gene

Orthologs for INHBB Gene

This gene was present in the common ancestor of animals.

Orthologs for INHBB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INHBB 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INHBB 35
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inhbb 34
  • 90.99 (n)
cow
(Bos Taurus)
Mammalia INHBB 34 35
  • 90.91 (n)
mouse
(Mus musculus)
Mammalia Inhbb 34 16 35
  • 90.34 (n)
oppossum
(Monodelphis domestica)
Mammalia INHBB 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves INHBB 34 35
  • 79.44 (n)
lizard
(Anolis carolinensis)
Reptilia INHBB 35
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1090 34
zebrafish
(Danio rerio)
Actinopterygii inhbb 34 35
  • 70.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta activin-bgr 36
  • 30 (a)
Actbeta 35
  • 12 (a)
OneToMany
Species where no ortholog for INHBB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INHBB Gene

ENSEMBL:
Gene Tree for INHBB (if available)
TreeFam:
Gene Tree for INHBB (if available)

Paralogs for INHBB Gene

Paralogs for INHBB Gene

(4) SIMAP similar genes for INHBB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INHBB: view

Variants for INHBB Gene

Sequence variations from dbSNP and Humsavar for INHBB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000200391 -- 120,346,279(+) CACCC(A/C)CGCCC downstream-variant-500B, reference, missense
rs1000606272 -- 120,351,918(+) GGCCT(A/G)CTCCT downstream-variant-500B
rs1000829657 -- 120,347,611(+) ACTGC(C/G)GAGAA intron-variant
rs1001095566 -- 120,349,462(+) AGAGT(C/T)GCACC reference, missense
rs1001218969 -- 120,346,936(+) GGCAG(A/G)TGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INHBB Gene

Variant ID Type Subtype PubMed ID
nsv1126562 CNV deletion 24896259
nsv1143957 CNV deletion 24896259
nsv582786 CNV loss 21841781
nsv582787 CNV loss 21841781
nsv829640 CNV loss 20364138
nsv829641 CNV gain 20364138
nsv954803 CNV deletion 24416366

Variation tolerance for INHBB Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.05; 80.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INHBB Gene

Human Gene Mutation Database (HGMD)
INHBB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INHBB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INHBB Gene

Disorders for INHBB Gene

MalaCards: The human disease database

(3) MalaCards diseases for INHBB Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
eclampsia
  • eclampsia in puerperium
pre-eclampsia
  • preeclampsia
epididymo-orchitis
- elite association - COSMIC cancer census association via MalaCards
Search INHBB in MalaCards View complete list of genes associated with diseases

Relevant External Links for INHBB

Genetic Association Database (GAD)
INHBB
Human Genome Epidemiology (HuGE) Navigator
INHBB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INHBB
genes like me logo Genes that share disorders with INHBB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INHBB Gene

Publications for INHBB Gene

  1. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue M.P. … McGlynn K.A. (Cancer Res. 2008) 3 22 46 64
  2. A genome-wide association study on obesity and obesity-related traits. (PMID: 21552555) Wang K. … Price R.A. (PLoS ONE 2011) 3 46 64
  3. Family-based analysis of candidate genes for polycystic ovary syndrome. (PMID: 20200332) Ewens K.G. … Spielman R.S. (J. Clin. Endocrinol. Metab. 2010) 3 46 64
  4. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PMID: 20634197) Canzian F. … Feigelson H.S. (Hum. Mol. Genet. 2010) 3 46 64
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64

Products for INHBB Gene

Sources for INHBB Gene

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