Aliases for ING1 Gene
External Ids for ING1 Gene
Previous GeneCards Identifiers for ING1 Gene
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for ING1 Gene
ING1 (Inhibitor Of Growth Family, Member 1) is a Protein Coding gene. Diseases associated with ING1 include squamous cell carcinoma, head and neck and hepatocellular carcinoma. Among its related pathways are Senescence and Autophagy. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is ING4.
UniProtKB/Swiss-Prot for ING1 Gene
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.