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Aliases for ING1 Gene

Aliases for ING1 Gene

  • Inhibitor Of Growth Family, Member 1 2 3
  • Growth Inhibitory Protein ING1 2 3
  • Tumor Suppressor ING1 2 3
  • Growth Inhibitor ING1 2 3
  • Inhibitor Of Growth Protein 1 3
  • Inhibitor Of Growth 1 2
  • P24ING1c 3
  • P33ING1b 3
  • P47ING1a 3
  • P33ING1 3
  • P33 3
  • P47 3

External Ids for ING1 Gene

Summaries for ING1 Gene

Entrez Gene Summary for ING1 Gene

  • This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for ING1 Gene

ING1 (Inhibitor Of Growth Family, Member 1) is a Protein Coding gene. Diseases associated with ING1 include squamous cell carcinoma, head and neck and hepatocellular carcinoma. Among its related pathways are Senescence and Autophagy. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is ING4.

UniProtKB/Swiss-Prot for ING1 Gene

  • Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Gene Wiki entry for ING1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ING1 Gene

Genomics for ING1 Gene

Genomic Location for ING1 Gene

Start:
110,712,623 bp from pter
End:
110,723,339 bp from pter
Size:
10,717 bases
Orientation:
Plus strand

Genomic View for ING1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ING1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ING1 Gene

Regulatory Elements for ING1 Gene

Proteins for ING1 Gene

  • Protein details for ING1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK53-ING1_HUMAN
    Recommended name:
    Inhibitor of growth protein 1
    Protein Accession:
    Q9UK53
    Secondary Accessions:
    • O00532
    • O43658
    • Q53ZR3
    • Q5T9G8
    • Q5T9G9
    • Q5T9H0
    • Q5T9H1
    • Q9H007
    • Q9HD98
    • Q9HD99
    • Q9NS83
    • Q9P0U6
    • Q9UBC6
    • Q9UIJ1
    • Q9UIJ2
    • Q9UIJ3
    • Q9UIJ4
    • Q9UK52

    Protein attributes for ING1 Gene

    Size:
    422 amino acids
    Molecular mass:
    46738 Da
    Quaternary structure:
    • Interacts with H3K4me3 and to a lesser extent with H3K4me2. Interacts with TP53. Isoform 2 interacts with RSL1D1.
    SequenceCaution:
    • Sequence=AAB60879.1; Type=Frameshift; Positions=149; Evidence={ECO:0000305}; Sequence=AAG02579.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ING1 Gene

    Alternative splice isoforms for ING1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ING1 Gene

Proteomics data for ING1 Gene at MOPED

Post-translational modifications for ING1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ING1 Gene

Domains for ING1 Gene

Gene Families for ING1 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

UniProtKB/Swiss-Prot:

ING1_HUMAN
Domain:
  • The PHD-type zinc finger mediates the binding to H3K4me3.:
    • Q9UK53
  • The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).:
    • Q9UK53
Family:
  • Belongs to the ING family.:
    • Q9UK53
Similarity:
  • Contains 1 PHD-type zinc finger.:
    • Q9UK53
genes like me logo Genes that share domains with ING1: view

Function for ING1 Gene

Molecular function for ING1 Gene

GENATLAS Biochemistry: inhibitor of cell growth 1,located in the nucleus,underexpressed in breast cancer and neuroblastoma cells
UniProtKB/Swiss-Prot Function: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Gene Ontology (GO) - Molecular Function for ING1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18388957
GO:0008270 zinc ion binding IEA --
GO:0035064 methylated histone binding IDA 16728974
genes like me logo Genes that share ontologies with ING1: view
genes like me logo Genes that share phenotypes with ING1: view

Animal Models for ING1 Gene

MGI Knock Outs for ING1:

miRNA for ING1 Gene

miRTarBase miRNAs that target ING1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ING1 Gene

Localization for ING1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ING1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ING1 Gene COMPARTMENTS Subcellular localization image for ING1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ING1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10866301
genes like me logo Genes that share ontologies with ING1: view

Pathways for ING1 Gene

SuperPathways for ING1 Gene

Superpath Contained pathways
1 Senescence and Autophagy
genes like me logo Genes that share pathways with ING1: view

Pathways by source for ING1 Gene

1 BioSystems pathway for ING1 Gene

Gene Ontology (GO) - Biological Process for ING1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA --
GO:0007049 cell cycle IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0010941 regulation of cell death IEA --
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with ING1: view

Compounds for ING1 Gene

(5) Novoseek inferred chemical compound relationships for ING1 Gene

Compound -log(P) Hits PubMed IDs
etoposide 14.9 2
zinc 0 1
estrogen 0 12
cisplatin 0 4
paclitaxel 0 5
genes like me logo Genes that share compounds with ING1: view

Transcripts for ING1 Gene

Unigene Clusters for ING1 Gene

Inhibitor of growth family, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ING1 Gene

No ASD Table

Relevant External Links for ING1 Gene

GeneLoc Exon Structure for
ING1
ECgene alternative splicing isoforms for
ING1

Expression for ING1 Gene

mRNA expression in normal human tissues for ING1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ING1 Gene

SOURCE GeneReport for Unigene cluster for ING1 Gene Hs.46700

mRNA Expression by UniProt/SwissProt for ING1 Gene

Q9UK53-ING1_HUMAN
Tissue specificity: Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.
genes like me logo Genes that share expressions with ING1: view

Orthologs for ING1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ING1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ING1 36
  • 99.64 (n)
  • 100 (a)
ING1 37
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ING1 36
  • 87.41 (n)
  • 89.21 (a)
ING1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 77 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
ING1 36
  • 82.68 (n)
  • 89.96 (a)
mouse
(Mus musculus)
Mammalia Ing1 36
  • 85.78 (n)
  • 90.32 (a)
Ing1 16
Ing1 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ING1 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ING1 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ing1 36
  • 84.47 (n)
  • 89.25 (a)
chicken
(Gallus gallus)
Aves ING1 36
  • 75.32 (n)
  • 87.23 (a)
ING1 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ING1 37
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ing1 36
  • 73.12 (n)
  • 83.15 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2460 36
zebrafish
(Danio rerio)
Actinopterygii ing1 36
  • 67.5 (n)
  • 68.46 (a)
ing1 37
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7379 36
  • 59.9 (n)
  • 47.4 (a)
CG7379 37
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO23 37
  • 20 (a)
OneToMany
PHO23 39
corn
(Zea mays)
Liliopsida Zm.8482 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10422 37
  • 29 (a)
OneToMany
Species with no ortholog for ING1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ING1 Gene

ENSEMBL:
Gene Tree for ING1 (if available)
TreeFam:
Gene Tree for ING1 (if available)

Paralogs for ING1 Gene

Paralogs for ING1 Gene

Selected SIMAP similar genes for ING1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ING1 Gene

genes like me logo Genes that share paralogs with ING1: view

Variants for ING1 Gene

Sequence variations from dbSNP and Humsavar for ING1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1061386 -- 110,721,021(+) Ttgaa(C/G)attat utr-variant-3-prime
rs1063195 -- 110,720,438(+) GTAAA(A/T)GGTTA utr-variant-3-prime
rs1063196 -- 110,720,638(+) CTTGT(A/T)ATATT utr-variant-3-prime
rs1063197 -- 110,720,674(+) GCTGT(C/T)GTGAA utr-variant-3-prime
rs2119479 -- 110,718,834(+) AAATG(A/C)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ING1 Gene

Variant ID Type Subtype PubMed ID
nsv901014 CNV Loss 21882294

Relevant External Links for ING1 Gene

HapMap Linkage Disequilibrium report
ING1

Disorders for ING1 Gene

(1) OMIM Diseases for ING1 Gene (601566)

UniProtKB/Swiss-Prot

ING1_HUMAN
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. {ECO:0000269 PubMed:10866301}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(20) Novoseek inferred disease relationships for ING1 Gene

Disease -log(P) Hits PubMed IDs
tumors 54.8 105
allelic loss 46.2 1
melanoma 32.3 25
cancer 29.7 17
glioma 29.1 16

Relevant External Links for ING1

Genetic Association Database (GAD)
ING1
Human Genome Epidemiology (HuGE) Navigator
ING1
genes like me logo Genes that share disorders with ING1: view

Publications for ING1 Gene

  1. Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. (PMID: 8944021) Garkavtsev I.A. … Riabowol K. (Nat. Genet. 1996) 2 3 4 23
  2. Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1). (PMID: 9186514) Garkavtsev I. … Riabowol K. (Cytogenet. Cell Genet. 1997) 2 3 23
  3. The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control. (PMID: 9440695) Garkavtsev I.A. … Gudkov A.V. (Nature 1998) 3 4 23
  4. Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene. (PMID: 10626813) Jaeger D. … Chen Y.-T. (Cancer Res. 1999) 3 4 23
  5. Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. (PMID: 10866301) Gunduz M. … Shimizu K. (Cancer Res. 2000) 3 4 23

Products for ING1 Gene

Sources for ING1 Gene

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