Aliases for ING1 Gene
External Ids for ING1 Gene
Previous GeneCards Identifiers for ING1 Gene
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for ING1 Gene
ING1 (Inhibitor Of Growth Family, Member 1) is a Protein Coding gene. Diseases associated with ING1 include squamous cell carcinoma, head and neck and fibrosarcoma of bone. Among its related pathways are Chromatin Regulation / Acetylation and Senescence and Autophagy. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is ING4.
UniProtKB/Swiss-Prot for ING1 Gene
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.