Free for academic non-profit institutions. Other users need a Commercial license

Aliases for INCENP Gene

Aliases for INCENP Gene

  • Inner Centromere Protein 2 3 5
  • Inner Centromere Protein Antigens (135kD, 155kD) 2
  • Inner Centromere Protein Antigens 135/155kDa 2

External Ids for INCENP Gene

Previous GeneCards Identifiers for INCENP Gene

  • GC11U990069
  • GC11P063467
  • GC11P061666
  • GC11P061648
  • GC11P061891
  • GC11P058219

Summaries for INCENP Gene

Entrez Gene Summary for INCENP Gene

  • In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INCENP Gene

INCENP (Inner Centromere Protein) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases.

UniProtKB/Swiss-Prot for INCENP Gene

  • Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1.

Gene Wiki entry for INCENP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INCENP Gene

Genomics for INCENP Gene

Regulatory Elements for INCENP Gene

Promoters for INCENP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around INCENP on UCSC Golden Path with GeneCards custom track

Genomic Location for INCENP Gene

Chromosome:
11
Start:
62,123,973 bp from pter
End:
62,153,163 bp from pter
Size:
29,191 bases
Orientation:
Plus strand

Genomic View for INCENP Gene

Genes around INCENP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INCENP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INCENP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INCENP Gene

Proteins for INCENP Gene

  • Protein details for INCENP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQS7-INCE_HUMAN
    Recommended name:
    Inner centromere protein
    Protein Accession:
    Q9NQS7
    Secondary Accessions:
    • A8MQD2
    • Q5Y192

    Protein attributes for INCENP Gene

    Size:
    918 amino acids
    Molecular mass:
    105429 Da
    Quaternary structure:
    • Homodimer or heterodimer. Interacts with H2AFZ (By similarity). Interacts with CBX3. Interacts with tubulin beta chain. Interacts with AURKB and AURKC. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with EVI5. Interacts with CDCA8 and BIRC5; interaction is direct. Interacts with CBX5; POGZ and INCENP compete for interaction with CBX5. Interacts with POGZ. Interacts with JTB.

    Three dimensional structures from OCA and Proteopedia for INCENP Gene

    Alternative splice isoforms for INCENP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INCENP Gene

Proteomics data for INCENP Gene at MOPED

Post-translational modifications for INCENP Gene

  • Phosphorylation by AURKB at its C-terminal part is important for AURKB activation by INCENP.
  • Ubiquitination at Lys 51, Lys 321, and Lys 602
  • Modification sites at PhosphoSitePlus

Other Protein References for INCENP Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for INCENP (INCENP)

No data available for DME Specific Peptides for INCENP Gene

Domains & Families for INCENP Gene

Protein Domains for INCENP Gene

Suggested Antigen Peptide Sequences for INCENP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQS7

UniProtKB/Swiss-Prot:

INCE_HUMAN :
  • Belongs to the INCENP family.
Family:
  • Belongs to the INCENP family.
genes like me logo Genes that share domains with INCENP: view

No data available for Gene Families for INCENP Gene

Function for INCENP Gene

Molecular function for INCENP Gene

UniProtKB/Swiss-Prot Function:
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1.
genes like me logo Genes that share phenotypes with INCENP: view

Animal Models for INCENP Gene

MGI Knock Outs for INCENP:

Animal Model Products

miRNA for INCENP Gene

miRTarBase miRNAs that target INCENP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INCENP Gene

Localization for INCENP Gene

Subcellular locations from UniProtKB/Swiss-Prot for INCENP Gene

Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome, centromere, kinetochore. Note=Colocalized at synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocenters. Colocalizes with AURKB at a connecting strand traversing the centromere region and joining sister kinetochores, in metaphase II centromeres. This strand disappears at the metaphase II/anaphase II transition and relocalizes to the spindle midzone (By similarity). Colocalizes with AURKB at mitotic chromosomes (PubMed:11453556). Localizes to inner kinetochore (PubMed:16760428). Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:15316025). Cocalizes to the equatorial cell cortex at anaphase (PubMed:11453556). {ECO:0000250 UniProtKB:Q9WU62, ECO:0000269 PubMed:11453556, ECO:0000269 PubMed:15316025, ECO:0000269 PubMed:16760428}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INCENP Gene COMPARTMENTS Subcellular localization image for INCENP gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for INCENP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000795 synaptonemal complex IEA --
GO:0000801 central element IEA --
GO:0005654 nucleoplasm TAS --
GO:0005721 pericentric heterochromatin IDA 9864353
genes like me logo Genes that share ontologies with INCENP: view

Pathways & Interactions for INCENP Gene

genes like me logo Genes that share pathways with INCENP: view

SIGNOR curated interactions for INCENP Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for INCENP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0016925 protein sumoylation TAS --
genes like me logo Genes that share ontologies with INCENP: view

Drugs & Compounds for INCENP Gene

(4) Drugs for INCENP Gene - From: Novoseek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine Experimental Pharma Target 0
genes like me logo Genes that share compounds with INCENP: view

Transcripts for INCENP Gene

Unigene Clusters for INCENP Gene

Inner centromere protein antigens 135/155kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INCENP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b
SP1: - -
SP2:
SP3: -
SP4: -

Relevant External Links for INCENP Gene

GeneLoc Exon Structure for
INCENP
ECgene alternative splicing isoforms for
INCENP

Expression for INCENP Gene

mRNA expression in normal human tissues for INCENP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INCENP Gene

This gene is overexpressed in Synovial fluid (47.5), Fetal gut (8.3), and Spleen (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INCENP Gene



SOURCE GeneReport for Unigene cluster for INCENP Gene Hs.142179

genes like me logo Genes that share expression patterns with INCENP: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for INCENP Gene

Orthologs for INCENP Gene

This gene was present in the common ancestor of animals.

Orthologs for INCENP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INCENP 36
  • 100 (a)
OneToOne
INCENP 35
  • 99.12 (n)
  • 99.45 (a)
cow
(Bos Taurus)
Mammalia INCENP 35
  • 84.09 (n)
  • 81.09 (a)
dog
(Canis familiaris)
Mammalia INCENP 35
  • 84.36 (n)
  • 81.93 (a)
INCENP 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Incenp 16
Incenp 35
  • 77.3 (n)
  • 72.58 (a)
Incenp 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INCENP 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INCENP 36
  • 34 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Incenp 35
  • 77.03 (n)
  • 71.75 (a)
chicken
(Gallus gallus)
Aves INCENP 35
  • 58.26 (n)
  • 53.85 (a)
-- 36
  • 48 (a)
OneToMany
INCENP 36
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia incenp 35
  • 56.75 (n)
  • 51.93 (a)
zebrafish
(Danio rerio)
Actinopterygii INCENP 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Incenp 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea icp-1 36
  • 21 (a)
OneToOne
Species with no ortholog for INCENP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INCENP Gene

ENSEMBL:
Gene Tree for INCENP (if available)
TreeFam:
Gene Tree for INCENP (if available)

Paralogs for INCENP Gene

No data available for Paralogs for INCENP Gene

Variants for INCENP Gene

Sequence variations from dbSNP and Humsavar for INCENP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1792947 - 62,128,166(-) TCGTC(A/C)CCATG reference, missense
rs12281503 - 62,129,826(+) CCGAC(A/C/G)CCTCC reference, missense
rs34441559 - 62,129,937(+) CATGG(C/T)ATTGG reference, missense
rs2277283 - 62,140,968(-) GGGTC(A/G/T)TGAGC reference, missense
rs7129085 - 62,145,724(+) GAGGA(G/T)GCACG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for INCENP Gene

Variant ID Type Subtype PubMed ID
dgv391e1 CNV Complex 17122850
esv2751033 CNV Gain 17911159
nsv7219 OTHER Inversion 18451855
nsv897620 CNV Loss 21882294
esv997129 CNV Gain 20482838
esv2744601 CNV Deletion 23290073
esv2658380 CNV Deletion 23128226
esv259660 OTHER Complex 20981092
esv259724 OTHER Complex 20981092
esv2480486 CNV Deletion 19546169

Variation tolerance for INCENP Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.71; 98.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INCENP Gene

HapMap Linkage Disequilibrium report
INCENP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INCENP Gene

Disorders for INCENP Gene

Relevant External Links for INCENP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INCENP

No disorders were found for INCENP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INCENP Gene

Publications for INCENP Gene

  1. Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. (PMID: 11453556) Adams R.R. … Earnshaw W.C. (Chromosoma 2001) 2 3 4 23 67
  2. Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation. (PMID: 1860899) Earnshaw W.C. … Cooke C.A. (J. Cell. Sci. 1991) 2 3 23
  3. INCENP (inner centromere protein) is overexpressed in high grade non-Hodgkin B-cell lymphomas. (PMID: 18752045) Barbanis S. … Koukoulis G. (Pathol. Oncol. Res. 2009) 3 23
  4. RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation- deconjugation cycle on Borealin. (PMID: 18946085) Klein U.R. … Muller S. (Mol. Biol. Cell 2009) 3 23
  5. Molecular distinctions between Aurora A and B: a single residue change transforms Aurora A into correctly localized and functional Aurora B. (PMID: 19494039) Hans F. … Margolis R.L. (Mol. Biol. Cell 2009) 3 23

Products for INCENP Gene

Sources for INCENP Gene

Back to Top

Content