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Aliases for IMPG1 Gene

Aliases for IMPG1 Gene

  • Interphotoreceptor Matrix Proteoglycan 1 2 3
  • Sialoprotein Associated With Cones And Rods 2 3 4
  • IPM150 3 4 6
  • Interphotoreceptor Matrix Proteoglycan Of 150 KDa 3 4
  • SPACR 3 4
  • IPM-150 4
  • GP147 3
  • VMD4 3

External Ids for IMPG1 Gene

Previous HGNC Symbols for IMPG1 Gene


Previous GeneCards Identifiers for IMPG1 Gene

  • GC06M076578
  • GC06M076626
  • GC06M076687
  • GC06M073829

Summaries for IMPG1 Gene

Entrez Gene Summary for IMPG1 Gene

  • This gene encodes a protein that is a major component of the retinal interphotoreceptor matrix. The encoded protein is a proteoglycan that is thought to play a role in maintaining viability of photoreceptor cells and in adhesion of the neural retina to the retinal pigment epithelium. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for IMPG1 Gene

IMPG1 (Interphotoreceptor Matrix Proteoglycan 1) is a Protein Coding gene. Diseases associated with IMPG1 include macular dystrophy, vitelliform, 4 and north carolina macular dystrophy. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is IMPG2.

UniProtKB/Swiss-Prot for IMPG1 Gene

  • May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.

Gene Wiki entry for IMPG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMPG1 Gene

Genomics for IMPG1 Gene

Regulatory Elements for IMPG1 Gene

Genomic Location for IMPG1 Gene

75,921,114 bp from pter
76,072,678 bp from pter
151,565 bases
Minus strand

Genomic View for IMPG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IMPG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMPG1 Gene

Proteins for IMPG1 Gene

  • Protein details for IMPG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interphotoreceptor matrix proteoglycan 1
    Protein Accession:
    Secondary Accessions:
    • A6NNZ6
    • O43686
    • O95094
    • Q68D53
    • Q9BWZ1

    Protein attributes for IMPG1 Gene

    797 amino acids
    Molecular mass:
    89387 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IMPG1 Gene


neXtProt entry for IMPG1 Gene

Proteomics data for IMPG1 Gene at MOPED

Post-translational modifications for IMPG1 Gene

  • Highly glycosylated (N- and O-linked carbohydrates and sialic acid).
  • The N-terminus is blocked.
  • Glycosylation at Asn42, Asn143, Asn191, Asn215, Thr403, Thr421, Thr432, Thr442, Asn592, Asn616, Asn630, and Asn648
  • Modification sites at PhosphoSitePlus

Other Protein References for IMPG1 Gene

No data available for DME Specific Peptides for IMPG1 Gene

Domains for IMPG1 Gene

Protein Domains for IMPG1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q17R60
  • Contains 2 SEA domains.
genes like me logo Genes that share domains with IMPG1: view

No data available for Gene Families for IMPG1 Gene

Function for IMPG1 Gene

Molecular function for IMPG1 Gene

GENATLAS Biochemistry: interphotoreceptor matrix,not chondroitin 6-sulfate proteoglycan 1
UniProtKB/Swiss-Prot Function: May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.

Gene Ontology (GO) - Molecular Function for IMPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent TAS 9691169
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IMPG1: view

Animal Model Products

CRISPR Products

miRNA for IMPG1 Gene

miRTarBase miRNAs that target IMPG1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IMPG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IMPG1 Gene

Localization for IMPG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IMPG1 Gene


Subcellular locations from

Jensen Localization Image for IMPG1 Gene COMPARTMENTS Subcellular localization image for IMPG1 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IMPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix TAS 9691169
genes like me logo Genes that share ontologies with IMPG1: view

Pathways for IMPG1 Gene

genes like me logo Genes that share pathways with IMPG1: view

Pathways by source for IMPG1 Gene

Interacting Proteins for IMPG1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000358966 for IMPG1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for IMPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception TAS 9691169
genes like me logo Genes that share ontologies with IMPG1: view

Transcripts for IMPG1 Gene

Unigene Clusters for IMPG1 Gene

Interphotoreceptor matrix proteoglycan 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IMPG1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IMPG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IMPG1 Gene

No ASD Table

Relevant External Links for IMPG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IMPG1 Gene

mRNA expression in normal human tissues for IMPG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IMPG1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (8.4), Brain - Caudate (basal ganglia) (5.1), and Brain - Putamen (basal ganglia) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IMPG1 Gene

SOURCE GeneReport for Unigene cluster for IMPG1 Gene Hs.590893

mRNA Expression by UniProt/SwissProt for IMPG1 Gene

Tissue specificity: Abundantly expressed in retina where it is specifically expressed by cone and rod photoreceptor cells. Localizes to cone and rod photoreceptor cells surrounding the interphotoreceptor matrix of the retina.
genes like me logo Genes that share expressions with IMPG1: view

In Situ Assay Products

Orthologs for IMPG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IMPG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IMPG1 35
  • 99.08 (n)
  • 97.87 (a)
IMPG1 36
  • 98 (a)
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
IMPG1 35
  • 79.21 (n)
  • 70.03 (a)
IMPG1 36
  • 69 (a)
(Canis familiaris)
Mammalia IMPG1 35
  • 85.7 (n)
  • 77.85 (a)
IMPG1 36
  • 75 (a)
(Mus musculus)
Mammalia Impg1 35
  • 77.74 (n)
  • 67.05 (a)
Impg1 16
Impg1 36
  • 65 (a)
(Monodelphis domestica)
Mammalia IMPG1 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia IMPG1 36
  • 50 (a)
(Rattus norvegicus)
Mammalia Impg1 35
  • 75.86 (n)
  • 65.65 (a)
(Gallus gallus)
Aves IMPG1 35
  • 64.16 (n)
  • 55.54 (a)
IMPG1 36
  • 42 (a)
(Anolis carolinensis)
Reptilia IMPG1 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia impg1 35
  • 61.45 (n)
  • 54.47 (a)
Str.13905 35
(Danio rerio)
Actinopterygii impg1a 36
  • 21 (a)
impg1b 36
  • 27 (a)
Species with no ortholog for IMPG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IMPG1 Gene

Gene Tree for IMPG1 (if available)
Gene Tree for IMPG1 (if available)

Paralogs for IMPG1 Gene

Paralogs for IMPG1 Gene

genes like me logo Genes that share paralogs with IMPG1: view

Variants for IMPG1 Gene

Sequence variations from dbSNP and Humsavar for IMPG1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs720154 -- 76,043,215(-) CGGTA(A/T)TTTTT intron-variant
rs720155 -- 76,043,595(-) TCTAC(A/G)CAGAG intron-variant
rs724941 -- 76,013,294(+) CACTT(C/T)CTGCC intron-variant
rs764632 -- 75,986,080(+) TGACA(C/T)GTGTT intron-variant
rs764633 -- 75,986,004(+) GGCAG(A/T)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IMPG1 Gene

Variant ID Type Subtype PubMed ID
esv1561860 CNV Deletion 17803354
esv270048 CNV Insertion 20981092
esv2674046 CNV Deletion 23128226
nsv5355 CNV Insertion 18451855
esv2658811 CNV Deletion 23128226
esv2672500 CNV Deletion 23128226
esv271179 CNV Insertion 20981092
nsv518093 CNV Loss 19592680
esv2732315 CNV Deletion 23290073
esv1934970 CNV Deletion 18987734
esv5072 CNV Deletion 18987735
esv2732316 CNV Deletion 23290073
esv1003005 CNV Deletion 20482838
esv1097945 CNV Deletion 17803354
esv2732318 CNV Deletion 23290073

Relevant External Links for IMPG1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMPG1 Gene

Disorders for IMPG1 Gene


  • Macular dystrophy, vitelliform, 4 (VMD4) [MIM:616151]: A form of macular dystrophy, a retinal disease in which various forms of deposits, pigmentary changes, and atrophic lesions are observed in the macula lutea. Vitelliform macular dystrophies are characterized by yellow, lipofuscin-containing deposits, usually localized at the center of the macula. VMD4 features include late-onset moderate visual impairment, small satellite drusen-like lesions in the foveal area, and preservation of retinal pigment epithelium reflectivity. {ECO:0000269 PubMed:23993198}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for IMPG1 Gene

Relevant External Links for IMPG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IMPG1: view

Publications for IMPG1 Gene

  1. Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan. (PMID: 10601738) Kuehn M.H. … Hageman G.S. (Matrix Biol. 1999) 3 4 23
  2. The benign concentric annular macular dystrophy locus maps to 6p12.3-q16. (PMID: 14691150) van Lith-Verhoeven J.J. … Cremers F.P. (Invest. Ophthalmol. Vis. Sci. 2004) 3 4 23
  3. Molecular genetic analysis of two functional candidate genes in the autosomal recessive retinitis pigmentosa, RP25, locus. (PMID: 16354621) Abd El-Aziz M.M. … Bhattacharya S.S. (Curr. Eye Res. 2005) 3 23
  4. Characterization of SPACR, a sialoprotein associated with cones and rods present in the interphotoreceptor matrix of the human retina: immunological and lectin binding analysis. (PMID: 9719680) Acharya S. … Hollyfield J.G. (Glycobiology 1998) 3 4
  5. SPACR, a novel interphotoreceptor matrix glycoprotein in human retina that interacts with hyaluronan. (PMID: 9813076) Acharya S. … Hollyfield J.G. (J. Biol. Chem. 1998) 3 4

Products for IMPG1 Gene

Sources for IMPG1 Gene

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