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Aliases for IMPA2 Gene

Aliases for IMPA2 Gene

  • Inositol(Myo)-1(Or 4)-Monophosphatase 2 2 3
  • EC 3.1.3.25 4 63
  • Inositol-1(Or 4)-Monophosphatase 2 4
  • Myo-Inositol Monophosphatase A2 4
  • IMPase 2 4
  • IMP.18P 4
  • IMP 2 4

External Ids for IMPA2 Gene

Summaries for IMPA2 Gene

Entrez Gene Summary for IMPA2 Gene

  • This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]

GeneCards Summary for IMPA2 Gene

IMPA2 (Inositol(Myo)-1(Or 4)-Monophosphatase 2) is a Protein Coding gene. Diseases associated with IMPA2 include bipolar disorder and schizophrenia. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and inositol monophosphate 3-phosphatase activity. An important paralog of this gene is IMPA1.

UniProtKB/Swiss-Prot for IMPA2 Gene

  • Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.

Gene Wiki entry for IMPA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMPA2 Gene

Genomics for IMPA2 Gene

Genomic Location for IMPA2 Gene

Start:
11,981,025 bp from pter
End:
12,030,886 bp from pter
Size:
49,862 bases
Orientation:
Plus strand

Genomic View for IMPA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IMPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMPA2 Gene

Regulatory Elements for IMPA2 Gene

Proteins for IMPA2 Gene

  • Protein details for IMPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14732-IMPA2_HUMAN
    Recommended name:
    Inositol monophosphatase 2
    Protein Accession:
    O14732
    Secondary Accessions:
    • B0YJ29
    • Q9UJT3

    Protein attributes for IMPA2 Gene

    Size:
    288 amino acids
    Molecular mass:
    31321 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for IMPA2 Gene

    Alternative splice isoforms for IMPA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IMPA2 Gene

Proteomics data for IMPA2 Gene at MOPED

Selected DME Specific Peptides for IMPA2 Gene

Post-translational modifications for IMPA2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys184

Other Protein References for IMPA2 Gene

Domains for IMPA2 Gene

Gene Families for IMPA2 Gene

Graphical View of Domain Structure for InterPro Entry

O14732

UniProtKB/Swiss-Prot:

IMPA2_HUMAN
Family:
  • Belongs to the inositol monophosphatase family.:
    • O14732
genes like me logo Genes that share domains with IMPA2: view

Function for IMPA2 Gene

Molecular function for IMPA2 Gene

GENATLAS Biochemistry: inositol(myo)-1(or 4)-monophosphatase 2,widely expressed in adult and fetal tissues but minimally in brain
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=5 mM for myo-inositol 1-monophosphate {ECO:0000269 PubMed:17068342}; pH dependence: Optimum pH is 7.5-8.0. {ECO:0000269 PubMed:17068342};
UniProtKB/Swiss-Prot CatalyticActivity: Myo-inositol phosphate + H(2)O = myo-inositol + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by high Li(+) and restricted Mg(2+) concentrations.
UniProtKB/Swiss-Prot Function: Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
UniProtKB/Swiss-Prot Induction: Repressed by Li(+)

Enzyme Numbers (IUBMB) for IMPA2 Gene

Gene Ontology (GO) - Molecular Function for IMPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008934 inositol monophosphate 1-phosphatase activity IDA 17068342
GO:0042803 protein homodimerization activity IDA 17068342
GO:0046872 metal ion binding IEA --
GO:0052832 inositol monophosphate 3-phosphatase activity IEA --
genes like me logo Genes that share ontologies with IMPA2: view
genes like me logo Genes that share phenotypes with IMPA2: view

Animal Models for IMPA2 Gene

MGI Knock Outs for IMPA2:

miRNA for IMPA2 Gene

miRTarBase miRNAs that target IMPA2

No data available for Transcription Factor Targeting and HOMER Transcription for IMPA2 Gene

Localization for IMPA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IMPA2 Gene COMPARTMENTS Subcellular localization image for IMPA2 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IMPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17068342
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IMPA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IMPA2 Gene

Pathways for IMPA2 Gene

genes like me logo Genes that share pathways with IMPA2: view

UniProtKB/Swiss-Prot O14732-IMPA2_HUMAN

  • Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2

Gene Ontology (GO) - Biological Process for IMPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006021 inositol biosynthetic process IEA --
GO:0006796 phosphate-containing compound metabolic process TAS 9322233
GO:0007165 signal transduction TAS 9322233
GO:0043647 inositol phosphate metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with IMPA2: view

Compounds for IMPA2 Gene

(9) HMDB Compounds for IMPA2 Gene

Compound Synonyms Cas Number PubMed IDs
1D-myo-Inositol 3-phosphate
  • D-myo-Inositol 3-phosphate
2831-74-5
D-Myo-inositol 4-phosphate
  • 1D-myo-inositol 4-monophosphate
46495-39-0
Inositol phosphate
  • 1D-myo-Inositol 1-monophosphate
15421-51-9
Lithium
  • Li
7439-93-2
Magnesium
  • Magnesium
7439-95-4

(1) Drugbank Compounds for IMPA2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Lithium
7439-93-2 target inhibitor

(4) Novoseek inferred chemical compound relationships for IMPA2 Gene

Compound -log(P) Hits PubMed IDs
inositol 84 17
inositol monophosphate 77.7 1
lithium 74 10
calcium 1.92 3
genes like me logo Genes that share compounds with IMPA2: view

Transcripts for IMPA2 Gene

Unigene Clusters for IMPA2 Gene

Inositol(myo)-1(or 4)-monophosphatase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IMPA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for IMPA2 Gene

GeneLoc Exon Structure for
IMPA2
ECgene alternative splicing isoforms for
IMPA2

Expression for IMPA2 Gene

mRNA expression in normal human tissues for IMPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IMPA2 Gene

This gene is overexpressed in Pancreas (7.0), Muscle - Skeletal (5.8), and Whole Blood (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IMPA2 Gene

SOURCE GeneReport for Unigene cluster for IMPA2 Gene Hs.743311

genes like me logo Genes that share expressions with IMPA2: view

No data available for mRNA Expression by UniProt/SwissProt for IMPA2 Gene

Orthologs for IMPA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IMPA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IMPA2 35
  • 99.42 (n)
  • 99.65 (a)
IMPA2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IMPA2 35
  • 82.75 (n)
  • 90.28 (a)
IMPA2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IMPA2 35
  • 88.98 (n)
  • 94.16 (a)
IMPA2 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Impa2 35
  • 87.38 (n)
  • 90.97 (a)
Impa2 16
Impa2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IMPA2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IMPA2 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Impa2 35
  • 88.08 (n)
  • 90.28 (a)
chicken
(Gallus gallus)
Aves IMPA2 35
  • 77.2 (n)
  • 84.03 (a)
IMPA2 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia impa2 35
  • 71.48 (n)
  • 78.34 (a)
Str.15017 35
zebrafish
(Danio rerio)
Actinopterygii impa2 35
  • 65.93 (n)
  • 69.74 (a)
impa2 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17026 36
  • 31 (a)
ManyToMany
CG17027 36
  • 32 (a)
ManyToMany
CG17028 36
  • 34 (a)
ManyToMany
CG17029 36
  • 33 (a)
ManyToMany
CG9389 35
  • 51.44 (n)
  • 47.24 (a)
CG17027 37
  • 34 (a)
CG17029 37
  • 36 (a)
CG9389 37
  • 38 (a)
CG9391 37
  • 46 (a)
CG17026 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea ttx-7 36
  • 38 (a)
OneToMany
F13G3.5 37
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes INM1 36
  • 27 (a)
ManyToMany
INM2 36
  • 27 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06022 35
  • 49.22 (n)
  • 39.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for IMPA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IMPA2 Gene

ENSEMBL:
Gene Tree for IMPA2 (if available)
TreeFam:
Gene Tree for IMPA2 (if available)

Paralogs for IMPA2 Gene

Paralogs for IMPA2 Gene

genes like me logo Genes that share paralogs with IMPA2: view

Variants for IMPA2 Gene

Sequence variations from dbSNP and Humsavar for IMPA2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs583965 -- 12,026,504(-) GGATT(A/G)GAGTC intron-variant
rs586585 -- 11,998,735(+) GAGAA(A/G)TTGTT intron-variant
rs588257 -- 11,992,480(+) GACAG(C/G)AAAGA intron-variant
rs589247 -- 11,992,726(+) ATTGC(C/T)GGTGG intron-variant
rs590100 -- 11,992,908(+) CTCAC(C/T)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IMPA2 Gene

Variant ID Type Subtype PubMed ID
dgv1011e1 CNV Complex 17122850
nsv909384 CNV Gain 21882294
nsv909385 CNV Loss 21882294
nsv909386 CNV Loss 21882294
nsv909387 CNV Loss 21882294
dgv3385n71 CNV Gain 21882294
nsv528699 CNV Loss 19592680
esv2663207 CNV Deletion 23128226
esv9600 CNV Gain 19470904

Relevant External Links for IMPA2 Gene

HapMap Linkage Disequilibrium report
IMPA2
Human Gene Mutation Database (HGMD)
IMPA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMPA2 Gene

Disorders for IMPA2 Gene

(1) University of Copenhagen DISEASES for IMPA2 Gene

(4) Novoseek inferred disease relationships for IMPA2 Gene

Disease -log(P) Hits PubMed IDs
bipolar disorder 74.1 19
seizures febrile 71.6 4
mood disorders 51.4 1
schizophrenia 34 5

Relevant External Links for IMPA2

Genetic Association Database (GAD)
IMPA2
Human Genome Epidemiology (HuGE) Navigator
IMPA2
genes like me logo Genes that share disorders with IMPA2: view

No data available for UniProtKB/Swiss-Prot for IMPA2 Gene

Publications for IMPA2 Gene

  1. A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. (PMID: 9322233) Yoshikawa T. … Detera-Wadleigh S.D. (Mol. Psychiatry 1997) 2 3 4 23
  2. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. (PMID: 17068342) Ohnishi T. … Yoshikawa T. (J. Biol. Chem. 2007) 3 4 23 25
  3. A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic- depressive patients. (PMID: 10822345) Sjoeholt G. … Steen V.M. (Mol. Psychiatry 2000) 3 4 23
  4. Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples. (PMID: 11317223) Yoshikawa T. … Detera-Wadleigh S.D. (Mol. Psychiatry 2001) 3 23 48
  5. Association study of myo-inositol monophosphatase 2 (IMPA2) polymorphisms with bipolar affective disorder and response to lithium treatment. (PMID: 15505643) Dimitrova A. … Kirov G. (Pharmacogenomics J. 2005) 3 23 48

Products for IMPA2 Gene

Sources for IMPA2 Gene

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