Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IMPA1 Gene

Aliases for IMPA1 Gene

  • Inositol Monophosphatase 1 2 3
  • Inositol(Myo)-1(Or 4)-Monophosphatase 1 2 3 5
  • Lithium-Sensitive Myo-Inositol Monophosphatase A1 3 4
  • D-Galactose 1-Phosphate Phosphatase 3 4
  • Inositol-1(Or 4)-Monophosphatase 1 3 4
  • Myo-Inositol Monophosphatase 1 2 3
  • EC 3.1.3.25 4 63
  • IMPase 1 3 4
  • IMP 1 3 4
  • IMPA 3 4
  • Testicular Tissue Protein Li 94 3
  • EC 3.1.3.94 4
  • IMP 3

External Ids for IMPA1 Gene

Previous HGNC Symbols for IMPA1 Gene

  • IMPA

Previous GeneCards Identifiers for IMPA1 Gene

  • GC08M081447
  • GC08M082618
  • GC08M082293
  • GC08M082620
  • GC08M082732
  • GC08M082569
  • GC08M078058

Summaries for IMPA1 Gene

Entrez Gene Summary for IMPA1 Gene

  • This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]

GeneCards Summary for IMPA1 Gene

IMPA1 (Inositol Monophosphatase 1) is a Protein Coding gene. Diseases associated with IMPA1 include bipolar disorder and chronic intestinal vascular insufficiency. Among its related pathways are Metabolism and Integrated Breast Cancer Pathway. GO annotations related to this gene include protein homodimerization activity and magnesium ion binding. An important paralog of this gene is IMPA2.

UniProtKB/Swiss-Prot for IMPA1 Gene

  • Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates.

Gene Wiki entry for IMPA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMPA1 Gene

Genomics for IMPA1 Gene

Regulatory Elements for IMPA1 Gene

Promoters for IMPA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IMPA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IMPA1 Gene

Chromosome:
8
Start:
81,656,916 bp from pter
End:
81,686,693 bp from pter
Size:
29,778 bases
Orientation:
Minus strand

Genomic View for IMPA1 Gene

Genes around IMPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IMPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IMPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMPA1 Gene

Proteins for IMPA1 Gene

  • Protein details for IMPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29218-IMPA1_HUMAN
    Recommended name:
    Inositol monophosphatase 1
    Protein Accession:
    P29218
    Secondary Accessions:
    • B2R733
    • B4DLN3
    • B7Z6Q4
    • J3KQT7
    • Q9UK71

    Protein attributes for IMPA1 Gene

    Size:
    277 amino acids
    Molecular mass:
    30189 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for IMPA1 Gene

    Alternative splice isoforms for IMPA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IMPA1 Gene

Proteomics data for IMPA1 Gene at MOPED

Selected DME Specific Peptides for IMPA1 Gene

Post-translational modifications for IMPA1 Gene

  • Ubiquitination at Lys 145
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for IMPA1 Gene

Gene Families for IMPA1 Gene

Graphical View of Domain Structure for InterPro Entry

P29218

UniProtKB/Swiss-Prot:

IMPA1_HUMAN :
  • Belongs to the inositol monophosphatase family.
Family:
  • Belongs to the inositol monophosphatase family.
genes like me logo Genes that share domains with IMPA1: view

Function for IMPA1 Gene

Molecular function for IMPA1 Gene

GENATLAS Biochemistry:
myo-inositol monophosphatase 1,putatively involved in response to lithium treatment
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=42 uM for D-myo-inositol 1-phosphate {ECO:0000269 PubMed:8068620}; KM=62 uM for L-myo-inositol 1-phosphate {ECO:0000269 PubMed:8068620}; pH dependence: Optimum pH is 7.0-7.5. {ECO:0000269 PubMed:17068342};
UniProtKB/Swiss-Prot CatalyticActivity:
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Alpha-D-galactose 1-phosphate + H(2)O = D-galactose + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity with myo-inositol monophosphate and D-galactose 1-phosphate is inhibited by Li(+), Ca(2+) and Mn(2+), but also by Mg(2+) at concentrations above 3 mM.
UniProtKB/Swiss-Prot Function:
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates.

Enzyme Numbers (IUBMB) for IMPA1 Gene

Gene Ontology (GO) - Molecular Function for IMPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030145 manganese ion binding IDA 9462881
GO:0042802 identical protein binding IPI 16189514
GO:0042803 protein homodimerization activity IDA 17068342
GO:0052833 inositol monophosphate 4-phosphatase activity IEA,TAS --
genes like me logo Genes that share ontologies with IMPA1: view
genes like me logo Genes that share phenotypes with IMPA1: view

Animal Models for IMPA1 Gene

MGI Knock Outs for IMPA1:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IMPA1 Gene

Localization for IMPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IMPA1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IMPA1 Gene COMPARTMENTS Subcellular localization image for IMPA1 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 4
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for IMPA1 Gene

Pathways & Interactions for IMPA1 Gene

genes like me logo Genes that share pathways with IMPA1: view

UniProtKB/Swiss-Prot P29218-IMPA1_HUMAN

  • Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Gene Ontology (GO) - Biological Process for IMPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process IMP 1377913
GO:0006796 phosphate-containing compound metabolic process IMP 1377913
genes like me logo Genes that share ontologies with IMPA1: view

No data available for SIGNOR curated interactions for IMPA1 Gene

Drugs & Compounds for IMPA1 Gene

(12) Drugs for IMPA1 Gene - From: Novoseek, HMDB, DrugBank, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lithium Approved Pharma Target, inhibitor 0
L-Myo-Inositol-1-Phosphate Experimental Pharma Target 0
Magnesium Nutra 0
LI<SUP>+</SUP> Pharma 0

(18) Additional Compounds for IMPA1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1D-myo-Inositol 3-phosphate
  • 1D-Myo-Inositol 3-monophosphate
  • 1L-Myo-Inositol 1-phosphate
  • D-Myo-Inositol 3-monophosphate
  • D-Myo-Inositol 3-phosphate
  • Inositol 3-monophosphate
2831-74-5
D-Myo-inositol 4-phosphate
  • 1D-Myo-inositol 4-monophosphate
  • 1D-Myo-inositol 4-phosphate
  • D-Myo-inositol-4-phosphate
  • D-Myoinositol 4-phosphate
  • Inositol 4-phosphate
46495-39-0
Inositol phosphate
  • 1D-Myo-Inositol 1-monophosphate
  • 1D-Myo-Inositol 1-phosphate
  • D-Myo-Inositol-1-Phosphate
  • Inositol 1-monophosphate
15421-51-9
Myoinositol
  • cis-1,2,3,5-trans-4,6-Cyclohexanehexol
  • i-Inositol
  • Iso-Inositol
  • Meat sugar
  • Meso-Inositol
87-89-8
Myo-inositol 1-phosphate
  • 1-(Dihydrogen phosphate) DL-myo-Inositol
  • 1-(Dihydrogen phosphate) myo-Inositol
  • DL-myo-Inositol 1-phosphate
  • Myo-Inositol 1-monophosphate
  • Myo-Inositol 1-phosphate
573-35-3
genes like me logo Genes that share compounds with IMPA1: view

Transcripts for IMPA1 Gene

Unigene Clusters for IMPA1 Gene

Inositol(myo)-1(or 4)-monophosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IMPA1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for IMPA1 Gene

GeneLoc Exon Structure for
IMPA1
ECgene alternative splicing isoforms for
IMPA1

Expression for IMPA1 Gene

mRNA expression in normal human tissues for IMPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IMPA1 Gene



SOURCE GeneReport for Unigene cluster for IMPA1 Gene Hs.656694

genes like me logo Genes that share expression patterns with IMPA1: view

Protein tissue co-expression partners for IMPA1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IMPA1 Gene

Orthologs for IMPA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IMPA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IMPA1 36
  • 99 (a)
OneToOne
LOC100613673 35
  • 99.21 (n)
  • 98.81 (a)
cow
(Bos Taurus)
Mammalia IMPA1 35
  • 90.13 (n)
  • 88.45 (a)
IMPA1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IMPA1 36
  • 90 (a)
OneToOne
IMPA1 35
  • 90.97 (n)
  • 90.25 (a)
mouse
(Mus musculus)
Mammalia Impa1 16
Impa1 36
  • 86 (a)
OneToOne
Impa1 35
  • 83.57 (n)
  • 86.59 (a)
oppossum
(Monodelphis domestica)
Mammalia IMPA1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IMPA1 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Impa1 35
  • 83.09 (n)
  • 85.14 (a)
chicken
(Gallus gallus)
Aves IMPA1 35
  • 76.69 (n)
  • 80.07 (a)
IMPA1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IMPA1 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia impa1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia impa1 35
  • 72.48 (n)
  • 79.27 (a)
Str.15926 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9875 35
zebrafish
(Danio rerio)
Actinopterygii impa1 36
  • 66 (a)
OneToOne
impa1 35
  • 69.33 (n)
  • 67.64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006570 35
  • 49.69 (n)
  • 47.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17026 37
  • 37 (a)
CG17027 37
  • 36 (a)
CG17029 37
  • 34 (a)
CG9389 37
  • 34 (a)
CG9391 37
  • 46 (a)
CG9391 35
  • 51.18 (n)
  • 46.47 (a)
CG17026 36
  • 34 (a)
ManyToMany
CG17027 36
  • 33 (a)
ManyToMany
CG17028 36
  • 31 (a)
ManyToMany
CG17029 36
  • 32 (a)
ManyToMany
CG9389 36
  • 19 (a)
ManyToMany
CG9391 36
  • 45 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ttx-7 35
  • 52.13 (n)
  • 47.74 (a)
ttx-7 36
  • 45 (a)
OneToMany
F13G3.5 37
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes INM2 35
  • 52.74 (n)
  • 44.13 (a)
INM1 36
  • 31 (a)
ManyToMany
INM2 36
  • 32 (a)
ManyToMany
INM2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons VTC4 35
  • 50.57 (n)
  • 41.06 (a)
rice
(Oryza sativa)
Liliopsida Os03g0587000 35
  • 51.94 (n)
  • 45.74 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06348 35
  • 46.87 (n)
  • 42.19 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11400 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for IMPA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IMPA1 Gene

ENSEMBL:
Gene Tree for IMPA1 (if available)
TreeFam:
Gene Tree for IMPA1 (if available)

Paralogs for IMPA1 Gene

Paralogs for IMPA1 Gene

Pseudogenes.org Pseudogenes for IMPA1 Gene

genes like me logo Genes that share paralogs with IMPA1: view

Variants for IMPA1 Gene

Sequence variations from dbSNP and Humsavar for IMPA1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs204781 - 81,676,257(-) TTTCA(A/G)TTGGC reference, missense
rs459801 -- 81,681,561(-) CAGAA(A/G)ATGGC reference, synonymous-codon, utr-variant-5-prime
rs465178 -- 81,681,564(-) TTTCA(A/G)AAAAT reference, synonymous-codon, utr-variant-5-prime
rs204790 -- 81,667,620(-) tctaa(C/G)ccctc intron-variant
rs204791 -- 81,666,740(-) gctac(C/G)cacca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IMPA1 Gene

Variant ID Type Subtype PubMed ID
nsv465721 CNV Gain 19166990
nsv831368 CNV Gain 17160897
nsv831369 CNV Gain+Loss 17160897
esv2737230 CNV Deletion 23290073
esv2665097 CNV Deletion 23128226
esv1774004 CNV Insertion 17803354

Variation tolerance for IMPA1 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IMPA1 Gene

HapMap Linkage Disequilibrium report
IMPA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMPA1 Gene

Disorders for IMPA1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IMPA1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bipolar disorder
  • bipolar depression
chronic intestinal vascular insufficiency
  • chronic mesenteric ischemia
- elite association - COSMIC cancer census association via MalaCards
Search IMPA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IMPA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IMPA1
genes like me logo Genes that share disorders with IMPA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IMPA1 Gene

Publications for IMPA1 Gene

  1. cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme. (PMID: 1377913) McAllister G. … Ragan C.I. (Biochem. J. 1992) 2 3 4 23 67
  2. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. (PMID: 17068342) Ohnishi T. … Yoshikawa T. (J. Biol. Chem. 2007) 3 23 25 26
  3. A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription. (PMID: 17251911) Ohnishi T. … Yoshikawa T. (Neuropsychopharmacology 2007) 23 25 26
  4. Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. (PMID: 16874097) Sarkar S. … Rubinsztein D.C. (Autophagy 2006) 23 25 26
  5. Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans. (PMID: 17158747) Tanizawa Y. … Mori I. (Genes Dev. 2006) 25 26

Products for IMPA1 Gene

Sources for IMPA1 Gene

Back to Top

Content