Aliases for AQP4 Gene
External Ids for AQP4 Gene
Previous GeneCards Identifiers for AQP4 Gene
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for AQP4 Gene
AQP4 (Aquaporin 4) is a Protein Coding gene. Diseases associated with AQP4 include myelitis and transverse myelitis. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Spinal Cord Injury. GO annotations related to this gene include porin activity and water transmembrane transporter activity. An important paralog of this gene is AQP1.
UniProtKB/Swiss-Prot for AQP4 Gene
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system
Aquaporins (AQPs)are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.