Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ILF2 Gene

Aliases for ILF2 Gene

  • Interleukin Enhancer Binding Factor 2 2 3 5
  • Interleukin Enhancer Binding Factor 2, 45kDa 2 3
  • Interleukin Enhancer Binding Factor 2, 45kD 2 3
  • NF45 3 4
  • Nuclear Factor Of Activated T-Cells, 45-KDa 3
  • Nuclear Factor Of Activated T-Cells 45 KDa 4
  • PRO3063 3

External Ids for ILF2 Gene

Previous GeneCards Identifiers for ILF2 Gene

  • GC01M151483
  • GC01M149365
  • GC01M150409
  • GC01M150851
  • GC01M150447
  • GC01M151900
  • GC01M124997

Summaries for ILF2 Gene

Entrez Gene Summary for ILF2 Gene

  • The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]

GeneCards Summary for ILF2 Gene

ILF2 (Interleukin Enhancer Binding Factor 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and double-stranded RNA binding. An important paralog of this gene is ZFR.

UniProtKB/Swiss-Prot for ILF2 Gene

  • Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.

Gene Wiki entry for ILF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ILF2 Gene

Genomics for ILF2 Gene

Regulatory Elements for ILF2 Gene

Promoters for ILF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ILF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ILF2 Gene

Chromosome:
1
Start:
153,661,788 bp from pter
End:
153,671,048 bp from pter
Size:
9,261 bases
Orientation:
Minus strand

Genomic View for ILF2 Gene

Genes around ILF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ILF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ILF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ILF2 Gene

Proteins for ILF2 Gene

  • Protein details for ILF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12905-ILF2_HUMAN
    Recommended name:
    Interleukin enhancer-binding factor 2
    Protein Accession:
    Q12905
    Secondary Accessions:
    • A6NDB0
    • B2R8G7
    • Q5SR10
    • Q5SR11
    • Q7L7R3
    • Q9BWD4
    • Q9P1N0

    Protein attributes for ILF2 Gene

    Size:
    390 amino acids
    Molecular mass:
    43062 Da
    Quaternary structure:
    • Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1.
    SequenceCaution:
    • Sequence=AAA20993.1; Type=Frameshift; Positions=376; Evidence={ECO:0000305}; Sequence=AAF29591.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=CAI13611.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ILF2 Gene

Proteomics data for ILF2 Gene at MOPED

Post-translational modifications for ILF2 Gene

  • Ubiquitination at Lys 45, Lys 59, and Lys 141
  • Modification sites at PhosphoSitePlus

Other Protein References for ILF2 Gene

Antibody Products

No data available for DME Specific Peptides for ILF2 Gene

Domains & Families for ILF2 Gene

Protein Domains for ILF2 Gene

Suggested Antigen Peptide Sequences for ILF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12905

UniProtKB/Swiss-Prot:

ILF2_HUMAN :
  • Contains 1 DZF domain.
Domain:
  • Contains 1 DZF domain.
genes like me logo Genes that share domains with ILF2: view

No data available for Gene Families for ILF2 Gene

Function for ILF2 Gene

Molecular function for ILF2 Gene

UniProtKB/Swiss-Prot Function:
Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.

Gene Ontology (GO) - Molecular Function for ILF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 7519613
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ILF2: view
genes like me logo Genes that share phenotypes with ILF2: view

Animal Models for ILF2 Gene

MGI Knock Outs for ILF2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ILF2 Gene

Localization for ILF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILF2 Gene

Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ILF2 Gene COMPARTMENTS Subcellular localization image for ILF2 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ILF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA,IDA 11790298
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ILF2: view

Drugs & Compounds for ILF2 Gene

(2) Drugs for ILF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ILF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ILF2: view

Transcripts for ILF2 Gene

Unigene Clusters for ILF2 Gene

Interleukin enhancer binding factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ILF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -
SP8:
SP9:

Relevant External Links for ILF2 Gene

GeneLoc Exon Structure for
ILF2
ECgene alternative splicing isoforms for
ILF2

Expression for ILF2 Gene

mRNA expression in normal human tissues for ILF2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ILF2 Gene



SOURCE GeneReport for Unigene cluster for ILF2 Gene Hs.75117

genes like me logo Genes that share expression patterns with ILF2: view

Protein tissue co-expression partners for ILF2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ILF2 Gene

Orthologs for ILF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ILF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ILF2 36
  • 100 (a)
OneToOne
ILF2 35
  • 99.91 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia ILF2 35
  • 94.02 (n)
  • 99.74 (a)
ILF2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ILF2 36
  • 100 (a)
OneToOne
ILF2 35
  • 93.25 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Ilf2 36
  • 100 (a)
OneToOne
Ilf2 16
Ilf2 35
  • 91.54 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia ILF2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ILF2 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ILF2 35
  • 80.52 (n)
  • 96.87 (a)
ILF2 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ilf2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75701 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1694 35
zebrafish
(Danio rerio)
Actinopterygii ilf2 36
  • 89 (a)
OneToOne
ilf2 35
  • 77.71 (n)
  • 91.57 (a)
wufb34h01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001997 35
  • 58.81 (n)
  • 61.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5641 35
  • 60.83 (n)
  • 59.82 (a)
CG5641 37
  • 58 (a)
CG5641 36
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_R11H6.5 35
  • 45.9 (n)
  • 39.02 (a)
R11H6.5 36
  • 36 (a)
OneToOne
R11H6.5 37
  • 36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3994 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5584 36
  • 58 (a)
OneToOne
Species with no ortholog for ILF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ILF2 Gene

ENSEMBL:
Gene Tree for ILF2 (if available)
TreeFam:
Gene Tree for ILF2 (if available)

Paralogs for ILF2 Gene

Paralogs for ILF2 Gene

Pseudogenes.org Pseudogenes for ILF2 Gene

genes like me logo Genes that share paralogs with ILF2: view

Variants for ILF2 Gene

Sequence variations from dbSNP and Humsavar for ILF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2229382 -- 153,668,492(-) TTGCT(A/G)AAGAG reference, synonymous-codon
rs4351684 -- 153,664,384(+) GTTAG(A/G)GAGGG intron-variant
rs4845564 -- 153,669,536(+) ACCTC(C/T)GCGTC intron-variant
rs4515830 -- 153,663,996(+) ACTAC(C/T)AGTAA intron-variant
rs6427671 -- 153,664,928(+) TAGAA(A/G)CATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ILF2 Gene

Variant ID Type Subtype PubMed ID
nsv464028 CNV Gain 19166990

Variation tolerance for ILF2 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 3.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ILF2 Gene

HapMap Linkage Disequilibrium report
ILF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILF2 Gene

Disorders for ILF2 Gene

Relevant External Links for ILF2

Human Genome Epidemiology (HuGE) Navigator
ILF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ILF2

No disorders were found for ILF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ILF2 Gene

Publications for ILF2 Gene

  1. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PMID: 7519613) Kao P.N. … Corthesy B. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. NF45 and NF90 regulate HS4-dependent interleukin-13 transcription in T cells. (PMID: 20051514) Kiesler P. … Vercelli D. (J. Biol. Chem. 2010) 3 23
  3. NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response. (PMID: 19893574) Graber T.E. … Holcik M. (Cell Death Differ. 2010) 3 23
  4. The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway. (PMID: 19398578) Sakamoto S. … Agata Y. (Mol. Cell. Biol. 2009) 3 23
  5. Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control. (PMID: 18458058) Guan D. … Mathews M.B. (Mol. Cell. Biol. 2008) 3 23

Products for ILF2 Gene

Sources for ILF2 Gene

Back to Top

Content