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Aliases for IL18 Gene

Aliases for IL18 Gene

  • Interleukin 18 2 3
  • IGIF 3 4 6
  • Interleukin 18 (Interferon-Gamma-Inducing Factor) 2 3
  • IFN-Gamma-Inducing Factor 3 4
  • Interleukin-1 Gamma 3 4
  • Iboctadekin 3 4
  • IL-1 Gamma 3 4
  • IL-18 3 4
  • IL1F4 3 4
  • Interferon-Gamma-Inducing Factor 2
  • Interferon Gamma-Inducing Factor 4
  • Interleukin-18 3
  • IL-1g 3

External Ids for IL18 Gene

Summaries for IL18 Gene

Entrez Gene Summary for IL18 Gene

  • The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for IL18 Gene

IL18 (Interleukin 18) is a Protein Coding gene. Diseases associated with IL18 include acute graft versus host disease and adult-onset stills disease. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for IL18 Gene

  • Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells

Gene Wiki entry for IL18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL18 Gene

Genomics for IL18 Gene

Genomic Location for IL18 Gene

112,143,251 bp from pter
112,164,117 bp from pter
20,867 bases
Minus strand

Genomic View for IL18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18 Gene

Regulatory Elements for IL18 Gene

Proteins for IL18 Gene

  • Protein details for IL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O75599
    • Q6FGY3
    • Q6WWJ7

    Protein attributes for IL18 Gene

    193 amino acids
    Molecular mass:
    22326 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL18 Gene

    Alternative splice isoforms for IL18 Gene


neXtProt entry for IL18 Gene

Proteomics data for IL18 Gene at MOPED

Post-translational modifications for IL18 Gene

  • The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL18 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IL18 Gene

Domains for IL18 Gene

Gene Families for IL18 Gene

  • IL :Interleukins and interleukin receptors

Protein Domains for IL18 Gene


  • Belongs to the IL-1 family.:
    • Q14116
genes like me logo Genes that share domains with IL18: view

Function for IL18 Gene

Molecular function for IL18 Gene

GENATLAS Biochemistry: interleukin 18,interferon-gamma inducing factor,involved in Th1-mediated cellular immunity
UniProtKB/Swiss-Prot Function: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells

Gene Ontology (GO) - Molecular Function for IL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 11598150
GO:0005515 protein binding IPI 25261253
genes like me logo Genes that share ontologies with IL18: view
genes like me logo Genes that share phenotypes with IL18: view

Animal Models for IL18 Gene

MGI Knock Outs for IL18:

miRNA for IL18 Gene

miRTarBase miRNAs that target IL18

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL18 Gene

Localization for IL18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18 Gene


Subcellular locations from

Jensen Localization Image for IL18 Gene COMPARTMENTS Subcellular localization image for IL18 gene
Compartment Confidence
extracellular 5
cytosol 4
golgi apparatus 3
nucleus 3
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for IL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 11598150
GO:0005615 extracellular space IBA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IL18: view

Pathways for IL18 Gene

genes like me logo Genes that share pathways with IL18: view

Gene Ontology (GO) - Biological Process for IL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IMP 21147091
GO:0001525 angiogenesis IDA 11466388
GO:0006954 inflammatory response IDA 21147091
GO:0006955 immune response TAS 8999896
GO:0007267 cell-cell signaling TAS 9792649
genes like me logo Genes that share ontologies with IL18: view

Compounds for IL18 Gene

(136) Novoseek inferred chemical compound relationships for IL18 Gene

Compound -log(P) Hits PubMed IDs
il-12 69.2 21
lfa703 66.9 7
il 10 60.7 14
rantes 57.3 42
pralnacasan 55.1 1
genes like me logo Genes that share compounds with IL18: view

Transcripts for IL18 Gene

Unigene Clusters for IL18 Gene

Interleukin 18 (interferon-gamma-inducing factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL18 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3: -

Relevant External Links for IL18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL18 Gene

mRNA expression in normal human tissues for IL18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL18 Gene

This gene is overexpressed in Esophagus - Mucosa (7.1), Skin - Sun Exposed (Lower leg) (6.4), Skin - Not Sun Exposed (Suprapubic) (6.0), and Vagina (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL18 Gene

SOURCE GeneReport for Unigene cluster for IL18 Gene Hs.83077

genes like me logo Genes that share expressions with IL18: view

Orthologs for IL18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL18 36
  • 99.48 (n)
  • 100 (a)
IL18 37
  • 100 (a)
(Bos Taurus)
Mammalia IL18 36
  • 86.36 (n)
  • 77.72 (a)
IL18 37
  • 78 (a)
(Canis familiaris)
Mammalia IL18 36
  • 84.55 (n)
  • 73.96 (a)
IL18 37
  • 69 (a)
(Mus musculus)
Mammalia Il18 36
  • 75.53 (n)
  • 65.96 (a)
Il18 16
Il18 37
  • 64 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 35 (a)
-- 37
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia IL18 37
  • 36 (a)
(Rattus norvegicus)
Mammalia Il18 36
  • 74.39 (n)
  • 63.68 (a)
(Gallus gallus)
Aves IL18 37
  • 33 (a)
(Anolis carolinensis)
Reptilia IL18 37
  • 29 (a)
Species with no ortholog for IL18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18 Gene

Gene Tree for IL18 (if available)
Gene Tree for IL18 (if available)

Paralogs for IL18 Gene

Selected SIMAP similar genes for IL18 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IL18: view

No data available for Paralogs for IL18 Gene

Variants for IL18 Gene

Sequence variations from dbSNP and Humsavar for IL18 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs183116 -- 112,149,178(+) tccca(C/G)ctact intron-variant
rs184862 -- 112,149,172(+) ctgta(A/G)tccca intron-variant
rs187238 -- 112,164,265(-) GAAAA(C/G)ATTTC upstream-variant-2KB
rs189667 -- 112,162,881(+) TGGCT(A/G)TCCTG intron-variant
rs191710 -- 112,149,190(+) gggag(A/G)ctgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL18 Gene

Variant ID Type Subtype PubMed ID
esv2745077 CNV Deletion 23290073
nsv519192 CNV Gain 19592680

Relevant External Links for IL18 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for IL18 Gene

(3) University of Copenhagen DISEASES for IL18 Gene

(95) Novoseek inferred disease relationships for IL18 Gene

Disease -log(P) Hits PubMed IDs
inflammation 74.3 123
stills disease adult-onset 73.5 19
necrosis 71.5 108
rheumatoid arthritis 63.9 92
autoimmune diseases 55.2 42

Relevant External Links for IL18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IL18: view

No data available for UniProtKB/Swiss-Prot for IL18 Gene

Publications for IL18 Gene

  1. Association of single nucleotide polymorphisms in the IL-18 gene with sarcoidosis in a Japanese population. (PMID: 12366781) Takada T. … Gejyo F. (Tissue Antigens 2002) 3 23 49
  2. Interleukin-18 promoter polymorphisms in type 1 diabetes. (PMID: 12401730) Kretowski A. … Kinalska I. (Diabetes 2002) 3 23 49
  3. Association between adult-onset Still's disease and interleukin-18 gene polymorphisms. (PMID: 12424620) Sugiura T. … Kamatani N. (Genes Immun. 2002) 3 23 49
  4. IL18 polymorphism is associated with an increased risk of Crohn's disease. (PMID: 12572878) Tamura K. … Shimoyama T. (J. Gastroenterol. 2002) 3 23 49
  5. IL-18 promoter polymorphisms correlate with the development of post-injury sepsis. (PMID: 12947340) Stassen N.A. … Polk H.C. (Surgery 2003) 3 23 49

Products for IL18 Gene

Sources for IL18 Gene

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