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Aliases for IL18 Gene

Aliases for IL18 Gene

  • Interleukin 18 2 3 5
  • Interleukin 18 (Interferon-Gamma-Inducing Factor) 2 3
  • IFN-Gamma-Inducing Factor 3 4
  • Interleukin-1 Gamma 3 4
  • Iboctadekin 3 4
  • IL-1 Gamma 3 4
  • IL-18 3 4
  • IL1F4 3 4
  • IGIF 3 4
  • Interferon-Gamma-Inducing Factor 2
  • Interferon Gamma-Inducing Factor 4
  • IL-1g 3

External Ids for IL18 Gene

Previous GeneCards Identifiers for IL18 Gene

  • GC11M114366
  • GC11M113526
  • GC11M112047
  • GC11M111551
  • GC11M111519
  • GC11M107938
  • GC11M112013

Summaries for IL18 Gene

Entrez Gene Summary for IL18 Gene

  • The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for IL18 Gene

IL18 (Interleukin 18) is a Protein Coding gene. Diseases associated with IL18 include Adult-Onset Still's Disease and Pleural Tuberculosis. Among its related pathways are Toll-Like receptor Signaling Pathways and ERK Signaling. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for IL18 Gene

  • Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

Gene Wiki entry for IL18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL18 Gene

Genomics for IL18 Gene

Regulatory Elements for IL18 Gene

Enhancers for IL18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL18 on UCSC Golden Path with GeneCards custom track

Promoters for IL18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL18 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL18 Gene

112,143,251 bp from pter
112,164,117 bp from pter
20,867 bases
Minus strand

Genomic View for IL18 Gene

Genes around IL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18 Gene

Proteins for IL18 Gene

  • Protein details for IL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O75599
    • Q6FGY3
    • Q6WWJ7

    Protein attributes for IL18 Gene

    193 amino acids
    Molecular mass:
    22326 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL18 Gene

    Alternative splice isoforms for IL18 Gene


neXtProt entry for IL18 Gene

Proteomics data for IL18 Gene at MOPED

Post-translational modifications for IL18 Gene

  • The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL18 Gene

Antibody Products

No data available for DME Specific Peptides for IL18 Gene

Domains & Families for IL18 Gene

Gene Families for IL18 Gene

Protein Domains for IL18 Gene

Suggested Antigen Peptide Sequences for IL18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IL-1 family.
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL18: view

Function for IL18 Gene

Molecular function for IL18 Gene

GENATLAS Biochemistry:
interleukin 18,interferon-gamma inducing factor,involved in Th1-mediated cellular immunity
UniProtKB/Swiss-Prot Function:
Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
genes like me logo Genes that share phenotypes with IL18: view

Animal Models for IL18 Gene

MGI Knock Outs for IL18:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL18 Gene

Localization for IL18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18 Gene


Subcellular locations from

Jensen Localization Image for IL18 Gene COMPARTMENTS Subcellular localization image for IL18 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4
cytoskeleton 2
golgi apparatus 2
lysosome 2
mitochondrion 2
plasma membrane 2
vacuole 2

No data available for Gene Ontology (GO) - Cellular Components for IL18 Gene

Pathways & Interactions for IL18 Gene

genes like me logo Genes that share pathways with IL18: view

SIGNOR curated interactions for IL18 Gene


Gene Ontology (GO) - Biological Process for IL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IMP 21147091
GO:0001525 angiogenesis IDA 11466388
GO:0006954 inflammatory response IDA 21147091
GO:0006955 immune response TAS 8999896
GO:0007267 cell-cell signaling TAS 9792649
genes like me logo Genes that share ontologies with IL18: view

Drugs & Compounds for IL18 Gene

(74) Drugs for IL18 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tacrolimus Approved, Investigational Pharma 1045

(62) Additional Compounds for IL18 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL18: view

Transcripts for IL18 Gene

Unigene Clusters for IL18 Gene

Interleukin 18 (interferon-gamma-inducing factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL18 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3: -

Relevant External Links for IL18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL18 Gene

mRNA expression in normal human tissues for IL18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL18 Gene

This gene is overexpressed in Esophagus - Mucosa (x7.1), Skin - Sun Exposed (Lower leg) (x6.4), Skin - Not Sun Exposed (Suprapubic) (x6.0), and Vagina (x4.5).

Protein differential expression in normal tissues from HIPED for IL18 Gene

This gene is overexpressed in Lymph node (11.0), Oral epithelium (10.0), and Heart (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL18 Gene

SOURCE GeneReport for Unigene cluster for IL18 Gene Hs.83077

genes like me logo Genes that share expression patterns with IL18: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IL18 Gene

Orthologs for IL18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL18 35
  • 86.36 (n)
  • 77.72 (a)
IL18 36
  • 78 (a)
(Canis familiaris)
Mammalia IL18 35
  • 84.55 (n)
  • 73.96 (a)
IL18 36
  • 69 (a)
(Mus musculus)
Mammalia Il18 35
  • 75.53 (n)
  • 65.96 (a)
Il18 16
Il18 36
  • 64 (a)
(Pan troglodytes)
Mammalia IL18 35
  • 99.48 (n)
  • 100 (a)
IL18 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Il18 35
  • 74.39 (n)
  • 63.68 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
-- 36
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia IL18 36
  • 36 (a)
(Gallus gallus)
Aves IL18 36
  • 33 (a)
(Anolis carolinensis)
Reptilia IL18 36
  • 29 (a)
Species with no ortholog for IL18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18 Gene

Gene Tree for IL18 (if available)
Gene Tree for IL18 (if available)

Paralogs for IL18 Gene

(1) SIMAP similar genes for IL18 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IL18: view

No data available for Paralogs for IL18 Gene

Variants for IL18 Gene

Sequence variations from dbSNP and Humsavar for IL18 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs549908 -- 112,150,193(+) TAATC(A/G/T)GATTC reference, synonymous-codon
rs608717 -- 112,145,889(-) ATCAA(A/T)ACTAG intron-variant
rs795467 -- 112,160,357(+) ATCCC(A/G)TAACT intron-variant
rs812703 -- 112,149,680(-) tgctt(G/T)aggcc intron-variant
rs813972 -- 112,149,591(-) tgtct(C/T)taaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL18 Gene

Variant ID Type Subtype PubMed ID
esv2745077 CNV Deletion 23290073
nsv519192 CNV Gain 19592680

Variation tolerance for IL18 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL18 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL18 Gene

Disorders for IL18 Gene

MalaCards: The human disease database

(53) MalaCards diseases for IL18 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adult-onset still's disease
  • adult onset still's disease
pleural tuberculosis
  • pearly disease
  • inflammatory disorder of joint
rheumatoid arthritis
  • rheumatoid arthritis, progression of
acute kidney failure
  • renal failure acute
- elite association - COSMIC cancer census association via MalaCards
Search IL18 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL18 Gene

Publications for IL18 Gene

  1. [Correlations between serum interleukin-18 (IL-18) level, IL-18 gene promoter polymorphisms and the development of sepsis in children]. (PMID: 20441695) Cai L.L. … Zeng X. (Zhonghua Er Ke Za Zhi 2010) 3 23 48 67
  2. Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors. (PMID: 19131059) Kaya C. … Satiroglu H. (Fertil. Steril. 2010) 3 23
  3. IL-18 downregulates collagen production in human dermal fibroblasts via the ERK pathway. (PMID: 19865096) Kim H.J. … Park H.J. (J. Invest. Dermatol. 2010) 3 23
  4. Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils. (PMID: 19907017) Silliman C.C. … Banerjee A. (Am. J. Physiol., Cell Physiol. 2010) 3 23
  5. Commonly studied polymorphisms in inflammatory cytokine genes show only minor effects on mortality and related risk factors in nonagenarians. (PMID: 20083555) Dato S. … Christiansen L. (J. Gerontol. A Biol. Sci. Med. Sci. 2010) 3 23

Products for IL18 Gene

Sources for IL18 Gene