External Ids for IL15 Gene
Previous GeneCards Identifiers for IL15 Gene
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
GeneCards Summary for IL15 Gene
IL15 (Interleukin 15) is a Protein Coding gene. Diseases associated with IL15 include Rheumatoid Arthritis and Celiac Disease. Among its related pathways are HTLV-I infection and TNF signaling pathway. GO annotations related to this gene include cytokine activity and cytokine receptor binding.
UniProtKB/Swiss-Prot for IL15 Gene
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.