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Aliases for IL15 Gene

Aliases for IL15 Gene

  • Interleukin 15 2 3
  • IL-15 3 4
  • Interleukin-15 3

External Ids for IL15 Gene

Summaries for IL15 Gene

Entrez Gene Summary for IL15 Gene

  • The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]

GeneCards Summary for IL15 Gene

IL15 (Interleukin 15) is a Protein Coding gene. Diseases associated with IL15 include lung cancer and malaria. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and cytokine receptor binding.

UniProtKB/Swiss-Prot for IL15 Gene

  • Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha

Gene Wiki entry for IL15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL15 Gene

Genomics for IL15 Gene

Genomic Location for IL15 Gene

Start:
141,636,596 bp from pter
End:
141,733,987 bp from pter
Size:
97,392 bases
Orientation:
Plus strand

Genomic View for IL15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL15 Gene

Regulatory Elements for IL15 Gene

Proteins for IL15 Gene

  • Protein details for IL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40933-IL15_HUMAN
    Recommended name:
    Interleukin-15
    Protein Accession:
    P40933
    Secondary Accessions:
    • D3DNZ2
    • O00440
    • O43512
    • Q495Z8
    • Q6FGX7
    • Q93058
    • Q9UBA3

    Protein attributes for IL15 Gene

    Size:
    162 amino acids
    Molecular mass:
    18086 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA71044.1; Type=Miscellaneous discrepancy; Note=Man-made cDNA with a signal peptide sequence to increase protein secretion (substitution with a signal peptide derived from the mouse IgV kappa chain).; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL15 Gene

    Alternative splice isoforms for IL15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL15 Gene

Proteomics data for IL15 Gene at MOPED

Post-translational modifications for IL15 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn127

Other Protein References for IL15 Gene

No data available for DME Specific Peptides for IL15 Gene

Domains for IL15 Gene

Gene Families for IL15 Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Protein Domains for IL15 Gene

UniProtKB/Swiss-Prot:

IL15_HUMAN
Family:
  • Belongs to the IL-15/IL-21 family.:
    • P40933
genes like me logo Genes that share domains with IL15: view

Function for IL15 Gene

Molecular function for IL15 Gene

GENATLAS Biochemistry: interleukin 15,structurally and functionally related to IL2,involved in the differentiation of natural killer cells
UniProtKB/Swiss-Prot Function: Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha

LifeMap Function Summary for IL15 Gene

IL15 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for IL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding IEA --
GO:0005515 protein binding IPI 16284400
genes like me logo Genes that share ontologies with IL15: view
genes like me logo Genes that share phenotypes with IL15: view

Animal Models for IL15 Gene

MGI Knock Outs for IL15:

miRNA for IL15 Gene

miRTarBase miRNAs that target IL15

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL15 Gene

Localization for IL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL15 Gene

Isoform IL15-S48AA: Secreted.
Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL15 Gene COMPARTMENTS Subcellular localization image for IL15 gene
Compartment Confidence
extracellular 5
nucleus 5
endosome 4
golgi apparatus 4
plasma membrane 4
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with IL15: view

Pathways for IL15 Gene

genes like me logo Genes that share pathways with IL15: view

Gene Ontology (GO) - Biological Process for IL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001779 natural killer cell differentiation IEA --
GO:0001866 NK T cell proliferation IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 8178155
genes like me logo Genes that share ontologies with IL15: view

Compounds for IL15 Gene

(72) Novoseek inferred chemical compound relationships for IL15 Gene

Compound -log(P) Hits PubMed IDs
rantes 70.1 57
il-12 52.5 8
gliadin 46.1 10
alpha-galactosylceramide 45.9 10
blys 43.4 1
genes like me logo Genes that share compounds with IL15: view

Transcripts for IL15 Gene

Unigene Clusters for IL15 Gene

Interleukin 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - -
SP5: - - -
SP6:

Relevant External Links for IL15 Gene

GeneLoc Exon Structure for
IL15
ECgene alternative splicing isoforms for
IL15

Expression for IL15 Gene

mRNA expression in normal human tissues for IL15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for IL15 Gene Hs.168132

mRNA Expression by UniProt/SwissProt for IL15 Gene

P40933-IL15_HUMAN
Tissue specificity: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus
genes like me logo Genes that share expressions with IL15: view

Orthologs for IL15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL15 36
  • 100 (n)
  • 100 (a)
IL15 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL15 36
  • 87.86 (n)
  • 78.4 (a)
IL15 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL15 36
  • 84.16 (n)
  • 84.57 (a)
IL15 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il15 36
  • 80.45 (n)
  • 72.84 (a)
Il15 16
Il15 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL15 37
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL15 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il15 36
  • 79.84 (n)
  • 72.22 (a)
chicken
(Gallus gallus)
Aves IL15 37
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL15 37
  • 26 (a)
OneToOne
Species with no ortholog for IL15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL15 Gene

ENSEMBL:
Gene Tree for IL15 (if available)
TreeFam:
Gene Tree for IL15 (if available)

Paralogs for IL15 Gene

No data available for Paralogs for IL15 Gene

Variants for IL15 Gene

Sequence variations from dbSNP and Humsavar for IL15 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs10833 -- 141,733,394(-) ACAGT(A/G)TAAAG utr-variant-3-prime, nc-transcript-variant
rs932209 -- 141,667,294(-) TCTAA(C/T)CGATC intron-variant
rs957077 -- 141,658,663(+) GACTT(C/T)AAGGA intron-variant
rs990851 -- 141,646,450(+) caccc(C/G)cttcc intron-variant
rs1021446 -- 141,727,404(+) agtcc(A/G)tttac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL15 Gene

Variant ID Type Subtype PubMed ID
nsv880172 CNV Loss 21882294
nsv880173 CNV Gain 21882294
nsv830094 CNV Loss 17160897

Relevant External Links for IL15 Gene

HapMap Linkage Disequilibrium report
IL15

Disorders for IL15 Gene

(1) University of Copenhagen DISEASES for IL15 Gene

(89) Novoseek inferred disease relationships for IL15 Gene

Disease -log(P) Hits PubMed IDs
severe combined immunodeficiency, x-linked 80.6 19
necrosis 64.5 102
rheumatoid arthritis 61.1 65
tumors 54.4 130
autoimmune diseases 54.1 24

Relevant External Links for IL15

Genetic Association Database (GAD)
IL15
Human Genome Epidemiology (HuGE) Navigator
IL15
genes like me logo Genes that share disorders with IL15: view

No data available for UniProtKB/Swiss-Prot for IL15 Gene

Publications for IL15 Gene

  1. Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines. (PMID: 8668345) Meazza R. … Ferrini S. (Oncogene 1996) 3 4 23
  2. Polymorphisms in interleukin-15 gene on chromosome 4q31.2 are associated with psoriasis vulgaris in Chinese population. (PMID: 17554368) Zhang X.J. … Liu J.J. (J. Invest. Dermatol. 2007) 3 23 49
  3. Molecular screening and association study of IL15 gene polymorphisms in rheumatoid arthritis. (PMID: 17616399) Rueda B. … Martin J. (Cytokine 2007) 3 23 49
  4. IL15 gene variants are not associated with asthma and atopy. (PMID: 19133918) Pinto L.A. … Kabesch M. (Allergy 2009) 3 23 49
  5. Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. (PMID: 19505916) Van Dyke A.L. … Schwartz A.G. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 23 49

Products for IL15 Gene

Sources for IL15 Gene

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