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Aliases for DPPA3 Gene

Aliases for DPPA3 Gene

  • Developmental Pluripotency Associated 3 2 3 5
  • Stella-Related Protein 3 4
  • STELLAR 4
  • STELLA 3

External Ids for DPPA3 Gene

Previous GeneCards Identifiers for DPPA3 Gene

  • GC00U909444
  • GC12U900415
  • GC12P007757
  • GC12P007864

Summaries for DPPA3 Gene

Entrez Gene Summary for DPPA3 Gene

  • This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPPA3 Gene

DPPA3 (Developmental Pluripotency Associated 3) is a Protein Coding gene. GO annotations related to this gene include methylated histone binding.

UniProtKB/Swiss-Prot for DPPA3 Gene

  • Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at Lys-9 (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).

Gene Wiki entry for DPPA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPPA3 Gene

Genomics for DPPA3 Gene

Genomic Location for DPPA3 Gene

Chromosome:
12
Start:
7,711,454 bp from pter
End:
7,717,559 bp from pter
Size:
6,106 bases
Orientation:
Plus strand

Genomic View for DPPA3 Gene

Genes around DPPA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPPA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPPA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPPA3 Gene

Proteins for DPPA3 Gene

  • Protein details for DPPA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6W0C5-DPPA3_HUMAN
    Recommended name:
    Developmental pluripotency-associated protein 3
    Protein Accession:
    Q6W0C5
    Secondary Accessions:
    • Q0P5U3
    • Q6JZS6

    Protein attributes for DPPA3 Gene

    Size:
    159 amino acids
    Molecular mass:
    17851 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DPPA3 Gene

Proteomics data for DPPA3 Gene at MOPED

Post-translational modifications for DPPA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPPA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DPPA3 Gene

Domains & Families for DPPA3 Gene

Protein Domains for DPPA3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DPPA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6W0C5

UniProtKB/Swiss-Prot:

DPPA3_HUMAN :
  • Mediates binding to H3K9me2 via N-terminal region, while ability to exclude TET3 from the maternal pronucleus requires the C-terminal part.
Domain:
  • Mediates binding to H3K9me2 via N-terminal region, while ability to exclude TET3 from the maternal pronucleus requires the C-terminal part.
genes like me logo Genes that share domains with DPPA3: view

No data available for Gene Families for DPPA3 Gene

Function for DPPA3 Gene

Molecular function for DPPA3 Gene

UniProtKB/Swiss-Prot Function:
Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at Lys-9 (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).

Phenotypes for DPPA3 Gene

GenomeRNAi human phenotypes for DPPA3:
genes like me logo Genes that share phenotypes with DPPA3: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DPPA3 Gene

Localization for DPPA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPPA3 Gene

Nucleus. Cytoplasm. Note=Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPPA3 Gene COMPARTMENTS Subcellular localization image for DPPA3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for DPPA3 Gene

Pathways & Interactions for DPPA3 Gene

SuperPathways for DPPA3 Gene

No Data Available

Interacting Proteins for DPPA3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000339250%0d%0a9606.ENSP00000261574%0d%0a
Selected Interacting proteins: Q6W0C5-DPPA3_HUMAN ENSP00000339250 for DPPA3 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for DPPA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0040016 embryonic cleavage IEA --
GO:0044726 protection of DNA demethylation of female pronucleus IEA,ISS --
genes like me logo Genes that share ontologies with DPPA3: view

No data available for Pathways by source and SIGNOR curated interactions for DPPA3 Gene

Drugs & Compounds for DPPA3 Gene

No Compound Related Data Available

Transcripts for DPPA3 Gene

mRNA/cDNA for DPPA3 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DPPA3 Gene

Developmental pluripotency associated 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPPA3 Gene

No ASD Table

Relevant External Links for DPPA3 Gene

GeneLoc Exon Structure for
DPPA3
ECgene alternative splicing isoforms for
DPPA3

Expression for DPPA3 Gene

mRNA expression in normal human tissues for DPPA3 Gene

mRNA differential expression in normal tissues according to GTEx for DPPA3 Gene

This gene is overexpressed in Testis (x26.0), Ovary (x21.8), and Whole Blood (x4.0).

SOURCE GeneReport for Unigene cluster for DPPA3 Gene Hs.131358

mRNA Expression by UniProt/SwissProt for DPPA3 Gene

Q6W0C5-DPPA3_HUMAN
Tissue specificity: Low expression in testis, ovary and thymus. Expressed in embryonic stem and carcinoma cells. Highly expressed in testicular germ cell tumors.
genes like me logo Genes that share expression patterns with DPPA3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DPPA3 Gene

Orthologs for DPPA3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPPA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPPA3 35
  • 99.58 (n)
  • 99.37 (a)
DPPA3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPPA3 36
  • 29 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPPA3 36
  • 24 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dppa3 36
  • 35 (a)
OneToOne
Species with no ortholog for DPPA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPPA3 Gene

ENSEMBL:
Gene Tree for DPPA3 (if available)
TreeFam:
Gene Tree for DPPA3 (if available)

Paralogs for DPPA3 Gene

genes like me logo Genes that share paralogs with DPPA3: view

No data available for Paralogs for DPPA3 Gene

Variants for DPPA3 Gene

Sequence variations from dbSNP and Humsavar for DPPA3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2024320 - 7,715,251(+) GTAGC(C/G)AATCT reference, missense
rs999074 -- 7,711,716(+) GGCTG(C/T)CGTCT intron-variant
rs999075 -- 7,713,207(-) GAAGG(C/T)GTTGG intron-variant
rs999076 -- 7,713,185(-) CTGCC(A/G)CCACC intron-variant
rs7133011 -- 7,709,942(+) cctcc(C/T)aaagt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DPPA3 Gene

Variant ID Type Subtype PubMed ID
dgv5e196 CNV Duplication 17116639
dgv6e196 CNV Duplication 17116639
esv2422393 CNV Duplication 17116639
dgv57e55 CNV Gain 17911159
dgv454e1 CNV Complex 17122850
dgv455e1 CNV Complex 17122850
nsv428270 CNV Gain 18775914

Variation tolerance for DPPA3 Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPPA3 Gene

HapMap Linkage Disequilibrium report
DPPA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPPA3 Gene

Disorders for DPPA3 Gene

Relevant External Links for DPPA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPPA3

No disorders were found for DPPA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPPA3 Gene

Publications for DPPA3 Gene

  1. NANOS3 function in human germ cell development. (PMID: 21421998) Julaton V.T. … Reijo Pera R.A. (Hum. Mol. Genet. 2011) 3 4 67
  2. Inhibition of maintenance DNA methylation by Stella. (PMID: 25280994) Funaki S. … Nakano T. (Biochem. Biophys. Res. Commun. 2014) 3
  3. STELLA facilitates differentiation of germ cell and endodermal lineages of human embryonic stem cells. (PMID: 23457636) Wongtrakoongate P. … Andrews P.W. (PLoS ONE 2013) 3
  4. PGC7/Stella protects against DNA demethylation in early embryogenesis. (PMID: 17143267) Nakamura T. … Nakano T. (Nat. Cell Biol. 2007) 3
  5. Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin. (PMID: 16291741) Elliman S.J. … Kemp D.M. (J. Biol. Chem. 2006) 3

Products for DPPA3 Gene

Sources for DPPA3 Gene

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