Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL10RB Gene

Aliases for IL10RB Gene

  • Interleukin 10 Receptor, Beta 2 3
  • CRFB4 3 4 6
  • Cytokine Receptor Class-II Member 4 3 4
  • Cytokine Receptor Family 2 Member 4 3 4
  • Interleukin-10 Receptor Subunit 2 3 4
  • IL-10 Receptor Subunit Beta 3 4
  • IL-10R Subunit Beta 3 4
  • IL-10R Subunit 2 3 4
  • IL-10R2 3 4
  • IL-10RB 3 4
  • D21S58 3 4
  • D21S66 3 4
  • CRF2-4 3 4
  • Cytokine Receptor Family II, Member 4 3
  • Interleukin-10 Receptor Subunit Beta 3
  • Cytokine Receptor Class-II CRF2-4 3
  • CDw210b Antigen 4
  • CDW210B 3
  • IBD25 6

External Ids for IL10RB Gene

Previous Symbols for IL10RB Gene

  • CRFB4
  • D21S58
  • D21S66

Summaries for IL10RB Gene

Entrez Gene Summary for IL10RB Gene

  • The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL10RB Gene

IL10RB (Interleukin 10 Receptor, Beta) is a Protein Coding gene. Diseases associated with IL10RB include inflammatory bowel disease 25, early onset, autosomal recessive and inflammatory bowel disease. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include receptor activity and interleukin-10 receptor activity. An important paralog of this gene is IFNAR1.

UniProtKB/Swiss-Prot for IL10RB Gene

  • Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.

Gene Wiki entry for IL10RB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL10RB Gene

Genomics for IL10RB Gene

Genomic Location for IL10RB Gene

Start:
33,266,358 bp from pter
End:
33,297,234 bp from pter
Size:
30,877 bases
Orientation:
Plus strand

Genomic View for IL10RB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL10RB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL10RB Gene

Regulatory Elements for IL10RB Gene

Proteins for IL10RB Gene

  • Protein details for IL10RB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08334-I10R2_HUMAN
    Recommended name:
    Interleukin-10 receptor subunit beta
    Protein Accession:
    Q08334
    Secondary Accessions:
    • Q9BUU4

    Protein attributes for IL10RB Gene

    Size:
    325 amino acids
    Molecular mass:
    36995 Da
    Quaternary structure:
    • Heterodimer with IFNLR1.

    Three dimensional structures from OCA and Proteopedia for IL10RB Gene

neXtProt entry for IL10RB Gene

Proteomics data for IL10RB Gene at MOPED

Post-translational modifications for IL10RB Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn49, Asn68, Asn102, and Asn161

Other Protein References for IL10RB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL10RB Gene

Domains for IL10RB Gene

Gene Families for IL10RB Gene

HGNC:
  • CD :CD molecules
  • IL :Interleukins and interleukin receptors
IUPHAR :

Protein Domains for IL10RB Gene

UniProtKB/Swiss-Prot:

I10R2_HUMAN
Domain:
  • Contains 2 fibronectin type-III domains.:
    • Q08334
Family:
  • Belongs to the type II cytokine receptor family.:
    • Q08334
genes like me logo Genes that share domains with IL10RB: view

Function for IL10RB Gene

Molecular function for IL10RB Gene

GENATLAS Biochemistry: interleukin 10,receptor beta,cytokine receptor family II,member 4 (CRF2-4)
UniProtKB/Swiss-Prot Function: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.

Gene Ontology (GO) - Molecular Function for IL10RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8314576
GO:0004920 contributes_to interleukin-10 receptor activity TAS 10954742
GO:0005515 protein binding IPI 12483210
genes like me logo Genes that share ontologies with IL10RB: view
genes like me logo Genes that share phenotypes with IL10RB: view

Animal Models for IL10RB Gene

MGI Knock Outs for IL10RB:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL10RB Gene

Localization for IL10RB Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL10RB Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL10RB Gene COMPARTMENTS Subcellular localization image for IL10RB gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL10RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 10954742
GO:0016021 integral component of membrane TAS 9312047
GO:0032002 interleukin-28 receptor complex NAS 12483210
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IL10RB: view

Pathways for IL10RB Gene

genes like me logo Genes that share pathways with IL10RB: view

Pathways by source for IL10RB Gene

Gene Ontology (GO) - Biological Process for IL10RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 10954742
GO:0006955 immune response TAS 9463407
GO:0007165 signal transduction TAS 10954742
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with IL10RB: view

Transcripts for IL10RB Gene

Unigene Clusters for IL10RB Gene

Interleukin 10 receptor, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL10RB Gene

No ASD Table

Relevant External Links for IL10RB Gene

GeneLoc Exon Structure for
IL10RB
ECgene alternative splicing isoforms for
IL10RB

Expression for IL10RB Gene

mRNA expression in normal human tissues for IL10RB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL10RB Gene

This gene is overexpressed in Whole Blood (11.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL10RB Gene

SOURCE GeneReport for Unigene cluster for IL10RB Gene Hs.654593

genes like me logo Genes that share expressions with IL10RB: view

Orthologs for IL10RB Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL10RB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 97 (a)
OneToMany
IL10RB 36
  • 99.59 (n)
  • 99.69 (a)
cow
(Bos Taurus)
Mammalia IL10RB 36
  • 84.23 (n)
  • 79.18 (a)
IL10RB 37
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 68 (a)
ManyToMany
-- 37
  • 68 (a)
ManyToMany
IL10RB 36
  • 83.28 (n)
  • 79.44 (a)
mouse
(Mus musculus)
Mammalia Gm21970 37
  • 50 (a)
ManyToMany
Il10rb 36
  • 76.65 (n)
  • 69.44 (a)
Il10rb 16
Il10rb 37
  • 64 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 40 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Il10rb 36
  • 76.95 (n)
  • 72.53 (a)
chicken
(Gallus gallus)
Aves IL10R2 37
  • 38 (a)
OneToMany
IL10RB 36
  • 55.01 (n)
  • 43.03 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 29 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia il10rb 36
  • 48.83 (n)
  • 35.66 (a)
zebrafish
(Danio rerio)
Actinopterygii crfb15 37
  • 25 (a)
ManyToMany
crfb15 37
  • 19 (a)
ManyToMany
crfb4 36
  • 45.26 (n)
  • 30.08 (a)
crfb4 37
  • 23 (a)
ManyToMany
Species with no ortholog for IL10RB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL10RB Gene

ENSEMBL:
Gene Tree for IL10RB (if available)
TreeFam:
Gene Tree for IL10RB (if available)

Paralogs for IL10RB Gene

Paralogs for IL10RB Gene

genes like me logo Genes that share paralogs with IL10RB: view

Variants for IL10RB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IL10RB Gene

Q08334-I10R2_HUMAN
Genetic variations in IL10RB influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424]

Sequence variations from dbSNP and Humsavar for IL10RB Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs735299 -- 33,292,285(+) TGCCC(A/G)TGGGG intron-variant
rs743332 -- 33,294,825(+) AGGAA(G/T)ATGAA intron-variant
rs765429 -- 33,287,696(-) tctgc(A/G)tgaac intron-variant
rs872708 -- 33,293,145(-) GAGAT(C/T)CAGGG intron-variant
rs872709 -- 33,292,916(-) GGGGC(C/T)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL10RB Gene

Variant ID Type Subtype PubMed ID
nsv913714 CNV Gain 21882294
nsv913715 CNV Loss 21882294
nsv913716 CNV Loss 21882294
nsv913717 CNV Gain 21882294
nsv913718 CNV Gain 21882294
nsv913719 CNV Loss 21882294
nsv913720 CNV Loss 21882294

Relevant External Links for IL10RB Gene

HapMap Linkage Disequilibrium report
IL10RB
Human Gene Mutation Database (HGMD)
IL10RB

Disorders for IL10RB Gene

(2) OMIM Diseases for IL10RB Gene (123889)

UniProtKB/Swiss-Prot

I10R2_HUMAN
  • Inflammatory bowel disease 25 (IBD25) [MIM:612567]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:19890111}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) Novoseek inferred disease relationships for IL10RB Gene

Disease -log(P) Hits PubMed IDs
colitis 31.3 1
tumors 0 2

Relevant External Links for IL10RB

Genetic Association Database (GAD)
IL10RB
Human Genome Epidemiology (HuGE) Navigator
IL10RB
genes like me logo Genes that share disorders with IL10RB: view

Publications for IL10RB Gene

  1. A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. (PMID: 8314576) Lutfalla G. … Uze G. (Genomics 1993) 2 3 4 23
  2. Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis. (PMID: 18588853) Hikami K. … Tsuchiya N. (Biochem. Biophys. Res. Commun. 2008) 3 23 49
  3. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. (PMID: 19890111) Glocker E.O. … Klein C. (N. Engl. J. Med. 2009) 3 4 23
  4. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. (PMID: 9312047) Kotenko S.V. … Pestka S. (EMBO J. 1997) 2 3 4
  5. Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. (PMID: 17152005) Dhiman N. … Jacobson R.M. (J. Infect. Dis. 2007) 3 49

Products for IL10RB Gene

Sources for IL10RB Gene

Back to Top

Content