Aliases for IL10RA Gene
External Ids for IL10RA Gene
Previous HGNC Symbols for IL10RA Gene
Previous GeneCards Identifiers for IL10RA Gene
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
GeneCards Summary for IL10RA Gene
IL10RA (Interleukin 10 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL10RA include inflammatory bowel disease 28, early onset, autosomal recessive and autoinflammation, antibody deficiency, and immune dysregulation syndrome. Among its related pathways are ERK Signaling and Akt Signaling. GO annotations related to this gene include signal transducer activity and interleukin-10 receptor activity.
UniProtKB/Swiss-Prot for IL10RA Gene
Receptor for IL10; binds IL10 with a high affinity.