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Aliases for IL10RA Gene

Aliases for IL10RA Gene

  • Interleukin 10 Receptor Subunit Alpha 2 3 5
  • Interleukin-10 Receptor Subunit 1 3 4
  • Interleukin 10 Receptor, Alpha 2 3
  • IL-10 Receptor Subunit Alpha 3 4
  • IL-10R Subunit Alpha 3 4
  • IL-10R Subunit 1 3 4
  • CDW210A 3 4
  • IL-10R1 3 4
  • IL-10RA 3 4
  • IL10R 3 4
  • Interleukin-10 Receptor Subunit Alpha 3
  • Interleukin-10 Receptor Alpha Chain 3
  • CD210 Antigen 4
  • HIL-10R 3
  • CD210a 3
  • CD210 3

External Ids for IL10RA Gene

Previous HGNC Symbols for IL10RA Gene

  • IL10R

Previous GeneCards Identifiers for IL10RA Gene

  • GC11P120213
  • GC11P119368
  • GC11P117891
  • GC11P117394
  • GC11P117362
  • GC11P113790
  • GC11P117857

Summaries for IL10RA Gene

Entrez Gene Summary for IL10RA Gene

  • The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

GeneCards Summary for IL10RA Gene

IL10RA (Interleukin 10 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL10RA include Inflammatory Bowel Disease 28, Early Onset, Autosomal Recessive and Inflammatory Bowel Disease 25, Early Onset, Autosomal Recessive. Among its related pathways are Akt Signaling and Jak-STAT signaling pathway (KEGG). GO annotations related to this gene include signal transducer activity and interleukin-10 receptor activity.

UniProtKB/Swiss-Prot for IL10RA Gene

  • Receptor for IL10; binds IL10 with a high affinity.

Gene Wiki entry for IL10RA Gene

Additional gene information for IL10RA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL10RA Gene

Genomics for IL10RA Gene

Regulatory Elements for IL10RA Gene

Enhancers for IL10RA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H117997 2 FANTOM5 Ensembl ENCODE dbSUPER 30.1 +19.7 19718 17.5 HDGF PKNOX1 ARNT YBX1 ZNF766 ZNF143 ZNF207 FOS MCM5 JUNB IL10RA ENSG00000254528 ARCN1 RNF214 KMT2A ENSG00000254909 UBE4A RPL5P30 FXYD2 TMPRSS13
GH11H117978 1.6 FANTOM5 Ensembl ENCODE dbSUPER 27.1 -6.5 -6488 1.9 SMARCE1 PKNOX1 ZNF687 TAL1 JUN MAX EBF1 DPF2 RELA FOSL1 IL10RA TMPRSS13 TMPRSS4 GC11P117950
GH11H117944 1.3 FANTOM5 Ensembl ENCODE 27.1 -41.2 -41212 1.3 EBF1 DPF2 ATF2 RELA CTBP1 GATA2 SMARCA4 EED IKZF1 CREB1 IL10RA ENSG00000254844 DSCAML1 ENSG00000254528 FXYD2 FXYD6 FXYD6-FXYD2 GC11P117950 GC11M117924
GH11H117949 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.4 -34.6 -34557 5.4 HDAC1 HDGF FOXA2 PKNOX1 NFIB TBL1XR1 RAD21 ZNF766 GATA2 ATF7 IL10RA TMPRSS13 CD3E CD3G DSCAML1 ENSG00000254844 FXYD6 FXYD6-FXYD2 ENSG00000254528 FXYD2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL10RA on UCSC Golden Path with GeneCards custom track

Promoters for IL10RA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for IL10RA Gene

Genomic Locations for IL10RA Gene
16,690 bases
Plus strand

Genomic View for IL10RA Gene

Genes around IL10RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL10RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL10RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL10RA Gene

Proteins for IL10RA Gene

  • Protein details for IL10RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-10 receptor subunit alpha
    Protein Accession:
    Secondary Accessions:
    • A8K6I0
    • B0YJ27

    Protein attributes for IL10RA Gene

    578 amino acids
    Molecular mass:
    63003 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL10RA Gene

neXtProt entry for IL10RA Gene

Post-translational modifications for IL10RA Gene

  • Glycosylation at posLast=5050, isoforms=74, isoforms=110, isoforms=154, posLast=177177, and posLast=189189
  • Modification sites at PhosphoSitePlus

Other Protein References for IL10RA Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

  • Abcam proteins for IL10RA

No data available for DME Specific Peptides for IL10RA Gene

Domains & Families for IL10RA Gene

Gene Families for IL10RA Gene

Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Predicted membrane proteins

Protein Domains for IL10RA Gene


Suggested Antigen Peptide Sequences for IL10RA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type II cytokine receptor family.
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL10RA: view

Function for IL10RA Gene

Molecular function for IL10RA Gene

GENATLAS Biochemistry:
interleukin 10,receptor alpha,90-110kDa,expressed in hemopoietic cells and cell lines
UniProtKB/Swiss-Prot Function:
Receptor for IL10; binds IL10 with a high affinity.

Phenotypes From GWAS Catalog for IL10RA Gene

Gene Ontology (GO) - Molecular Function for IL10RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 8120391
GO:0004872 receptor activity TAS 8407942
GO:0004920 interleukin-10 receptor activity IBA,TAS --
GO:0005515 protein binding IPI 11485736
GO:0019969 interleukin-10 binding IEA --
genes like me logo Genes that share ontologies with IL10RA: view
genes like me logo Genes that share phenotypes with IL10RA: view

Human Phenotype Ontology for IL10RA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL10RA Gene

MGI Knock Outs for IL10RA:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL10RA Gene

Localization for IL10RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL10RA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL10RA gene
Compartment Confidence
plasma membrane 4
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IL10RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with IL10RA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL10RA Gene

Pathways & Interactions for IL10RA Gene

genes like me logo Genes that share pathways with IL10RA: view

Pathways by source for IL10RA Gene

SIGNOR curated interactions for IL10RA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL10RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0032496 response to lipopolysaccharide IEA --
GO:0050807 regulation of synapse organization IEA --
genes like me logo Genes that share ontologies with IL10RA: view

Drugs & Compounds for IL10RA Gene

(2) Drugs for IL10RA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IL10RA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL10RA: view

Transcripts for IL10RA Gene

Unigene Clusters for IL10RA Gene

Interleukin 10 receptor, alpha:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL10RA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: -
SP2: -
SP3: - -

Relevant External Links for IL10RA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL10RA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL10RA Gene

mRNA differential expression in normal tissues according to GTEx for IL10RA Gene

This gene is overexpressed in Whole Blood (x13.0) and Spleen (x8.2).

Protein differential expression in normal tissues from HIPED for IL10RA Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL10RA Gene

Protein tissue co-expression partners for IL10RA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL10RA Gene:


SOURCE GeneReport for Unigene cluster for IL10RA Gene:


mRNA Expression by UniProt/SwissProt for IL10RA Gene:

Tissue specificity: Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.

Evidence on tissue expression from TISSUES for IL10RA Gene

  • Blood(4.6)
  • Spleen(2.9)
  • Lymph node(2.7)
  • Intestine(2.4)
  • Bone marrow(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL10RA Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • reproductive
  • respiratory
  • intestine
  • large intestine
  • small intestine
  • stomach
  • anus
  • rectum
  • vagina
  • blood
  • bone marrow
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with IL10RA: view

Orthologs for IL10RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL10RA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL10RA 33 34
  • 98.96 (n)
(Canis familiaris)
Mammalia IL10RA 34 33
  • 79.64 (n)
(Bos Taurus)
Mammalia IL10RA 33 34
  • 78.68 (n)
(Mus musculus)
Mammalia Il10ra 16 34 33
  • 68.97 (n)
(Rattus norvegicus)
Mammalia Il10ra 33
  • 68.49 (n)
(Monodelphis domestica)
Mammalia IL10RA 34
  • 41 (a)
(Ornithorhynchus anatinus)
Mammalia IL10RA 34
  • 35 (a)
(Gallus gallus)
Aves IL10RA 33
  • 49.59 (n)
IL10R1 34
  • 29 (a)
(Anolis carolinensis)
Reptilia IL10RA 34
  • 30 (a)
Species where no ortholog for IL10RA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL10RA Gene

Gene Tree for IL10RA (if available)
Gene Tree for IL10RA (if available)

Paralogs for IL10RA Gene

No data available for Paralogs for IL10RA Gene

Variants for IL10RA Gene

Sequence variations from dbSNP and Humsavar for IL10RA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs137853579 Pathogenic, Inflammatory bowel disease 28 (IBD28) [MIM:613148] 117,993,294(+) TCCTC(A/G)GGAAG nc-transcript-variant, reference, missense
rs137853580 Pathogenic, Inflammatory bowel disease 28 (IBD28) [MIM:613148] 117,989,504(+) CCTTA(C/T)CGCAG nc-transcript-variant, reference, missense
rs149491038 Pathogenic, Inflammatory bowel disease 28 (IBD28) [MIM:613148] 117,995,684(+) TGCGG(C/T)GCCGA nc-transcript-variant, reference, missense
rs199989396 Inflammatory bowel disease 28 (IBD28) [MIM:613148] 117,989,603(+) CACCC(A/G)CTTCT nc-transcript-variant, reference, missense
rs368287711 Pathogenic, Inflammatory bowel disease 28 (IBD28) [MIM:613148] 117,989,554(+) GAGTG(A/C/T)GGGCT nc-transcript-variant, reference, synonymous-codon

Variation tolerance for IL10RA Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.86; 67.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL10RA Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL10RA Gene

Disorders for IL10RA Gene

MalaCards: The human disease database

(10) MalaCards diseases for IL10RA Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 28, early onset, autosomal recessive
  • inflammatory bowel disease 28
inflammatory bowel disease 25, early onset, autosomal recessive
  • inflammatory bowel disease 25
cytomegalovirus retinitis
  • cmv retinitis
inflammatory bowel disease
  • inflammatory bowel diseases
crohn's disease
  • crohn disease
- elite association - COSMIC cancer census association via MalaCards


  • Inflammatory bowel disease 28 (IBD28) [MIM:613148]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:19890111, ECO:0000269 PubMed:23839161, ECO:0000269 PubMed:24785691}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IL10RA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL10RA: view

No data available for Genatlas for IL10RA Gene

Publications for IL10RA Gene

  1. Expression cloning and characterization of a human IL-10 receptor. (PMID: 8120391) Liu Y … Moore KW (Journal of immunology (Baltimore, Md. : 1950) 1994) 2 3 4 22 60
  2. Environmental and genetic factors influence the relationship between circulating IL-10 and obesity phenotypes. (PMID: 19798061) Bassols J … Fernandez-Real JM (Obesity (Silver Spring, Md.) 2010) 3 22 45 60
  3. Interleukin 10 receptor alpha subunit (IL-10RA) gene polymorphism and IL-10 serum levels in Egyptian atopic patients. (PMID: 20232770) Hussein PY … Bakr N (Journal of investigational allergology & clinical immunology 2010) 3 22 45 60
  4. The IL-10R1 S138G loss-of-function allele and ulcerative colitis. (PMID: 18800073) Grundtner P … Gasche C (Genes and immunity 2009) 3 22 45 60
  5. Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor. (PMID: 19409109) Sivula J … Partanen J (BMC immunology 2009) 3 22 45 60

Products for IL10RA Gene

Sources for IL10RA Gene

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