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Aliases for IL9R Gene

Aliases for IL9R Gene

  • Interleukin 9 Receptor 2 3
  • IL-9 Receptor 3 4
  • IL-9R 3 4
  • Interleukin-9 Receptor 3
  • CD129 Antigen 4
  • CD129 3

External Ids for IL9R Gene

Summaries for IL9R Gene

Entrez Gene Summary for IL9R Gene

  • The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL9R Gene

IL9R (Interleukin 9 Receptor) is a Protein Coding gene. Diseases associated with IL9R include bronchitis and adult t-cell leukemia. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include interleukin-9 receptor activity.

UniProtKB/Swiss-Prot for IL9R Gene

  • This is a receptor for interleukin-9

Gene Wiki entry for IL9R Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL9R Gene

Genomics for IL9R Gene

Genomic Location for IL9R Gene

Start:
155,997,581 bp from pter
End:
156,010,817 bp from pter
Size:
13,237 bases
Orientation:
Plus strand

Genomic View for IL9R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL9R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL9R Gene

Regulatory Elements for IL9R Gene

Transcription factor binding sites by QIAGEN in the IL9R gene promoter:

Proteins for IL9R Gene

  • Protein details for IL9R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01113-IL9R_HUMAN
    Recommended name:
    Interleukin-9 receptor
    Protein Accession:
    Q01113
    Secondary Accessions:
    • B9ZVT0
    • Q14634
    • Q8WWU1
    • Q96TF0

    Protein attributes for IL9R Gene

    Size:
    521 amino acids
    Molecular mass:
    57147 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes
    SequenceCaution:
    • Sequence=AAB30844.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for IL9R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL9R Gene

Proteomics data for IL9R Gene at MOPED

Post-translational modifications for IL9R Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys94, Lys187, Lys19, and Lys48
  • Glycosylation at Asn117 and Asn156

Other Protein References for IL9R Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL9R Gene

Domains for IL9R Gene

Gene Families for IL9R Gene

HGNC:
  • CD :CD molecules
  • PAR2 :Pseudoautosomal regions / PAR2
  • IL :Interleukins and interleukin receptors
IUPHAR :

Protein Domains for IL9R Gene

UniProtKB/Swiss-Prot:

IL9R_HUMAN
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding:
    • Q01113
  • The box 1 motif is required for JAK interaction and/or activation:
    • Q01113
  • Contains 1 fibronectin type-III domain.:
    • Q01113
Family:
  • Belongs to the type I cytokine receptor family. Type 4 subfamily.:
    • Q01113
genes like me logo Genes that share domains with IL9R: view

Function for IL9R Gene

Molecular function for IL9R Gene

GENATLAS Biochemistry: interleukin 9 receptor,X-linked,escaping X inactivation,subtelomeric long arm pseudoautosomal region (PARXQ),with several alternatively spliced forms
UniProtKB/Swiss-Prot Function: This is a receptor for interleukin-9

Gene Ontology (GO) - Molecular Function for IL9R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004919 interleukin-9 receptor activity IEA --
GO:0005515 protein binding --
GO:0019983 interleukin-9 binding IEA --
genes like me logo Genes that share ontologies with IL9R: view

Phenotypes for IL9R Gene

GenomeRNAi human phenotypes for IL9R:
genes like me logo Genes that share phenotypes with IL9R: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IL9R Gene

Localization for IL9R Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL9R Gene

Cell membrane; Single-pass type I membrane protein. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL9R Gene COMPARTMENTS Subcellular localization image for IL9R gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for IL9R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 1376929
GO:0005887 integral component of plasma membrane TAS 1376929
genes like me logo Genes that share ontologies with IL9R: view

Pathways for IL9R Gene

genes like me logo Genes that share pathways with IL9R: view

Pathways by source for IL9R Gene

Gene Ontology (GO) - Biological Process for IL9R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 1376929
GO:0008283 cell proliferation TAS 1376929
GO:0030307 positive regulation of cell growth IEA --
GO:0038113 interleukin-9-mediated signaling pathway IEA --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with IL9R: view

Compounds for IL9R Gene

(1) Novoseek inferred chemical compound relationships for IL9R Gene

Compound -log(P) Hits PubMed IDs
chloride 31.5 2
genes like me logo Genes that share compounds with IL9R: view

Transcripts for IL9R Gene

Unigene Clusters for IL9R Gene

Interleukin 9 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL9R Gene

No ASD Table

Relevant External Links for IL9R Gene

GeneLoc Exon Structure for
IL9R
ECgene alternative splicing isoforms for
IL9R

Expression for IL9R Gene

mRNA expression in normal human tissues for IL9R Gene

SOURCE GeneReport for Unigene cluster for IL9R Gene Hs.406228

genes like me logo Genes that share expressions with IL9R: view

Orthologs for IL9R Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL9R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL9R 37
  • 68 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL9R 36
  • 74.4 (n)
  • 65.2 (a)
IL9R 37
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL9R 36
  • 78.35 (n)
  • 65.56 (a)
IL9R 37
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il9r 36
  • 74.4 (n)
  • 61.38 (a)
Il9r 37
  • 58 (a)
OneToOne
MGI:96564 16
oppossum
(Monodelphis domestica)
Mammalia IL9R 37
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL9R 37
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il9r 36
  • 72.41 (n)
  • 58.61 (a)
chicken
(Gallus gallus)
Aves IL9R 36
  • 51 (n)
  • 36.94 (a)
IL9R 37
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL9R 37
  • 30 (a)
OneToOne
Species with no ortholog for IL9R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL9R Gene

ENSEMBL:
Gene Tree for IL9R (if available)
TreeFam:
Gene Tree for IL9R (if available)

Paralogs for IL9R Gene

genes like me logo Genes that share paralogs with IL9R: view

No data available for Paralogs for IL9R Gene

Variants for IL9R Gene

Sequence variations from dbSNP and Humsavar for IL9R Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_014804 -
VAR_033920 -
VAR_038784 -
VAR_055348 -
VAR_055349 -

Structural Variations from Database of Genomic Variants (DGV) for IL9R Gene

Variant ID Type Subtype PubMed ID
esv22690 CNV Loss 19812545

Relevant External Links for IL9R Gene

HapMap Linkage Disequilibrium report
IL9R
Locus Specific Mutation Databases (LSDB)
IL9R

Disorders for IL9R Gene

(4) Novoseek inferred disease relationships for IL9R Gene

Disease -log(P) Hits PubMed IDs
asthma 43.3 5
airways disease 36.7 1
bronchitis chronic 35.5 1
cystic fibrosis 9.19 5

Relevant External Links for IL9R

Genetic Association Database (GAD)
IL9R
Human Genome Epidemiology (HuGE) Navigator
IL9R
genes like me logo Genes that share disorders with IL9R: view

No data available for UniProtKB/Swiss-Prot for IL9R Gene

Publications for IL9R Gene

  1. The IL-9 receptor gene (IL9R): genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter. (PMID: 8666384) Kermouni A. … Renauld J.-C. (Genomics 1995) 2 3 4 23
  2. The IL9R region contribution in asthma is supported by genetic association in an isolated population. (PMID: 11039580) Kauppi P. … Kere J. (Eur. J. Hum. Genet. 2000) 3 23 49
  3. Expression cloning of the murine and human interleukin 9 receptor cDNAs. (PMID: 1376929) Renauld J.-C. … van Snick J. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4
  4. T(H)2 cytokines modulate the IL-9R expression on human neutrophils. (PMID: 19401191) Dragon S. … Gounni A.S. (Biochem. Biophys. Res. Commun. 2009) 3 23
  5. Isolation and characterization of the human interleukin-9 receptor gene. (PMID: 8193355) Chang M.S. … McNinch J. (Blood 1994) 3 4

Products for IL9R Gene

Sources for IL9R Gene

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