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CXCR2 Gene(Protein Coding)

C-X-C Motif Chemokine Receptor 2

GCID:
GC02P218125
GIFtS:
68
Genes Participants
UDN Logo

Aliases for CXCR2 Gene

Aliases for CXCR2 Gene

  • C-X-C Motif Chemokine Receptor 2 2 3 5
  • High Affinity Interleukin-8 Receptor B 3 4
  • Interleukin 8 Receptor, Beta 2 3
  • IL-8 Receptor Type 2 3 4
  • GRO/MGSA Receptor 3 4
  • IL-8R B 3 4
  • CDw128b 3 4
  • CXC-R2 3 4
  • CXCR-2 3 4
  • IL8RB 3 4
  • Chemokine (C-X-C Motif) Receptor 2 2
  • CXCR2 Gene For IL8 Receptor Type B 3
  • C-X-C Chemokine Receptor Type 2 3
  • Interleukin 8 Receptor Type 2 3
  • Interleukin-8 Receptor Type B 3
  • Chemokine (CXC) Receptor 2 3
  • CD182 Antigen 4
  • CMKAR2 3
  • IL8RA 3
  • CD182 3
  • IL8R2 3

External Ids for CXCR2 Gene

Previous HGNC Symbols for CXCR2 Gene

  • IL8RB

Previous GeneCards Identifiers for CXCR2 Gene

  • GC02P218699
  • GC02P218991
  • GC02P210842
  • GC02P218994
  • GC02P219006
  • GC02P219012
  • GC02P219021

Summaries for CXCR2 Gene

Entrez Gene Summary for CXCR2 Gene

  • The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

GeneCards Summary for CXCR2 Gene

CXCR2 (C-X-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CXCR2 include Autosomal Recessive Severe Congenital Neutropenia Due To Cxcr2 Deficiency and Human Granulocytic Anaplasmosis. Among its related pathways are Peptide ligand-binding receptors and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CXCR1.

UniProtKB/Swiss-Prot for CXCR2 Gene

  • Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

Tocris Summary for CXCR2 Gene

  • Chemokine CXC receptors (CXCRs) predominantly recognize CXC chemokines. CXC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being separated by a single amino acid. There are six chemokine CXC receptors.

Gene Wiki entry for CXCR2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCR2 Gene

Genomics for CXCR2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CXCR2 Gene

Enhancers for CXCR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G218145 0.9 FANTOM5 89.4 +20.0 20037 0.3 CTCF NFIB CEBPG RAD21 GATAD1 THAP11 GATAD2A ZNF263 NFIA FOXA3 CXCR2 CXCR1 ENSG00000261338 TNS1 SLC11A1 CTDSP1 ARPC2 GC02P218136
GH02G218366 1.6 FANTOM5 ENCODE dbSUPER 7.3 +244.6 244587 6.8 HDGF ATF1 CREB3L1 SIN3A YY1 ETS1 ZNF143 ZNF207 ZNF263 PAF1 SLC11A1 ENSG00000261338 ARPC2 CXCR2 CXCR1 CATIP PNKD CNOT9 TMBIM1 USP37
GH02G218156 0.5 FANTOM5 22.5 +31.0 30993 0.3 CTCF CEBPB CXCR1 CXCR2 ENSG00000261338 CTDSP1 SLC11A1 ARPC2 GC02P218136
GH02G218080 0.8 dbSUPER 11 -43.9 -43902 1.3 PKNOX1 BMI1 RELA FOSL1 EED ZNF239 IKZF2 CREM CHD2 SRF ENSG00000261338 TNS1 CXCR2 PIR54369 CXCR2P1
GH02G217939 1.6 FANTOM5 ENCODE dbSUPER 5.1 -183.3 -183320 5.5 HDGF FOXA2 ARNT MLX ARID4B DMAP1 FEZF1 YY1 ZNF143 FOS TNS1 LOC105373878 CXCR2 GC02P217941 GC02P217959
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CXCR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CXCR2 Gene

Chromosome:
2
Start:
218,125,289 bp from pter
End:
218,137,253 bp from pter
Size:
11,965 bases
Orientation:
Plus strand

Genomic View for CXCR2 Gene

Genes around CXCR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCR2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CXCR2 Gene

Proteins for CXCR2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CXCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25025-CXCR2_HUMAN
    Recommended name:
    C-X-C chemokine receptor type 2
    Protein Accession:
    P25025
    Secondary Accessions:
    • Q8IUZ1
    • Q9P2T6
    • Q9P2T7

    Protein attributes for CXCR2 Gene

    Size:
    360 amino acids
    Molecular mass:
    40759 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCR2 Gene

neXtProt entry for CXCR2 Gene

Protein Expression for CXCR2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CXCR2 Gene

  • Phosphorylated upon ligand binding; which is required for desensitization.
  • Glycosylation at Asn22
  • Modification sites at PhosphoSitePlus

Other Protein References for CXCR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CXCR2 (CXCR2/IL-8 RB)
  • Cloud-Clone Corp. Antibodies for CXCR2

No data available for DME Specific Peptides for CXCR2 Gene

Domains & Families for CXCR2 Gene

Gene Families for CXCR2 Gene

HGNC:
IUPHAR :

Protein Domains for CXCR2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CXCR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25025

UniProtKB/Swiss-Prot:

CXCR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR2: view

Function for CXCR2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CXCR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

Gene Ontology (GO) - Molecular Function for CXCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IDA,IEA 10438939
GO:0004918 interleukin-8 receptor activity IDA 10820279
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 23597562
GO:0016494 C-X-C chemokine receptor activity IEA,IDA 10878382
genes like me logo Genes that share ontologies with CXCR2: view
genes like me logo Genes that share phenotypes with CXCR2: view

Animal Models for CXCR2 Gene

MGI Knock Outs for CXCR2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCR2 Gene

Localization for CXCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCR2 gene
Compartment Confidence
plasma membrane 5
lysosome 5
extracellular 2
cytoskeleton 2
nucleus 1
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for CXCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 10878382
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10438939
GO:0009986 cell surface IDA 10878382
GO:0016020 membrane IEA,IDA 10725748
genes like me logo Genes that share ontologies with CXCR2: view

Pathways & Interactions for CXCR2 Gene

genes like me logo Genes that share pathways with CXCR2: view

SIGNOR curated interactions for CXCR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CXCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0006935 chemotaxis IDA,IEA 10725748
GO:0006954 inflammatory response TAS 9725262
GO:0006968 cellular defense response IDA 10725748
GO:0007165 signal transduction IEA,IDA 10820279
genes like me logo Genes that share ontologies with CXCR2: view

Drugs & Compounds for CXCR2 Gene

Products:

  1. Drug

(63) Drugs for CXCR2 Gene - From: ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fludarabine Approved Pharma DNA synthsis inhibitor 1154,1154
Aldesleukin Approved Pharma 405
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2935
Mesna Approved Pharma 263
Vidarabine Approved Pharma 521

(19) Additional Compounds for CXCR2 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CXCL1
Full agonist, Agonist
[<sup>125</sup>I]CXCL5
Full agonist, Agonist
[<sup>125</sup>I]CXCL7
Full agonist, Agonist

(9) ApexBio Compounds for CXCR2 Gene

Compound Action Cas Number
Plerixafor 8HCl (AMD3100 8HCl) CXCR4 antagonist 155148-31-5
Reparixin Inhibitor of CXCL8 receptor and CXCR1/CXCR2 activation 266359-83-5
Reparixin L-lysine salt CXCR1/CXCR2 inhibitor 266359-93-7
SB 225002 CXCR2 antagonist, potent and selective 182498-32-4
SB 265610 CXCR2 antagonist, potent 211096-49-0
SCH 527123 CXCR1 and CXCR2 receptors antagonist 473727-83-2
SCH 563705 CXCR2/CXCR1 antagonist,potent 473728-58-4
SRT3190 CXCR2 ligand,SIRT1 activator 1204707-73-2
WZ811 Competitive CXR4 antagonist,highly potent 55778-02-4
genes like me logo Genes that share compounds with CXCR2: view

Drug Products

Transcripts for CXCR2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CXCR2 Gene

(6) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCR2 Gene

Chemokine (C-X-C motif) receptor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for CXCR2 Gene

GeneLoc Exon Structure for
CXCR2
ECgene alternative splicing isoforms for
CXCR2

Expression for CXCR2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCR2 Gene

mRNA expression in normal human tissues for CXCR2 Gene
mRNA expression by BioGPS for CXCR2 GenemRNA expression by GTEx for CXCR2 Gene

mRNA differential expression in normal tissues according to GTEx for CXCR2 Gene

This gene is overexpressed in Whole Blood (x48.3).

Protein differential expression in normal tissues from HIPED for CXCR2 Gene

This gene is overexpressed in Nasal epithelium (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCR2 Gene



Protein tissue co-expression partners for CXCR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCR2 Gene:

CXCR2

SOURCE GeneReport for Unigene cluster for CXCR2 Gene:

Hs.846

Evidence on tissue expression from TISSUES for CXCR2 Gene

  • Blood(4.8)
  • Nervous system(4.3)
  • Lung(2.7)
  • Intestine(2.6)
  • Spleen(2.4)
  • Bone marrow(2.3)
  • Heart(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with CXCR2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCR2 Gene

Orthologs for CXCR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CXCR2 35 34
  • 99.26 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CXCR2 34 35
  • 82.25 (n)
-- 35
  • 73 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia CXCR2 34 35 35
  • 80.73 (n)
mouse
(Mus musculus)
 Mammalia Cxcr2 16 35 34
  • 77.72 (n)
rat
(Rattus norvegicus)
 Mammalia Cxcr2 34
  • 76.63 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 70 (a)
 ManyToMany
-- 35
  • 67 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 59 (a)
 ManyToMany
-- 35
  • 59 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 57 (a)
 ManyToMany
-- 35
  • 56 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC101732165 34
  • 65.33 (n)
zebrafish
(Danio rerio)
 Actinopterygii LOC796724 34
  • 55.25 (n)
CXCR1 35
  • 43 (a)
 OneToMany
Species where no ortholog for CXCR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXCR2 Gene

ENSEMBL:
Gene Tree for CXCR2 (if available)
TreeFam:
Gene Tree for CXCR2 (if available)

Paralogs for CXCR2 Gene

Paralogs for CXCR2 Gene

(65) SIMAP similar genes for CXCR2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CXCR2 Gene

genes like me logo Genes that share paralogs with CXCR2: view

Variants for CXCR2 Gene

Sequence variations from dbSNP and Humsavar for CXCR2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs149364972 Likely benign 218,135,036(+) GGGTC(A/G)GCCGC reference, missense
rs1000203679 -- 218,134,137(+) ACTTT(C/T)AGAAA intron-variant
rs1000470944 -- 218,125,923(+) ACCCC(A/G)GAAAG intron-variant, upstream-variant-2KB
rs1000720972 -- 218,134,456(+) GCCAC(C/T)GAAGG intron-variant
rs1000821382 -- 218,133,443(+) TACAG(C/G)TGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXCR2 Gene

Variant ID Type Subtype PubMed ID
nsv961560 CNV duplication 23825009

Variation tolerance for CXCR2 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CXCR2 Gene

Human Gene Mutation Database (HGMD)
CXCR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR2 Gene

Disorders for CXCR2 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CXCR2 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
autosomal recessive severe congenital neutropenia due to cxcr2 deficiency
human granulocytic anaplasmosis
  • hge
acute pyelonephritis
  • acute pyelonephritis nos
septicemic plague
  • plague, septicemic
lipid pneumonia
  • exogenous lipoid pneumonia
- elite association - COSMIC cancer census association via MalaCards
Search CXCR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CXCR2

Genetic Association Database (GAD)
CXCR2
Human Genome Epidemiology (HuGE) Navigator
CXCR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXCR2
genes like me logo Genes that share disorders with CXCR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCR2 Gene

Publications for CXCR2 Gene

  1. Single nucleotide polymorphisms in the coding regions of human CXC- chemokine receptors CXCR1, CXCR2 and CXCR3. (PMID: 11196695) Kato H. … Tokunaga K. (Genes Immun. 2000) 3 4 22 64
  2. Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor. (PMID: 9079638) Mueller S.G. … Richmond A. (J. Biol. Chem. 1997) 3 4 22 64
  3. Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B. (PMID: 7929358) Ahuja S.K. … Murphy P.M. (J. Biol. Chem. 1994) 3 4 22 64
  4. Characterization of two high affinity human interleukin-8 receptors. (PMID: 1379593) Lee J. … Wood W.I. (J. Biol. Chem. 1992) 3 4 22 64
  5. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 3 46 64

Products for CXCR2 Gene

  • Cloud-Clone Corp. Antibodies for CXCR2
  • Cloud-Clone Corp. Proteins for CXCR2
  • Cloud-Clone Corp Assay Kits for CXCR2
  • Addgene plasmids for CXCR2

Sources for CXCR2 Gene

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