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Aliases for CXCR2 Gene

Aliases for CXCR2 Gene

  • Chemokine (C-X-C Motif) Receptor 2 2 3
  • IL8RB 3 4 6
  • High Affinity Interleukin-8 Receptor B 3 4
  • Interleukin 8 Receptor, Beta 2 3
  • IL-8 Receptor Type 2 3 4
  • GRO/MGSA Receptor 3 4
  • IL-8R B 3 4
  • CDw128b 3 4
  • CXC-R2 3 4
  • CXCR-2 3 4
  • IL8R2 3 6
  • CXCR2 Gene For IL8 Receptor Type B 3
  • C-X-C Chemokine Receptor Type 2 3
  • Interleukin 8 Receptor Type 2 3
  • Interleukin-8 Receptor Type B 3
  • Chemokine (CXC) Receptor 2 3
  • Interleukin 8 Receptor B 3
  • CD182 Antigen 4
  • CMKAR2 3
  • CD182 3
  • IL8RA 3

External Ids for CXCR2 Gene

Previous HGNC Symbols for CXCR2 Gene

  • IL8RB

Previous GeneCards Identifiers for CXCR2 Gene

  • GC02P218699
  • GC02P218991
  • GC02P210842
  • GC02P218994
  • GC02P219006
  • GC02P219012
  • GC02P219021

Summaries for CXCR2 Gene

Entrez Gene Summary for CXCR2 Gene

  • The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

GeneCards Summary for CXCR2 Gene

CXCR2 (Chemokine (C-X-C Motif) Receptor 2) is a Protein Coding gene. Diseases associated with CXCR2 include human granulocytic anaplasmosis and classic kaposi sarcoma. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include signal transducer activity and interleukin-8 binding. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CXCR2 Gene

  • Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2

Gene Wiki entry for CXCR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCR2 Gene

Genomics for CXCR2 Gene

Genomic Location for CXCR2 Gene

Start:
218,125,289 bp from pter
End:
218,137,253 bp from pter
Size:
11,965 bases
Orientation:
Plus strand

Genomic View for CXCR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR2 Gene

No data available for Regulatory Elements for CXCR2 Gene

Proteins for CXCR2 Gene

  • Protein details for CXCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25025-CXCR2_HUMAN
    Recommended name:
    C-X-C chemokine receptor type 2
    Protein Accession:
    P25025
    Secondary Accessions:
    • Q8IUZ1
    • Q9P2T6
    • Q9P2T7

    Protein attributes for CXCR2 Gene

    Size:
    360 amino acids
    Molecular mass:
    40759 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCR2 Gene

neXtProt entry for CXCR2 Gene

Proteomics data for CXCR2 Gene at MOPED

Post-translational modifications for CXCR2 Gene

  • Phosphorylated upon ligand binding; which is required for desensitization.
  • Glycosylation at Asn22
  • Modification sites at PhosphoSitePlus

Other Protein References for CXCR2 Gene

Antibody Products

  • R&D Systems Antibodies for CXCR2 (CXCR2/IL-8 RB)

No data available for DME Specific Peptides for CXCR2 Gene

Domains for CXCR2 Gene

Gene Families for CXCR2 Gene

HGNC:
  • CD :CD molecules
  • CXCR :GPCR / Class A : Chemokine receptors : C-X-C motif
  • IL :Interleukins and interleukin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for CXCR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25025

UniProtKB/Swiss-Prot:

CXCR2_HUMAN :
  • P25025
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR2: view

Function for CXCR2 Gene

Molecular function for CXCR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2

Gene Ontology (GO) - Molecular Function for CXCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IDA 10438939
GO:0004918 interleukin-8 receptor activity IDA 10820279
GO:0004930 G-protein coupled receptor activity --
GO:0005515 protein binding IPI 23597562
GO:0016494 C-X-C chemokine receptor activity IDA 10878382
genes like me logo Genes that share ontologies with CXCR2: view
genes like me logo Genes that share phenotypes with CXCR2: view

Animal Models for CXCR2 Gene

MGI Knock Outs for CXCR2:

Animal Model Products

miRNA for CXCR2 Gene

miRTarBase miRNAs that target CXCR2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CXCR2 Gene

Localization for CXCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCR2 Gene COMPARTMENTS Subcellular localization image for CXCR2 gene
Compartment Confidence
lysosome 5
plasma membrane 5
vacuole 5
extracellular 2
nucleus 2
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for CXCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 10878382
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10438939
GO:0009986 cell surface IDA 10878382
GO:0016020 membrane IDA 10725748
genes like me logo Genes that share ontologies with CXCR2: view

Pathways for CXCR2 Gene

genes like me logo Genes that share pathways with CXCR2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CXCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0002438 acute inflammatory response to antigenic stimulus --
GO:0002690 positive regulation of leukocyte chemotaxis --
GO:0006935 chemotaxis IDA 10725748
GO:0006954 inflammatory response TAS 9725262
genes like me logo Genes that share ontologies with CXCR2: view

Compounds for CXCR2 Gene

Compound Products

(5) ApexBio Compounds for CXCR2 Gene

Compound Action Cas Number
Plerixafor 8HCl (AMD3100 8HCl) CXCR4 antagonist [155148-31-5]
Reparixin Inhibitor of CXCL8 receptor and CXCR1/CXCR2 activation [266359-83-5]
SB 225002 [182498-32-4]
SCH 527123 CXCR1 and CXCR2 receptors antagonist [473727-83-2]
WZ811 "Competitive CXR4 antagonist,highly potent" [55778-02-4]

(1) HMDB Compounds for CXCR2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(14) IUPHAR Ligand for CXCR2 Gene

Ligand Type Action Affinity Pubmed IDs
CXCL1 Agonist Full agonist 9.7
CXCL8 Agonist Full agonist 9.5
[125I]CXCL8 (human) Agonist Full agonist 9.4
CXCL7 Agonist Full agonist 9.3
CXCL3 Agonist Full agonist 9.2
CXCL2 Agonist Full agonist 9.1
CXCL5 Agonist Full agonist 9
SB 225002 Antagonist Antagonist 7.7
CXCL6 Agonist Full agonist 7
SK&F 83589 Antagonist Antagonist 6.3
[125I]CXCL7 Agonist Full agonist
[125I]CXCL1 Agonist Full agonist
vCXCL-1 Agonist Agonist
[125I]CXCL5 Agonist Full agonist

(31) Novoseek inferred chemical compound relationships for CXCR2 Gene

Compound -log(P) Hits PubMed IDs
groalpha 91.1 30
grogamma 81.7 5
grobeta 79.2 9
rantes 69.2 5
fmlp 48.9 8
genes like me logo Genes that share compounds with CXCR2: view

Transcripts for CXCR2 Gene

Unigene Clusters for CXCR2 Gene

Chemokine (C-X-C motif) receptor 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCR2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for CXCR2 Gene

GeneLoc Exon Structure for
CXCR2
ECgene alternative splicing isoforms for
CXCR2

Expression for CXCR2 Gene

mRNA expression in normal human tissues for CXCR2 Gene

mRNA differential expression in normal tissues according to GTEx for CXCR2 Gene

This gene is overexpressed in Whole Blood (48.3).

Protein differential expression in normal tissues for CXCR2 Gene

This gene is overexpressed in Nasal epithelium (66.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CXCR2 Gene

SOURCE GeneReport for Unigene cluster for CXCR2 Gene Hs.846

genes like me logo Genes that share expressions with CXCR2: view

Expression partners for CXCR2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CXCR2 Gene

Orthologs for CXCR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CXCR2 35
  • 80.73 (n)
  • 75.43 (a)
CXCR2 36
  • 77 (a)
OneToMany
CXCR2 36
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CXCR2 35
  • 82.25 (n)
  • 75.49 (a)
-- 36
  • 73 (a)
OneToMany
CXCR2 36
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cxcr2 35
  • 77.72 (n)
  • 71.31 (a)
Cxcr2 16
Cxcr2 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CXCR2 35
  • 99.26 (n)
  • 100 (a)
CXCR2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxcr2 35
  • 76.63 (n)
  • 71.51 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732165 35
  • 65.33 (n)
  • 59 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC796724 35
  • 55.25 (n)
  • 45.26 (a)
CXCR1 36
  • 43 (a)
OneToMany
Species with no ortholog for CXCR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXCR2 Gene

ENSEMBL:
Gene Tree for CXCR2 (if available)
TreeFam:
Gene Tree for CXCR2 (if available)

Paralogs for CXCR2 Gene

Pseudogenes.org Pseudogenes for CXCR2 Gene

genes like me logo Genes that share paralogs with CXCR2: view

Variants for CXCR2 Gene

Sequence variations from dbSNP and Humsavar for CXCR2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1126579 -- 218,136,011(+) GGAAG(C/T)AGAGG utr-variant-3-prime
rs1126580 -- 218,136,243(+) acggg(A/G)tgaaa utr-variant-3-prime
rs2228413 -- 218,135,682(+) CGACC(A/G)GGCTC missense, reference
rs2228414 -- 218,135,470(+) GTGCC(A/G)CTGCT reference, synonymous-codon
rs2230054 -- 218,135,587(+) CTGCT(C/T)TGCTG reference, synonymous-codon

Relevant External Links for CXCR2 Gene

HapMap Linkage Disequilibrium report
CXCR2
Human Gene Mutation Database (HGMD)
CXCR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CXCR2 Gene

Disorders for CXCR2 Gene

(2) University of Copenhagen DISEASES for CXCR2 Gene

(51) Novoseek inferred disease relationships for CXCR2 Gene

Disease -log(P) Hits PubMed IDs
inflammation 57 17
melanoma 44.1 50
pulmonary disease chronic obstructive 42.6 4
neovascularization 35.2 2
leukemia basophilic 32.8 2

Relevant External Links for CXCR2

Genetic Association Database (GAD)
CXCR2
Human Genome Epidemiology (HuGE) Navigator
CXCR2
genes like me logo Genes that share disorders with CXCR2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CXCR2 Gene

Publications for CXCR2 Gene

  1. Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor. (PMID: 9079638) Mueller S.G. … Richmond A. (J. Biol. Chem. 1997) 3 4 23
  2. Characterization of two high affinity human interleukin-8 receptors. (PMID: 1379593) Lee J. … Wood W.I. (J. Biol. Chem. 1992) 3 4 23
  3. Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B. (PMID: 7929358) Ahuja S.K. … Murphy P.M. (J. Biol. Chem. 1994) 3 4 23
  4. Single nucleotide polymorphisms in the coding regions of human CXC- chemokine receptors CXCR1, CXCR2 and CXCR3. (PMID: 11196695) Kato H. … Tokunaga K. (Genes Immun. 2000) 3 4 23
  5. Phosphorylation-independent association of CXCR2 with the protein phosphatase 2A core enzyme. (PMID: 11278485) Fan G.H. … Richmond A. (J. Biol. Chem. 2001) 3 23

Products for CXCR2 Gene

Sources for CXCR2 Gene

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