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Aliases for CXCR1 Gene

Aliases for CXCR1 Gene

  • Chemokine (C-X-C Motif) Receptor 1 2 3
  • IL8RA 3 4 6
  • High Affinity Interleukin-8 Receptor A 3 4
  • Interleukin 8 Receptor, Alpha 2 3
  • IL-8 Receptor Type 1 3 4
  • IL-8R A 3 4
  • CDw128a 3 4
  • CMKAR1 3 4
  • CXC-R1 3 4
  • CXCR-1 3 4
  • C-X-C Chemokine Receptor Type 1 3
  • Interleukin-8 Receptor Type 1 3
  • Interleukin-8 Receptor Type A 3
  • CD181 Antigen 4
  • C-C-CKR-1 3
  • IL8RBA 3
  • CKR-1 3
  • CD128 3
  • CD181 3
  • IL8R1 3
  • C-C 3

External Ids for CXCR1 Gene

Previous Symbols for CXCR1 Gene

  • CMKAR1
  • IL8RA

Summaries for CXCR1 Gene

Entrez Gene Summary for CXCR1 Gene

  • The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

GeneCards Summary for CXCR1 Gene

CXCR1 (Chemokine (C-X-C Motif) Receptor 1) is a Protein Coding gene. Diseases associated with CXCR1 include acute pyelonephritis and denture stomatitis. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include G-protein coupled receptor activity and interleukin-8 binding. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CXCR1 Gene

  • Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity

Tocris Summary for CXCR1 Gene

  • Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed migration of immune cells. Over fifty human chemokines have been identified that can be categorised into four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are classified according to the class of chemokines that they bind. The major function of chemokines is to regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by cytotoxic T-cells and macrophages.

Gene Wiki entry for CXCR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCR1 Gene

Genomics for CXCR1 Gene

Genomic Location for CXCR1 Gene

Start:
218,162,845 bp from pter
End:
218,166,995 bp from pter
Size:
4,151 bases
Orientation:
Minus strand

Genomic View for CXCR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR1 Gene

No data available for Regulatory Elements for CXCR1 Gene

Proteins for CXCR1 Gene

  • Protein details for CXCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25024-CXCR1_HUMAN
    Recommended name:
    C-X-C chemokine receptor type 1
    Protein Accession:
    P25024
    Secondary Accessions:
    • B2R6Q3
    • Q2YEF8
    • Q2YEG4
    • Q2YEG5
    • Q2YEG7
    • Q2YEG8
    • Q53R18
    • Q6IN95
    • Q8N6T6
    • Q9P2T8
    • Q9P2T9
    • Q9P2U0
    • Q9P2U1
    • Q9P2U2

    Protein attributes for CXCR1 Gene

    Size:
    350 amino acids
    Molecular mass:
    39791 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCR1 Gene

neXtProt entry for CXCR1 Gene

Proteomics data for CXCR1 Gene at MOPED

Post-translational modifications for CXCR1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn3 and Asn16

Other Protein References for CXCR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCR1 Gene

Domains for CXCR1 Gene

Gene Families for CXCR1 Gene

HGNC:
  • CD :CD molecules
  • IL :Interleukins and interleukin receptors
  • CXCR :GPCR / Class A : Chemokine receptors : C-X-C motif
IUPHAR :

Suggested Antigen Peptide Sequences for CXCR1 Gene

Graphical View of Domain Structure for InterPro Entry

P25024

UniProtKB/Swiss-Prot:

CXCR1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P25024
genes like me logo Genes that share domains with CXCR1: view

Function for CXCR1 Gene

Molecular function for CXCR1 Gene

UniProtKB/Swiss-Prot Function: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity

Gene Ontology (GO) - Molecular Function for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004918 interleukin-8 receptor activity IDA 10734056
GO:0004930 G-protein coupled receptor activity TAS 8381837
GO:0004950 chemokine receptor activity TAS 1840701
GO:0019959 interleukin-8 binding IPI 11564821
genes like me logo Genes that share ontologies with CXCR1: view

Phenotypes for CXCR1 Gene

MGI mutant phenotypes for CXCR1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CXCR1: view

Animal Models for CXCR1 Gene

MGI Knock Outs for CXCR1:

miRNA for CXCR1 Gene

miRTarBase miRNAs that target CXCR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CXCR1 Gene

Localization for CXCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCR1 Gene COMPARTMENTS Subcellular localization image for CXCR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 10725748
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CXCR1: view

Pathways for CXCR1 Gene

genes like me logo Genes that share pathways with CXCR1: view

Gene Ontology (GO) - Biological Process for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0006935 chemotaxis TAS 10725748
GO:0006954 inflammatory response TAS 10725748
GO:0007166 cell surface receptor signaling pathway IDA 10734056
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with CXCR1: view

Compounds for CXCR1 Gene

(5) Tocris Compounds for CXCR1 Gene

Compound Action Cas Number
Maraviroc Selective CCR5 antagonist [376348-65-1]
RS 504393 Highly selective CCR2 chemokine receptor antagonist [300816-15-3]
SB 225002 Potent and selective CXCR2 antagonist [182498-32-4]
SB 265610 Potent CXCR2 antagonist [211096-49-0]
TC 14012 CXCR4 antagonist; CXCR7 agonist [368874-34-4]

(1) HMDB Compounds for CXCR1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for CXCR1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ketoprofen
22071-15-4 target other

(7) IUPHAR Ligand for CXCR1 Gene

Ligand Type Action Affinity Pubmed IDs
CXCL1 Agonist Full agonist 9.7
CXCL8 Agonist Full agonist 9.5
[125I]CXCL8 (human) Agonist Full agonist 9.4
mini-TyrRS Agonist Full agonist 8.1
[125I]mini-TyrRS Agonist Full agonist 7.7
CXCL6 Agonist Full agonist 7
cytokine domain of tyrosyl tRNA synthetase Agonist Agonist

(36) Novoseek inferred chemical compound relationships for CXCR1 Gene

Compound -log(P) Hits PubMed IDs
groalpha 88.1 13
grogamma 80.7 2
rantes 76.2 18
grobeta 74.2 2
fmlp 65.8 14
genes like me logo Genes that share compounds with CXCR1: view

Transcripts for CXCR1 Gene

mRNA/cDNA for CXCR1 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCR1 Gene

Chemokine (C-X-C motif) receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR1 Gene

No ASD Table

Relevant External Links for CXCR1 Gene

GeneLoc Exon Structure for
CXCR1
ECgene alternative splicing isoforms for
CXCR1

Expression for CXCR1 Gene

mRNA expression in normal human tissues for CXCR1 Gene

mRNA differential expression in normal tissues according to GTEx for CXCR1 Gene

This gene is overexpressed in Whole Blood (50.8).

SOURCE GeneReport for Unigene cluster for CXCR1 Gene Hs.194778

genes like me logo Genes that share expressions with CXCR1: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for CXCR1 Gene

Orthologs for CXCR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCR1 35
  • 99.52 (n)
  • 98.86 (a)
CXCR1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcr1 35
  • 75.75 (n)
  • 68.56 (a)
Cxcr1 16
Cxcr1 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cxcr1 35
  • 75.64 (n)
  • 71.25 (a)
chicken
(Gallus gallus)
Aves CXCR2 35
  • 62.12 (n)
  • 53.24 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia CXCR2 35
zebrafish
(Danio rerio)
Actinopterygii CXCR1 36
  • 43 (a)
OneToMany
Species with no ortholog for CXCR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXCR1 Gene

ENSEMBL:
Gene Tree for CXCR1 (if available)
TreeFam:
Gene Tree for CXCR1 (if available)

Paralogs for CXCR1 Gene

genes like me logo Genes that share paralogs with CXCR1: view

Variants for CXCR1 Gene

Sequence variations from dbSNP and Humsavar for CXCR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs885816 -- 218,165,926(-) GGAAA(A/T)ATATT intron-variant
rs1805038 - 218,165,001(-) TCGGC(C/T)GCTCC reference, missense
rs2234671 - 218,164,385(-) GGAGA(C/G)CTGTG missense, reference
rs2285021 -- 218,166,433(-) tgaga(G/T)ggagt intron-variant
rs2671222 -- 218,167,879(-) AAGCC(A/G)TTCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CXCR1 Gene

Variant ID Type Subtype PubMed ID
nsv3164 CNV Insertion 18451855

Relevant External Links for CXCR1 Gene

HapMap Linkage Disequilibrium report
CXCR1
Human Gene Mutation Database (HGMD)
CXCR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR1 Gene

Disorders for CXCR1 Gene

(1) OMIM Diseases for CXCR1 Gene (146929)

(3) University of Copenhagen DISEASES for CXCR1 Gene

(63) Novoseek inferred disease relationships for CXCR1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 59.6 19
melanoma 45.2 35
urinary tract infection recurrent 43.1 4
acute pyelonephritis 41.1 3
leukemia basophilic 39 1

Relevant External Links for CXCR1

Genetic Association Database (GAD)
CXCR1
Human Genome Epidemiology (HuGE) Navigator
CXCR1
genes like me logo Genes that share disorders with CXCR1: view

No data available for UniProtKB/Swiss-Prot for CXCR1 Gene

Publications for CXCR1 Gene

  1. Characterization of two high affinity human interleukin-8 receptors. (PMID: 1379593) Lee J. … Wood W.I. (J. Biol. Chem. 1992) 3 4 23
  2. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. (PMID: 1427896) Morris S.W. … Cerretti D.P. (Genomics 1992) 2 3 23
  3. Structure of a CXC chemokine-receptor fragment in complex with interleukin-8. (PMID: 10368283) Skelton N.J. … Lowman H. (Structure 1999) 3 4 23
  4. Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils. (PMID: 16205979) Liu Y. … Su B. (J. Mol. Evol. 2005) 3 4 23
  5. Association of interleukin-8 receptor alpha polymorphisms with chronic obstructive pulmonary disease and asthma. (PMID: 15772681) Stemmler S. … Epplen J.T. (Genes Immun. 2005) 3 23

Products for CXCR1 Gene

Sources for CXCR1 Gene

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