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Aliases for IL7 Gene

Aliases for IL7 Gene

  • Interleukin 7 2 3
  • IL-7 3 4
  • Interleukin-7 3

External Ids for IL7 Gene

Previous GeneCards Identifiers for IL7 Gene

  • GC08M079682
  • GC08M079311
  • GC08M079694
  • GC08M079807
  • GC08M075134
  • GC08M079587

Summaries for IL7 Gene

Entrez Gene Summary for IL7 Gene

  • The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

GeneCards Summary for IL7 Gene

IL7 (Interleukin 7) is a Protein Coding gene. Diseases associated with IL7 include lymphocytic choriomeningitis and natural killer cell leukemia. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and interleukin-7 receptor binding.

UniProtKB/Swiss-Prot for IL7 Gene

  • Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation

Gene Wiki entry for IL7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL7 Gene

Genomics for IL7 Gene

Regulatory Elements for IL7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IL7 Gene

78,675,743 bp from pter
78,805,523 bp from pter
129,781 bases
Minus strand

Genomic View for IL7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL7 Gene

Proteins for IL7 Gene

  • Protein details for IL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0N0L3
    • Q5FBY5
    • Q5FBY9

    Protein attributes for IL7 Gene

    177 amino acids
    Molecular mass:
    20187 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL7 Gene

    Alternative splice isoforms for IL7 Gene


neXtProt entry for IL7 Gene

Proteomics data for IL7 Gene at MOPED

Post-translational modifications for IL7 Gene

  • Glycosylation at Asn95, Asn116, and Asn141

Other Protein References for IL7 Gene

Antibody Products

Protein Products

No data available for DME Specific Peptides for IL7 Gene

Domains for IL7 Gene

Gene Families for IL7 Gene

  • IL :Interleukins and interleukin receptors

Protein Domains for IL7 Gene

Suggested Antigen Peptide Sequences for IL7 Gene

Graphical View of Domain Structure for InterPro Entry



  • P13232
  • Belongs to the IL-7/IL-9 family.
genes like me logo Genes that share domains with IL7: view

Function for IL7 Gene

Molecular function for IL7 Gene

GENATLAS Biochemistry:
interleukin 7,20.2kDa,stimulating the proliferation of lymphoid progenitor cells
UniProtKB/Swiss-Prot Function:
Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation

LifeMap Function Summary for IL7 Gene

It affects the following cells:
IL7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for IL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding --
GO:0005139 interleukin-7 receptor binding IEA --
GO:0005515 protein binding IPI 8266077
GO:0008083 growth factor activity ISS --
genes like me logo Genes that share ontologies with IL7: view
genes like me logo Genes that share phenotypes with IL7: view

Animal Models for IL7 Gene

MGI Knock Outs for IL7:

Animal Model Products

miRNA for IL7 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL7 Gene

Localization for IL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL7 Gene


Subcellular locations from

Jensen Localization Image for IL7 Gene COMPARTMENTS Subcellular localization image for IL7 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for IL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IL7: view

Pathways for IL7 Gene

genes like me logo Genes that share pathways with IL7: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002360 T cell lineage commitment IBA --
GO:0006955 immune response --
GO:0006959 humoral immune response TAS 2643102
GO:0007267 cell-cell signaling TAS 2643102
GO:0008284 positive regulation of cell proliferation TAS 2643102
genes like me logo Genes that share ontologies with IL7: view

Compounds for IL7 Gene

(63) Novoseek inferred chemical compound relationships for IL7 Gene

Compound -log(P) Hits PubMed IDs
rantes 61.2 48
tyrosine 44.3 40
alpha-galactosylceramide 42.5 10
methylcellulose 42.1 5
hemocyanin 35.7 7
genes like me logo Genes that share compounds with IL7: view

Transcripts for IL7 Gene

Unigene Clusters for IL7 Gene

Interleukin 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for IL7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL7 Gene

mRNA expression in normal human tissues for IL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for IL7 Gene Hs.591873

genes like me logo Genes that share expressions with IL7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for IL7 Gene

Orthologs for IL7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL7 35
  • 84.85 (n)
  • 74.43 (a)
IL7 36
  • 76 (a)
(Canis familiaris)
Mammalia IL7 35
  • 84.39 (n)
  • 69.62 (a)
IL7 36
  • 68 (a)
(Mus musculus)
Mammalia Il7 35
  • 80.83 (n)
  • 69.93 (a)
Il7 16
Il7 36
  • 69 (a)
(Pan troglodytes)
Mammalia IL7 35
  • 99.81 (n)
  • 100 (a)
IL7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Il7 35
  • 80 (n)
  • 71.33 (a)
(Monodelphis domestica)
Mammalia IL7 36
  • 34 (a)
Species with no ortholog for IL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL7 Gene

Gene Tree for IL7 (if available)
Gene Tree for IL7 (if available)

Paralogs for IL7 Gene

No data available for Paralogs for IL7 Gene

Variants for IL7 Gene

Sequence variations from dbSNP and Humsavar for IL7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs894221 -- 78,736,822(+) GTATA(C/G)TAGCA intron-variant
rs894222 -- 78,737,034(+) AAGGT(G/T)ACTTG intron-variant
rs1119642 -- 78,752,248(+) caggt(A/G)tccct intron-variant
rs1441850 -- 78,745,431(+) ATTTC(C/T)CCAAA intron-variant
rs1561763 -- 78,790,642(+) GGTAA(A/G)TATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL7 Gene

Variant ID Type Subtype PubMed ID
nsv891059 CNV Loss 21882294
essv4456 CNV CNV 17122850

Relevant External Links for IL7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL7 Gene

Disorders for IL7 Gene

(3) University of Copenhagen DISEASES for IL7 Gene

(97) Novoseek inferred disease relationships for IL7 Gene

Disease -log(P) Hits PubMed IDs
severe combined immunodeficiency, x-linked 86.8 24
lymphopenia 66.3 26
lymphoblastic leukemia acute 61.2 27
necrosis 58.1 105
severe combined immunodeficiency 56.5 5

Relevant External Links for IL7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IL7: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for IL7 Gene

Publications for IL7 Gene

  1. Disulfide bond assignment in human interleukin-7 by matrix-assisted laser desorption/ionization mass spectroscopy and site-directed cysteine to serine mutational analysis. (PMID: 9407080) Cosenza L. … Murphy J.R. (J. Biol. Chem. 1997) 3 4 23
  2. Genetic association analysis of the interleukin 7 gene (IL7) in multiple sclerosis. (PMID: 17913246) Lundmark F. … Hillert J. (J. Neuroimmunol. 2007) 3 23 48
  3. IL-7 decreases IL-7 receptor alpha (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. (PMID: 17956896) Vranjkovic A. … Angel J.B. (Int. Immunol. 2007) 3 23
  4. Serum cytokine profiling as a diagnostic and prognostic tool in ovarian cancer: a potential role for interleukin 7. (PMID: 17438097) Lambeck A.J. … Kast W.M. (Clin. Cancer Res. 2007) 3 23
  5. Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis. (PMID: 17665400) Timmer T.C. … van der Pouw Kraan T.C. (Arthritis Rheum. 2007) 3 23

Products for IL7 Gene

  • Addgene plasmids for IL7

Sources for IL7 Gene

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