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Aliases for IL7 Gene

Aliases for IL7 Gene

  • Interleukin 7 2 3 5
  • IL-7 3 4

External Ids for IL7 Gene

Previous GeneCards Identifiers for IL7 Gene

  • GC08M079682
  • GC08M079311
  • GC08M079694
  • GC08M079807
  • GC08M075134
  • GC08M079587

Summaries for IL7 Gene

Entrez Gene Summary for IL7 Gene

  • The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

GeneCards Summary for IL7 Gene

IL7 (Interleukin 7) is a Protein Coding gene. Diseases associated with IL7 include thyroid lymphoma and lymphopenia. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include cytokine activity and cytokine receptor binding.

UniProtKB/Swiss-Prot for IL7 Gene

  • Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

Gene Wiki entry for IL7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL7 Gene

Genomics for IL7 Gene

Regulatory Elements for IL7 Gene

Promoters for IL7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL7 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL7 Gene

Chromosome:
8
Start:
78,675,743 bp from pter
End:
78,805,523 bp from pter
Size:
129,781 bases
Orientation:
Minus strand

Genomic View for IL7 Gene

Genes around IL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL7 Gene

Proteins for IL7 Gene

  • Protein details for IL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13232-IL7_HUMAN
    Recommended name:
    Interleukin-7
    Protein Accession:
    P13232
    Secondary Accessions:
    • A0N0L3
    • Q5FBY5
    • Q5FBY9

    Protein attributes for IL7 Gene

    Size:
    177 amino acids
    Molecular mass:
    20187 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL7 Gene

    Alternative splice isoforms for IL7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL7 Gene

Proteomics data for IL7 Gene at MOPED

Post-translational modifications for IL7 Gene

  • Glycosylation at Asn 95, Asn 116, and Asn 141

Antibody Products

No data available for DME Specific Peptides for IL7 Gene

Domains & Families for IL7 Gene

Gene Families for IL7 Gene

Protein Domains for IL7 Gene

Suggested Antigen Peptide Sequences for IL7 Gene

Graphical View of Domain Structure for InterPro Entry

P13232

UniProtKB/Swiss-Prot:

IL7_HUMAN :
  • Belongs to the IL-7/IL-9 family.
Family:
  • Belongs to the IL-7/IL-9 family.
genes like me logo Genes that share domains with IL7: view

Function for IL7 Gene

Molecular function for IL7 Gene

GENATLAS Biochemistry:
interleukin 7,20.2kDa,stimulating the proliferation of lymphoid progenitor cells
UniProtKB/Swiss-Prot Function:
Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

LifeMap Function Summary for IL7 Gene

It affects the following cells:
IL7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for IL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005139 interleukin-7 receptor binding IEA --
GO:0005515 protein binding IPI 8266077
genes like me logo Genes that share ontologies with IL7: view
genes like me logo Genes that share phenotypes with IL7: view

Animal Models for IL7 Gene

MGI Knock Outs for IL7:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL7 Gene

Localization for IL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL7 Gene COMPARTMENTS Subcellular localization image for IL7 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for IL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with IL7: view

Pathways & Interactions for IL7 Gene

genes like me logo Genes that share pathways with IL7: view

SIGNOR curated interactions for IL7 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002360 T cell lineage commitment IBA --
GO:0006955 immune response IEA --
GO:0007267 cell-cell signaling TAS 2643102
GO:0008284 positive regulation of cell proliferation TAS 2643102
GO:0009887 organ morphogenesis TAS 2643102
genes like me logo Genes that share ontologies with IL7: view

Drugs & Compounds for IL7 Gene

(29) Drugs for IL7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(34) Additional Compounds for IL7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL7: view

Transcripts for IL7 Gene

Unigene Clusters for IL7 Gene

Interleukin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for IL7 Gene

GeneLoc Exon Structure for
IL7
ECgene alternative splicing isoforms for
IL7

Expression for IL7 Gene

mRNA expression in normal human tissues for IL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for IL7 Gene Hs.591873

genes like me logo Genes that share expression patterns with IL7: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IL7 Gene

Orthologs for IL7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL7 35
  • 99.81 (n)
  • 100 (a)
IL7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL7 36
  • 76 (a)
OneToOne
IL7 35
  • 84.85 (n)
  • 74.43 (a)
dog
(Canis familiaris)
Mammalia IL7 35
  • 84.39 (n)
  • 69.62 (a)
IL7 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il7 16
Il7 36
  • 69 (a)
OneToOne
Il7 35
  • 80.83 (n)
  • 69.93 (a)
oppossum
(Monodelphis domestica)
Mammalia IL7 36
  • 34 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il7 35
  • 80 (n)
  • 71.33 (a)
Species with no ortholog for IL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL7 Gene

ENSEMBL:
Gene Tree for IL7 (if available)
TreeFam:
Gene Tree for IL7 (if available)

Paralogs for IL7 Gene

No data available for Paralogs for IL7 Gene

Variants for IL7 Gene

Sequence variations from dbSNP and Humsavar for IL7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs894222 -- 78,737,034(+) AAGGT(G/T)ACTTG intron-variant
rs1441438 -- 78,729,534(-) CTTAA(C/T)GTAAA intron-variant, utr-variant-3-prime
rs1036751 -- 78,729,671(-) TTCTA(A/G)TAGAA intron-variant, utr-variant-3-prime
rs1561763 -- 78,790,642(+) GGTAA(A/G)TATAC intron-variant
rs2717541 -- 78,753,799(-) aactg(A/G)ctagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL7 Gene

Variant ID Type Subtype PubMed ID
nsv891059 CNV Loss 21882294
essv4456 CNV CNV 17122850

Variation tolerance for IL7 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL7 Gene

HapMap Linkage Disequilibrium report
IL7
Human Gene Mutation Database (HGMD)
IL7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL7 Gene

Disorders for IL7 Gene

MalaCards: The human disease database

(13) MalaCards diseases for IL7 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search IL7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL7

Genetic Association Database (GAD)
IL7
Human Genome Epidemiology (HuGE) Navigator
IL7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL7
genes like me logo Genes that share disorders with IL7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL7 Gene

Publications for IL7 Gene

  1. Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. (PMID: 19141282) McElroy C.A. … Walsh S.T. (Structure 2009) 3 4 67
  2. Increased expression of interleukin-7 in labial salivary glands of patients with primary SjAPgren's syndrome correlates with increased inflammation. (PMID: 20131250) Bikker A. … van Roon J.A. (Arthritis Rheum. 2010) 3 23
  3. Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway. (PMID: 19864382) Juffroy O. … Chakrabarti L.A. (J. Virol. 2010) 3 23
  4. Bone invading NSCLC cells produce IL-7: mice model and human histologic data. (PMID: 20067635) Roato I. … Ferracini R. (BMC Cancer 2010) 3 23
  5. Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response. (PMID: 20167604) Rose T. … ThA"ze J. (J. Biol. Chem. 2010) 3 23

Products for IL7 Gene

Sources for IL7 Gene

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