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Aliases for IL6R Gene

Aliases for IL6R Gene

  • Interleukin 6 Receptor 2 3
  • IL-6 Receptor Subunit Alpha 3 4
  • Membrane Glycoprotein 80 3 4
  • CD126 Antigen 3 4
  • IL-6R 1 3 4
  • IL-6RA 3 4
  • IL6RQ 3 6
  • IL6Q 3 6
  • Gp80 3 4
  • Interleukin-6 Receptor Subunit Alpha 3
  • IL-6R Subunit Alpha 4
  • IL-6R-Alpha 4
  • IL-6R-1 3
  • CD126 3
  • IL6RA 3

External Ids for IL6R Gene

Summaries for IL6R Gene

Entrez Gene Summary for IL6R Gene

  • This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

GeneCards Summary for IL6R Gene

IL6R (Interleukin 6 Receptor) is a Protein Coding gene. Diseases associated with IL6R include pleomorphic malignant fibrous histiocytoma and nodular goiter. Among its related pathways are PI3K-Akt signaling pathway and Akt Signaling. GO annotations related to this gene include protein homodimerization activity and interleukin-6 receptor binding. An important paralog of this gene is IL11RA.

UniProtKB/Swiss-Prot for IL6R Gene

  • Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis

  • Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity

Gene Wiki entry for IL6R Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL6R Gene

Genomics for IL6R Gene

Genomic Location for IL6R Gene

Start:
154,405,193 bp from pter
End:
154,469,450 bp from pter
Size:
64,258 bases
Orientation:
Plus strand

Genomic View for IL6R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL6R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL6R Gene

Regulatory Elements for IL6R Gene

Transcription factor binding sites by QIAGEN in the IL6R gene promoter:

Proteins for IL6R Gene

  • Protein details for IL6R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08887-IL6RA_HUMAN
    Recommended name:
    Interleukin-6 receptor subunit alpha
    Protein Accession:
    P08887
    Secondary Accessions:
    • A8KAE8
    • B2R6V4
    • Q16202
    • Q53EQ7
    • Q5FWG2
    • Q5VZ23

    Protein attributes for IL6R Gene

    Size:
    468 amino acids
    Molecular mass:
    51548 Da
    Quaternary structure:
    • Hexamer of two molecules each of IL6, IL6R and IL6ST

    Three dimensional structures from OCA and Proteopedia for IL6R Gene

    Alternative splice isoforms for IL6R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL6R Gene

Proteomics data for IL6R Gene at MOPED

Post-translational modifications for IL6R Gene

  • A short soluble form may also be released from the membrane by proteolysis
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn55, Asn93, and Asn221

Other Protein References for IL6R Gene

No data available for DME Specific Peptides for IL6R Gene

Domains for IL6R Gene

Gene Families for IL6R Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • IL :Interleukins and interleukin receptors
IUPHAR :

UniProtKB/Swiss-Prot:

IL6RA_HUMAN
Domain:
  • The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain:
    • P08887
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding:
    • P08887
  • Contains 2 fibronectin type-III domains.:
    • P08887
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • P08887
Family:
  • Belongs to the type I cytokine receptor family. Type 3 subfamily.:
    • P08887
genes like me logo Genes that share domains with IL6R: view

Function for IL6R Gene

Molecular function for IL6R Gene

GENATLAS Biochemistry: interleukin 6,receptor,alpha subunit,low activity receptor,heterodimerizing with IL6ST
UniProtKB/Swiss-Prot Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis
UniProtKB/Swiss-Prot Function: Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity

Gene Ontology (GO) - Molecular Function for IL6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004897 contributes_to ciliary neurotrophic factor receptor activity IMP 12643274
GO:0004915 contributes_to interleukin-6 receptor activity IDA 2261637
GO:0005138 contributes_to interleukin-6 receptor binding IPI 12829785
GO:0005515 protein binding IPI 11238858
GO:0019899 enzyme binding IPI 12748171
genes like me logo Genes that share ontologies with IL6R: view
genes like me logo Genes that share phenotypes with IL6R: view

Animal Models for IL6R Gene

MGI Knock Outs for IL6R:

miRNA for IL6R Gene

miRTarBase miRNAs that target IL6R

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL6R Gene

Localization for IL6R Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL6R Gene

Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL6R Gene COMPARTMENTS Subcellular localization image for IL6R gene
Compartment Confidence
extracellular 5
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 12419823
GO:0005886 plasma membrane TAS --
GO:0005896 interleukin-6 receptor complex IDA 12829785
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with IL6R: view

Pathways for IL6R Gene

genes like me logo Genes that share pathways with IL6R: view

Gene Ontology (GO) - Biological Process for IL6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002384 hepatic immune response TAS 12832423
GO:0002446 neutrophil mediated immunity TAS 16034137
GO:0002548 monocyte chemotaxis IC 10510402
GO:0002690 positive regulation of leukocyte chemotaxis TAS 15100312
GO:0006953 acute-phase response TAS 12832423
genes like me logo Genes that share ontologies with IL6R: view

Compounds for IL6R Gene

(2) Drugbank Compounds for IL6R Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target
Tocilizumab
  • Atlizumab
375823-41-9 target antibody

(48) Novoseek inferred chemical compound relationships for IL6R Gene

Compound -log(P) Hits PubMed IDs
gp 130 97 224
tocilizumab 91.6 43
tapi 64.4 3
af 10 42.8 6
dexamethasone 37.7 17
genes like me logo Genes that share compounds with IL6R: view

Transcripts for IL6R Gene

Unigene Clusters for IL6R Gene

Interleukin 6 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL6R Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: -

Relevant External Links for IL6R Gene

GeneLoc Exon Structure for
IL6R
ECgene alternative splicing isoforms for
IL6R

Expression for IL6R Gene

mRNA expression in normal human tissues for IL6R Gene

mRNA differential expression in normal tissues according to GTEx for IL6R Gene

This gene is overexpressed in Whole Blood (11.4) and Muscle - Skeletal (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL6R Gene

SOURCE GeneReport for Unigene cluster for IL6R Gene Hs.135087

mRNA Expression by UniProt/SwissProt for IL6R Gene

P08887-IL6RA_HUMAN
Tissue specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum
genes like me logo Genes that share expressions with IL6R: view

Orthologs for IL6R Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL6R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL6R 36
  • 99.36 (n)
  • 99.57 (a)
IL6R 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL6R 36
  • 81.54 (n)
  • 74.35 (a)
IL6R 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL6R 36
  • 79.79 (n)
  • 74.5 (a)
IL6R 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il6ra 36
  • 68.37 (n)
  • 55.35 (a)
Il6ra 16
Il6ra 37
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL6R 37
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il6r 36
  • 69.2 (n)
  • 55.99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il6r 36
  • 45.02 (n)
  • 35.57 (a)
zebrafish
(Danio rerio)
Actinopterygii il6r 36
  • 43.38 (n)
  • 32.6 (a)
il6r 37
  • 20 (a)
OneToOne
Species with no ortholog for IL6R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL6R Gene

ENSEMBL:
Gene Tree for IL6R (if available)
TreeFam:
Gene Tree for IL6R (if available)

Paralogs for IL6R Gene

Paralogs for IL6R Gene

Pseudogenes.org Pseudogenes for IL6R Gene

genes like me logo Genes that share paralogs with IL6R: view

Variants for IL6R Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IL6R Gene

P08887-IL6RA_HUMAN
Genetic variations in IL6R define the IL6 serum level quantitative trait locus [MIM:614752]

Sequence variations from dbSNP and Humsavar for IL6R Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1138004 -- 154,465,962(+) CAGTT(C/G)AAAAA utr-variant-3-prime
rs1138006 -- 154,466,001(+) AGTAT(C/G)TCAGG utr-variant-3-prime
rs1138007 -- 154,466,591(+) catgg(A/T)ggccc utr-variant-3-prime
rs1386820 -- 154,409,579(-) ACACT(C/T)TATTT intron-variant
rs1386821 -- 154,409,573(-) tattt(A/C)atacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL6R Gene

Variant ID Type Subtype PubMed ID
nsv521887 CNV Gain 19592680

Relevant External Links for IL6R Gene

HapMap Linkage Disequilibrium report
IL6R
Human Gene Mutation Database (HGMD)
IL6R

Disorders for IL6R Gene

(2) OMIM Diseases for IL6R Gene (147880)

(2) University of Copenhagen DISEASES for IL6R Gene

(88) Novoseek inferred disease relationships for IL6R Gene

Disease -log(P) Hits PubMed IDs
myeloma 75.8 61
castleman disease 62.6 2
rheumatoid arthritis 56.3 24
carcinoma giant cell 54.8 1
leukemia 54.3 26

Relevant External Links for IL6R

Genetic Association Database (GAD)
IL6R
Human Genome Epidemiology (HuGE) Navigator
IL6R
genes like me logo Genes that share disorders with IL6R: view

No data available for UniProtKB/Swiss-Prot for IL6R Gene

Publications for IL6R Gene

  1. Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130. (PMID: 8467812) Yawata H. … Kishimoto T. (EMBO J. 1993) 3 4 23
  2. The cytoplasmic domain of the interleukin-6 receptor gp80 mediates its basolateral sorting in polarized Madin-Darby canine kidney cells. (PMID: 11017875) Martens A.S. … Graeve L. (J. Cell Sci. 2000) 3 4 23
  3. Structure of the extracellular domains of the human interleukin-6 receptor alpha-chain. (PMID: 12461182) Varghese J.N. … Simpson R.J. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  4. Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced. (PMID: 15306846) Galicia J.C. … Yoshie H. (Genes Immun. 2004) 3 23 49
  5. Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites. (PMID: 15561970) Hamid Y.H. … Pedersen O. (Diabetes 2004) 3 23 49

Products for IL6R Gene

Sources for IL6R Gene

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