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Aliases for IL5RA Gene

Aliases for IL5RA Gene

  • Interleukin 5 Receptor, Alpha 2 3
  • IL-5 Receptor Subunit Alpha 3 4
  • IL-5R Subunit Alpha 3 4
  • CD125 Antigen 3 4
  • CDw125 3 4
  • IL5R 3 4
  • Interleukin-5 Receptor Subunit Alpha 3
  • Interleukin-5 Receptor Alpha Chain 3
  • Interleukin 5 Receptor Type 3 3
  • IL-5R-Alpha 4
  • HSIL5R3 3
  • IL-5RA 4
  • CD125 3

External Ids for IL5RA Gene

Previous HGNC Symbols for IL5RA Gene

  • IL5R

Previous GeneCards Identifiers for IL5RA Gene

  • GC03M003040
  • GC03M003086
  • GC03M003045

Summaries for IL5RA Gene

Entrez Gene Summary for IL5RA Gene

  • The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

GeneCards Summary for IL5RA Gene

IL5RA (Interleukin 5 Receptor, Alpha) is a Protein Coding gene. Diseases associated with IL5RA include atopy. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include interleukin-5 receptor activity. An important paralog of this gene is IL13RA1.

UniProtKB/Swiss-Prot for IL5RA Gene

  • This is the receptor for interleukin-5. The alpha chain binds to IL5

Tocris Summary for IL5RA Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL5RA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL5RA Gene

Genomics for IL5RA Gene

Regulatory Elements for IL5RA Gene

Genomic Location for IL5RA Gene

3,066,324 bp from pter
3,126,613 bp from pter
60,290 bases
Minus strand

Genomic View for IL5RA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL5RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL5RA Gene

Proteins for IL5RA Gene

  • Protein details for IL5RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-5 receptor subunit alpha
    Protein Accession:
    Secondary Accessions:
    • B3IU77
    • B4E2G0
    • Q14633
    • Q15469
    • Q6ISX9

    Protein attributes for IL5RA Gene

    420 amino acids
    Molecular mass:
    47685 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP.

    Three dimensional structures from OCA and Proteopedia for IL5RA Gene

    Alternative splice isoforms for IL5RA Gene


neXtProt entry for IL5RA Gene

Proteomics data for IL5RA Gene at MOPED

Post-translational modifications for IL5RA Gene

  • Glycosylation at Asn35, Asn131, Asn216, and Asn244
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for IL5RA (IL-5 R alpha/CD125)

No data available for DME Specific Peptides for IL5RA Gene

Domains for IL5RA Gene

Gene Families for IL5RA Gene

  • CD :CD molecules
  • IL :Interleukins and interleukin receptors

Graphical View of Domain Structure for InterPro Entry



  • Q01344
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding
  • The box 1 motif is required for JAK interaction and/or activation
  • Contains 2 fibronectin type-III domains.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
genes like me logo Genes that share domains with IL5RA: view

Function for IL5RA Gene

Molecular function for IL5RA Gene

GENATLAS Biochemistry:
interleukin 5,receptor,alpha subunit,with a membrane anchored and an alternatively spliced secreted form heterodimerizing with CSF2RB
UniProtKB/Swiss-Prot Function:
This is the receptor for interleukin-5. The alpha chain binds to IL5

Gene Ontology (GO) - Molecular Function for IL5RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity --
GO:0004914 interleukin-5 receptor activity TAS 1495999
GO:0005515 protein binding IPI 1495999
genes like me logo Genes that share ontologies with IL5RA: view

Phenotypes for IL5RA Gene

genes like me logo Genes that share phenotypes with IL5RA: view

Animal Models for IL5RA Gene

MGI Knock Outs for IL5RA:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL5RA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL5RA Gene

Localization for IL5RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL5RA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IL5RA Gene COMPARTMENTS Subcellular localization image for IL5RA gene
Compartment Confidence
extracellular 4
plasma membrane 4
cytosol 1

Gene Ontology (GO) - Cellular Components for IL5RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 1495999
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL5RA: view

Pathways for IL5RA Gene

genes like me logo Genes that share pathways with IL5RA: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IL5RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0007165 signal transduction TAS 1732409
GO:0008283 cell proliferation TAS 1732409
GO:0019221 cytokine-mediated signaling pathway --
GO:0032674 regulation of interleukin-5 production IEA --
genes like me logo Genes that share ontologies with IL5RA: view

Compounds for IL5RA Gene

(4) Tocris Compounds for IL5RA Gene

Compound Action Cas Number
AF 12198 Potent, selective human type I IL-1 receptor antagonist [185413-30-3]
Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable [222018-18-0]
Ro 26-4550 trifluoroacetate Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction [1217448-66-2]
YM 90709 Interleukin-5 receptor antagonist [163769-88-8]

(1) IUPHAR Ligand for IL5RA Gene

Ligand Type Action Affinity Pubmed IDs
IL-5 Agonist Agonist

(10) Novoseek inferred chemical compound relationships for IL5RA Gene

Compound -log(P) Hits PubMed IDs
gp 130 41.4 1
tyrosine 31.7 6
budesonide 22.5 3
retinoic acid 21.4 6
lysine 0 1
genes like me logo Genes that share compounds with IL5RA: view

Transcripts for IL5RA Gene

Unigene Clusters for IL5RA Gene

Interleukin 5 receptor, alpha:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL5RA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL5RA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - - -
SP8: - - - -

Relevant External Links for IL5RA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL5RA Gene

mRNA expression in normal human tissues for IL5RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL5RA Gene

This gene is overexpressed in Whole Blood (5.0) and Pituitary (4.1).

Protein differential expression in normal tissues for IL5RA Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL5RA Gene

SOURCE GeneReport for Unigene cluster for IL5RA Gene Hs.68876

mRNA Expression by UniProt/SwissProt for IL5RA Gene

Tissue specificity: Expressed on eosinophils and basophils
genes like me logo Genes that share expressions with IL5RA: view

Expression partners for IL5RA Gene

In Situ Assay Products

Orthologs for IL5RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL5RA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL5RA 35
  • 81.98 (n)
  • 74.88 (a)
IL5RA 36
  • 74 (a)
(Canis familiaris)
Mammalia IL5RA 35
  • 80.9 (n)
  • 76.02 (a)
IL5RA 36
  • 73 (a)
(Mus musculus)
Mammalia Il5ra 35
  • 76.94 (n)
  • 69.17 (a)
Il5ra 16
Il5ra 36
  • 68 (a)
(Pan troglodytes)
Mammalia IL5RA 35
  • 98.89 (n)
  • 98.33 (a)
IL5RA 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Il5ra 35
  • 76.72 (n)
  • 67.88 (a)
(Monodelphis domestica)
Mammalia IL5RA 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia IL5RA 36
  • 57 (a)
(Gallus gallus)
Aves IL5RA 35
  • 55.96 (n)
  • 44.04 (a)
IL5RA 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il5ra 35
  • 46.36 (n)
  • 34.43 (a)
Species with no ortholog for IL5RA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL5RA Gene

Gene Tree for IL5RA (if available)
Gene Tree for IL5RA (if available)

Paralogs for IL5RA Gene

Paralogs for IL5RA Gene

Selected SIMAP similar genes for IL5RA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IL5RA: view

Variants for IL5RA Gene

Sequence variations from dbSNP and Humsavar for IL5RA Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs162879 -- 3,108,518(+) GCAAT(C/T)TGTCA intron-variant
rs163546 -- 3,081,642(-) TGTAA(C/T)CATGG intron-variant
rs163547 -- 3,081,381(-) GTCAG(A/G)ATACT intron-variant
rs163548 -- 3,079,928(+) actag(C/G)gaggc intron-variant
rs163549 -- 3,086,046(-) TGGCC(A/C)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL5RA Gene

Variant ID Type Subtype PubMed ID
esv2422274 CNV Duplication 17116639
esv2751994 CNV Gain 17911159
nsv521796 CNV Loss 19592680
nsv819643 CNV Loss 19587683
nsv518298 CNV Gain 19592680
nsv876405 CNV Gain 21882294

Relevant External Links for IL5RA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL5RA Gene

Disorders for IL5RA Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for IL5RA Gene in MalaCards »

(1) Diseases for IL5RA Gene including...

(11) Novoseek inferred disease relationships for IL5RA Gene

Disease -log(P) Hits PubMed IDs
eosinophilia 59.1 3
asthma 50.9 5
airways disease 40.2 1
promyelocytic leukemia 38.6 1
inflammation 31.1 3

Relevant External Links for IL5RA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IL5RA: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for IL5RA Gene

Publications for IL5RA Gene

  1. Molecular cloning and expression of the human interleukin 5 receptor. (PMID: 1732409) Murata Y. … Takatsu K. (J. Exp. Med. 1992) 2 3 4 23
  2. A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. (PMID: 1833065) Tavernier J. … Plaetinck G. (Cell 1991) 3 4 23
  3. Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit. (PMID: 1495999) Tavernier J. … Devos R. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  4. Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma. (PMID: 16217591) Cheong H.S. … Shin H.D. (J. Hum. Genet. 2005) 3 23 48
  5. IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans. (PMID: 17620072) Namkung J.H. … Yang J.M. (Allergy 2007) 3 23 48

Products for IL5RA Gene

Sources for IL5RA Gene

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