Aliases for IL5RA Gene
External Ids for IL5RA Gene
Previous HGNC Symbols for IL5RA Gene
Previous GeneCards Identifiers for IL5RA Gene
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]
GeneCards Summary for IL5RA Gene
IL5RA (Interleukin 5 Receptor, Alpha) is a Protein Coding gene. Diseases associated with IL5RA include atopy. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include interleukin-5 receptor activity. An important paralog of this gene is IL13RA1.
UniProtKB/Swiss-Prot for IL5RA Gene
This is the receptor for interleukin-5. The alpha chain binds to IL5
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.