Aliases for IL5 Gene
External Ids for IL5 Gene
Previous GeneCards Identifiers for IL5 Gene
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
GeneCards Summary for IL5 Gene
IL5 (Interleukin 5) is a Protein Coding gene. Diseases associated with IL5 include Allergic Hypersensitivity Disease and Pulmonary Eosinophilia. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and G beta-gamma signalling through PI3Kgamma. GO annotations related to this gene include cytokine activity and interleukin-5 receptor binding.
UniProtKB/Swiss-Prot for IL5 Gene
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.