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Aliases for IL5 Gene

Aliases for IL5 Gene

  • Interleukin 5 2 3
  • Eosinophil Differentiation Factor 2 3 4
  • T-Cell Replacing Factor 2 3 4
  • B-Cell Differentiation Factor I 3 4
  • Interleukin-5 2 3
  • IL-5 3 4
  • TRF 3 4
  • Interleukin 5 (Colony-Stimulating Factor, Eosinophil) 2
  • Colony-Stimulating Factor, Eosinophil 3
  • B Cell Differentiation Factor I 2
  • Colony-Stimulating Factor 2
  • Eosinophil 2
  • EDF 3

External Ids for IL5 Gene

Previous GeneCards Identifiers for IL5 Gene

  • GC05M131399
  • GC05M132324
  • GC05M131907
  • GC05M131953
  • GC05M131905
  • GC05M127069
  • GC05M131881

Summaries for IL5 Gene

Entrez Gene Summary for IL5 Gene

  • This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]

GeneCards Summary for IL5 Gene

IL5 (Interleukin 5) is a Protein Coding gene. Diseases associated with IL5 include gastroenteritis and eosinophilic gastroenteritis. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and interleukin-5 receptor binding.

UniProtKB/Swiss-Prot for IL5 Gene

  • Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells

Tocris Summary for IL5 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL5 Gene

Genomics for IL5 Gene

Regulatory Elements for IL5 Gene

Genomic Location for IL5 Gene

132,541,444 bp from pter
132,556,863 bp from pter
15,420 bases
Minus strand

Genomic View for IL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL5 Gene

Proteins for IL5 Gene

  • Protein details for IL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q13840

    Protein attributes for IL5 Gene

    134 amino acids
    Molecular mass:
    15238 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for IL5 Gene

neXtProt entry for IL5 Gene

Proteomics data for IL5 Gene at MOPED

Post-translational modifications for IL5 Gene

  • Glycosylation at Thr22 and Asn47
  • Modification sites at PhosphoSitePlus

Other Protein References for IL5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for IL5 Gene

Domains for IL5 Gene

Gene Families for IL5 Gene

Protein Domains for IL5 Gene

Suggested Antigen Peptide Sequences for IL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IL-5 family.
  • Belongs to the IL-5 family.
genes like me logo Genes that share domains with IL5: view

Function for IL5 Gene

Molecular function for IL5 Gene

GENATLAS Biochemistry:
interleukin 5,colony-stimulating factor (eosinophil),homodimerizing,inducing terminal differentiation of B cells to immunoglobulin secreting cells
UniProtKB/Swiss-Prot Function:
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells

Gene Ontology (GO) - Molecular Function for IL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005137 interleukin-5 receptor binding IEA --
GO:0005515 protein binding IPI 1495999
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with IL5: view
genes like me logo Genes that share phenotypes with IL5: view

Animal Models for IL5 Gene

MGI Knock Outs for IL5:

Animal Model Products

miRNA for IL5 Gene

miRTarBase miRNAs that target IL5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL5 Gene

Localization for IL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL5 Gene


Subcellular locations from

Jensen Localization Image for IL5 Gene COMPARTMENTS Subcellular localization image for IL5 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
lysosome 1

Gene Ontology (GO) - Cellular Components for IL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 3024129
genes like me logo Genes that share ontologies with IL5: view

Pathways for IL5 Gene

genes like me logo Genes that share pathways with IL5: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0008284 positive regulation of cell proliferation --
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0030890 positive regulation of B cell proliferation IEA --
genes like me logo Genes that share ontologies with IL5: view

Compounds for IL5 Gene

(1) Drugbank Compounds for IL5 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • ONO-RS 411
103177-37-3 115100 Target antagonist approved

(5) Tocris Compounds for IL5 Gene

Compound Action Cas Number
4-IPP Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate [41270-96-6]
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo [53179-13-8]
SC 144 hydrochloride gp130 inhibitor; blocks cytokine-triggered gp130 signaling [917497-70-2]
Thalidomide TNF-alpha synthesis inhibitor [50-35-1]

(1) ApexBio Compounds for IL5 Gene

Compound Action Cas Number
Suplatast Tosylate [94055-76-2]

(129) Novoseek inferred chemical compound relationships for IL5 Gene

Compound -log(P) Hits PubMed IDs
mepolizumab 85.3 24
rantes 82.4 161
sch 55700 75.5 5
allergens 74.2 33
il 10 67.2 32
genes like me logo Genes that share compounds with IL5: view

Transcripts for IL5 Gene

mRNA/cDNA for IL5 Gene

(6) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL5 Gene

Interleukin 5 (colony-stimulating factor, eosinophil):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL5 Gene

No ASD Table

Relevant External Links for IL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL5 Gene

mRNA expression in normal human tissues for IL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL5 Gene

This gene is overexpressed in Testis (25.2).

Protein differential expression in normal tissues for IL5 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL5 Gene

SOURCE GeneReport for Unigene cluster for IL5 Gene Hs.2247

genes like me logo Genes that share expressions with IL5: view

Expression partners for IL5 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IL5 Gene

Orthologs for IL5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL5 35
  • 81.09 (n)
  • 66.42 (a)
IL5 36
  • 66 (a)
(Canis familiaris)
Mammalia IL5 35
  • 80.6 (n)
  • 64.93 (a)
IL5 36
  • 65 (a)
(Mus musculus)
Mammalia Il5 35
  • 79.2 (n)
  • 71.79 (a)
Il5 16
Il5 36
  • 70 (a)
(Pan troglodytes)
Mammalia IL5 35
  • 99.75 (n)
  • 100 (a)
IL5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Il5 35
  • 78.63 (n)
  • 71.79 (a)
(Monodelphis domestica)
Mammalia IL5 36
  • 53 (a)
Species with no ortholog for IL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL5 Gene

Gene Tree for IL5 (if available)
Gene Tree for IL5 (if available)

Paralogs for IL5 Gene

No data available for Paralogs for IL5 Gene

Variants for IL5 Gene

Sequence variations from dbSNP and Humsavar for IL5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1800474 -- 132,543,356(-) CATCG(A/G)ACTCT reference, synonymous-codon
rs1986009 -- 132,552,294(+) aacaa(A/C)aaaAA intron-variant
rs2057687 -- 132,551,553(-) tgcac(A/G)cacac intron-variant
rs2057688 -- 132,551,253(-) TTTGC(C/T)TTTTA intron-variant
rs2057689 -- 132,551,089(-) GAAAA(A/T)ACACA intron-variant

Relevant External Links for IL5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL5 Gene

Disorders for IL5 Gene

(97) Novoseek inferred disease relationships for IL5 Gene

Disease -log(P) Hits PubMed IDs
eosinophilia 91.9 202
asthma 86.9 269
asthma allergic 84.7 67
hypereosinophilic syndrome 81.7 21
inflammation 80.3 122

Relevant External Links for IL5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IL5: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for IL5 Gene

Publications for IL5 Gene

  1. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. (PMID: 15007355) Hoffjan S. … Ober C. (J. Allergy Clin. Immunol. 2004) 3 23 48
  2. Risk of small-for-gestational age is associated with common anti-inflammatory cytokine polymorphisms. (PMID: 15951665) Engel S.A. … Chanock S.J. (Epidemiology 2005) 3 23 48
  3. Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma. (PMID: 16449530) Lan Q. … Chanock S. (Blood 2006) 3 23 48
  4. Heterogeneity of interleukin 5 genetic background in atopic dermatitis patients: significant difference between those with blood eosinophilia and normal eosinophil levels. (PMID: 14581138) Yamamoto N. … Uehara M. (J. Dermatol. Sci. 2003) 3 23 48
  5. IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma. (PMID: 15805995) Hong S.J. … Hong T.J. (J. Allergy Clin. Immunol. 2005) 3 23 48

Products for IL5 Gene

Sources for IL5 Gene

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