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Aliases for IL5 Gene

Aliases for IL5 Gene

  • Interleukin 5 2 3 5
  • Eosinophil Differentiation Factor 2 3 4
  • T-Cell Replacing Factor 2 3 4
  • B-Cell Differentiation Factor I 3 4
  • IL-5 3 4
  • TRF 3 4
  • Interleukin 5 (Colony-Stimulating Factor, Eosinophil) 2
  • Colony-Stimulating Factor, Eosinophil 3
  • B Cell Differentiation Factor I 2
  • Colony-Stimulating Factor 2
  • Interleukin-5 2
  • Eosinophil 2
  • EDF 3

External Ids for IL5 Gene

Previous GeneCards Identifiers for IL5 Gene

  • GC05M131399
  • GC05M132324
  • GC05M131907
  • GC05M131953
  • GC05M131905
  • GC05M127069
  • GC05M131881

Summaries for IL5 Gene

Entrez Gene Summary for IL5 Gene

  • This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]

GeneCards Summary for IL5 Gene

IL5 (Interleukin 5) is a Protein Coding gene. Diseases associated with IL5 include eosinophilic pneumonia and pulmonary eosinophilia. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include cytokine activity and interleukin-5 receptor binding.

UniProtKB/Swiss-Prot for IL5 Gene

  • Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

Tocris Summary for IL5 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL5 Gene

Genomics for IL5 Gene

Regulatory Elements for IL5 Gene

Promoters for IL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL5 Gene

Chromosome:
5
Start:
132,541,444 bp from pter
End:
132,556,890 bp from pter
Size:
15,447 bases
Orientation:
Minus strand

Genomic View for IL5 Gene

Genes around IL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL5 Gene

Proteins for IL5 Gene

  • Protein details for IL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05113-IL5_HUMAN
    Recommended name:
    Interleukin-5
    Protein Accession:
    P05113
    Secondary Accessions:
    • Q13840

    Protein attributes for IL5 Gene

    Size:
    134 amino acids
    Molecular mass:
    15238 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for IL5 Gene

neXtProt entry for IL5 Gene

Proteomics data for IL5 Gene at MOPED

Post-translational modifications for IL5 Gene

  • Glycosylation at Thr 22 and Asn 47
  • Modification sites at PhosphoSitePlus

Other Protein References for IL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IL5 Gene

Domains & Families for IL5 Gene

Gene Families for IL5 Gene

Protein Domains for IL5 Gene

Suggested Antigen Peptide Sequences for IL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05113

UniProtKB/Swiss-Prot:

IL5_HUMAN :
  • Belongs to the IL-5 family.
Family:
  • Belongs to the IL-5 family.
genes like me logo Genes that share domains with IL5: view

Function for IL5 Gene

Molecular function for IL5 Gene

GENATLAS Biochemistry:
interleukin 5,colony-stimulating factor (eosinophil),homodimerizing,inducing terminal differentiation of B cells to immunoglobulin secreting cells
UniProtKB/Swiss-Prot Function:
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

Gene Ontology (GO) - Molecular Function for IL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005137 interleukin-5 receptor binding IEA --
genes like me logo Genes that share ontologies with IL5: view
genes like me logo Genes that share phenotypes with IL5: view

Animal Models for IL5 Gene

MGI Knock Outs for IL5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL5 Gene

Localization for IL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL5 Gene COMPARTMENTS Subcellular localization image for IL5 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
cytoskeleton 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for IL5 Gene

Pathways & Interactions for IL5 Gene

SuperPathways for IL5 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PEDF Induced Signaling
3 Allograft rejection
.44
4 TGF-Beta Pathway
5 Signaling by GPCR
genes like me logo Genes that share pathways with IL5: view

SIGNOR curated interactions for IL5 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with IL5: view

Drugs & Compounds for IL5 Gene

(82) Drugs for IL5 Gene - From: Novoseek, DGIdb, ApexBio, Tocris, ClinicalTrials, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pranlukast Approved Pharma Antagonist, Target, antagonist 3
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 808
Pirfenidone Investigational Pharma TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo 42
Mepolizumab Pharma antibody 0
Interleukin-12 Pharma 125

(55) Additional Compounds for IL5 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
10Z-Hymenialdisine
82005-12-7
Chicago Sky Blue 6B
2610-05-1
genes like me logo Genes that share compounds with IL5: view

Transcripts for IL5 Gene

mRNA/cDNA for IL5 Gene

Unigene Clusters for IL5 Gene

Interleukin 5 (colony-stimulating factor, eosinophil):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL5 Gene

No ASD Table

Relevant External Links for IL5 Gene

GeneLoc Exon Structure for
IL5
ECgene alternative splicing isoforms for
IL5

Expression for IL5 Gene

mRNA expression in normal human tissues for IL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL5 Gene

This gene is overexpressed in Testis (x25.2).

Protein differential expression in normal tissues from HIPED for IL5 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL5 Gene



SOURCE GeneReport for Unigene cluster for IL5 Gene Hs.2247

genes like me logo Genes that share expression patterns with IL5: view

Protein tissue co-expression partners for IL5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IL5 Gene

Orthologs for IL5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL5 35
  • 99.75 (n)
  • 100 (a)
IL5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL5 36
  • 66 (a)
OneToOne
IL5 35
  • 81.09 (n)
  • 66.42 (a)
dog
(Canis familiaris)
Mammalia IL5 35
  • 80.6 (n)
  • 64.93 (a)
IL5 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il5 16
Il5 36
  • 70 (a)
OneToOne
Il5 35
  • 79.2 (n)
  • 71.79 (a)
oppossum
(Monodelphis domestica)
Mammalia IL5 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il5 35
  • 78.63 (n)
  • 71.79 (a)
Species with no ortholog for IL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL5 Gene

ENSEMBL:
Gene Tree for IL5 (if available)
TreeFam:
Gene Tree for IL5 (if available)

Paralogs for IL5 Gene

No data available for Paralogs for IL5 Gene

Variants for IL5 Gene

Sequence variations from dbSNP and Humsavar for IL5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2057689 -- 132,551,089(-) GAAAA(A/T)ACACA intron-variant
rs2067070 -- 132,542,435(-) TATAA(A/G)CTTCA intron-variant
rs1986009 -- 132,552,294(+) aacaa(A/C)aaaAA intron-variant
rs2069807 -- 132,545,030(-) AAGTG(C/T)GCAAA intron-variant, upstream-variant-2KB
rs2069808 -- 132,544,705(+) AAAAC(A/T)ATGAG intron-variant, upstream-variant-2KB

Variation tolerance for IL5 Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL5 Gene

HapMap Linkage Disequilibrium report
IL5
Human Gene Mutation Database (HGMD)
IL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL5 Gene

Disorders for IL5 Gene

MalaCards: The human disease database

(84) MalaCards diseases for IL5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
eosinophilic pneumonia
  • pneumonia, eosinophilic
pulmonary eosinophilia
  • asthmatic pulmonary eosinophilia
chronic eosinophilic pneumonia
  • cryptogenic pulmonary eosinophilia
eosinophilia-myalgia syndrome
  • eosinophilia myalgia syndrome
filariasis
  • disease due to superfamily filarioidea
- elite association - COSMIC cancer census association via MalaCards
Search IL5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL5

Genetic Association Database (GAD)
IL5
Human Genome Epidemiology (HuGE) Navigator
IL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL5
genes like me logo Genes that share disorders with IL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL5 Gene

Publications for IL5 Gene

  1. Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5). (PMID: 3498940) Campbell H.D. … Young I.G. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3 4 67
  2. Pranlukast, a leukotriene receptor antagonist, inhibits interleukin-5 production via a mechanism distinct from leukotriene receptor antagonism. (PMID: 15650315) Fukushima C. … Kohno S. (Int. Arch. Allergy Immunol. 2005) 23 25 26
  3. Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs. (PMID: 11972613) Nabe T. … Kohno S. (Clin. Exp. Allergy 2002) 23 25 26
  4. [Study on the effect of cysteinyl leukotriene antagonist, pranlukast hydrate, on adhesive interaction between eosinophils and pulmonary endothelial cells]. (PMID: 12692940) Nogimura M. … Sakamoto Y. (Nihon Kokyuki Gakkai Zasshi 2002) 23 25 26
  5. Increased serum interleukin-5 and vascular endothelial growth factor in children with acute mycoplasma pneumonia and wheeze. (PMID: 19360850) Choi I.S. … Choung J.T. (Pediatr. Pulmonol. 2009) 3 23

Products for IL5 Gene

Sources for IL5 Gene

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