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Aliases for FASLG Gene

Aliases for FASLG Gene

  • Fas Ligand (TNF Superfamily, Member 6) 2 3
  • APT1LG1 3 4 6
  • TNFSF6 3 4 6
  • FASL 3 4 6
  • Apoptosis Antigen Ligand 3 4
  • Fas Antigen Ligand 3 4
  • CD95 Ligand 3 4
  • ALPS1B 3 6
  • CD95-L 3 4
  • CD95L 3 4
  • APTL 3 4
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 6 2
  • Tumor Necrosis Factor Ligand Superfamily Member 6 3
  • Apoptosis (APO-1) Antigen Ligand 1 3
  • CD178 Antigen 4
  • Fas Ligand 4
  • CD178 3

External Ids for FASLG Gene

Previous HGNC Symbols for FASLG Gene

  • APT1LG1
  • TNFSF6

Previous GeneCards Identifiers for FASLG Gene

  • GC01P169360
  • GC01P170894
  • GC01P143852

Summaries for FASLG Gene

Entrez Gene Summary for FASLG Gene

  • This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]

GeneCards Summary for FASLG Gene

FASLG (Fas Ligand (TNF Superfamily, Member 6)) is a Protein Coding gene. Diseases associated with FASLG include faslg-related autoimmune lymphoproliferative syndrome and autoimmune lymphoproliferative syndrome. Among its related pathways are PI3K-Akt signaling pathway and MAPK signaling pathway. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNF.

UniProtKB/Swiss-Prot for FASLG Gene

  • Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.

  • The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.

Gene Wiki entry for FASLG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASLG Gene

Genomics for FASLG Gene

Regulatory Elements for FASLG Gene

Genomic Location for FASLG Gene

Start:
172,659,018 bp from pter
End:
172,666,874 bp from pter
Size:
7,857 bases
Orientation:
Plus strand

Genomic View for FASLG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FASLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASLG Gene

Proteins for FASLG Gene

  • Protein details for FASLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48023-TNFL6_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 6
    Protein Accession:
    P48023
    Secondary Accessions:
    • Q9BZP9

    Protein attributes for FASLG Gene

    Size:
    281 amino acids
    Molecular mass:
    31485 Da
    Quaternary structure:
    • Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.

    Three dimensional structures from OCA and Proteopedia for FASLG Gene

    Alternative splice isoforms for FASLG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FASLG Gene

Proteomics data for FASLG Gene at MOPED

Post-translational modifications for FASLG Gene

  • Monoubiquitinated
  • N-glycosylated
  • Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.
  • The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells.
  • Glycosylation at Asn184, Asn250, and Asn260
  • Modification sites at PhosphoSitePlus

Other Protein References for FASLG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FASLG Gene

Domains for FASLG Gene

Gene Families for FASLG Gene

HGNC:
  • CD :CD molecules
  • ENDOLIG :Endogenous ligands
  • TNFSF :Tumor necrosis factor (ligand) superfamily

Graphical View of Domain Structure for InterPro Entry

P48023

UniProtKB/Swiss-Prot:

TNFL6_HUMAN :
  • P48023
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with FASLG: view

Function for FASLG Gene

Molecular function for FASLG Gene

UniProtKB/Swiss-Prot Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
UniProtKB/Swiss-Prot Function: The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.

Gene Ontology (GO) - Molecular Function for FASLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7826947
GO:0005123 death receptor binding IEA --
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 12198154
genes like me logo Genes that share ontologies with FASLG: view
genes like me logo Genes that share phenotypes with FASLG: view

Animal Models for FASLG Gene

MGI Knock Outs for FASLG:

miRNA for FASLG Gene

miRTarBase miRNAs that target FASLG

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FASLG Gene

Localization for FASLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for FASLG Gene

Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane.
Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted. Note=May be released into the extracellular fluid, probably by cleavage form the cell surface. {ECO:0000250}.
FasL intracellular domain: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FASLG Gene COMPARTMENTS Subcellular localization image for FASLG gene
Compartment Confidence
extracellular 5
lysosome 5
nucleus 5
plasma membrane 5
vacuole 5
mitochondrion 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FASLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18835034
GO:0005634 nucleus IDA 17557115
GO:0005764 lysosome --
GO:0005886 plasma membrane IDA 12201652
genes like me logo Genes that share ontologies with FASLG: view

Pathways for FASLG Gene

genes like me logo Genes that share pathways with FASLG: view

Gene Ontology (GO) - Biological Process for FASLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 17557115
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process TAS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0006925 inflammatory cell apoptotic process IEA --
genes like me logo Genes that share ontologies with FASLG: view

Compounds for FASLG Gene

(146) Novoseek inferred chemical compound relationships for FASLG Gene

Compound -log(P) Hits PubMed IDs
concanamycin a 61 2
dutp 60.1 6
ionomycin 50 26
sp 600125 46.1 4
cycloheximide 43.9 9
genes like me logo Genes that share compounds with FASLG: view

Transcripts for FASLG Gene

mRNA/cDNA for FASLG Gene

(14) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FASLG Gene

Fas ligand (TNF superfamily, member 6):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FASLG Gene

No ASD Table

Relevant External Links for FASLG Gene

GeneLoc Exon Structure for
FASLG
ECgene alternative splicing isoforms for
FASLG

Expression for FASLG Gene

mRNA expression in normal human tissues for FASLG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FASLG Gene

This gene is overexpressed in Whole Blood (17.4) and Spleen (11.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FASLG Gene

SOURCE GeneReport for Unigene cluster for FASLG Gene Hs.2007

genes like me logo Genes that share expressions with FASLG: view

No data available for mRNA Expression by UniProt/SwissProt for FASLG Gene

Orthologs for FASLG Gene

This gene was present in the common ancestor of chordates.

Orthologs for FASLG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FASLG 35
  • 99.64 (n)
  • 99.64 (a)
FASLG 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FASLG 35
  • 87.24 (n)
  • 85.56 (a)
FASLG 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FASLG 35
  • 87.9 (n)
  • 87.54 (a)
FASLG 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fasl 35
  • 82.8 (n)
  • 75.63 (a)
Fasl 16
Fasl 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FASLG 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Faslg 35
  • 81.65 (n)
  • 74.82 (a)
chicken
(Gallus gallus)
Aves FASLG 35
  • 62.02 (n)
  • 55.38 (a)
FASLG 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FASLG 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia faslg 35
  • 53.87 (n)
  • 47.2 (a)
zebrafish
(Danio rerio)
Actinopterygii faslg 35
  • 48.95 (n)
  • 35.27 (a)
faslg 36
  • 29 (a)
OneToOne
Species with no ortholog for FASLG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FASLG Gene

ENSEMBL:
Gene Tree for FASLG (if available)
TreeFam:
Gene Tree for FASLG (if available)

Paralogs for FASLG Gene

Paralogs for FASLG Gene

Selected SIMAP similar genes for FASLG Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FASLG: view

Variants for FASLG Gene

Sequence variations from dbSNP and Humsavar for FASLG Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs17475 -- 172,666,249(+) CCATG(A/T)GAAGA utr-variant-3-prime
rs17476 -- 172,666,266(+) AGCAT(C/G)AAAAA utr-variant-3-prime
rs749154 -- 172,658,079(+) TGTCT(C/T)GAAGC upstream-variant-2KB
rs749155 -- 172,658,116(+) CATAG(A/C)AAGTC upstream-variant-2KB
rs763110 -- 172,658,358(+) CATTG(C/T)GAAAT upstream-variant-2KB

Relevant External Links for FASLG Gene

HapMap Linkage Disequilibrium report
FASLG
Human Gene Mutation Database (HGMD)
FASLG
Locus Specific Mutation Databases (LSDB)
FASLG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FASLG Gene

Disorders for FASLG Gene

(2) OMIM Diseases for FASLG Gene (134638)

UniProtKB/Swiss-Prot

TNFL6_HUMAN
  • Autoimmune lymphoproliferative syndrome 1B (ALPS1B) [MIM:601859]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. {ECO:0000269 PubMed:8787672}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(95) Novoseek inferred disease relationships for FASLG Gene

Disease -log(P) Hits PubMed IDs
autoimmune lymphoproliferative syndrome 72.6 4
necrosis 72.1 107
tumors 70.7 311
tumor escape 66.9 8
leukemia lymphocytic large granular 61.7 2

Relevant External Links for FASLG

GeneTests
FASLG
GeneReviews
FASLG
Genetic Association Database (GAD)
FASLG
Human Genome Epidemiology (HuGE) Navigator
FASLG
genes like me logo Genes that share disorders with FASLG: view

Publications for FASLG Gene

  1. Human Fas ligand: gene structure, chromosomal location and species specificity. (PMID: 7826947) Takahashi T. … Nagata S. (Int. Immunol. 1994) 2 3 4 23
  2. Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease. (PMID: 8787672) Wu J. … Mountz J.D. (J. Clin. Invest. 1996) 3 4 23 48
  3. Fas and Fas ligand gene polymorphisms in primary SjAPgren's syndrome. (PMID: 11036836) Bolstad A.I. … Jonsson R. (J. Rheumatol. 2000) 3 23 48
  4. Characterization of Fas (Apo-1, CD95)-Fas ligand interaction. (PMID: 9228058) Schneider P. … Tschopp J. (J. Biol. Chem. 1997) 3 4 23
  5. Fas ligand gene polymorphisms are not associated with Hashimoto's thyroiditis and Graves' disease. (PMID: 12559631) Stuck B.J. … Badenhoop K. (Hum. Immunol. 2003) 3 23 48

Products for FASLG Gene

Sources for FASLG Gene

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