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Aliases for IL2 Gene

Aliases for IL2 Gene

  • Interleukin 2 2 3 5
  • T Cell Growth Factor 2 3
  • Aldesleukin 3 4
  • IL-2 3 4
  • TCGF 3 4
  • Involved In Regulation Of T-Cell Clonal Expansion 3
  • T-Cell Growth Factor 4
  • Interleukin-2 3
  • Lymphokine 3

External Ids for IL2 Gene

Previous GeneCards Identifiers for IL2 Gene

  • GC04M124285
  • GC04M123652
  • GC04M123765
  • GC04M123831
  • GC04M123730
  • GC04M123592
  • GC04M123372
  • GC04M119099

Summaries for IL2 Gene

Entrez Gene Summary for IL2 Gene

  • The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL2 Gene

IL2 (Interleukin 2) is a Protein Coding gene. Diseases associated with IL2 include Kidney Cancer and Capillary Leak Syndrome. Among its related pathways are Allograft rejection and GPCR Pathway. GO annotations related to this gene include carbohydrate binding and growth factor activity.

UniProtKB/Swiss-Prot for IL2 Gene

  • Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Tocris Summary for IL2 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL2 Gene

Genomics for IL2 Gene

Regulatory Elements for IL2 Gene

Enhancers for IL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G122150 1.7 FANTOM5 ENCODE dbSUPER 6.3 +304.7 304722 3.7 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 SP3 IL2 KIAA1109 IL21 RN7SL335P
GH04G122175 0.7 FANTOM5 1.9 +281.4 281443 0.1 CTCF GATA3 CTBP1 PKNOX1 GATA2 PBX2 ZNF843 TRPC3 IL2 KIAA1109 GC04P122268
GH04G122458 0.8 Ensembl ENCODE 0.7 -2.0 -1993 0.6 IRF2 HMBOX1 MAX MNT IRF1 IL2 IL21-AS1
GH04G122583 1.3 Ensembl ENCODE 0.1 -127.8 -127781 1.4 FOXA2 ZFP64 ZNF133 SIN3A ARID4B DMAP1 ZNF48 ZNF2 YY1 FOS IL21-AS1 KIAA1109 IL2
GH04G122578 0.9 Ensembl ENCODE 0.1 -122.0 -121965 1.1 CTCF CBX3 ZNF10 HLF TRIM22 SMC3 HMBOX1 TRIM28 IL21-AS1 TRPC3 IL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IL2 gene promoter:

Genomic Location for IL2 Gene

122,451,470 bp from pter
122,456,725 bp from pter
5,256 bases
Minus strand

Genomic View for IL2 Gene

Genes around IL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL2 Gene

Proteins for IL2 Gene

  • Protein details for IL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • P01585

    Protein attributes for IL2 Gene

    153 amino acids
    Molecular mass:
    17628 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA59140.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL2 Gene

neXtProt entry for IL2 Gene

Post-translational modifications for IL2 Gene

  • Glycosylation at posLast=2323
  • Modification sites at PhosphoSitePlus

Other Protein References for IL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL2 Gene

Domains & Families for IL2 Gene

Gene Families for IL2 Gene

Protein Domains for IL2 Gene

Suggested Antigen Peptide Sequences for IL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IL-2 family.
  • Belongs to the IL-2 family.
genes like me logo Genes that share domains with IL2: view

Function for IL2 Gene

Molecular function for IL2 Gene

GENATLAS Biochemistry:
interleukin 2,30-35kDa,involved in activation and proliferation of T cell
UniProtKB/Swiss-Prot Function:
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Gene Ontology (GO) - Molecular Function for IL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005125 cytokine activity IDA 1830926
GO:0005134 interleukin-2 receptor binding IDA,TAS 3925347
GO:0008083 growth factor activity TAS 8476561
GO:0019209 kinase activator activity TAS 8476561
genes like me logo Genes that share ontologies with IL2: view
genes like me logo Genes that share phenotypes with IL2: view

Animal Models for IL2 Gene

MGI Knock Outs for IL2:

Animal Model Products

miRNA for IL2 Gene

miRTarBase miRNAs that target IL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL2 Gene

Localization for IL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for IL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 6608729
GO:0005622 intracellular IEA --
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with IL2: view

Pathways & Interactions for IL2 Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PEDF Induced Signaling
4 Allograft rejection
5 GPCR Pathway
genes like me logo Genes that share pathways with IL2: view

Pathways by source for IL2 Gene

SIGNOR curated interactions for IL2 Gene


Gene Ontology (GO) - Biological Process for IL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002250 adaptive immune response IEA --
GO:0002366 leukocyte activation involved in immune response IDA 16204630
genes like me logo Genes that share ontologies with IL2: view

Drugs & Compounds for IL2 Gene

(114) Drugs for IL2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dacarbazine Approved, Investigational Pharma 688
rituximab Approved Pharma Therapeutic Antibodies 1692
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 1142
Apremilast Approved, Investigational Pharma Target 75
Pseudoephedrine Approved Pharma Target 628

(47) Additional Compounds for IL2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AS 2444697

(5) Tocris Compounds for IL2 Gene

Compound Action Cas Number
4-IPP Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate 41270-96-6
AS 2444697 Potent and selective IRAK4 inhibitor 1287665-60-4
ISO 1 Macrophage migration inhibitory factor (MIF) inhibitor 478336-92-4
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo 53179-13-8
Thalidomide TNF-alpha synthesis inhibitor 50-35-1

(1) ApexBio Compounds for IL2 Gene

Compound Action Cas Number
Triptolide IL-2/MMP-3/MMP7/MMP19 inhibitor 38748-32-2
genes like me logo Genes that share compounds with IL2: view

Transcripts for IL2 Gene

mRNA/cDNA for IL2 Gene

Unigene Clusters for IL2 Gene

Interleukin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b

Relevant External Links for IL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x9.9) and Bladder (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of IL2 Gene:


SOURCE GeneReport for Unigene cluster for IL2 Gene:


Evidence on tissue expression from TISSUES for IL2 Gene

  • Blood(4.8)
  • Spleen(3.6)
  • Lymph node(3.3)
  • Skin(3.1)
  • Bone marrow(2.9)
  • Lung(2.9)
  • Intestine(2.7)
  • Kidney(2.6)
  • Liver(2.6)
  • Nervous system(2.4)
  • Heart(2.1)
  • Muscle(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with IL2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL2 Gene

Orthologs for IL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL2 34 35
  • 100 (n)
(Canis familiaris)
Mammalia IL2 34 35
  • 86.93 (n)
(Rattus norvegicus)
Mammalia Il2 34
  • 76.25 (n)
(Mus musculus)
Mammalia Il2 34 16 35
  • 69.98 (n)
(Bos Taurus)
Mammalia IL2 35
  • 64 (a)
Species where no ortholog for IL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL2 Gene

Gene Tree for IL2 (if available)
Gene Tree for IL2 (if available)

Paralogs for IL2 Gene

(1) SIMAP similar genes for IL2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IL2: view

No data available for Paralogs for IL2 Gene

Variants for IL2 Gene

Sequence variations from dbSNP and Humsavar for IL2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000418138 -- 122,451,843(+) CACAC(A/G)TGAAT intron-variant, reference, missense
rs1000644297 -- 122,449,661(+) ATCAC(C/T)AGTGT intron-variant
rs1000811052 -- 122,450,022(+) TATAG(C/T)ATTAC intron-variant
rs1000871948 -- 122,451,364(+) AAAGA(C/G)TGACT intron-variant, downstream-variant-500B
rs1000947301 -- 122,457,457(+) TAACC(G/T)GGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL2 Gene

Variant ID Type Subtype PubMed ID
esv3894021 CNV loss 25118596

Variation tolerance for IL2 Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL2 Gene

Disorders for IL2 Gene

MalaCards: The human disease database

(158) MalaCards diseases for IL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kidney cancer
  • renal cell carcinoma
capillary leak syndrome
farmer's lung
  • farmer lung
tropical spastic paraparesis
  • htlv-associated myelopathy
immune defect due to absence of thymus
  • nezelof syndrome
- elite association - COSMIC cancer census association via MalaCards
Search IL2 in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. {ECO:0000269 PubMed:1396583}.

Genatlas disease for IL2 Gene


Relevant External Links for IL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL2: view

Publications for IL2 Gene

  1. Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis. (PMID: 17444587) Mattuzzi S. … Scarpa A. (J. Rheumatol. 2007) 3 22 46 64
  2. Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. (PMID: 17355643) Huang H.Y. … Helzlsouer K.J. (BMC Genet. 2007) 3 22 46 64
  3. Frequency distribution of cytokine gene polymorphisms in the healthy North Indian population. (PMID: 17257312) Kaur G. … Mehra N.K. (Tissue Antigens 2007) 3 22 46 64
  4. Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium. (PMID: 16389181) Rothman N. … Nieters A. (Lancet Oncol. 2006) 3 22 46 64
  5. Polymorphisms in cytokine genes and risk of Helicobacter pylori infection among Jamaican children. (PMID: 16961803) Tseng F.C. … Hisada M. (Helicobacter 2006) 3 22 46 64

Products for IL2 Gene

Sources for IL2 Gene

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