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Aliases for IKBKB Gene

Aliases for IKBKB Gene

  • Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta 2 3 5
  • Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta 2 3
  • Nuclear Factor NF-Kappa-B Inhibitor Kinase Beta 3 4
  • I-Kappa-B-Kinase Beta 3 4
  • I-Kappa-B Kinase 2 3 4
  • EC 2.7.11.10 4 61
  • IKK-Beta 3 4
  • NFKBIKB 3 4
  • IKK-B 3 4
  • IKK2 3 4
  • IKKB 3 4
  • Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Beta 3
  • EC 2.7.11 61
  • IMD15 3
  • IkBKB 4

External Ids for IKBKB Gene

Previous GeneCards Identifiers for IKBKB Gene

  • GC08M041757
  • GC08P042157
  • GC08P041869
  • GC08P042146
  • GC08P040656

Summaries for IKBKB Gene

Entrez Gene Summary for IKBKB Gene

  • The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for IKBKB Gene

IKBKB (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta) is a Protein Coding gene. Diseases associated with IKBKB include Immunodeficiency 15 and Cd3delta Deficiency. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Development IGF-1 receptor signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CHUK.

UniProtKB/Swiss-Prot for IKBKB Gene

  • Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

Tocris Summary for IKBKB Gene

  • IkappaB Kinase (IKK) is an enzyme complex that forms part of the NF-kappaB signaling pathway. The IKK complex is comprised of three subunits (IKKalpha (IKK1), IKKbeta (IKK2) and IKKgamma (NEMO)), the alpha- and beta-subunits are catalytically active whereas the gamma-subunit has a regulatory function.

Gene Wiki entry for IKBKB Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKBKB Gene

Genomics for IKBKB Gene

Regulatory Elements for IKBKB Gene

Enhancers for IKBKB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G042194 2 FANTOM5 Ensembl ENCODE dbSUPER 30.6 -74.0 -74045 6.5 CREB3L1 MLX DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC IKBKB ENSG00000254165 AP3M2 KAT6A POLB SMIM19 PLAT PIR61234
GH08G042151 1.4 ENCODE dbSUPER 39.7 -116.7 -116732 5.9 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D IKBKB AP3M2 ENSG00000254165 LOC101929897 POLB KAT6A DKK4 ENSG00000238966 PIR61234
GH08G042049 1.8 FANTOM5 ENCODE dbSUPER 21.1 -219.8 -219835 3.4 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF610 IKBKB KAT6A ENSG00000254165 AP3M2 PLAT GPAT4 POLB GC08M041977 LOC105379393
GH08G041528 1.1 ENCODE 31.2 -741.9 -741873 1.9 HDGF ARID4B SIN3A DMAP1 ZNF143 FOS DEK SP3 SP5 MXD4 IKBKB KAT6A PIR57220 GINS4 GC08P041531
GH08G042171 1.3 Ensembl ENCODE dbSUPER 24.6 -99.5 -99460 1.1 ATF1 SIN3A ARID4B NFXL1 ZNF2 RAD21 ZNF121 SCRT2 ZNF391 ZNF263 IKBKB POLB ENSG00000254165 PLAT HOOK3 LOC101929897 VDAC3 DKK4 KAT6A PIR61234
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IKBKB on UCSC Golden Path with GeneCards custom track

Promoters for IKBKB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000224064 98 1201 PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 SP3 JUNB SMARCB1 KAT8

Genomic Location for IKBKB Gene

Chromosome:
8
Start:
42,271,302 bp from pter
End:
42,332,653 bp from pter
Size:
61,352 bases
Orientation:
Plus strand

Genomic View for IKBKB Gene

Genes around IKBKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IKBKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IKBKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IKBKB Gene

Proteins for IKBKB Gene

  • Protein details for IKBKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14920-IKKB_HUMAN
    Recommended name:
    Inhibitor of nuclear factor kappa-B kinase subunit beta
    Protein Accession:
    O14920
    Secondary Accessions:
    • B4DZ30
    • B4E0U4
    • O75327

    Protein attributes for IKBKB Gene

    Size:
    756 amino acids
    Molecular mass:
    86564 Da
    Quaternary structure:
    • Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex (PubMed:12612076). The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65 (By similarity). Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP (PubMed:11971985). Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14 (PubMed:9751059). Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (PubMed:17287217). Interacts with SQSTM1 through PRKCZ or PRKCI (PubMed:10356400). Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6 (By similarity). May interact with MAVS/IPS1 (PubMed:16177806). Interacts with NALP2 (PubMed:15456791). Interacts with TICAM1 (PubMed:14739303). Interacts with FAF1; the interaction disrupts the IKK complex formation (PubMed:17684021). Interacts with ATM (PubMed:16497931). Part of a ternary complex consisting of TANK, IKBKB and IKBKG (PubMed:12133833). Interacts with NIBP; the interaction is direct (PubMed:15951441). Interacts with ARRB1 and ARRB2 (PubMed:15173580). Interacts with TRIM21 (PubMed:19675099). Interacts with NLRC5; prevents IKBKB phosphorylation and kinase activity (PubMed:20434986). Interacts with PDPK1 (PubMed:16207722). Interacts with EIF2AK2/PKR (PubMed:10848580). The phosphorylated form interacts with PPM1A and PPM1B (PubMed:18930133). Interacts with ZNF268 isoform 2; the interaction is further increased in a TNF-alpha-dependent manner (PubMed:23091055). Interacts with IKBKE (PubMed:23453969). Interacts with NAA10, leading to NAA10 degradation (PubMed:19716809). Interacts with FOXO3 (PubMed:15084260). Interacts with AKAP13 (PubMed:23090968). Interacts with IFIT5; the interaction synergizes the recruitment of IKK to MAP3K7 and enhances IKK phosphorylation (PubMed:26334375).
    • (Microbial infection) Interacts with Yersinia yopJ.

    Three dimensional structures from OCA and Proteopedia for IKBKB Gene

    Alternative splice isoforms for IKBKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IKBKB Gene

Selected DME Specific Peptides for IKBKB Gene

O14920:
  • DQGSLCTSFVGTLQYLAPEL
  • HKIIDLGYAK
  • PLLAMEYC
  • QGQRAAM
  • RLGTGGFGNV
  • QLSKTVVCKQKALELLPKVEEVV
  • RDLKPEN
  • QQLKAKL
  • IIHRDLKPENIVLQ
  • MKERLGTGGFG
  • TVDYWSFGT

Post-translational modifications for IKBKB Gene

  • (Microbial infection) Acetylation of Thr-180 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B pathway.
  • (Microbial infection) Monoubiquitination by TRIM21 is disrupted by Yersinia yopJ.
  • Hydroxylated by PHD1/EGLN2, loss of hydroxylation under hypoxic conditions results in activation of NF-kappa-B.
  • Ubiquitinated. Monoubiquitination involves TRIM21 that leads to inhibition of Tax-induced NF-kappa-B signaling. According to PubMed:19675099, Ser-163 does not serve as a monoubiquitination site. According to PubMed:16267042, ubiquitination on Ser-163 modulates phosphorylation on C-terminal serine residues.
  • Upon cytokine stimulation, phosphorylated on Ser-177 and Ser-181 by MEKK1 and/or MAP3K14/NIK as well as TBK1 and PRKCZ; which enhances activity. Once activated, autophosphorylates on the C-terminal serine cluster; which decreases activity and prevents prolonged activation of the inflammatory response. Phosphorylated by the IKK-related kinases TBK1 and IKBKE, which is associated with reduced CHUK/IKKA and IKBKB activity and NF-kappa-B-dependent gene transcription. Dephosphorylated at Ser-177 and Ser-181 by PPM1A and PPM1B.
  • Ubiquitination at posLast=106106, posLast=163163, and posLast=555555
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IKBKB (IKKB)
  • Cloud-Clone Corp. Antibodies for IKBKB

Domains & Families for IKBKB Gene

Graphical View of Domain Structure for InterPro Entry

O14920

UniProtKB/Swiss-Prot:

IKKB_HUMAN :
  • The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and hetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKG.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Domain:
  • The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and hetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKG.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
genes like me logo Genes that share domains with IKBKB: view

Function for IKBKB Gene

Molecular function for IKBKB Gene

GENATLAS Biochemistry:
inhibitor of kappa light polypeptide enhancer in B cells,kinase beta,complexing with IKBKA
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
UniProtKB/Swiss-Prot Function:
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

Enzyme Numbers (IUBMB) for IKBKB Gene

Gene Ontology (GO) - Molecular Function for IKBKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA,IEA 20434986
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI 9520446
GO:0005524 ATP binding IEA --
GO:0008384 IkappaB kinase activity TAS 18626576
genes like me logo Genes that share ontologies with IKBKB: view
genes like me logo Genes that share phenotypes with IKBKB: view

Human Phenotype Ontology for IKBKB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IKBKB Gene

MGI Knock Outs for IKBKB:

Animal Model Products

  • Taconic Biosciences Mouse Models for IKBKB

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for IKBKB Gene

Localization for IKBKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKBKB Gene

Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269 PubMed:17287217}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IKBKB gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
extracellular 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IKBKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
GO:0008385 IkappaB kinase complex TAS 18626576
GO:0009898 cytoplasmic side of plasma membrane ISS --
genes like me logo Genes that share ontologies with IKBKB: view

Pathways & Interactions for IKBKB Gene

SuperPathways for IKBKB Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 TNFR1 Pathway
3 4-1BB Pathway
4 Toll-Like receptor Signaling Pathways
5 Cytosolic sensors of pathogen-associated DNA
genes like me logo Genes that share pathways with IKBKB: view

Pathways by source for IKBKB Gene

SIGNOR curated interactions for IKBKB Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for IKBKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006468 protein phosphorylation IEA,NAS 9346484
GO:0006954 inflammatory response TAS 18626576
GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS 18626576
genes like me logo Genes that share ontologies with IKBKB: view

Drugs & Compounds for IKBKB Gene

(66) Drugs for IKBKB Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arsenic trioxide Approved, Investigational Pharma inhibitor, Target, inducer 122
Auranofin Approved Pharma Activation, Activator, inhibitor, Target Thioredoxin reductase inhibitor; induces MPT 11
Sulfasalazine Approved Pharma Inhibition, Inhibitor, Target, inhibitor NF-κB activation inhibitor 60
Mesalazine Approved Pharma Target, inhibitor 0
Aspirin Approved, Vet_approved Pharma Channel blocker, Target 1152

(28) Additional Compounds for IKBKB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(5) Tocris Compounds for IKBKB Gene

Compound Action Cas Number
ACHP Selective IKKalpha and IKKbeta inhibitor 406208-42-2
Amlexanox Inhibitor of TBK1 and IKKeta; antiallergic agent 68302-57-8
BMS 345541 Selective allosteric inhibitor of IKK; anti-inflammatory 547757-23-3
PF 184 Potent and selective IKKbeta inhibitor 1187460-81-6
PS 1145 dihydrochloride Selective IKK inhibitor; orally active 1049743-58-9

(25) ApexBio Compounds for IKBKB Gene

Compound Action Cas Number
ACHP IκB kinase inhibitor 406208-42-2
Andrographolide NF-κB signaling Inhibitor 5508-58-7
Bardoxolone methyl IKK inhibitor, potent antioxidant inflammation modulator 218600-53-4
Bay 11-7085 NK-κB activation inhibitor 196309-76-9
Bay 11-7821(BAY 11-7082) IKK/NF-κB/TNFα inhibitor 19542-67-7
Bay 65-1942 free base IKKβ kinase inhibitor,ATP-competitive 600734-02-9
Bay 65-1942 HCl salt 600734-06-3
Bay 65-1942 R form IKKβ inhibitor, ATP-competitive and selective 758683-21-5
BMS-345541 IKK inhibitor,highly selective 547757-23-3
BMS-345541(free base) IKK-1/IKK-2 inhibitor,potent and selective 445430-58-0
Choline Fenofibrate Choline salt of fenofibric acid 856676-23-8
Honokiol Antioxidant/antitumor/antiangiogenic agent 35354-74-6
IKK-16 (IKK Inhibitor VII) Selective IκB kinase inhibitor 873225-46-8
IKK-2 inhibitor VIII IKK-2 inhibitor,potent and selective 406209-26-5
IMD 0354 978-62-1
Luteolin Antioxidant and free radical scavenger 491-70-3
LY2409881 946518-60-1
ML 120B dihydrochloride
MLN120B IκB Kinase β Inhibitor 783348-36-7
PF 184 1187460-81-6
PS 1145 dihydrochloride 1049743-58-9
SC-514 ATP-competitive IKK-2 inhibitor, orally active 354812-17-2
Tanshinone IIA Antioxidant and anti-inflammatory reagent 568-72-9
TPCA-1 IKK-2 inhibitor,potent and selective 507475-17-4
WS6 1421227-53-3
genes like me logo Genes that share compounds with IKBKB: view

Drug Products

Transcripts for IKBKB Gene

Unigene Clusters for IKBKB Gene

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IKBKB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: -
SP6:
SP7:
SP8:

ExUns: 20b ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6: -
SP7: -
SP8:

Relevant External Links for IKBKB Gene

GeneLoc Exon Structure for
IKBKB
ECgene alternative splicing isoforms for
IKBKB

Expression for IKBKB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IKBKB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IKBKB Gene

This gene is overexpressed in Lymph node (21.0) and Peripheral blood mononuclear cells (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IKBKB Gene



Protein tissue co-expression partners for IKBKB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IKBKB Gene:

IKBKB

SOURCE GeneReport for Unigene cluster for IKBKB Gene:

Hs.597664

mRNA Expression by UniProt/SwissProt for IKBKB Gene:

O14920-IKKB_HUMAN
Tissue specificity: Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.

Evidence on tissue expression from TISSUES for IKBKB Gene

  • Heart(4.5)
  • Lung(4.5)
  • Liver(4.4)
  • Nervous system(4.2)
  • Skin(3)
  • Blood(2.7)
  • Intestine(2.5)
  • Muscle(2.4)
  • Lymph node(2.3)
  • Spleen(2.3)
  • Kidney(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IKBKB Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • lymphatic
  • respiratory
Organs:
Thorax:
  • bronchus
  • lung
Abdomen:
  • intestine
  • large intestine
  • small intestine
Pelvis:
  • anus
  • rectum
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with IKBKB: view

Primer Products

No data available for mRNA differential expression in normal tissues for IKBKB Gene

Orthologs for IKBKB Gene

This gene was present in the common ancestor of animals.

Orthologs for IKBKB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IKBKB 34 35
  • 98.48 (n)
dog
(Canis familiaris)
Mammalia IKBKB 34 35
  • 90.11 (n)
oppossum
(Monodelphis domestica)
Mammalia IKBKB 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IKBKB 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ikbkb 34 16 35
  • 87.15 (n)
rat
(Rattus norvegicus)
Mammalia Ikbkb 34
  • 87.11 (n)
cow
(Bos Taurus)
Mammalia IKBKB 34 35
  • 86.86 (n)
chicken
(Gallus gallus)
Aves IKBKB 34 35
  • 67.94 (n)
lizard
(Anolis carolinensis)
Reptilia IKBKB 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ikbkb 34
  • 70.54 (n)
Str.17591 34
zebrafish
(Danio rerio)
Actinopterygii ikbkb 34 35
  • 62.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta ird5 35 36
  • 22 (a)
OneToMany
Species where no ortholog for IKBKB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IKBKB Gene

ENSEMBL:
Gene Tree for IKBKB (if available)
TreeFam:
Gene Tree for IKBKB (if available)

Paralogs for IKBKB Gene

Variants for IKBKB Gene

Sequence variations from dbSNP and Humsavar for IKBKB Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_035626 Breast cancer samples
rs200296680 Pathogenic 42,316,223(+) CTGAG(C/T)GACTG nc-transcript-variant, reference, stop-gained, utr-variant-5-prime
rs886041036 Pathogenic 42,318,603(+) TGGGG(-/G)CCAGG nc-transcript-variant, reference, frameshift-variant
rs1000021730 -- 42,316,522(+) AGGTC(A/T)TAGCC intron-variant
rs1000025454 -- 42,282,403(+) AGTCT(C/T)GCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IKBKB Gene

Variant ID Type Subtype PubMed ID
dgv128n16 CNV deletion 17901297
dgv36e209 CNV deletion 24192839
dgv7185n100 CNV gain 25217958
esv1003654 CNV deletion 20482838
esv1761681 CNV deletion 17803354
esv2736935 CNV deletion 23290073
esv3543424 CNV deletion 23714750
esv3543425 CNV deletion 23714750
esv3617007 CNV loss 21293372
nsv1132145 CNV deletion 24896259
nsv1145767 CNV deletion 26484159
nsv398024 CNV deletion 16902084
nsv476099 CNV novel sequence insertion 20440878
nsv508508 CNV deletion 20534489
nsv611131 CNV gain 21841781
nsv6169 CNV deletion 18451855
nsv831301 CNV loss 17160897

Variation tolerance for IKBKB Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IKBKB Gene

Human Gene Mutation Database (HGMD)
IKBKB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IKBKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IKBKB Gene

Disorders for IKBKB Gene

MalaCards: The human disease database

(7) MalaCards diseases for IKBKB Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 15
  • imd15
cd3delta deficiency
  • cd3d
neurodermatitis
human t-cell leukemia virus type 1
  • htlv-1
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards
Search IKBKB in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IKKB_HUMAN
  • Immunodeficiency 15 (IMD15) [MIM:615592]: An autosomal recessive primary immunodeficiency disorder characterized by onset in infancy of life-threatening bacterial, fungal, and viral infections and failure to thrive. Laboratory studies show hypo- or agammaglobulinemia with relatively normal numbers of B and T-cells, and impaired differentiation and activation of immune cells. {ECO:0000269 PubMed:24369075}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IKBKB

Genetic Association Database (GAD)
IKBKB
Human Genome Epidemiology (HuGE) Navigator
IKBKB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IKBKB
genes like me logo Genes that share disorders with IKBKB: view

No data available for Genatlas for IKBKB Gene

Publications for IKBKB Gene

  1. PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. (PMID: 18930133) Sun W. … Yang J. (Cell. Signal. 2009) 3 4 22 64
  2. Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling. (PMID: 19675099) Wada K. … Kamitani T. (J. Biochem. 2009) 3 4 22 64
  3. Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. (PMID: 19716809) Kuo H.P. … Hung M.C. (Biochem. Biophys. Res. Commun. 2009) 3 4 22 64
  4. IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB. (PMID: 18308615) Schmid J.A. … Birbach A. (Cytokine Growth Factor Rev. 2008) 2 3 22 64
  5. FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly. (PMID: 17684021) Park M.Y. … Kim E. (J. Biol. Chem. 2007) 3 4 22 64

Products for IKBKB Gene