Aliases for IGLL1 Gene
External Ids for IGLL1 Gene
Previous HGNC Symbols for IGLL1 Gene
Previous GeneCards Identifiers for IGLL1 Gene
The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for IGLL1 Gene
IGLL1 (Immunoglobulin Lambda-Like Polypeptide 1) is a Protein Coding gene. Diseases associated with IGLL1 include agammaglobulinemia 2 and autosomal recessive disease. Among its related pathways are Primary immunodeficiency. An important paralog of this gene is IGLC1.
UniProtKB/Swiss-Prot for IGLL1 Gene
Critical for B-cell development.