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Aliases for KLK3 Gene

Aliases for KLK3 Gene

  • Kallikrein Related Peptidase 3 2 3 5
  • Gamma-Seminoprotein 3 4
  • P-30 Antigen 3 4
  • Kallikrein-3 3 4
  • Semenogelase 3 4
  • Seminin 3 4
  • APS 3 4
  • PSA 3 4
  • Kallikrein 3, (Prostate Specific Antigen) 2
  • Kallikrein-Related Peptidase 3 3
  • Prostate Specific Antigen 3
  • EC 3.4.21.77 4
  • EC 3.4.21 63
  • KLK2A1 3
  • HK3 3

External Ids for KLK3 Gene

Previous HGNC Symbols for KLK3 Gene

  • APS

Previous GeneCards Identifiers for KLK3 Gene

  • GC19P051987
  • GC19P051719
  • GC19P056034
  • GC19P056049
  • GC19P051358
  • GC19P047693

Summaries for KLK3 Gene

Entrez Gene Summary for KLK3 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLK3 Gene

KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. Diseases associated with KLK3 include fletcher factor deficiency and prostatic adenoma. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for KLK3 Gene

  • Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Gene Wiki entry for KLK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK3 Gene

Genomics for KLK3 Gene

Regulatory Elements for KLK3 Gene

Transcription factor binding sites by QIAGEN in the KLK3 gene promoter:

Genomic Location for KLK3 Gene

Chromosome:
19
Start:
50,854,915 bp from pter
End:
50,877,702 bp from pter
Size:
22,788 bases
Orientation:
Plus strand

Genomic View for KLK3 Gene

Genes around KLK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK3 Gene

Proteins for KLK3 Gene

  • Protein details for KLK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07288-KLK3_HUMAN
    Recommended name:
    Prostate-specific antigen
    Protein Accession:
    P07288
    Secondary Accessions:
    • C9JXH3
    • G3V0H4
    • G3XAE3
    • Q15096
    • Q16272
    • Q86TG8
    • Q8IXI4

    Protein attributes for KLK3 Gene

    Size:
    261 amino acids
    Molecular mass:
    28741 Da
    Quaternary structure:
    • Forms a heterodimer with SERPINA5.
    SequenceCaution:
    • Sequence=AAD14185.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA32124.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KLK3 Gene

    Alternative splice isoforms for KLK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK3 Gene

Proteomics data for KLK3 Gene at MOPED

Selected DME Specific Peptides for KLK3 Gene

Post-translational modifications for KLK3 Gene

  • Glycosylation at Asn 69
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for KLK3 (Kallikrein 3/PSA)
  • Cell Signaling Technology (CST) Antibodies for KLK3 (PSA)

Protein Products

Domains & Families for KLK3 Gene

Gene Families for KLK3 Gene

Graphical View of Domain Structure for InterPro Entry

P07288

UniProtKB/Swiss-Prot:

KLK3_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK3: view

Function for KLK3 Gene

Molecular function for KLK3 Gene

GENATLAS Biochemistry:
kallikrein 3,prostate specific antigen,serine protease,overexpressed in prostate and breast carcinomas
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: -Tyr- -Xaa-.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders.
UniProtKB/Swiss-Prot Function:
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Enzyme Numbers (IUBMB) for KLK3 Gene

genes like me logo Genes that share phenotypes with KLK3: view

Animal Model Products

CRISPR Products

miRNA for KLK3 Gene

miRTarBase miRNAs that target KLK3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLK3 Gene

Localization for KLK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLK3 Gene COMPARTMENTS Subcellular localization image for KLK3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2
plasma membrane 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for KLK3 Gene

Pathways & Interactions for KLK3 Gene

genes like me logo Genes that share pathways with KLK3: view

Gene Ontology (GO) - Biological Process for KLK3 Gene

None

No data available for SIGNOR curated interactions for KLK3 Gene

Drugs & Compounds for KLK3 Gene

(82) Drugs for KLK3 Gene - From: Novoseek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PRX302 Investigational Pharma 0
MVA-BN Pharma 0

(43) Additional Compounds for KLK3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK3: view

Transcripts for KLK3 Gene

Unigene Clusters for KLK3 Gene

Kallikrein-related peptidase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLK3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9: - -
SP10: - - -
SP11: - -
SP12: - - - -
SP13: - - - - -

Relevant External Links for KLK3 Gene

GeneLoc Exon Structure for
KLK3
ECgene alternative splicing isoforms for
KLK3

Expression for KLK3 Gene

mRNA expression in normal human tissues for KLK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLK3 Gene

This gene is overexpressed in Prostate (x52.7).

Protein differential expression in normal tissues from HIPED for KLK3 Gene

This gene is overexpressed in Cervix (32.5) and Prostate (27.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLK3 Gene



SOURCE GeneReport for Unigene cluster for KLK3 Gene Hs.171995

genes like me logo Genes that share expression patterns with KLK3: view

Protein tissue co-expression partners for KLK3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KLK3 Gene

Orthologs for KLK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLK3 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Klk1b22 35
  • 65.49 (n)
  • 56.86 (a)
Klk1b9 16
Klk1b16 36
  • 51 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 27 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia KLK2 36
  • 56 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KLK3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
OneToMany
Species with no ortholog for KLK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK3 Gene

ENSEMBL:
Gene Tree for KLK3 (if available)
TreeFam:
Gene Tree for KLK3 (if available)

Paralogs for KLK3 Gene

genes like me logo Genes that share paralogs with KLK3: view

Variants for KLK3 Gene

Sequence variations from dbSNP and Humsavar for KLK3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2271092 - 50,856,287(-) CTTCT(C/T)GCACT nc-transcript-variant, reference, missense
rs2003783 - 50,858,216(-) CGTGA(A/G/T)CTCGG nc-transcript-variant, reference, missense
rs17632542 - 50,858,501(+) TGTTA(C/T)TTCCA nc-transcript-variant, reference, missense
rs6998 -- 50,860,405(+) GTGGG(A/G)TACAG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs11573 -- 50,856,241(+) GCAGG(C/T)GCTGC nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for KLK3 Gene

Variant ID Type Subtype PubMed ID
nsv2531 CNV Loss 18451855
nsv524465 CNV Loss 19592680

Variation tolerance for KLK3 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 47.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLK3 Gene

HapMap Linkage Disequilibrium report
KLK3
Human Gene Mutation Database (HGMD)
KLK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK3 Gene

Disorders for KLK3 Gene

MalaCards: The human disease database

(73) MalaCards diseases for KLK3 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fletcher factor deficiency
  • fletcher factor deficiency
prostatic adenoma
  • adenoma - prostate
prostatitis
prostate disease
  • prostatic diseases
clear cell adenocarcinoma
  • clear cell adenocarcinoma nos
- elite association - COSMIC cancer census association via MalaCards
Search KLK3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLK3

Genetic Association Database (GAD)
KLK3
Human Genome Epidemiology (HuGE) Navigator
KLK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLK3
genes like me logo Genes that share disorders with KLK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLK3 Gene

Publications for KLK3 Gene

  1. Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence. (PMID: 2456523) Schulz P. … Fittler F. (Nucleic Acids Res. 1988) 2 3 4 67
  2. Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis. (PMID: 19855435) Puri C. … Buss F. (Oncogene 2010) 3 23
  3. Clinical utility of the interaction between lectin and serum prostate specific antigen in prostate cancer. (PMID: 19152248) Batabyal S.K. … Basu P.S. (Neoplasma 2009) 3 23
  4. Prostate-specific antigen enhances bioavailability of insulin-like growth factor by degrading insulin-like growth factor binding protein 5. (PMID: 19250630) Maeda H. … Ochiai A. (Biochem. Biophys. Res. Commun. 2009) 3 23
  5. Tea polyphenols decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit production of hepatocyte growth factor and vascular endothelial growth factor in vitro. (PMID: 19542190) McLarty J. … Cardelli J.A. (Cancer Prev Res (Phila) 2009) 3 23

Products for KLK3 Gene

Sources for KLK3 Gene

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