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Aliases for IGLC2 Gene

Aliases for IGLC2 Gene

  • Immunoglobulin Lambda Constant 2 (Kern-Oz- Marker) 2 3
  • Immunoglobulin Lambda Constant Region 2 (Kern- Oz- Marker) 3
  • Ig Light-Chain, Partial Ke-Oz- Polypeptide, C-Term 3
  • C2 Segment 3
  • IGLC 3

External Ids for IGLC2 Gene

Previous HGNC Symbols for IGLC2 Gene

  • IGLC

Previous GeneCards Identifiers for IGLC2 Gene

  • GC22U990026
  • GC22P021090
  • GC22P021093
  • GC22P021096
  • GC22P021100
  • GC22P021102
  • GC22P021567
  • GC22P021296
  • GC22P021574
  • GC22P023243
  • GC22P006211

Summaries for IGLC2 Gene

GeneCards Summary for IGLC2 Gene

IGLC2 (Immunoglobulin Lambda Constant 2 (Kern-Oz- Marker)) is a Protein Coding gene. Among its related pathways are PI3K/AKT Signaling in Cancer and Immune System. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC1.

Gene Wiki entry for IGLC2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC2 Gene

Genomics for IGLC2 Gene

Genomic Location for IGLC2 Gene

Chromosome:
22
Start:
22,900,976 bp from pter
End:
22,901,437 bp from pter
Size:
462 bases
Orientation:
Plus strand

Genomic View for IGLC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for IGLC2 Gene

No data available for Regulatory Elements for IGLC2 Gene

Proteins for IGLC2 Gene

  • Protein details for IGLC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG05-LAC2_HUMAN
    Recommended name:
    Ig lambda-2 chain C regions
    Protein Accession:
    P0CG05
    Secondary Accessions:
    • A0M8Q4
    • P80423

    Protein attributes for IGLC2 Gene

    Size:
    106 amino acids
    Molecular mass:
    11294 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83
    SequenceCaution:
    • Sequence=AAA59107.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20015.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20026.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20028.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA36049.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB38569.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW59547.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW59549.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGLC2 Gene

neXtProt entry for IGLC2 Gene

Proteomics data for IGLC2 Gene at MOPED

Post-translational modifications for IGLC2 Gene

No Post-translational modifications

Other Protein References for IGLC2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLC2 Gene

Domains & Families for IGLC2 Gene

Gene Families for IGLC2 Gene

Protein Domains for IGLC2 Gene

Suggested Antigen Peptide Sequences for IGLC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG05

UniProtKB/Swiss-Prot:

LAC2_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGLC2: view

Function for IGLC2 Gene

Molecular function for IGLC2 Gene

GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 2 (Kern-Oz-marker)

Gene Ontology (GO) - Molecular Function for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGLC2: view

miRNA for IGLC2 Gene

miRTarBase miRNAs that target IGLC2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLC2 Gene

Localization for IGLC2 Gene

Gene Ontology (GO) - Cellular Components for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 22664934
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
genes like me logo Genes that share ontologies with IGLC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGLC2 Gene

Pathways & Interactions for IGLC2 Gene

genes like me logo Genes that share pathways with IGLC2: view

Interacting Proteins for IGLC2 Gene

Gene Ontology (GO) - Biological Process for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
genes like me logo Genes that share ontologies with IGLC2: view

No data available for SIGNOR curated interactions for IGLC2 Gene

Drugs & Compounds for IGLC2 Gene

No Compound Related Data Available

Transcripts for IGLC2 Gene

mRNA/cDNA for IGLC2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC2 Gene

No ASD Table

Relevant External Links for IGLC2 Gene

GeneLoc Exon Structure for
IGLC2
ECgene alternative splicing isoforms for
IGLC2

Expression for IGLC2 Gene

mRNA expression in normal human tissues for IGLC2 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC2 Gene

This gene is overexpressed in Spleen (x14.6), Colon - Transverse (x7.3), Minor Salivary Gland (x6.9), and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for IGLC2 Gene

This gene is overexpressed in Pancreatic juice (15.8), Plasma (12.3), and Cerebrospinal fluid (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC2 Gene



genes like me logo Genes that share expression patterns with IGLC2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IGLC2 Gene

Orthologs for IGLC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 34 (a)
ManyToMany
IGLL1 36
  • 34 (a)
ManyToMany
VPREB 36
  • 30 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 35 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 85 (a)
ManyToMany
-- 36
  • 85 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 9 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Iglc2 36
  • 63 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 36
  • 11 (a)
ManyToMany
Species with no ortholog for IGLC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLC2 Gene

ENSEMBL:
Gene Tree for IGLC2 (if available)
TreeFam:
Gene Tree for IGLC2 (if available)

Paralogs for IGLC2 Gene

Paralogs for IGLC2 Gene

Pseudogenes.org Pseudogenes for IGLC2 Gene

genes like me logo Genes that share paralogs with IGLC2: view

Variants for IGLC2 Gene

Relevant External Links for IGLC2 Gene

HapMap Linkage Disequilibrium report
IGLC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC2 Gene

Disorders for IGLC2 Gene

genes like me logo Genes that share disorders with IGLC2: view

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLC2 Gene

Publications for IGLC2 Gene

  1. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naA^ve to therapy. (PMID: 23580065) Pieragostino D. … Del Boccio P. (Mol Biosyst 2013) 67
  2. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) BAPhm D. … Grus F.H. (Oncol. Rep. 2012) 67
  3. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. (PMID: 22516433) Bastos-Amador P. … Falcon-Perez J.M. (J Proteomics 2012) 67
  4. Inhibition of pathologic immunoglobulin-free light chain production by small interfering RNA molecules. (PMID: 20637260) Phipps J.E. … Wall J.S. (Exp. Hematol. 2010) 67
  5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 67

Products for IGLC2 Gene

Sources for IGLC2 Gene

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