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Aliases for IGLC2 Gene

Aliases for IGLC2 Gene

  • Immunoglobulin Lambda Constant 2 (Kern-Oz- Marker) 2 3
  • Immunoglobulin Lambda Constant Region 2 (Kern- Oz- Marker) 3
  • Ig Light-Chain, Partial Ke-Oz- Polypeptide, C-Term 3
  • C2 Segment 3
  • IGLC 3

External Ids for IGLC2 Gene

Previous Symbols for IGLC2 Gene

  • IGLC

Summaries for IGLC2 Gene

GeneCards Summary for IGLC2 Gene

IGLC2 (Immunoglobulin Lambda Constant 2 (Kern-Oz- Marker)) is a Protein Coding gene. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC1.

Gene Wiki entry for IGLC2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC2 Gene

Genomics for IGLC2 Gene

Genomic Location for IGLC2 Gene

Start:
22,900,976 bp from pter
End:
22,901,437 bp from pter
Size:
462 bases
Orientation:
Plus strand

Genomic View for IGLC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGLC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC2 Gene

No data available for Regulatory Elements for IGLC2 Gene

Proteins for IGLC2 Gene

  • Protein details for IGLC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG05-LAC2_HUMAN
    Recommended name:
    Ig lambda-2 chain C regions
    Protein Accession:
    P0CG05
    Secondary Accessions:
    • A0M8Q4
    • P80423

    Protein attributes for IGLC2 Gene

    Size:
    106 amino acids
    Molecular mass:
    11294 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83
    SequenceCaution:
    • Sequence=AAA59107.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20015.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20026.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20028.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA36049.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB38569.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW59547.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW59549.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGLC2 Gene

neXtProt entry for IGLC2 Gene

Proteomics data for IGLC2 Gene at MOPED

Post-translational modifications for IGLC2 Gene

No Post-translational modifications

Other Protein References for IGLC2 Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for IGLC2 Gene

Domains for IGLC2 Gene

Gene Families for IGLC2 Gene

HGNC:
  • IGL :Immunoglobulins / IGL locus

Protein Domains for IGLC2 Gene

Suggested Antigen Peptide Sequences for IGLC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG05

UniProtKB/Swiss-Prot:

LAC2_HUMAN
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.:
    • P0CG05
genes like me logo Genes that share domains with IGLC2: view

Function for IGLC2 Gene

Molecular function for IGLC2 Gene

GENATLAS Biochemistry: immunoglobulin,lambda,constant segment 2 (Kern-Oz-marker)

Gene Ontology (GO) - Molecular Function for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGLC2: view

miRNA for IGLC2 Gene

miRTarBase miRNAs that target IGLC2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGLC2 Gene

Localization for IGLC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGLC2 Gene COMPARTMENTS Subcellular localization image for IGLC2 gene
Compartment Confidence
extracellular 4
plasma membrane 4
nucleus 1

Gene Ontology (GO) - Cellular Components for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 22664934
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 19199708
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGLC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IGLC2 Gene

Pathways for IGLC2 Gene

genes like me logo Genes that share pathways with IGLC2: view

Interacting Proteins for IGLC2 Gene

Gene Ontology (GO) - Biological Process for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
genes like me logo Genes that share ontologies with IGLC2: view

Transcripts for IGLC2 Gene

mRNA/cDNA for IGLC2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC2 Gene

No ASD Table

Relevant External Links for IGLC2 Gene

GeneLoc Exon Structure for
IGLC2
ECgene alternative splicing isoforms for
IGLC2

Expression for IGLC2 Gene

mRNA expression in normal human tissues for IGLC2 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC2 Gene

This gene is overexpressed in Spleen (14.6), Colon - Transverse (7.3), Minor Salivary Gland (6.9), and Small Intestine - Terminal Ileum (5.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGLC2 Gene

genes like me logo Genes that share expressions with IGLC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGLC2 Gene

Orthologs for IGLC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 34 (a)
ManyToMany
IGLL1 36
  • 34 (a)
ManyToMany
VPREB 36
  • 30 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 35 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 85 (a)
ManyToMany
-- 36
  • 85 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Iglc2 36
  • 63 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 9 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 36
  • 11 (a)
ManyToMany
Species with no ortholog for IGLC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLC2 Gene

ENSEMBL:
Gene Tree for IGLC2 (if available)
TreeFam:
Gene Tree for IGLC2 (if available)

Paralogs for IGLC2 Gene

Paralogs for IGLC2 Gene

Pseudogenes.org Pseudogenes for IGLC2 Gene

genes like me logo Genes that share paralogs with IGLC2: view

Variants for IGLC2 Gene

Relevant External Links for IGLC2 Gene

HapMap Linkage Disequilibrium report
IGLC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IGLC2 Gene

Disorders for IGLC2 Gene

No disorders were found for IGLC2 Gene.

No data available for UniProtKB/Swiss-Prot for IGLC2 Gene

Publications for IGLC2 Gene

  1. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek T.J. … Leder P. (J. Exp. Med. 1990) 3 4
  2. Immunoglobulin lambda-chains. The complete amino acid sequence of a Bence-Jones protein. (PMID: 4883841) Milstein C. … Jarvis J.M. (Biochem. J. 1968) 3 4
  3. The amino acid sequence of a lambda type Bence-Jones protein. 3. The complete amino acid sequence and the location of the disulfide bridges. (PMID: 4909564) Titani K. … Putnam F.W. (J. Biol. Chem. 1970) 3 4
  4. Structural rule of antibodies. Primary structure of a monoclonal immunoglobulin-L-chain of the lambda type, subgroup IV (Bence-Jones- protein Kern). V. The complete amino acid sequence and its genetic interpretation. (PMID: 5549568) Ponstingl H. … Hilschmann N. (Hoppe-Seyler's Z. Physiol. Chem. 1971) 3 4
  5. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PMID: 6273747) Hieter P.A. … Leder P. (Nature 1981) 3 4

Products for IGLC2 Gene

Sources for IGLC2 Gene

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