Aliases for GPR141 Gene
Aliases for GPR141 Gene
External Ids for GPR141 Gene
- HGNC: 19997
- Entrez Gene: 353345
- Ensembl: ENSG00000187037
- OMIM: 609045
- UniProtKB: Q7Z602
Previous GeneCards Identifiers for GPR141 Gene
- GC07U900327
- GC07P037520
- GC07P037553
- GC07P037746
- GC07P037659
Summaries for GPR141 Gene
-
GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
GeneCards Summary for GPR141 Gene
GPR141 (G Protein-Coupled Receptor 141) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity.
UniProtKB/Swiss-Prot for GPR141 Gene
-
Orphan receptor.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR141 Gene
Genomics for GPR141 Gene
Regulatory Elements for GPR141 Gene
Enhancers for GPR141 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around GPR141 on UCSC Golden Path with GeneCards custom track
Promoters for GPR141 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around GPR141 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for GPR141 Gene
- Chromosome:
- 7
- Start:
- 37,683,625 bp from pter
- End:
- 37,833,788 bp from pter
- Size:
- 150,164 bases
- Orientation:
- Plus strand
Genomic View for GPR141 Gene
Genes around GPR141 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p14.1 by Ensembl
- 7p14.1 by Entrez Gene
- 7p14.1 by HGNC
GPR141 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR141 Gene
Proteins for GPR141 Gene
-
Protein details for GPR141 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z602-GP141_HUMAN
- Recommended name:
- Probable G-protein coupled receptor 141
- Protein Accession:
- Q7Z602
- A4D1X7
- Q0VAR5
- Q86SP3
Protein attributes for GPR141 Gene
- Size:
- 305 amino acids
- Molecular mass:
- 35464 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for GPR141 Gene
Other Protein References for GPR141 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GPR141
- Invitrogen Antibodies for GPR141
- Search GeneTex for Antibodies for GPR141
-
Santa Cruz Biotechnology (SCBT) Antibodies for GPR141
Protein Products
-
OriGene Purified Proteins for GPR141
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR141
- Origene Custom Protein Services for GPR141
- Search GeneTex for Proteins for GPR141
Assay Products
No data available for DME Specific Peptides for GPR141 Gene
Domains & Families for GPR141 Gene
Gene Families for GPR141 Gene
- HGNC:
- IUPHAR :
Protein Domains for GPR141 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR141 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7Z602- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR141 Gene
Molecular function for GPR141 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan receptor.
Phenotypes for GPR141 Gene
- GenomeRNAi human phenotypes for GPR141:
-
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
- Increased G1 DNA content
- Decreased homologous recombination repair frequency
- Decreased viability with paclitaxel
Animal Model Products
-
Taconic Biosciences Mouse Models for GPR141
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR141 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR141 gene
- Search ViGene Biosciences for GPR141
CRISPR Products
-
OriGene CRISPR knockouts for GPR141
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR141
- GenScript: Design CRISPR guide RNA sequences for GPR141
miRNA for GPR141 Gene
- miRTarBase miRNAs that target GPR141
-
- hsa-mir-552-5p (MIRT514937)
- hsa-mir-190a-3p (MIRT514938)
- hsa-mir-5011-5p (MIRT514939)
- hsa-mir-4775 (MIRT514940)
- hsa-mir-410-3p (MIRT514941)
- hsa-mir-590-3p (MIRT514942)
- hsa-mir-1277-5p (MIRT514943)
- hsa-mir-493-5p (MIRT563011)
- hsa-let-7g-3p (MIRT563012)
- hsa-let-7a-2-3p (MIRT563013)
- hsa-let-7c-3p (MIRT563014)
- hsa-mir-3613-5p (MIRT563015)
- hsa-mir-4740-3p (MIRT563016)
- hsa-mir-6729-3p (MIRT563017)
- hsa-mir-205-3p (MIRT563018)
- hsa-mir-6871-5p (MIRT563019)
- hsa-mir-5683 (MIRT563020)
miRNA Products
- Search ViGene Biosciences for GPR141
Clone Products
- OriGene clones in human for GPR141
- OriGene ORF clones in human,mouse,rat for GPR141
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for GPR141
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for GPR141 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR141 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR141 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR141 Gene
Localization for GPR141 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR141 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
More details on SuperPathways for GPR141Transcripts for GPR141 Gene
mRNA/cDNA for GPR141 Gene
- (17) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (21) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GPR141 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GPR141
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR141
- GenScript: Design CRISPR guide RNA sequences for GPR141
miRNA Products
- Search ViGene Biosciences for GPR141
Clone Products
- OriGene clones in human for GPR141
- OriGene ORF clones in human,mouse,rat for GPR141
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for GPR141
Flow Cytometry Products
Expression for GPR141 Gene
mRNA differential expression in normal tissues according to GTEx for GPR141 Gene
This gene is overexpressed in Whole Blood (x36.9).
SOURCE GeneReport for Unigene cluster for GPR141 Gene Hs.688230
Primer Products
-
OriGene qPCR primer pairs for GPR141
-
OriGene qPCR primer pairs and template standards for GPR141
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GPR141 Gene
Orthologs for GPR141 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | LOC538837 35 |
|
||
| GPR141 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | GPR141 35 |
|
||
| GPR141 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Gpr141 35 |
|
||
| Gpr141 16 |
|
||||
| Gpr141 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | GPR141 35 |
|
||
| GPR141 36 |
|
OneToOne | |||
| oppossum (Monodelphis domestica) |
Mammalia | GPR141 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GPR141 35 |
|
||
| GPR141 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | GPR141 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gpr141 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100003534 35 |
|
||
| GPR141 36 |
|
OneToMany |
- Species with no ortholog for GPR141:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GPR141 Gene
(7) SIMAP similar genes for GPR141 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for GPR141 Gene
No data available for Paralogs for GPR141 Gene
Variants for GPR141 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_074185 | - | ||||
| rs966053 | -- | 37,724,582(-) | TGGGA(C/T)GGCAG | intron-variant | |
| rs1006050 | -- | 37,694,261(-) | ccact(C/T)gctgc | intron-variant | |
| rs1013906 | -- | 37,687,443(+) | AAATA(A/G)AAATA | intron-variant | |
| rs1026166 | -- | 37,697,574(-) | ACAGC(A/G)TTCAG | intron-variant, utr-variant-5-prime |
Residual Variation Intolerance Score:
31.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.11;
22.48% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GPR141 Gene
Disorders for GPR141 Gene
Relevant External Links for GPR141
No disorders were found for GPR141 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR141 Gene
Publications for GPR141 Gene
- Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2003) 2 3 4 67
- The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3
- A genome-wide association study of periodontitis in a Japanese population. (PMID: 25672891) Shimizu S. … Furuichi Y. (J. Dent. Res. 2015) 3
- Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
Products for GPR141 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for GPR141
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for GPR141
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GPR141
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR141
- Origene Custom Protein Services for GPR141
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for GPR141
- Browse OriGene Inhibitory RNA Products For GPR141
- OriGene qPCR primer pairs for GPR141
- OriGene qPCR primer pairs and template standards for GPR141
- OriGene CRISPR knockouts for GPR141
- OriGene clones in human for GPR141
- OriGene ORF clones in human,mouse,rat for GPR141
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for GPR141
- GenScript Custom Assay Services for GPR141
- GenScript Custom overexpressing Cell Line Services for GPR141
- GenScript: Design CRISPR guide RNA sequences for GPR141
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for GPR141
- Novus Biologicals proteins and lysates for GPR141
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for GPR141
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- ViGene Biosciences adenoviral particle packaged cDNA for GPR141 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GPR141 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GPR141 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GPR141 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GPR141 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GPR141 gene
- Search ViGene Biosciences for GPR141
- Search ViGene Biosciences for GPR141
- Santa Cruz Biotechnology (SCBT) Antibodies for GPR141
- Search Santa Cruz Biotechnology (SCBT) for GPR141 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GPR141
Sources for GPR141 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
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- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
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- (93) GenomeRNAi
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- (95) miRTarBase
- (96) MalaCards
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- (99) Vector BioLabs
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- (149) ENCODE
- (150) ProSci
- (151) Horizon