Aliases for GPR141 Gene
Aliases for GPR141 Gene
External Ids for GPR141 Gene
- HGNC: 19997
- Entrez Gene: 353345
- Ensembl: ENSG00000187037
- OMIM: 609045
- UniProtKB: Q7Z602
Previous GeneCards Identifiers for GPR141 Gene
- GC07U900327
- GC07P037520
- GC07P037553
- GC07P037746
- GC07P037659
Summaries for GPR141 Gene
-
GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
GeneCards Summary for GPR141 Gene
GPR141 (G Protein-Coupled Receptor 141) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity.
UniProtKB/Swiss-Prot for GPR141 Gene
-
Orphan receptor.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR141 Gene
Genomics for GPR141 Gene
Regulatory Elements for GPR141 Gene
Enhancers for GPR141 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH07G037443 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 13.7 | -236.7 | -236722 | 6.2 | HDGF SIN3A FEZF1 ZNF2 ZNF48 ETS1 GLIS2 CBX5 ZNF143 FOS | GPR141 RNU6-565P EPDR1 ELMO1 TRGV3 ENSG00000201566 |
| GH07G037765 | 1.4 | FANTOM5 Ensembl ENCODE | 13.5 | +82.4 | 82449 | 1.7 | TBL1XR1 ASH2L RELA CBX5 EED NFE2 RELB IKZF2 CREM MTA2 | GPR141 EPDR1 STARD3NL ELMO1 LOC100420413 |
| GH07G037732 | 1.3 | Ensembl ENCODE dbSUPER | 11.2 | +48.8 | 48776 | 0.8 | GTF2F1 CTCF JUN MAX CEBPG RAD21 ZBTB40 RFX5 GATA3 ZNF766 | EPDR1 GPR141 NME8 LOC100420413 |
| GH07G037408 | 1.5 | Ensembl ENCODE dbSUPER | 9.4 | -273.8 | -273787 | 3.5 | HDGF SIN3A FEZF1 ZNF48 ZNF2 YY1 GLIS2 FOS ZNF263 REST | ELMO1 RNU6-565P EPDR1 GPR141 GC07P037419 RPS10P14 |
| GH07G037728 | 1.2 | Ensembl ENCODE dbSUPER | 11.1 | +45.5 | 45507 | 1.2 | JUN EED RELB IKZF2 CREM MTA2 JUNB CEBPB DPF2 GATAD2B | EPDR1 GPR141 NME8 LOC100420413 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around GPR141 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for GPR141 Gene
- Chromosome:
- 7
- Start:
- 37,683,625 bp from pter
- End:
- 37,833,788 bp from pter
- Size:
- 150,164 bases
- Orientation:
- Plus strand
Genomic View for GPR141 Gene
Genes around GPR141 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p14.1 by Ensembl
- 7p14.1 by Entrez Gene
- 7p14.1 by HGNC
GPR141 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR141 Gene
Proteins for GPR141 Gene
-
Protein details for GPR141 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z602-GP141_HUMAN
- Recommended name:
- Probable G-protein coupled receptor 141
- Protein Accession:
- Q7Z602
- A4D1X7
- Q0VAR5
- Q86SP3
Protein attributes for GPR141 Gene
- Size:
- 305 amino acids
- Molecular mass:
- 35464 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for GPR141 Gene
Other Protein References for GPR141 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GPR141
- Invitrogen Antibodies for GPR141
- Search GeneTex for Antibodies for GPR141
Protein Products
-
OriGene Purified Proteins for GPR141
- Search Origene for MassSpec and Protein Over-expression Lysates for GPR141
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- Search GeneTex for Proteins for GPR141
No data available for DME Specific Peptides for GPR141 Gene
Domains & Families for GPR141 Gene
Gene Families for GPR141 Gene
- HGNC:
- IUPHAR :
Protein Domains for GPR141 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR141 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7Z602- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR141 Gene
Molecular function for GPR141 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan receptor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
Phenotypes for GPR141 Gene
- GenomeRNAi human phenotypes for GPR141:
-
- Increased viability
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
- Increased G1 DNA content
- Decreased homologous recombination repair frequency
- Increased Nanog expression
- Decreased viability with paclitaxel
Animal Model Products
-
Taconic Biosciences Mouse Models for GPR141
- Cyagen custom Knockout/knockin (KOKI) mouse models for GPR141
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR141 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR141 gene
- Search ViGene Biosciences for GPR141
CRISPR Products
-
OriGene CRISPR knockouts for GPR141
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR141
- GenScript: Design CRISPR guide RNA sequences for GPR141
miRNA for GPR141 Gene
- miRTarBase miRNAs that target GPR141
-
- hsa-mir-552-5p (MIRT514937)
- hsa-mir-190a-3p (MIRT514938)
- hsa-mir-5011-5p (MIRT514939)
- hsa-mir-4775 (MIRT514940)
- hsa-mir-410-3p (MIRT514941)
- hsa-mir-590-3p (MIRT514942)
- hsa-mir-1277-5p (MIRT514943)
- hsa-mir-493-5p (MIRT563011)
- hsa-let-7g-3p (MIRT563012)
- hsa-let-7a-2-3p (MIRT563013)
- hsa-let-7c-3p (MIRT563014)
- hsa-mir-3613-5p (MIRT563015)
- hsa-mir-4740-3p (MIRT563016)
- hsa-mir-6729-3p (MIRT563017)
- hsa-mir-205-3p (MIRT563018)
- hsa-mir-6871-5p (MIRT563019)
- hsa-mir-5683 (MIRT563020)
miRNA Products
- Search ViGene Biosciences for GPR141
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GPR141
- Browse OriGene Inhibitory RNA Products For GPR141
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR141 gene
Clone Products
-
OriGene ORF clones in human for GPR141
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for GPR141
- VectorBuilder custom plasmid, inducible vectors for GPR141
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR141
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for GPR141
Cell Line Products
-
Horizon Cell Lines for GPR141
-
ViGene Biosciences adenoviral particle packaged cDNA for GPR141 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR141 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR141 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR141 Gene
Localization for GPR141 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR141 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for GPR141 Gene
No Data Available
Interacting Proteins for GPR141 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for GPR141 Gene
Transcripts for GPR141 Gene
mRNA/cDNA for GPR141 Gene
- (18) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (21) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GPR141 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GPR141
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR141
- GenScript: Design CRISPR guide RNA sequences for GPR141
miRNA Products
- Search ViGene Biosciences for GPR141
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for GPR141
- Browse OriGene Inhibitory RNA Products For GPR141
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR141 gene
Clone Products
-
OriGene ORF clones in human for GPR141
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for GPR141
- VectorBuilder custom plasmid, inducible vectors for GPR141
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR141
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for GPR141
Expression for GPR141 Gene
mRNA differential expression in normal tissues according to GTEx for GPR141 Gene
This gene is overexpressed in Whole Blood (x36.9).
NURSA nuclear receptor signaling pathways regulating expression of GPR141 Gene:
GPR141SOURCE GeneReport for Unigene cluster for GPR141 Gene:
Hs.688230Primer Products
-
OriGene qPCR primer pairs and template standards for GPR141
-
OriGene qPCR primer pairs for GPR141
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR141 Gene
Orthologs for GPR141 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GPR141 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | GPR141 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC538837 34 |
|
||
| GPR141 35 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Gpr141 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GPR141 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GPR141 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GPR141 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gpr141 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100003534 34 |
|
||
| GPR141 35 |
|
OneToMany |
- Species where no ortholog for GPR141 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GPR141 Gene
(7) SIMAP similar genes for GPR141 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for GPR141 Gene
No data available for Paralogs for GPR141 Gene
Variants for GPR141 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000012242 | -- | 37,732,472(+) | GATGC(A/G)GATCA | intron-variant | |
| rs1000058595 | -- | 37,685,859(+) | TCTAA(A/G)AGTGC | intron-variant | |
| rs1000074545 | -- | 37,714,067(+) | CTTAC(A/C)CATAT | intron-variant, upstream-variant-2KB | |
| rs1000084504 | -- | 37,725,659(+) | TTTCA(A/G)AGGAC | intron-variant, utr-variant-5-prime | |
| rs1000150760 | -- | 37,727,512(+) | TTCCA(C/T)TTTGC | intron-variant, utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1281e214 | CNV | loss | 21293372 |
| esv2759523 | CNV | loss | 17122850 |
| nsv526136 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
31.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.11;
22.48% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GPR141 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR141
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR141 Gene
Disorders for GPR141 Gene
Relevant External Links for GPR141
No disorders were found for GPR141 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR141 Gene
Publications for GPR141 Gene
- The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
- Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2003) 2 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
- Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas. (PMID: 25787250) Cromer M.K. … Lifton R.P. (Proc. Natl. Acad. Sci. U.S.A. 2015) 4 64
Products for GPR141 Gene
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- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for GPR141
- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for GPR141
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- OriGene Purified Proteins for GPR141
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- OriGene qPCR primer pairs and template standards for GPR141
- OriGene qPCR primer pairs for GPR141
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- Novus Biologicals proteins and lysates for GPR141
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- Humanized Mice
- Invitrogen Antibodies for GPR141
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- Addgene plasmids for GPR141
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- ViGene Biosciences adenoviral particle packaged cDNA for GPR141 gene
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- Horizon Cell Lines for GPR141
- Cyagen custom Knockout/knockin (KOKI) mouse models for GPR141
- VectorBuilder custom plasmid, inducible vectors for GPR141
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR141
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for GPR141 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer