Aliases for GPR141 Gene
Aliases for GPR141 Gene
External Ids for GPR141 Gene
- HGNC: 19997
- Entrez Gene: 353345
- Ensembl: ENSG00000187037
- OMIM: 609045
- UniProtKB: Q7Z602
Previous GeneCards Identifiers for GPR141 Gene
- GC07U900327
- GC07P037520
- GC07P037553
- GC07P037746
- GC07P037659
Summaries for GPR141 Gene
-
GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
GeneCards Summary for GPR141 Gene
GPR141 (G Protein-Coupled Receptor 141) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity.
UniProtKB/Swiss-Prot for GPR141 Gene
-
Orphan receptor.
Additional gene information for GPR141 Gene
- Monarch Initiative
- Search for GPR141 at DataMed
- Search for GPR141 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR141 Gene
Genomics for GPR141 Gene
GeneHancer (GH) Regulatory Elements for GPR141 Gene
Regulatory Element Products
Genomic Locations for GPR141 Gene
- chr7:37,683,625-37,833,788
- (GRCh38/hg38)
- Size:
- 150,164 bases
- Orientation:
- Plus strand
- chr7:37,723,399-37,873,390
- (GRCh37/hg19)
Genomic View for GPR141 Gene
- Cytogenetic band:
-
- 7p14.1 by Ensembl
- 7p14.1 by Entrez Gene
- 7p14.1 by HGNC


RefSeq DNA sequence for GPR141 Gene
Proteins for GPR141 Gene
-
Protein details for GPR141 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z602-GP141_HUMAN
- Recommended name:
- Probable G-protein coupled receptor 141
- Protein Accession:
- Q7Z602
- A4D1X7
- Q0VAR5
- Q86SP3
Protein attributes for GPR141 Gene
- Size:
- 305 amino acids
- Molecular mass:
- 35464 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for GPR141 Gene
- Glycosylation at isoforms=5 and isoforms=9
Other Protein References for GPR141 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GPR141
- Invitrogen Antibodies for GPR141
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Protein Products
-
OriGene Purified Proteins for GPR141
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- antibodies-online: Search results for 4 available GPR141 Proteins ranked by validation data
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-
Quality Products:
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Assay Products
No data available for DME Specific Peptides for GPR141 Gene
Domains & Families for GPR141 Gene
Gene Families for GPR141 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for GPR141 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR141 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7Z602- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPR141 Gene
Molecular function for GPR141 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan receptor.
Phenotypes From GWAS Catalog for GPR141 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G-protein coupled receptor activity | IEA | -- |
Phenotypes for GPR141 Gene
- GenomeRNAi human phenotypes for GPR141:
-
- Increased viability
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
- Increased G1 DNA content
- Decreased homologous recombination repair frequency
- Increased Nanog expression
- Decreased viability with paclitaxel
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR141 gene
-
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CRISPR Products
-
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- Overview of 85 available GPR141 gene related products
- Applied Biological Materials CRISPR for GPR141
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR141
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miRNA for GPR141 Gene
- miRTarBase miRNAs that target GPR141
-
- hsa-mir-552-5p (MIRT514937)
- hsa-mir-190a-3p (MIRT514938)
- hsa-mir-5011-5p (MIRT514939)
- hsa-mir-4775 (MIRT514940)
- hsa-mir-410-3p (MIRT514941)
- hsa-mir-590-3p (MIRT514942)
- hsa-mir-1277-5p (MIRT514943)
- hsa-mir-493-5p (MIRT563011)
- hsa-let-7g-3p (MIRT563012)
- hsa-let-7a-2-3p (MIRT563013)
- hsa-let-7c-3p (MIRT563014)
- hsa-mir-3613-5p (MIRT563015)
- hsa-mir-4740-3p (MIRT563016)
- hsa-mir-6729-3p (MIRT563017)
- hsa-mir-205-3p (MIRT563018)
- hsa-mir-6871-5p (MIRT563019)
- hsa-mir-5683 (MIRT563020)
miRNA Products
- Search ViGene Biosciences for GPR141
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for GPR141
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- genomics-online: shRNA clones - Search results for 85 available GPR141 gene related products
- Overview of 85 available GPR141 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR141 gene
Clone Products
- Sino Biological Human cDNA Clone for GPR141
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GPR141
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR141
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR141
- Applied Biological Materials Clones for GPR141
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GPR141
Cell Line Products
-
Horizon Cell Lines for GPR141
-
ViGene Biosciences adenoviral particle packaged cDNA for GPR141 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR141 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR141 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR141 Gene
Localization for GPR141 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR141 Gene
- Cell membrane; Multi-pass membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR141 Gene
Pathways & Interactions for GPR141 Gene
Interacting Proteins for GPR141 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for GPR141 Gene
Transcripts for GPR141 Gene
mRNA/cDNA for GPR141 Gene
- (18) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (21) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GPR141 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GPR141
- genomics-online: gRNA clones - Search results for 85 available GPR141 gene related products
- Overview of 85 available GPR141 gene related products
- Applied Biological Materials CRISPR for GPR141
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR141
- GenScript: Design CRISPR guide RNA sequences for GPR141
miRNA Products
- Search ViGene Biosciences for GPR141
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for GPR141
- Browse OriGene Inhibitory RNA Products For GPR141
- genomics-online: shRNA clones - Search results for 85 available GPR141 gene related products
- Overview of 85 available GPR141 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR141 gene
Clone Products
- Sino Biological Human cDNA Clone for GPR141
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GPR141
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR141
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR141
- Applied Biological Materials Clones for GPR141
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GPR141
Expression for GPR141 Gene
mRNA differential expression in normal tissues according to GTEx for GPR141 Gene
NURSA nuclear receptor signaling pathways regulating expression of GPR141 Gene:
GPR141SOURCE GeneReport for Unigene cluster for GPR141 Gene:
Hs.688230Primer Products
-
OriGene qPCR primer pairs and template standards for GPR141
-
OriGene qPCR primer pairs for GPR141
- genomics-online: primer clones - Search results for 85 available GPR141 gene related products
- Overview of 85 available GPR141 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR141 Gene
Orthologs for GPR141 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GPR141 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | GPR141 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | LOC538837 33 |
|
||
GPR141 34 |
|
OneToOne | |||
mouse (Mus musculus) |
Mammalia | Gpr141 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | GPR141 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | GPR141 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | GPR141 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | gpr141 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | LOC100003534 33 |
|
||
GPR141 34 |
|
OneToMany |
- Species where no ortholog for GPR141 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GPR141 Gene
(7) SIMAP similar genes for GPR141 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for GPR141 Gene
No data available for Paralogs for GPR141 Gene
Variants for GPR141 Gene
SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000012242 | -- | 37,732,472(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
rs1000058595 | -- | 37,685,859(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
rs1000074545 | -- | 37,714,067(+) | C/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000084504 | -- | 37,725,659(+) | A/G | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant | |
rs1000150760 | -- | 37,727,512(+) | C/T | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1281e214 | CNV | loss | 21293372 |
esv2759523 | CNV | loss | 17122850 |
nsv526136 | CNV | loss | 19592680 |
Additional Variant Information for GPR141 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR141
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR141 Gene
Disorders for GPR141 Gene
Additional Disease Information for GPR141
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GPR141 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR141 Gene
Publications for GPR141 Gene
- The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 58
- Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R … Schiöth HB (FEBS letters 2003) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for GPR141 Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR141
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GPR141
- antibodies-online: Search results for available GPR141 related products ranked by validation data
- antibodies-online: Search results for available GPR141 related products ranked by validation data
- antibodies-online: Search results for 4 available GPR141 Proteins ranked by validation data
- Compare Top GPR141 Proteins
- Quality Products:
- Search GeneTex for Antibodies for GPR141
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- Overview of 85 available GPR141 gene related products
Sources for GPR141 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
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- (125) NCBI Bookshelf
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- (128) ViGene Biosciences
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew