Aliases for IGH Gene
Aliases for IGH Gene
- Immunoglobulin Heavy Locus 2 3
- Immunoglobulin Heavy Polypeptide, Joining Region 3
- Immunglobulin Heavy Chain Variable Region 3
- Immunoglobulin Heavy Diversity Cluster 3
- Immunoglobulin Heavy Variable Cluster 3
- D (Diversity) Region Of Heavy Chains 3
- Immunoglobulin Heavy Diversity Group 3
- Immunoglobulin Heavy Diversity Locus 3
- Immunoglobulin Heavy Joining Cluster 3
- Immunoglobulin Heavy Variable Group 3
- J (Joining) Region Of Heavy Chains 3
Previous HGNC Symbols for IGH Gene
- IGHDY1
- IGH@
Previous GeneCards Identifiers for IGH Gene
- GC14M106034
- GC14M105584
- GC14M105611
- GC14M105629
- GC14M105638
- GC14M105660
- GC14M105674
- GC14M105680
Summaries for IGH Gene
-
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Due to polymorphism, the numbers of functional V, J, and D genes differ among individuals and some V, D, J, and C segments may be pseudogenes. [provided by RefSeq, Dec 2017]
GeneCards Summary for IGH Gene
IGH (Immunoglobulin Heavy Locus) is a Protein Coding gene. Diseases associated with IGH include Follicular Lymphoma 1 and Mantle Cell Lymphoma. Among its related pathways are Immune response Fc epsilon RI pathway and Immune response Lectin induced complement pathway.
Additional gene information for IGH Gene
- Monarch Initiative
- Search for IGH at DataMed
- Search for IGH at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGH Gene
Genomics for IGH Gene
GeneHancer (GH) Regulatory Elements for IGH Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH14I106879 | Enhancer | 0.7 | ENCODE | 550.8 | +0.5 | 455 | 0.2 | ELF3 CTCF PKNOX1 ZIC2 RAD21 GLIS2 ZNF143 PRDM10 ZNF444 KLF13 | IGH IGHVIII-82 IGHV2-70D IGHV7-81 | |
GH14I106843 | Enhancer | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 0.3 | +34.3 | 34316 | 4.3 | HDGF PKNOX1 ATF1 FOXA2 SMAD1 ARID4B FEZF1 DMAP1 ZNF48 GLIS2 | IGHV2-70D MIR5195 IGHVIII-76-1 IGH | |
GH14I106872 | Enhancer | 1.1 | Ensembl ENCODE | 0.4 | +6.7 | 6653 | 1.6 | HDGF PKNOX1 FOXA2 ARID4B NEUROD1 ZNF48 GLIS2 ZNF143 FOS RUNX3 | IGHV4-80 IGHV7-81 IGHV2-70D IGH | |
GH14I106875 | Enhancer | 0.5 | ENCODE | 0.8 | +4.1 | 4136 | 0.2 | CTCF ZNF654 TRIM22 RAD21 | IGHV7-81 IGHV2-70D IGH IGHVIII-82 | |
GH14I106848 | Enhancer | 0.9 | Ensembl ENCODE | 0.3 | +31.1 | 31111 | 1.1 | CTCF PKNOX1 TFAP4 SAP130 SIN3A FEZF1 ZIC2 RAD21 ZSCAN5C ZNF143 | MIR5195 IGHVIII-76-1 IGH |
Regulatory Element Products
Genomic Locations for IGH Gene
- chr14:105,566,277-106,879,844
- (GRCh38/hg38)
- Size:
- 1,313,568 bases
- Orientation:
- Minus strand
- chr14:106,032,614-107,288,051
- (GRCh37/hg19)
Genomic View for IGH Gene
- Cytogenetic band:
-
- 14q32.33 by Entrez Gene
- 14q32.33 by HGNC


RefSeq DNA sequence for IGH Gene
Proteins for IGH Gene
-
Protein details for IGH Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A2MZT1
- Recommended name:
- Immunglobulin heavy chain
- Protein Accession:
- A2MZT1
Protein attributes for IGH Gene
- Size:
- 8 amino acids
- Molecular mass:
- 943 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for IGH Gene
Protein Products
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Assay Products
No data available for DME Specific Peptides for IGH Gene
Domains & Families for IGH Gene
Gene Families for IGH Gene
Protein Domains for IGH Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for IGH Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for IGH Gene
Function for IGH Gene
Phenotypes From GWAS Catalog for IGH Gene
Animal Model Products
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CRISPR Products
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Inhibitory RNA Products
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGH Gene
Localization for IGH Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for IGH Gene
Pathways & Interactions for IGH Gene
Pathways by source for IGH Gene
7 GeneGo (Thomson Reuters) pathways for IGH Gene
Interacting Proteins for IGH Gene
No data available for SIGNOR curated interactions for IGH Gene
Transcripts for IGH Gene
mRNA/cDNA for IGH Gene
- (349) Additional mRNA sequences :
Unigene Clusters for IGH Gene
CRISPR Products
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Expression for IGH Gene
NURSA nuclear receptor signaling pathways regulating expression of IGH Gene:
IGHSOURCE GeneReport for Unigene cluster for IGH Gene:
Hs.699841Primer Products
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGH Gene
Orthologs for IGH Gene
No data available for Orthologs and Evolution for IGH Gene
Paralogs for IGH Gene
No data available for Paralogs for IGH Gene
Variants for IGH Gene
Additional Variant Information for IGH Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IGH
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGH Gene
Disorders for IGH Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
follicular lymphoma 1 |
|
|
mantle cell lymphoma |
|
|
lymphoma, mucosa-associated lymphoid type |
|
|
leukemia, acute lymphoblastic 3 |
|
|
leukemia, chronic lymphocytic |
|
Additional Disease Information for IGH
No data available for UniProtKB/Swiss-Prot and Genatlas for IGH Gene
Publications for IGH Gene
- Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6, and MALT1 gene loci in primary cutaneous B-cell lymphomas. (PMID: 15191563) Hallermann C … Neumann C (The Journal of investigative dermatology 2004) 3 22 58
- Next generation sequencing of the clonal IGH rearrangement detects ongoing mutations and interfollicular trafficking in in situ follicular neoplasia. (PMID: 28640838) Kosmidis P … Fend F (PloS one 2017) 3 58
- T-cell primary effusion lymphoma with pseudo-monoclonal rearrangements for immunoglobulin heavy chain. (PMID: 26734695) Wang HY … Thorson JA (Blood 2015) 3 58
- Prognostic value of circulating Bcl-2/IgH levels in patients with follicular lymphoma receiving first-line immunochemotherapy. (PMID: 26239087) Zohren F … Kobbe G (Blood 2015) 3 58
- Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma. (PMID: 25929340) Cowan G … Sahota SS (Oncotarget 2015) 3 58
Products for IGH Gene
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Sources for IGH Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
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- (122) MedlinePlus
- (123) CDC
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- (125) NCBI Bookshelf
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- (128) ViGene Biosciences
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew