Aliases for CYR61 Gene
External Ids for CYR61 Gene
Previous HGNC Symbols for CYR61 Gene
Previous GeneCards Identifiers for CYR61 Gene
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
GeneCards Summary for CYR61 Gene
CYR61 (Cysteine-Rich, Angiogenic Inducer, 61) is a Protein Coding gene. Diseases associated with CYR61 include epispadias and leiomyoma. Among its related pathways are Angiogenesis (CST) and amb2 Integrin signaling. GO annotations related to this gene include heparin binding and insulin-like growth factor binding. An important paralog of this gene is NOV.
UniProtKB/Swiss-Prot for CYR61 Gene
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.