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Aliases for IGFBP7 Gene

Aliases for IGFBP7 Gene

  • Insulin-Like Growth Factor Binding Protein 7 2 3
  • MAC25 3 4 6
  • Prostacyclin-Stimulating Factor 3 4
  • Tumor-Derived Adhesion Factor 3 4
  • PGI2-Stimulating Factor 3 4
  • IGF-Binding Protein 7 3 4
  • IGFBP-RP1 3 4
  • RAMSVPS 3 6
  • IGFBP-7 3 4
  • IBP-7 3 4
  • TAF 3 4
  • PSF 3 4
  • Insulin-Like Growth Factor-Binding Protein 7 3
  • MAC25 Protein 4
  • Angiomodulin 3
  • IGFBP-7v 3
  • IGFBPRP1 3
  • FSTL2 3
  • AGM 3

External Ids for IGFBP7 Gene

Previous GeneCards Identifiers for IGFBP7 Gene

  • GC04M057701
  • GC04M057893
  • GC04M057812
  • GC04M057738
  • GC04M057592
  • GC04M053850
  • GC04M057897

Summaries for IGFBP7 Gene

Entrez Gene Summary for IGFBP7 Gene

  • This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

GeneCards Summary for IGFBP7 Gene

IGFBP7 (Insulin-Like Growth Factor Binding Protein 7) is a Protein Coding gene. Diseases associated with IGFBP7 include retinal arterial macroaneurysm with supravalvular pulmonic stenosis and familial retinal arterial macroaneurysm. Among its related pathways are Cellular Senescence and Cellular Senescence. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is KAZALD1.

UniProtKB/Swiss-Prot for IGFBP7 Gene

  • Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.

Gene Wiki entry for IGFBP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP7 Gene

Genomics for IGFBP7 Gene

Regulatory Elements for IGFBP7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IGFBP7 Gene

57,030,773 bp from pter
57,110,385 bp from pter
79,613 bases
Minus strand

Genomic View for IGFBP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGFBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP7 Gene

Proteins for IGFBP7 Gene

  • Protein details for IGFBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin-like growth factor-binding protein 7
    Protein Accession:
    Secondary Accessions:
    • B4E1N2
    • B7Z9W7
    • Q07822
    • Q53YE6
    • Q9UCA8

    Protein attributes for IGFBP7 Gene

    282 amino acids
    Molecular mass:
    29130 Da
    Quaternary structure:
    • May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear

    Alternative splice isoforms for IGFBP7 Gene


neXtProt entry for IGFBP7 Gene

Proteomics data for IGFBP7 Gene at MOPED

Post-translational modifications for IGFBP7 Gene

Other Protein References for IGFBP7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IGFBP7 (IGFBP-rp1/IGFBP-7)

No data available for DME Specific Peptides for IGFBP7 Gene

Domains for IGFBP7 Gene

Gene Families for IGFBP7 Gene

Suggested Antigen Peptide Sequences for IGFBP7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 Kazal-like domain.
genes like me logo Genes that share domains with IGFBP7: view

Function for IGFBP7 Gene

Molecular function for IGFBP7 Gene

GENATLAS Biochemistry:
insuline-like growth factor binding protein 7 (related protein 1),expressed in both in situ and invasive neoplasm and increased in senescent cells
UniProtKB/Swiss-Prot Function:
Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.

Gene Ontology (GO) - Molecular Function for IGFBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9388210
GO:0005520 insulin-like growth factor binding IEA --
genes like me logo Genes that share ontologies with IGFBP7: view

Phenotypes for IGFBP7 Gene

MGI mutant phenotypes for IGFBP7:
inferred from 1 alleles
GenomeRNAi human phenotypes for IGFBP7:
genes like me logo Genes that share phenotypes with IGFBP7: view

Animal Model Products

miRNA for IGFBP7 Gene

miRTarBase miRNAs that target IGFBP7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFBP7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for IGFBP7 Gene

Localization for IGFBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP7 Gene


Subcellular locations from

Jensen Localization Image for IGFBP7 Gene COMPARTMENTS Subcellular localization image for IGFBP7 gene
Compartment Confidence
extracellular 5
plasma membrane 2
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGFBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 20551380
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IGFBP7: view

Pathways for IGFBP7 Gene

genes like me logo Genes that share pathways with IGFBP7: view

Pathways by source for IGFBP7 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IGFBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0007155 cell adhesion IDA 8117260
GO:0007566 embryo implantation IEA --
GO:0008285 negative regulation of cell proliferation TAS 8939990
GO:0009408 response to heat IEA --
genes like me logo Genes that share ontologies with IGFBP7: view

Drugs for IGFBP7 Gene

(2) Drugbank Compounds for IGFBP7 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Insulin Regular
  • Insulin human
11061-68-0 Target approved, experimental, investigational
Insulin, porcine
9004-14-2 Target approved

(9) Novoseek inferred chemical compound relationships for IGFBP7 Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 66.9 3
prostacyclin 63.4 20
agar 35 2
txb2 20.9 1
retinoic acid 19 4
genes like me logo Genes that share compounds with IGFBP7: view

Transcripts for IGFBP7 Gene

mRNA/cDNA for IGFBP7 Gene

Unigene Clusters for IGFBP7 Gene

Insulin-like growth factor binding protein 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGFBP7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: - - - -
SP4: -

Relevant External Links for IGFBP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGFBP7 Gene

mRNA expression in normal human tissues for IGFBP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBP7 Gene

This gene is overexpressed in Artery - Aorta (8.0), Artery - Coronary (6.3), and Artery - Tibial (5.7).

Protein differential expression in normal tissues for IGFBP7 Gene

This gene is overexpressed in Amniocyte (59.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IGFBP7 Gene

SOURCE GeneReport for Unigene cluster for IGFBP7 Gene Hs.479808

genes like me logo Genes that share expressions with IGFBP7: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for IGFBP7 Gene

Orthologs for IGFBP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IGFBP7 35
  • 95.13 (n)
  • 95.65 (a)
  • 96 (a)
(Canis familiaris)
Mammalia IGFBP7 35
  • 95.2 (n)
  • 95.34 (a)
  • 94 (a)
(Mus musculus)
Mammalia Igfbp7 35
  • 91.04 (n)
  • 90.91 (a)
Igfbp7 16
Igfbp7 36
  • 76 (a)
(Pan troglodytes)
Mammalia IGFBP7 35
  • 99.53 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Igfbp7 35
  • 91.57 (n)
  • 90.51 (a)
(Monodelphis domestica)
Mammalia IGFBP7 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia IGFBP7 36
  • 83 (a)
(Gallus gallus)
Aves IGFBP7 35
  • 76.76 (n)
  • 78.49 (a)
  • 64 (a)
(Anolis carolinensis)
Reptilia IGFBP7 36
  • 82 (a)
(Danio rerio)
Actinopterygii igfbp7 35
  • 61.02 (n)
  • 58.05 (a)
igfbp7 36
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for IGFBP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP7 Gene

Gene Tree for IGFBP7 (if available)
Gene Tree for IGFBP7 (if available)

Paralogs for IGFBP7 Gene

Paralogs for IGFBP7 Gene

(2) SIMAP similar genes for IGFBP7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGFBP7: view

Variants for IGFBP7 Gene

Sequence variations from dbSNP and Humsavar for IGFBP7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs11945217 -- 57,092,076(+) CTTTT(C/T)TTTTC intron-variant
rs11947115 -- 57,059,236(+) aattc(C/T)attgc intron-variant
rs11947401 -- 57,044,814(+) CTGTT(C/T)CCCCC intron-variant
rs12502257 -- 57,044,406(+) tttcg(A/T)gtcct intron-variant
rs12506619 -- 57,084,844(+) GGATT(A/G)TAGTC intron-variant

Relevant External Links for IGFBP7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IGFBP7 Gene

Disorders for IGFBP7 Gene

(1) OMIM Diseases for IGFBP7 Gene (602867)


  • Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]: An autosomal recessive condition characterized by the bilateral appearance of beading along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. {ECO:0000269 PubMed:21835307}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(24) Novoseek inferred disease relationships for IGFBP7 Gene

Disease -log(P) Hits PubMed IDs
diabetic angiopathies 56.9 2
bladder carcinoma 36.7 2
tumors 32.3 32
colon cancer 29.8 4
colorectal cancer 29.4 13

Relevant External Links for IGFBP7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IGFBP7: view

No data available for University of Copenhagen DISEASES and Genatlas for IGFBP7 Gene

Publications for IGFBP7 Gene

  1. Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells. (PMID: 7980422) Yamauchi T. … Nawata H. (Biochem. J. 1994) 2 3 4 23
  2. Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II. (PMID: 8939990) Oh Y. … Rosenfeld R.G. (J. Biol. Chem. 1996) 3 4 23
  3. Identification and characterization of genes differentially expressed in meningiomas. (PMID: 7694637) Murphy M. … George D.L. (Cell Growth Differ. 1993) 2 3 4
  4. Insulin-like growth factor binding protein-7 (IGFBP7) blocks vascular endothelial cell growth factor (VEGF)-induced angiogenesis in human vascular endothelial cells. (PMID: 19374835) Tamura K. … Sakurai T. (Eur. J. Pharmacol. 2009) 3 23
  5. IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. (PMID: 19638426) Suzuki H. … Toyota M. (Carcinogenesis 2010) 3 23

Products for IGFBP7 Gene

Sources for IGFBP7 Gene

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