Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGFBP5 Gene

Aliases for IGFBP5 Gene

  • Insulin Like Growth Factor Binding Protein 5 2 3 5
  • IGF-Binding Protein 5 3 4
  • IGFBP-5 3 4
  • IBP-5 3 4
  • IBP5 3 4
  • Insulin-Like Growth Factor Binding Protein 5 2
  • Insulin-Like Growth Factor-Binding Protein 5 3

External Ids for IGFBP5 Gene

Previous GeneCards Identifiers for IGFBP5 Gene

  • GC02M215637
  • GC02M216262
  • GC02M217504
  • GC02M217743
  • GC02M217362
  • GC02M217245
  • GC02M209391

Summaries for IGFBP5 Gene

GeneCards Summary for IGFBP5 Gene

IGFBP5 (Insulin Like Growth Factor Binding Protein 5) is a Protein Coding gene. Diseases associated with IGFBP5 include Insulin-Like Growth Factor I and Renal Osteodystrophy. Among its related pathways are Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling and Senescence and Autophagy in Cancer. GO annotations related to this gene include fibronectin binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP3.

UniProtKB/Swiss-Prot for IGFBP5 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Wiki entry for IGFBP5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP5 Gene

Genomics for IGFBP5 Gene

Regulatory Elements for IGFBP5 Gene

Enhancers for IGFBP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G216003 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +690.1 690052 3.8 HDGF FOXA2 PKNOX1 MLX WRNIP1 ZFP64 SIN3A ARID4B DMAP1 YY1 XRCC5 SMARCAL1 TNP1 IGFBP5 LINC01963 MREG GC02M216014 ENSG00000226276
GH02G217162 1.6 FANTOM5 Ensembl ENCODE 11.1 -467.2 -467194 1.2 PKNOX1 FOXA2 ATF1 ZNF133 FEZF1 ZNF2 FOS JUNB TSHZ1 ZNF488 IGFBP5 ENSG00000236886 ENSG00000231597 LOC105373872 LOC105373873
GH02G216649 1.4 Ensembl ENCODE dbSUPER 11 +43.1 43095 6.2 ELF3 RAD21 THRB RARA ZSCAN5C SCRT2 FOS CEBPB NR2F2 PBX2 LINC01280 ENSG00000225794 IGFBP5 ENSG00000236886 IGFBP2
GH02G216618 1.4 Ensembl ENCODE dbSUPER 10.5 +75.1 75064 3.3 HDGF FOXA2 ZNF2 YY1 TCF12 ZNF766 ZNF579 SMARCA4 NBN NR2C1 IGFBP2 SMARCAL1 ENSG00000236886 IGFBP5 PSMB3P2
GH02G216791 1.3 Ensembl ENCODE dbSUPER 10.5 -96.9 -96934 2.3 PKNOX1 RAD21 TCF12 FOS ELF4 ZHX2 CEBPB ELF1 ZNF398 ZNF518A ENSG00000227021 ENSG00000231597 TNP1 LOC105373876 LINC01921 ENSG00000236886 IGFBP5 ENSG00000236295 ENSG00000229352 RNA5SP120
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGFBP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGFBP5 Gene

Chromosome:
2
Start:
216,672,105 bp from pter
End:
216,695,549 bp from pter
Size:
23,445 bases
Orientation:
Minus strand

Genomic View for IGFBP5 Gene

Genes around IGFBP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP5 Gene

Proteins for IGFBP5 Gene

  • Protein details for IGFBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24593-IBP5_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 5
    Protein Accession:
    P24593
    Secondary Accessions:
    • Q5U0A3

    Protein attributes for IGFBP5 Gene

    Size:
    272 amino acids
    Molecular mass:
    30570 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IGFBP5 Gene

neXtProt entry for IGFBP5 Gene

Post-translational modifications for IGFBP5 Gene

  • Glycosylation at isoforms=123, isoforms=131, and posLast=172172
  • Modification sites at PhosphoSitePlus

Other Protein References for IGFBP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IGFBP5 Gene

Domains & Families for IGFBP5 Gene

Gene Families for IGFBP5 Gene

Suggested Antigen Peptide Sequences for IGFBP5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGFBP5: view

No data available for UniProtKB/Swiss-Prot for IGFBP5 Gene

Function for IGFBP5 Gene

Molecular function for IGFBP5 Gene

GENATLAS Biochemistry:
insulin-like growth factor binding protein 5,high affinity,complexing with IGF1 and IGF2 and acid labile subunit expressed predominantly in kidney,fetal tissues,adult conective tissues and CSF,present in the serum but decreasing with age after puberty. Binding to bone cells (skeletal growth factor)
UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Ontology (GO) - Molecular Function for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IBA --
GO:0005515 protein binding IPI 15700281
GO:0005520 insulin-like growth factor binding IEA --
GO:0019838 growth factor binding IEA --
GO:0031994 insulin-like growth factor I binding IPI 10766744
genes like me logo Genes that share ontologies with IGFBP5: view
genes like me logo Genes that share phenotypes with IGFBP5: view

Animal Models for IGFBP5 Gene

MGI Knock Outs for IGFBP5:

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFBP5

CRISPR Products

miRNA for IGFBP5 Gene

miRTarBase miRNAs that target IGFBP5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP5 Gene

Localization for IGFBP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBP5 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005622 intracellular IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0016942 insulin-like growth factor binding protein complex IC 10766744
GO:0042567 insulin-like growth factor ternary complex IDA 9497324
genes like me logo Genes that share ontologies with IGFBP5: view

Pathways & Interactions for IGFBP5 Gene

genes like me logo Genes that share pathways with IGFBP5: view

Gene Ontology (GO) - Biological Process for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0006006 glucose metabolic process IEA --
GO:0007165 signal transduction NAS 7525452
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with IGFBP5: view

No data available for SIGNOR curated interactions for IGFBP5 Gene

Drugs & Compounds for IGFBP5 Gene

(27) Drugs for IGFBP5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(22) Additional Compounds for IGFBP5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP5: view

Transcripts for IGFBP5 Gene

mRNA/cDNA for IGFBP5 Gene

Unigene Clusters for IGFBP5 Gene

Insulin-like growth factor binding protein 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP5 Gene

No ASD Table

Relevant External Links for IGFBP5 Gene

GeneLoc Exon Structure for
IGFBP5
ECgene alternative splicing isoforms for
IGFBP5

Expression for IGFBP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFBP5 Gene

mRNA differential expression in normal tissues according to GTEx for IGFBP5 Gene

This gene is overexpressed in Ovary (x5.9) and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for IGFBP5 Gene

This gene is overexpressed in Amniocyte (27.1), Cerebral cortex (15.8), and Serum (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGFBP5 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGFBP5 Gene:

IGFBP5

SOURCE GeneReport for Unigene cluster for IGFBP5 Gene:

Hs.607212

mRNA Expression by UniProt/SwissProt for IGFBP5 Gene:

P24593-IBP5_HUMAN
Tissue specificity: Osteosarcoma, and at lower levels in liver, kidney and brain.

Evidence on tissue expression from TISSUES for IGFBP5 Gene

  • Nervous system(5)
  • Lung(4.5)
  • Eye(4.3)
  • Bone marrow(4)
  • Intestine(3.4)
  • Kidney(3.4)
  • Muscle(3.3)
  • Pancreas(2.9)
  • Thyroid gland(2.8)
  • Heart(2.7)
  • Liver(2.6)
  • Skin(2.4)
  • Bone(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with IGFBP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP5 Gene

Orthologs for IGFBP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFBP5 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia IGFBP5 34 35
  • 95.87 (n)
cow
(Bos Taurus)
Mammalia IGFBP5 34 35
  • 95.54 (n)
mouse
(Mus musculus)
Mammalia Igfbp5 34 16 35
  • 91.47 (n)
rat
(Rattus norvegicus)
Mammalia Igfbp5 34
  • 91.21 (n)
oppossum
(Monodelphis domestica)
Mammalia IGFBP5 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGFBP5 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGFBP5 34 35
  • 80.61 (n)
lizard
(Anolis carolinensis)
Reptilia IGFBP5 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igfbp5 34
  • 75.63 (n)
Str.15961 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5266 34
zebrafish
(Danio rerio)
Actinopterygii igfbp5a 34 35
  • 64.08 (n)
igfbp5b 35
  • 53 (a)
OneToMany
Dr.24976 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for IGFBP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP5 Gene

ENSEMBL:
Gene Tree for IGFBP5 (if available)
TreeFam:
Gene Tree for IGFBP5 (if available)

Paralogs for IGFBP5 Gene

Paralogs for IGFBP5 Gene

(2) SIMAP similar genes for IGFBP5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IGFBP5: view

Variants for IGFBP5 Gene

Sequence variations from dbSNP and Humsavar for IGFBP5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000002503 -- 216,682,757(+) AGGCT(A/G)GAGTG intron-variant
rs1000191345 -- 216,678,284(+) ACCCA(A/G)CTGCG intron-variant
rs1000194504 -- 216,694,821(+) GAGCG(A/G)GAGTG utr-variant-5-prime
rs1000308028 -- 216,695,193(+) TTTAT(C/G)TTTAA utr-variant-5-prime
rs1000403432 -- 216,683,216(+) CTCAG(A/G)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGFBP5 Gene

Variant ID Type Subtype PubMed ID
esv3584350 CNV loss 25503493
nsv1072069 CNV deletion 25765185
nsv460098 CNV loss 19166990
nsv522718 CNV loss 19592680
nsv584454 CNV loss 21841781
nsv584455 CNV loss 21841781

Variation tolerance for IGFBP5 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFBP5 Gene

Human Gene Mutation Database (HGMD)
IGFBP5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFBP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP5 Gene

Disorders for IGFBP5 Gene

MalaCards: The human disease database

(6) MalaCards diseases for IGFBP5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
insulin-like growth factor i
  • insulin-like growth factor i deficiency
renal osteodystrophy
  • renal rickets
uv-sensitive syndrome
  • uv sensitive syndrome
diabetes mellitus, insulin-dependent, 13
  • type 1 diabetes mellitus 13
osteosarcoma, somatic
  • osteosarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGFBP5

Genetic Association Database (GAD)
IGFBP5
Human Genome Epidemiology (HuGE) Navigator
IGFBP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFBP5
genes like me logo Genes that share disorders with IGFBP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP5 Gene

Publications for IGFBP5 Gene

  1. Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5. (PMID: 7511611) Allander S.V. … Powell D.R. (J. Biol. Chem. 1994) 2 3 4 22 64
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64

Products for IGFBP5 Gene

Sources for IGFBP5 Gene

Content
Loading form....