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Aliases for IGFBP5 Gene

Aliases for IGFBP5 Gene

  • Insulin Like Growth Factor Binding Protein 5 2 3 5
  • Insulin-Like Growth Factor Binding Protein 5 2 3
  • IGF-Binding Protein 5 3 4
  • IGFBP-5 3 4
  • IBP-5 3 4
  • IBP5 3 4

External Ids for IGFBP5 Gene

Previous GeneCards Identifiers for IGFBP5 Gene

  • GC02M215637
  • GC02M216262
  • GC02M217504
  • GC02M217743
  • GC02M217362
  • GC02M217245
  • GC02M209391

Summaries for IGFBP5 Gene

GeneCards Summary for IGFBP5 Gene

IGFBP5 (Insulin Like Growth Factor Binding Protein 5) is a Protein Coding gene. Diseases associated with IGFBP5 include insulin-like growth factor i and renal osteodystrophy. Among its related pathways are Transport to the Golgi and subsequent modification and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include fibronectin binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP4.

UniProtKB/Swiss-Prot for IGFBP5 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Wiki entry for IGFBP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP5 Gene

Genomics for IGFBP5 Gene

Regulatory Elements for IGFBP5 Gene

Genomic Location for IGFBP5 Gene

Chromosome:
2
Start:
216,672,105 bp from pter
End:
216,695,549 bp from pter
Size:
23,445 bases
Orientation:
Minus strand

Genomic View for IGFBP5 Gene

Genes around IGFBP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP5 Gene

Proteins for IGFBP5 Gene

  • Protein details for IGFBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24593-IBP5_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 5
    Protein Accession:
    P24593
    Secondary Accessions:
    • Q5U0A3

    Protein attributes for IGFBP5 Gene

    Size:
    272 amino acids
    Molecular mass:
    30570 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IGFBP5 Gene

neXtProt entry for IGFBP5 Gene

Proteomics data for IGFBP5 Gene at MOPED

Post-translational modifications for IGFBP5 Gene

  • Glycosylation at Thr 123, Thr 131, and Thr 172
  • Modification sites at PhosphoSitePlus

Other Protein References for IGFBP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IGFBP5 Gene

Domains & Families for IGFBP5 Gene

Gene Families for IGFBP5 Gene

Suggested Antigen Peptide Sequences for IGFBP5 Gene

Graphical View of Domain Structure for InterPro Entry

P24593

UniProtKB/Swiss-Prot:

IBP5_HUMAN :
  • Contains 1 IGFBP N-terminal domain.
Domain:
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 thyroglobulin type-1 domain.
genes like me logo Genes that share domains with IGFBP5: view

Function for IGFBP5 Gene

Molecular function for IGFBP5 Gene

GENATLAS Biochemistry:
insulin-like growth factor binding protein 5,high affinity,complexing with IGF1 and IGF2 and acid labile subunit expressed predominantly in kidney,fetal tissues,adult conective tissues and CSF,present in the serum but decreasing with age after puberty. Binding to bone cells (skeletal growth factor)
UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
genes like me logo Genes that share phenotypes with IGFBP5: view

Animal Models for IGFBP5 Gene

MGI Knock Outs for IGFBP5:

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFBP5

miRNA for IGFBP5 Gene

miRTarBase miRNAs that target IGFBP5

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP5 Gene

Localization for IGFBP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFBP5 Gene COMPARTMENTS Subcellular localization image for IGFBP5 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with IGFBP5: view

Pathways & Interactions for IGFBP5 Gene

genes like me logo Genes that share pathways with IGFBP5: view

Gene Ontology (GO) - Biological Process for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0007165 signal transduction NAS 7525452
GO:0007565 female pregnancy IEA --
GO:0010906 regulation of glucose metabolic process IEA --
genes like me logo Genes that share ontologies with IGFBP5: view

No data available for SIGNOR curated interactions for IGFBP5 Gene

Drugs & Compounds for IGFBP5 Gene

(25) Drugs for IGFBP5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(24) Additional Compounds for IGFBP5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP5: view

Transcripts for IGFBP5 Gene

mRNA/cDNA for IGFBP5 Gene

Unigene Clusters for IGFBP5 Gene

Insulin-like growth factor binding protein 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP5 Gene

No ASD Table

Relevant External Links for IGFBP5 Gene

GeneLoc Exon Structure for
IGFBP5
ECgene alternative splicing isoforms for
IGFBP5

Expression for IGFBP5 Gene

mRNA expression in normal human tissues for IGFBP5 Gene

mRNA differential expression in normal tissues according to GTEx for IGFBP5 Gene

This gene is overexpressed in Ovary (x5.9) and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for IGFBP5 Gene

This gene is overexpressed in Amniocyte (27.1), Cerebral cortex (15.8), and Serum (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGFBP5 Gene



SOURCE GeneReport for Unigene cluster for IGFBP5 Gene Hs.607212

mRNA Expression by UniProt/SwissProt for IGFBP5 Gene

P24593-IBP5_HUMAN
Tissue specificity: Osteosarcoma, and at lower levels in liver, kidney and brain.
genes like me logo Genes that share expression patterns with IGFBP5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for IGFBP5 Gene

Orthologs for IGFBP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IGFBP5 35
  • 95.54 (n)
  • 98.43 (a)
IGFBP5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGFBP5 35
  • 95.87 (n)
  • 98.84 (a)
IGFBP5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igfbp5 35
  • 91.47 (n)
  • 96.85 (a)
Igfbp5 16
Igfbp5 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IGFBP5 35
  • 99.75 (n)
  • 99.63 (a)
IGFBP5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igfbp5 35
  • 91.21 (n)
  • 96.46 (a)
oppossum
(Monodelphis domestica)
Mammalia IGFBP5 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGFBP5 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGFBP5 35
  • 80.61 (n)
  • 82.47 (a)
IGFBP5 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGFBP5 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igfbp5 35
  • 75.63 (n)
  • 75.27 (a)
Str.15961 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5266 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24976 35
igfbp5a 35
  • 64.08 (n)
  • 57.14 (a)
igfbp5a 36
  • 47 (a)
OneToMany
igfbp5b 36
  • 53 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for IGFBP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP5 Gene

ENSEMBL:
Gene Tree for IGFBP5 (if available)
TreeFam:
Gene Tree for IGFBP5 (if available)

Paralogs for IGFBP5 Gene

Paralogs for IGFBP5 Gene

(2) SIMAP similar genes for IGFBP5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IGFBP5: view

Variants for IGFBP5 Gene

Sequence variations from dbSNP and Humsavar for IGFBP5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11575194 - 216,679,005(-) TCTTC(A/C/G/T)GGCCC reference, missense
rs3276 -- 216,672,275(+) TAAAC(A/G)GGAGC utr-variant-3-prime
rs12716 -- 216,672,531(+) AAAGA(A/C)AAAGA utr-variant-3-prime
rs722324 -- 216,679,512(-) TTCCC(A/G)GGTTC intron-variant
rs729596 -- 216,684,358(-) CCCAG(A/G)AACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGFBP5 Gene

Variant ID Type Subtype PubMed ID
nsv460098 CNV Loss 19166990
nsv522718 CNV Loss 19592680

Variation tolerance for IGFBP5 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFBP5 Gene

HapMap Linkage Disequilibrium report
IGFBP5
Human Gene Mutation Database (HGMD)
IGFBP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP5 Gene

Disorders for IGFBP5 Gene

MalaCards: The human disease database

(7) MalaCards diseases for IGFBP5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
insulin-like growth factor i
  • insulin-like growth factor i, resistance to
renal osteodystrophy
  • renal rickets
mn1
  • meningioma 1 gene
uv-sensitive syndrome
  • uv sensitive syndrome
osteoporosis
  • osteoporosis, postmenopausal, susceptibility
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGFBP5

Genetic Association Database (GAD)
IGFBP5
Human Genome Epidemiology (HuGE) Navigator
IGFBP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFBP5
genes like me logo Genes that share disorders with IGFBP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP5 Gene

Publications for IGFBP5 Gene

  1. Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5. (PMID: 7511611) Allander S.V. … Powell D.R. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. Genetic screen identifies insulin-like growth factor binding protein 5 as a modulator of tamoxifen resistance in breast cancer. (PMID: 20354179) Ahn B.Y. … Kim S.W. (Cancer Res. 2010) 3 23
  3. Nuclear factor I transcription factors regulate IGF binding protein 5 gene transcription in human osteoblasts. (PMID: 18809517) PAcrez-Casellas L.A. … Linkhart T.A. (Biochim. Biophys. Acta 2009) 3 23
  4. Association of sequence variations in the gene encoding insulin-like growth factor binding protein 5 with adiponectin. (PMID: 18957933) Kallio P. … Uusitupa M. (Int J Obes (Lond) 2009) 3 23
  5. Prostate-specific antigen enhances bioavailability of insulin-like growth factor by degrading insulin-like growth factor binding protein 5. (PMID: 19250630) Maeda H. … Ochiai A. (Biochem. Biophys. Res. Commun. 2009) 3 23

Products for IGFBP5 Gene

Sources for IGFBP5 Gene

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