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Aliases for IGFBP4 Gene

Aliases for IGFBP4 Gene

  • Insulin Like Growth Factor Binding Protein 4 2 3 5
  • IGF-Binding Protein 4 2 3 4
  • Insulin-Like Growth Factor Binding Protein 4 2 3
  • IGFBP-4 3 4
  • IBP-4 3 4
  • IBP4 3 4
  • Insulin-Like Growth Factor-Binding Protein 4 2
  • HT29-IGFBP 3
  • BP-4 3

External Ids for IGFBP4 Gene

Previous GeneCards Identifiers for IGFBP4 Gene

  • GC17P038099
  • GC17P040775
  • GC17P038508
  • GC17P038972
  • GC17P035854
  • GC17P038599
  • GC17P034392

Summaries for IGFBP4 Gene

Entrez Gene Summary for IGFBP4 Gene

  • This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGFBP4 Gene

IGFBP4 (Insulin Like Growth Factor Binding Protein 4) is a Protein Coding gene. Diseases associated with IGFBP4 include hereditary breast ovarian cancer and osteoporosis. Among its related pathways are Transport to the Golgi and subsequent modification and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot for IGFBP4 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Wiki entry for IGFBP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP4 Gene

Genomics for IGFBP4 Gene

Regulatory Elements for IGFBP4 Gene

Genomic Location for IGFBP4 Gene

Chromosome:
17
Start:
40,443,424 bp from pter
End:
40,457,731 bp from pter
Size:
14,308 bases
Orientation:
Plus strand

Genomic View for IGFBP4 Gene

Genes around IGFBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP4 Gene

Proteins for IGFBP4 Gene

  • Protein details for IGFBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22692-IBP4_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 4
    Protein Accession:
    P22692
    Secondary Accessions:
    • A0N9W2
    • B4E351
    • Q5U012
    • Q9UCL6

    Protein attributes for IGFBP4 Gene

    Size:
    258 amino acids
    Molecular mass:
    27934 Da
    Quaternary structure:
    • Binds IGF2 more than IGF1.

    Three dimensional structures from OCA and Proteopedia for IGFBP4 Gene

    Alternative splice isoforms for IGFBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFBP4 Gene

Proteomics data for IGFBP4 Gene at MOPED

Post-translational modifications for IGFBP4 Gene

  • Glycosylation at Asn 125 and Ser 173
  • Modification sites at PhosphoSitePlus

Other Protein References for IGFBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IGFBP4 Gene

Domains & Families for IGFBP4 Gene

Gene Families for IGFBP4 Gene

Graphical View of Domain Structure for InterPro Entry

P22692

UniProtKB/Swiss-Prot:

IBP4_HUMAN :
  • Contains 1 IGFBP N-terminal domain.
Domain:
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 thyroglobulin type-1 domain.
genes like me logo Genes that share domains with IGFBP4: view

Function for IGFBP4 Gene

Molecular function for IGFBP4 Gene

GENATLAS Biochemistry:
insulin-like growth factor binding protein 4 ,high affinity,functionnal antagonist of IGF1. Enhancer of apoptosis in malignant prostate cells
UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
UniProtKB/Swiss-Prot Induction:
By forskolin and N6,O2dibutyryl adenosine 3,5-cyclic monophosphate, but not by 1,9 dideoxyforskolin.

Gene Ontology (GO) - Molecular Function for IGFBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 24431302
genes like me logo Genes that share ontologies with IGFBP4: view
genes like me logo Genes that share phenotypes with IGFBP4: view

Animal Models for IGFBP4 Gene

MGI Knock Outs for IGFBP4:

Animal Model Products

miRNA for IGFBP4 Gene

miRTarBase miRNAs that target IGFBP4

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP4 Gene

Localization for IGFBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGFBP4 Gene COMPARTMENTS Subcellular localization image for IGFBP4 gene
Compartment Confidence
extracellular 5
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for IGFBP4 Gene

Pathways & Interactions for IGFBP4 Gene

genes like me logo Genes that share pathways with IGFBP4: view

Gene Ontology (GO) - Biological Process for IGFBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process TAS 1377672
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction TAS 1377672
GO:0008283 cell proliferation TAS 1377672
GO:0010906 regulation of glucose metabolic process IEA --
genes like me logo Genes that share ontologies with IGFBP4: view

No data available for SIGNOR curated interactions for IGFBP4 Gene

Drugs & Compounds for IGFBP4 Gene

(24) Drugs for IGFBP4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(13) Additional Compounds for IGFBP4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP4: view

Transcripts for IGFBP4 Gene

mRNA/cDNA for IGFBP4 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1457) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFBP4 Gene

Insulin-like growth factor binding protein 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP4 Gene

No ASD Table

Relevant External Links for IGFBP4 Gene

GeneLoc Exon Structure for
IGFBP4
ECgene alternative splicing isoforms for
IGFBP4

Expression for IGFBP4 Gene

mRNA expression in normal human tissues for IGFBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IGFBP4 Gene

This gene is overexpressed in Amniocyte (29.3), Serum (13.5), and Vitreous humor (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IGFBP4 Gene



SOURCE GeneReport for Unigene cluster for IGFBP4 Gene Hs.462998

genes like me logo Genes that share expression patterns with IGFBP4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IGFBP4 Gene

Orthologs for IGFBP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFBP4 35
  • 99.35 (n)
  • 99.61 (a)
IGFBP4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGFBP4 36
  • 97 (a)
OneToOne
IGFBP4 35
  • 95.22 (n)
  • 97.54 (a)
dog
(Canis familiaris)
Mammalia IGFBP4 35
  • 93.99 (n)
  • 97.54 (a)
IGFBP4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igfbp4 16
Igfbp4 36
  • 92 (a)
OneToOne
Igfbp4 35
  • 90 (n)
  • 92.5 (a)
oppossum
(Monodelphis domestica)
Mammalia IGFBP4 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGFBP4 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igfbp4 35
  • 89.17 (n)
  • 92.08 (a)
chicken
(Gallus gallus)
Aves IGFBP4 35
  • 79.13 (n)
  • 78.99 (a)
IGFBP4 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGFBP4 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igfbp4 35
  • 63.19 (n)
  • 65.65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12229 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for IGFBP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGFBP4 Gene

ENSEMBL:
Gene Tree for IGFBP4 (if available)
TreeFam:
Gene Tree for IGFBP4 (if available)

Paralogs for IGFBP4 Gene

Paralogs for IGFBP4 Gene

(4) SIMAP similar genes for IGFBP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IGFBP4: view

Variants for IGFBP4 Gene

Sequence variations from dbSNP and Humsavar for IGFBP4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs599199 - 40,443,860(+) CCCCG(G/T)GGGCT reference, missense
rs9520 -- 40,457,126(+) AGCTA(G/T)CCAGA utr-variant-3-prime
rs9890 -- 40,457,570(+) ATCTC(C/T)TTCCC utr-variant-3-prime
rs10498 -- 40,457,166(+) CAGAT(A/G)GAGTA utr-variant-3-prime
rs15207 -- 40,457,449(+) AGGGG(A/G)TGAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IGFBP4 Gene

Variant ID Type Subtype PubMed ID
nsv833445 CNV Loss 17160897
nsv908223 CNV Gain 21882294

Variation tolerance for IGFBP4 Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGFBP4 Gene

HapMap Linkage Disequilibrium report
IGFBP4
Human Gene Mutation Database (HGMD)
IGFBP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP4 Gene

Disorders for IGFBP4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IGFBP4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hereditary breast ovarian cancer
  • breast/ovarian cancer, hereditary
osteoporosis
  • osteoporosis, postmenopausal, susceptibility
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGFBP4

Genetic Association Database (GAD)
IGFBP4
Human Genome Epidemiology (HuGE) Navigator
IGFBP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGFBP4
genes like me logo Genes that share disorders with IGFBP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP4 Gene

Publications for IGFBP4 Gene

  1. Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human. (PMID: 1704481) Shimasaki S. … Ling N. (Mol. Endocrinol. 1990) 2 3 4 67
  2. Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5. (PMID: 17312271) Laursen L.S. … Oxvig C. (Mol. Endocrinol. 2007) 3 23
  3. Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. (PMID: 16586492) Moreno M.J. … Stanimirovic D.B. (Glia 2006) 3 23
  4. Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development. (PMID: 17070193) Wang T.H. … Wang H.S. (Fertil. Steril. 2006) 3 23
  5. Insulin-like growth factor, insulin-like growth factor-binding protein-4, and pregnancy-associated plasma protein-A gene expression in human granulosa cell tumors. (PMID: 17177834) Alexiadis M. … Fuller P.J. (Int. J. Gynecol. Cancer 2006) 3 23

Products for IGFBP4 Gene

Sources for IGFBP4 Gene

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