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Aliases for APOE Gene

Aliases for APOE Gene

  • Apolipoprotein E 2 3
  • APO-E 3 4
  • Alzheimer Disease 2 (APOE*E4-Associated, Late Onset) 2
  • Apolipoprotein E3 3
  • LDLCQ5 3
  • LPG 3
  • AD2 3

External Ids for APOE Gene

Previous HGNC Symbols for APOE Gene

  • AD2

Previous GeneCards Identifiers for APOE Gene

  • GC19P046053
  • GC19P045799
  • GC19P050085
  • GC19P050100
  • GC19P045408
  • GC19P041839

Summaries for APOE Gene

Entrez Gene Summary for APOE Gene

  • The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for APOE Gene

APOE (Apolipoprotein E) is a Protein Coding gene. Diseases associated with APOE include lipoprotein glomerulopathy and sea-blue histiocyte disease. Among its related pathways are Signaling by GPCR and Alzheimers Disease Pathway. GO annotations related to this gene include protein homodimerization activity and receptor binding.

UniProtKB/Swiss-Prot for APOE Gene

  • Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues

Gene Wiki entry for APOE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOE Gene

Genomics for APOE Gene

Regulatory Elements for APOE Gene

Genomic Location for APOE Gene

Chromosome:
19
Start:
44,905,749 bp from pter
End:
44,909,395 bp from pter
Size:
3,647 bases
Orientation:
Plus strand

Genomic View for APOE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOE Gene

Proteins for APOE Gene

  • Protein details for APOE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02649-APOE_HUMAN
    Recommended name:
    Apolipoprotein E
    Protein Accession:
    P02649
    Secondary Accessions:
    • B2RC15
    • C0JYY5
    • Q9P2S4

    Protein attributes for APOE Gene

    Size:
    317 amino acids
    Molecular mass:
    36154 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for APOE Gene

neXtProt entry for APOE Gene

Proteomics data for APOE Gene at MOPED

Post-translational modifications for APOE Gene

  • Glycated in plasma VLDL of normal subjects, and of hyperglycemic diabetic patients at a higher level (2-3 fold)
  • Phosphorylated by FAM20C in the extracellular medium.
  • Synthesized with the sialic acid attached by O-glycosidic linkage and is subsequently desialylated in plasma. O-glycosylated with core 1 or possibly core 8 glycans. Thr-307 and Ser-314 are minor glycosylation sites compared to Ser-308.
  • Glycosylation at Thr 26, Thr 36, Lys 93, Thr 212, Thr 307, Ser 308, and Ser 314
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for APOE (Apolipoprotein E/ApoE)
  • R&D Systems Antibodies for APOE (Apolipoprotein E3/ApoE3)
  • Cell Signaling Technology (CST) Antibodies for APOE (APOE)
  • Cell Signaling Technology (CST) Antibodies for APOE (APOE iso4)

No data available for DME Specific Peptides for APOE Gene

Domains & Families for APOE Gene

Gene Families for APOE Gene

Protein Domains for APOE Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOE Gene

Graphical View of Domain Structure for InterPro Entry

P02649

UniProtKB/Swiss-Prot:

APOE_HUMAN :
  • Belongs to the apolipoprotein A1/A4/E family.
Family:
  • Belongs to the apolipoprotein A1/A4/E family.
genes like me logo Genes that share domains with APOE: view

Function for APOE Gene

Molecular function for APOE Gene

GENATLAS Biochemistry:
apolipoprotein E,component of VLDL and ApoE receptors,putative susceptibility factor (epsilon 4 allele) for agressive multiple sclerosis and for early-onset coronary heart disease
UniProtKB/Swiss-Prot Function:
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues

Gene Ontology (GO) - Molecular Function for APOE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IDA 11305869
GO:0005319 lipid transporter activity IDA 17305370
GO:0005515 protein binding IPI 7566652
GO:0005543 phospholipid binding IDA 4066713
GO:0008201 heparin binding IDA 2745454
genes like me logo Genes that share ontologies with APOE: view
genes like me logo Genes that share phenotypes with APOE: view

Animal Models for APOE Gene

MGI Knock Outs for APOE:

Animal Model Products

miRNA for APOE Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOE

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for APOE Gene

Localization for APOE Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOE Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOE Gene COMPARTMENTS Subcellular localization image for APOE gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 4
endosome 4
golgi apparatus 4
plasma membrane 4
cytoskeleton 2
cytosol 2
lysosome 2
mitochondrion 2
peroxisome 2
vacuole 2

Gene Ontology (GO) - Cellular Components for APOE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm TAS 9622609
GO:0005769 early endosome TAS --
genes like me logo Genes that share ontologies with APOE: view

Pathways & Interactions for APOE Gene

genes like me logo Genes that share pathways with APOE: view

Pathways by source for APOE Gene

1 PharmGKB pathway for APOE Gene
1 KEGG pathway for APOE Gene
1 GeneGo (Thomson Reuters) pathway for APOE Gene
1 R&D Systems pathway for APOE Gene

PCR Array Products

SIGNOR curated interactions for APOE Gene

Activates:

Gene Ontology (GO) - Biological Process for APOE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species NAS 11743999
GO:0001523 retinoid metabolic process TAS --
GO:0001937 negative regulation of endothelial cell proliferation IDA 9685360
GO:0002021 response to dietary excess IEA --
GO:0006629 lipid metabolic process --
genes like me logo Genes that share ontologies with APOE: view

Drugs & Compounds for APOE Gene

(69) Drugs for APOE Gene - From: NovoSeek, HMDB, DrugBank, ClinicalTrials, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Human Serum Albumin Approved Pharma Target 0
Atorvastatin Approved Pharma Competitive, Inhibitor 690
Donepezil Approved Pharma 260
Fluvastatin Approved Pharma Competitive, Inhibitor 58
Galantamine Approved Pharma 102

(58) Additional Compounds for APOE Gene - From: NovoSeek and HMDB