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Aliases for IGF1 Gene

Aliases for IGF1 Gene

  • Insulin Like Growth Factor 1 2 3 5
  • Insulin-Like Growth Factor 1 (Somatomedin C) 2 3
  • Mechano Growth Factor 3 4
  • Somatomedin-C 3 4
  • IGF-I 3 4
  • MGF 3 4
  • Insulin-Like Growth Factor IB 3
  • Somatomedin C 2
  • IBP1 4
  • IGFI 3

External Ids for IGF1 Gene

Previous GeneCards Identifiers for IGF1 Gene

  • GC12M101888
  • GC12M102748
  • GC12M101292
  • GC12M099849

Summaries for IGF1 Gene

Entrez Gene Summary for IGF1 Gene

  • The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

GeneCards Summary for IGF1 Gene

IGF1 (Insulin Like Growth Factor 1) is a Protein Coding gene. Diseases associated with IGF1 include growth retardation with deafness and mental retardation due to igf1 deficiency and growth delay due to insulin-like growth factor type 1 deficiency. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include growth factor activity and integrin binding. An important paralog of this gene is IGF2.

UniProtKB/Swiss-Prot for IGF1 Gene

  • The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity).

Tocris Summary for IGF1 Gene

  • Insulin receptors (IRs) and insulin-like growth factor receptors (IGFRs) are formed from two subunits, each of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular tyrosine kinase activity. IR homodimers are activated by insulin.

Gene Wiki entry for IGF1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGF1 Gene

Genomics for IGF1 Gene

Regulatory Elements for IGF1 Gene

Promoters for IGF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IGF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGF1 Gene

Chromosome:
12
Start:
102,395,867 bp from pter
End:
102,481,786 bp from pter
Size:
85,920 bases
Orientation:
Minus strand

Genomic View for IGF1 Gene

Genes around IGF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF1 Gene

Proteins for IGF1 Gene

  • Protein details for IGF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05019-IGF1_HUMAN
    Recommended name:
    Insulin-like growth factor I
    Protein Accession:
    P05019
    Secondary Accessions:
    • B2RWM7
    • E9PD02
    • P01343
    • Q14620

    Protein attributes for IGF1 Gene

    Size:
    195 amino acids
    Molecular mass:
    21841 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA27250.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGF1 Gene

    Alternative splice isoforms for IGF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGF1 Gene

Proteomics data for IGF1 Gene at MOPED

Post-translational modifications for IGF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for IGF1 Gene

Domains & Families for IGF1 Gene

Gene Families for IGF1 Gene

Protein Domains for IGF1 Gene

Graphical View of Domain Structure for InterPro Entry

P05019

UniProtKB/Swiss-Prot:

IGF1_HUMAN :
  • Belongs to the insulin family.
Family:
  • Belongs to the insulin family.
genes like me logo Genes that share domains with IGF1: view

Function for IGF1 Gene

Molecular function for IGF1 Gene

GENATLAS Biochemistry:
insulin-like growth factor 1,expressed in liver,regulator of somatic growth and cellular proliferation,inducer of the phosphatidylinositol 3-kinase survival pathway through activation of AKT1,AKT2,inhibited by TNF in its neuroprotective role,also inducer of calcineurin mediated signaling and activation of GATA2,associated with intrauterine growth retardation and severe short stature in a patient carrying a homozygous deletion of IGF1
UniProtKB/Swiss-Prot Function:
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity).

LifeMap Function Summary for IGF1 Gene

It affects the following cells:
IGF1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
genes like me logo Genes that share phenotypes with IGF1: view

Human Phenotype Ontology for IGF1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IGF1 Gene

MGI Knock Outs for IGF1:

Animal Model Products

miRNA for IGF1 Gene

miRTarBase miRNAs that target IGF1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for IGF1 Gene

Localization for IGF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGF1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGF1 Gene COMPARTMENTS Subcellular localization image for IGF1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
mitochondrion 2
peroxisome 2
vacuole 2
endosome 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for IGF1 Gene

Pathways & Interactions for IGF1 Gene

genes like me logo Genes that share pathways with IGF1: view

SIGNOR curated interactions for IGF1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for IGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 10448861
GO:0001666 response to hypoxia IEA --
GO:0001775 cell activation IDA 22797923
GO:0002576 platelet degranulation TAS --
GO:0006260 DNA replication TAS 10766744
genes like me logo Genes that share ontologies with IGF1: view

Drugs & Compounds for IGF1 Gene

(91) Drugs for IGF1 Gene - From: Novoseek, DrugBank, Tocris, ClinicalTrials, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Deoxy-Bigchap Experimental Pharma Target 0
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate Experimental Pharma Target 0
Anesthetics Pharma 7385
Anesthetics, Local Pharma 2347
insulin Pharma 4278

(51) Additional Compounds for IGF1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BMS 536924
468740-43-4
Demethylasterriquinone B1
78860-34-1
Insulin (human) recombinant
11061-68-0
Picropodophyllotoxin
477-47-4

(5) Tocris Compounds for IGF1 Gene

Compound Action Cas Number
BMS 536924 Dual IR/IGF1R inhibitor 468740-43-4
Demethylasterriquinone B1 Selective insulin RTK activator 78860-34-1
Insulin (human) recombinant Endogenous peptide agonist 11061-68-0
Picropodophyllotoxin Selective IGF1R inhibitor 477-47-4
PQ 401 IGF1R inhibitor 196868-63-0
genes like me logo Genes that share compounds with IGF1: view

Transcripts for IGF1 Gene

Unigene Clusters for IGF1 Gene

Insulin-like growth factor 1 (somatomedin C):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGF1 Gene

No ASD Table

Relevant External Links for IGF1 Gene

GeneLoc Exon Structure for
IGF1
ECgene alternative splicing isoforms for
IGF1

Expression for IGF1 Gene

mRNA expression in normal human tissues for IGF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGF1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for IGF1 Gene

This gene is overexpressed in Serum (25.5), Plasma (19.7), Skin (16.2), and Synovial fluid (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGF1 Gene



SOURCE GeneReport for Unigene cluster for IGF1 Gene Hs.160562

genes like me logo Genes that share expression patterns with IGF1: view

Protein tissue co-expression partners for IGF1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IGF1 Gene

Orthologs for IGF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IGF1 35
  • 93.46 (n)
  • 96.08 (a)
IGF-I 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGF1 35
  • 93.68 (n)
  • 97.39 (a)
IGF1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igf1 35
  • 88.67 (n)
  • 91.5 (a)
Igf1 16
Igf1 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IGF1 35
  • 100 (n)
  • 100 (a)
IGF1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igf1 35
  • 88.02 (n)
  • 92.81 (a)
oppossum
(Monodelphis domestica)
Mammalia IGF1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGF1 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGF1 35
  • 80.61 (n)
  • 84.31 (a)
IGF1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGF1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486334 35
  • 77.56 (n)
  • 79.74 (a)
African clawed frog
(Xenopus laevis)
Amphibia igf1-A 35
zebrafish
(Danio rerio)
Actinopterygii igf1 35
  • 67.36 (n)
  • 65.97 (a)
igf1 36
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11904 35
Species with no ortholog for IGF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGF1 Gene

ENSEMBL:
Gene Tree for IGF1 (if available)
TreeFam:
Gene Tree for IGF1 (if available)

Paralogs for IGF1 Gene

Paralogs for IGF1 Gene

(3) SIMAP similar genes for IGF1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IGF1: view

Variants for IGF1 Gene

Sequence variations from dbSNP and Humsavar for IGF1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_013945 -
VAR_056113 -
rs35767 -- 102,481,791(-) TCATG(C/T)GGAAA upstream-variant-2KB
rs1019731 -- 102,470,647(-) TCAAA(G/T)TTAGG intron-variant
rs2162679 -- 102,477,481(-) TGTAG(A/G)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGF1 Gene

Variant ID Type Subtype PubMed ID
nsv899474 CNV Gain 21882294
nsv832498 CNV Gain 17160897
nsv819617 CNV Gain 19587683
nsv832499 CNV Gain 17160897
esv2663083 CNV Deletion 23128226
esv271788 CNV Insertion 20981092
esv273493 CNV Insertion 20981092

Variation tolerance for IGF1 Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGF1 Gene

HapMap Linkage Disequilibrium report
IGF1
Human Gene Mutation Database (HGMD)
IGF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGF1 Gene

Disorders for IGF1 Gene

MalaCards: The human disease database

(129) MalaCards diseases for IGF1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
growth retardation with deafness and mental retardation due to igf1 deficiency
  • insulin-like growth factor i deficiency
growth delay due to insulin-like growth factor type 1 deficiency
  • growth delay-deafness- intellectual disability syndrome
insulin-like growth factor i
  • insulin-like growth factor i, resistance to
pituitary gland disease
  • pituitary disease
uterine fibroid
  • leiomyoma of corpus uteri
- elite association - COSMIC cancer census association via MalaCards
Search IGF1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IGF1_HUMAN
  • Insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]: Autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. {ECO:0000269 PubMed:8857020}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IGF1

Genetic Association Database (GAD)
IGF1
Human Genome Epidemiology (HuGE) Navigator
IGF1
Tumor Gene Database (TGDB):
IGF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGF1
genes like me logo Genes that share disorders with IGF1: view

No data available for Genatlas for IGF1 Gene

Publications for IGF1 Gene

  1. Sequence of cDNA encoding human insulin-like growth factor I precursor. (PMID: 6358902) Jansen M. … van den Brande J.L. (Nature 1983) 2 3 4 67
  2. Relationships between critical period of estrogen exposure and circulating levels of insulin-like growth factor-I (IGF-I) in breast cancer: evidence from a case-control study. (PMID: 19585556) Wu M.H. … Sun C.A. (Int. J. Cancer 2010) 3 23
  3. Free insulin-like growth factor (IGF)-1 and IGF-binding proteins-2 and -3 in serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients. (PMID: 19845745) Corbo M. … Silani V. (Eur. J. Neurol. 2010) 3 23
  4. Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells. (PMID: 19906888) Tosca L. … Dupont J. (Reproduction 2010) 3 23
  5. Vitamin D metabolism and action in human bone marrow stromal cells. (PMID: 19966181) Zhou S. … Glowacki J. (Endocrinology 2010) 3 23

Products for IGF1 Gene

Sources for IGF1 Gene

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