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Aliases for SLC35B2 Gene

Aliases for SLC35B2 Gene

  • Solute Carrier Family 35 Member B2 2 3 4
  • Solute Carrier Family 35 (Adenosine 3-Phospho 5-Phosphosulfate Transporter), Member B2 2 3 5
  • Putative NF-Kappa-B-Activating Protein 48 3 4
  • Putative MAPK-Activating Protein PM15 3 4
  • Solute Carrier Family 35, Member B2 2 3
  • PAPS Transporter 1 3 4
  • PAPST1 3 4
  • 3-Phosphoadenosine 5-Phosphosulfate Transporter 3
  • Solute Carrier Family 35 Member B2 Variant 2 3
  • UGTrel4 3
  • SLL 3

External Ids for SLC35B2 Gene

Previous GeneCards Identifiers for SLC35B2 Gene

  • GC06M044225
  • GC06M044270
  • GC06M044271
  • GC06M044329
  • GC06M043943

Summaries for SLC35B2 Gene

Entrez Gene Summary for SLC35B2 Gene

  • Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC35B2 Gene

SLC35B2 (Solute Carrier Family 35 Member B2) is a Protein Coding gene. Diseases associated with SLC35B2 include chromosome 13q14 deletion syndrome and cll/sll. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include signal transducer activity and 3-phosphoadenosine 5-phosphosulfate transmembrane transporter activity. An important paralog of this gene is SLC35B1.

UniProtKB/Swiss-Prot for SLC35B2 Gene

  • Mediates the transport of adenosine 3-phospho 5-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.

Gene Wiki entry for SLC35B2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35B2 Gene

Genomics for SLC35B2 Gene

Regulatory Elements for SLC35B2 Gene

Promoters for SLC35B2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC35B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35B2 Gene

Chromosome:
6
Start:
44,254,096 bp from pter
End:
44,257,890 bp from pter
Size:
3,795 bases
Orientation:
Minus strand

Genomic View for SLC35B2 Gene

Genes around SLC35B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35B2 Gene

Proteins for SLC35B2 Gene

  • Protein details for SLC35B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB61-S35B2_HUMAN
    Recommended name:
    Adenosine 3-phospho 5-phosphosulfate transporter 1
    Protein Accession:
    Q8TB61
    Secondary Accessions:
    • B4DDM2
    • B4DDU9
    • F5H7Y9
    • Q2VY06
    • Q53GA3
    • Q5T9W1
    • Q5T9W2
    • Q7Z2G3
    • Q8NBK6
    • Q96AR6

    Protein attributes for SLC35B2 Gene

    Size:
    432 amino acids
    Molecular mass:
    47515 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI20100.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35B2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35B2 Gene

Proteomics data for SLC35B2 Gene at MOPED

Post-translational modifications for SLC35B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SLC35B2 Gene

Domains & Families for SLC35B2 Gene

Gene Families for SLC35B2 Gene

Protein Domains for SLC35B2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35B2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TB61

UniProtKB/Swiss-Prot:

S35B2_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
genes like me logo Genes that share domains with SLC35B2: view

Function for SLC35B2 Gene

Molecular function for SLC35B2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.8 uM for PAPS {ECO:0000269 PubMed:12716889};
UniProtKB/Swiss-Prot Function:
Mediates the transport of adenosine 3-phospho 5-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.

Phenotypes for SLC35B2 Gene

genes like me logo Genes that share phenotypes with SLC35B2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35B2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35B2 Gene

Localization for SLC35B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35B2 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35B2 Gene COMPARTMENTS Subcellular localization image for SLC35B2 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC35B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030173 integral component of Golgi membrane IBA --
genes like me logo Genes that share ontologies with SLC35B2: view

Pathways & Interactions for SLC35B2 Gene

genes like me logo Genes that share pathways with SLC35B2: view

Interacting Proteins for SLC35B2 Gene

Gene Ontology (GO) - Biological Process for SLC35B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046963 3-phosphoadenosine 5-phosphosulfate transport IDA 12716889
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
genes like me logo Genes that share ontologies with SLC35B2: view

No data available for SIGNOR curated interactions for SLC35B2 Gene

Drugs & Compounds for SLC35B2 Gene

(1) Drugs for SLC35B2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine Approved, Investigational Pharma Agonist 363

(2) Additional Compounds for SLC35B2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine phosphosulfate
  • Adenosine 5'-phosphosulfate
  • Adenosine 5'-phosphosulphate
  • Adenosine 5'-sulphatophosphate
  • Adenosine Phosphosulfate
  • Adenosine Phosphosulphate
485-84-7
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with SLC35B2: view

Transcripts for SLC35B2 Gene

Unigene Clusters for SLC35B2 Gene

Solute carrier family 35, member B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: -
SP2: -
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for SLC35B2 Gene

GeneLoc Exon Structure for
SLC35B2
ECgene alternative splicing isoforms for
SLC35B2

Expression for SLC35B2 Gene

mRNA expression in normal human tissues for SLC35B2 Gene

Protein differential expression in normal tissues from HIPED for SLC35B2 Gene

This gene is overexpressed in Nasal epithelium (59.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC35B2 Gene



SOURCE GeneReport for Unigene cluster for SLC35B2 Gene Hs.182885

mRNA Expression by UniProt/SwissProt for SLC35B2 Gene

Q8TB61-S35B2_HUMAN
Tissue specificity: Highly expressed in the placenta, pancreas, mammary gland and skeletal muscle. Weakly or not expressed in colon, heart and prostate.
genes like me logo Genes that share expression patterns with SLC35B2: view

Protein tissue co-expression partners for SLC35B2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC35B2 Gene

Orthologs for SLC35B2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35B2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC35B2 35
  • 89.74 (n)
  • 93.98 (a)
SLC35B2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC35B2 35
  • 91.28 (n)
  • 96.76 (a)
PAPST1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35b2 35
  • 88.13 (n)
  • 93.19 (a)
Slc35b2 16
Slc35b2 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35b2 35
  • 88.01 (n)
  • 91.88 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC35B2 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35B2 35
  • 72.5 (n)
  • 74.94 (a)
SLC35B2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35B2 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394918 35
slc35b2 35
  • 71.59 (n)
  • 74.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia slc35b1-prov 35
zebrafish
(Danio rerio)
Actinopterygii slc35b2 35
  • 68.16 (n)
  • 70.52 (a)
slc35b2 36
  • 69 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6248 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002571 35
  • 56.62 (n)
  • 53.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta sll 35
  • 55.7 (n)
  • 50.91 (a)
sll 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pst-1 35
  • 48.13 (n)
  • 42.86 (a)
pst-1 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUT1 36
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G59740 35
  • 47.56 (n)
  • 39 (a)
rice
(Oryza sativa)
Liliopsida Os05g0115700 35
  • 47.51 (n)
  • 38.64 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13223 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for SLC35B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35B2 Gene

ENSEMBL:
Gene Tree for SLC35B2 (if available)
TreeFam:
Gene Tree for SLC35B2 (if available)

Paralogs for SLC35B2 Gene

Paralogs for SLC35B2 Gene

(1) SIMAP similar genes for SLC35B2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC35B2: view

Variants for SLC35B2 Gene

Sequence variations from dbSNP and Humsavar for SLC35B2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_022657 -
rs520639 -- 44,257,254(-) GAGCT(A/G)CGGCT intron-variant, utr-variant-5-prime
rs575034 -- 44,257,187(+) CTCCA(A/C)GATCC intron-variant, utr-variant-5-prime
rs36092647 -- 44,257,012(+) AGAGC(-/CT)CTCTC intron-variant
rs35391757 -- 44,256,725(+) CCAGG(-/A)AGGTA intron-variant, reference, frameshift-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC35B2 Gene

Variant ID Type Subtype PubMed ID
nsv885851 CNV Loss 21882294
nsv5282 CNV Insertion 18451855
nsv885852 CNV Loss 21882294
nsv462936 CNV Loss 19166990
dgv6843n71 CNV Loss 21882294
nsv524398 CNV Loss 19592680
dgv6844n71 CNV Loss 21882294
nsv885857 CNV Loss 21882294

Variation tolerance for SLC35B2 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35B2 Gene

HapMap Linkage Disequilibrium report
SLC35B2
Human Gene Mutation Database (HGMD)
SLC35B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35B2 Gene

Disorders for SLC35B2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SLC35B2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 13q14 deletion syndrome
  • deletion 13q14
cll/sll
  • chronic lymphocytic leukemia/small lymphocytic lymphoma
lymphoplasmacytic lymphoma
  • waldenstrom macroglobulinemia
marginal zone b-cell lymphoma
  • marginal zone lymphoma
heart septal defect
  • cardiac septal defects
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC35B2

Genetic Association Database (GAD)
SLC35B2
Human Genome Epidemiology (HuGE) Navigator
SLC35B2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35B2
genes like me logo Genes that share disorders with SLC35B2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35B2 Gene

Publications for SLC35B2 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. MiR-22 is frequently downregulated in medulloblastomas and inhibits cell proliferation via the novel target PAPST1. (PMID: 24576181) Xu Q.F. … Lv S.Q. (Brain Pathol. 2014) 3
  4. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PMID: 23464991) Scifo E. … Lalowski M. (J. Proteome Res. 2013) 3
  5. Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma. (PMID: 20978009) Kamiyama S. … Nishihara S. (Glycobiology 2011) 3

Products for SLC35B2 Gene

Sources for SLC35B2 Gene

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