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Aliases for SLC35B2 Gene

Aliases for SLC35B2 Gene

  • Solute Carrier Family 35 Member B2 2 3 4 5
  • Solute Carrier Family 35 (Adenosine 3-Phospho 5-Phosphosulfate Transporter), Member B2 2 3
  • Putative NF-Kappa-B-Activating Protein 48 3 4
  • Putative MAPK-Activating Protein PM15 3 4
  • PAPS Transporter 1 3 4
  • PAPST1 3 4
  • Adenosine 3-Phospho 5-Phosphosulfate Transporter 1 3
  • 3-Phosphoadenosine 5-Phosphosulfate Transporter 3
  • Solute Carrier Family 35 Member B2 Variant 2 3
  • Solute Carrier Family 35, Member B2 2
  • UGTrel4 3
  • SLL 3

External Ids for SLC35B2 Gene

Previous GeneCards Identifiers for SLC35B2 Gene

  • GC06M044225
  • GC06M044270
  • GC06M044271
  • GC06M044329
  • GC06M043943

Summaries for SLC35B2 Gene

Entrez Gene Summary for SLC35B2 Gene

  • Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC35B2 Gene

SLC35B2 (Solute Carrier Family 35 Member B2) is a Protein Coding gene. Diseases associated with SLC35B2 include Cll/Sll and Chromosome 13Q14 Deletion Syndrome. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. GO annotations related to this gene include signal transducer activity and 3-phosphoadenosine 5-phosphosulfate transmembrane transporter activity. An important paralog of this gene is SLC35B1.

UniProtKB/Swiss-Prot for SLC35B2 Gene

  • Mediates the transport of adenosine 3-phospho 5-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.

Gene Wiki entry for SLC35B2 Gene

Additional gene information for SLC35B2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35B2 Gene

Genomics for SLC35B2 Gene

Regulatory Elements for SLC35B2 Gene

Enhancers for SLC35B2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H044040 2 FANTOM5 Ensembl ENCODE dbSUPER 21.7 +215.2 215198 4 HDGF FOXA2 ARNT YBX1 FEZF1 ZNF766 ZNF548 FOS SP5 SMARCB1 ZNF318 ABCC10 CUL7 POLH GTPBP2 RPS2P29 RPL34P14 XPO5 POLR1C SLC35B2
GH06H044245 1.5 ENCODE dbSUPER 19.4 +10.3 10343 4 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC PPARGC1A ZFP41 ZNF318 POLH GTPBP2 ABCC10 RPS2P29 POLR1C AARS2 CDC5L XPO5 RPL34P14
GH06H043910 2 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +343.4 343418 8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 ZNF766 RPS2P29 ZNF318 SLC35B2 CUL7 GTPBP2 ABCC10 POLH RPL24P4 POLR1C RPL34P14
GH06H043925 2 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +330.8 330768 3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 SLC30A9 ZNF766 ZNF318 XPO5 POLR1C ENSG00000271970 POLH ABCC10 RPS2P29 TJAP1 SLC35B2 CUL7
GH06H044056 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +195.6 195633 12 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A YY1 SLC30A9 POLH GTPBP2 ZNF318 NFKBIE ABCC10 RPS2P29 MRPL14 TMEM63B XPO5 POLR1C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35B2 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35B2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197294 690 1201 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 CBX5 ZNF143 FOS SP3

Genomic Location for SLC35B2 Gene

Chromosome:
6
Start:
44,254,096 bp from pter
End:
44,257,890 bp from pter
Size:
3,795 bases
Orientation:
Minus strand

Genomic View for SLC35B2 Gene

Genes around SLC35B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35B2 Gene

Proteins for SLC35B2 Gene

  • Protein details for SLC35B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB61-S35B2_HUMAN
    Recommended name:
    Adenosine 3-phospho 5-phosphosulfate transporter 1
    Protein Accession:
    Q8TB61
    Secondary Accessions:
    • B4DDM2
    • B4DDU9
    • F5H7Y9
    • Q2VY06
    • Q53GA3
    • Q5T9W1
    • Q5T9W2
    • Q7Z2G3
    • Q8NBK6
    • Q96AR6

    Protein attributes for SLC35B2 Gene

    Size:
    432 amino acids
    Molecular mass:
    47515 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI20100.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35B2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35B2 Gene

Post-translational modifications for SLC35B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC35B2 Gene

Domains & Families for SLC35B2 Gene

Gene Families for SLC35B2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35B2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35B2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TB61

UniProtKB/Swiss-Prot:

S35B2_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
genes like me logo Genes that share domains with SLC35B2: view

Function for SLC35B2 Gene

Molecular function for SLC35B2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.8 uM for PAPS {ECO:0000269 PubMed:12716889};
UniProtKB/Swiss-Prot Function:
Mediates the transport of adenosine 3-phospho 5-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.

Phenotypes From GWAS Catalog for SLC35B2 Gene

Gene Ontology (GO) - Molecular Function for SLC35B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0046964 3-phosphoadenosine 5-phosphosulfate transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC35B2: view
genes like me logo Genes that share phenotypes with SLC35B2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35B2

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35B2 Gene

Localization for SLC35B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35B2 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35B2 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
endoplasmic reticulum 3
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC35B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA,IDA 12716889
GO:0016020 membrane IEA,IDA 12716889
GO:0016021 integral component of membrane NAS 12716889
GO:0030173 integral component of Golgi membrane IBA --
genes like me logo Genes that share ontologies with SLC35B2: view

Pathways & Interactions for SLC35B2 Gene

genes like me logo Genes that share pathways with SLC35B2: view

Gene Ontology (GO) - Biological Process for SLC35B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007165 signal transduction IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
GO:0046963 3-phosphoadenosine 5-phosphosulfate transport IDA 12716889
GO:0050428 3-phosphoadenosine 5-phosphosulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with SLC35B2: view

No data available for SIGNOR curated interactions for SLC35B2 Gene

Drugs & Compounds for SLC35B2 Gene

(2) Drugs for SLC35B2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine Approved, Investigational Pharma Agonist 528
Adenosine phosphosulfate Experimental Pharma 0

(1) Additional Compounds for SLC35B2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with SLC35B2: view

Transcripts for SLC35B2 Gene

Unigene Clusters for SLC35B2 Gene

Solute carrier family 35, member B2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: -
SP2: -
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for SLC35B2 Gene

GeneLoc Exon Structure for
SLC35B2
ECgene alternative splicing isoforms for
SLC35B2

Expression for SLC35B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35B2 Gene

Protein differential expression in normal tissues from HIPED for SLC35B2 Gene

This gene is overexpressed in Nasal epithelium (59.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC35B2 Gene



Protein tissue co-expression partners for SLC35B2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC35B2 Gene:

SLC35B2

SOURCE GeneReport for Unigene cluster for SLC35B2 Gene:

Hs.182885

mRNA Expression by UniProt/SwissProt for SLC35B2 Gene:

Q8TB61-S35B2_HUMAN
Tissue specificity: Highly expressed in the placenta, pancreas, mammary gland and skeletal muscle. Weakly or not expressed in colon, heart and prostate.

Evidence on tissue expression from TISSUES for SLC35B2 Gene

  • Intestine(4.5)
  • Thyroid gland(4.3)
  • Lung(4.2)
  • Nervous system(4.2)
  • Heart(3.6)
  • Skin(3.1)
  • Stomach(3)
  • Muscle(2.9)
  • Liver(2.7)
  • Kidney(2.5)
  • Lymph node(2.3)
  • Blood(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with SLC35B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35B2 Gene

Orthologs for SLC35B2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35B2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PAPST1 34
  • 92 (a)
OneToOne
SLC35B2 33
  • 91.28 (n)
cow
(Bos Taurus)
Mammalia SLC35B2 33 34
  • 89.74 (n)
mouse
(Mus musculus)
Mammalia Slc35b2 33 16 34
  • 88.13 (n)
rat
(Rattus norvegicus)
Mammalia Slc35b2 33
  • 88.01 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35B2 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35B2 33 34
  • 72.5 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35B2 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35b2 33
  • 71.59 (n)
LOC394918 33
African clawed frog
(Xenopus laevis)
Amphibia slc35b1-prov 33
zebrafish
(Danio rerio)
Actinopterygii slc35b2 33 34
  • 68.16 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6248 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002571 33
  • 56.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta sll 33 34
  • 55.7 (n)
worm
(Caenorhabditis elegans)
Secernentea pst-1 33 34
  • 48.13 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUT1 34
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G59740 33
  • 47.56 (n)
rice
(Oryza sativa)
Liliopsida Os05g0115700 33
  • 47.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13223 33
Species where no ortholog for SLC35B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35B2 Gene

ENSEMBL:
Gene Tree for SLC35B2 (if available)
TreeFam:
Gene Tree for SLC35B2 (if available)

Paralogs for SLC35B2 Gene

Paralogs for SLC35B2 Gene

(1) SIMAP similar genes for SLC35B2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC35B2: view

Variants for SLC35B2 Gene

Sequence variations from dbSNP and Humsavar for SLC35B2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000894460 -- 44,259,307(+) GAGAA(A/G)CAAGA intron-variant, upstream-variant-2KB
rs1001629813 -- 44,254,364(+) AGTGA(C/G)TCTGG downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1002161394 -- 44,254,403(+) CTTAA(C/G)GGAAC upstream-variant-2KB, utr-variant-3-prime
rs1002388382 -- 44,259,719(+) GGCCT(A/G)CACTC intron-variant, upstream-variant-2KB
rs1002861252 -- 44,258,598(+) TGCCT(C/T)TACCA upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC35B2 Gene

Variant ID Type Subtype PubMed ID
dgv10641n54 CNV loss 21841781
nsv462936 CNV loss 19166990
nsv524398 CNV loss 19592680
nsv5282 CNV insertion 18451855
nsv603003 CNV gain 21841781

Variation tolerance for SLC35B2 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35B2 Gene

Human Gene Mutation Database (HGMD)
SLC35B2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35B2 Gene

Disorders for SLC35B2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SLC35B2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
cll/sll
  • chronic lymphocytic leukemia/small lymphocytic lymphoma
chromosome 13q14 deletion syndrome
  • deletion 13q14
third-degree atrioventricular block
  • complete av block
lymphoplasmacytic lymphoma
  • waldenstrom macroglobulinemia
marginal zone b-cell lymphoma
  • marginal zone lymphoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC35B2

Genetic Association Database (GAD)
SLC35B2
Human Genome Epidemiology (HuGE) Navigator
SLC35B2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35B2
genes like me logo Genes that share disorders with SLC35B2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35B2 Gene

Publications for SLC35B2 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 45 60
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  5. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 3 4 60

Products for SLC35B2 Gene

Sources for SLC35B2 Gene

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