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Aliases for LRRTM1 Gene

Aliases for LRRTM1 Gene

  • Leucine Rich Repeat Transmembrane Neuronal 1 2 3

External Ids for LRRTM1 Gene

Previous GeneCards Identifiers for LRRTM1 Gene

  • GC02U900202
  • GC02M080490
  • GC02M080499
  • GC02M080427
  • GC02M080382

Summaries for LRRTM1 Gene

GeneCards Summary for LRRTM1 Gene

LRRTM1 (Leucine Rich Repeat Transmembrane Neuronal 1) is a Protein Coding gene. Diseases associated with LRRTM1 include autism spectrum disorder. An important paralog of this gene is LRRTM2.

UniProtKB/Swiss-Prot for LRRTM1 Gene

  • Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.

Gene Wiki entry for LRRTM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRTM1 Gene

Genomics for LRRTM1 Gene

Regulatory Elements for LRRTM1 Gene

Genomic Location for LRRTM1 Gene

Start:
80,288,351 bp from pter
End:
80,304,749 bp from pter
Size:
16,399 bases
Orientation:
Minus strand

Genomic View for LRRTM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRTM1 Gene

Proteins for LRRTM1 Gene

  • Protein details for LRRTM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UE6-LRRT1_HUMAN
    Recommended name:
    Leucine-rich repeat transmembrane neuronal protein 1
    Protein Accession:
    Q86UE6
    Secondary Accessions:
    • A8K397
    • D6W5K1
    • Q96DN1

    Protein attributes for LRRTM1 Gene

    Size:
    522 amino acids
    Molecular mass:
    58641 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated paternally with handedness and schizophrenia

neXtProt entry for LRRTM1 Gene

Proteomics data for LRRTM1 Gene at MOPED

Post-translational modifications for LRRTM1 Gene

  • Glycosylation at Asn56, Asn63, Asn130, and Asn380
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRTM1 Gene

No data available for DME Specific Peptides for LRRTM1 Gene

Domains for LRRTM1 Gene

Protein Domains for LRRTM1 Gene

Suggested Antigen Peptide Sequences for LRRTM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UE6

UniProtKB/Swiss-Prot:

LRRT1_HUMAN :
  • Q86UE6
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the LRRTM family.
Similarity:
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRTM1: view

No data available for Gene Families for LRRTM1 Gene

Function for LRRTM1 Gene

Molecular function for LRRTM1 Gene

UniProtKB/Swiss-Prot Function: Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.

Gene Ontology (GO) - Molecular Function for LRRTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRTM1: view

Phenotypes for LRRTM1 Gene

genes like me logo Genes that share phenotypes with LRRTM1: view

Animal Models for LRRTM1 Gene

MGI Knock Outs for LRRTM1:

miRNA for LRRTM1 Gene

miRTarBase miRNAs that target LRRTM1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LRRTM1 Gene

Localization for LRRTM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRTM1 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRTM1 Gene COMPARTMENTS Subcellular localization image for LRRTM1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRRTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 17667961
GO:0009986 NOT cell surface IDA 17667961
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030424 axon IDA 17667961
genes like me logo Genes that share ontologies with LRRTM1: view

Pathways for LRRTM1 Gene

SuperPathways for LRRTM1 Gene

No Data Available

Interacting Proteins for LRRTM1 Gene

Gene Ontology (GO) - Biological Process for LRRTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002091 negative regulation of receptor internalization IEA --
GO:0007626 locomotory behavior IEA --
GO:0008150 biological_process ND --
GO:0035418 protein localization to synapse IEA --
GO:0035640 exploration behavior IEA --
genes like me logo Genes that share ontologies with LRRTM1: view

No data available for Pathways by source for LRRTM1 Gene

Transcripts for LRRTM1 Gene

mRNA/cDNA for LRRTM1 Gene

Unigene Clusters for LRRTM1 Gene

Leucine rich repeat transmembrane neuronal 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRTM1 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for LRRTM1 Gene

GeneLoc Exon Structure for
LRRTM1
ECgene alternative splicing isoforms for
LRRTM1

Expression for LRRTM1 Gene

mRNA expression in normal human tissues for LRRTM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRTM1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (7.8), Brain - Putamen (basal ganglia) (6.1), Brain - Caudate (basal ganglia) (5.6), Brain - Hippocampus (4.9), Brain - Cortex (4.9), Brain - Anterior cingulate cortex (BA24) (4.3), and Brain - Frontal Cortex (BA9) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LRRTM1 Gene

SOURCE GeneReport for Unigene cluster for LRRTM1 Gene Hs.591580

mRNA Expression by UniProt/SwissProt for LRRTM1 Gene

Q86UE6-LRRT1_HUMAN
Tissue specificity: Predominantly expressed in forebrain regions including thalamus and cerebral cortex.
genes like me logo Genes that share expressions with LRRTM1: view

Orthologs for LRRTM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRTM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRTM1 35
  • 99.81 (n)
  • 99.81 (a)
LRRTM1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRRTM1 35
  • 95.52 (n)
  • 97.31 (a)
dog
(Canis familiaris)
Mammalia LRRTM1 35
  • 95.98 (n)
  • 97.89 (a)
LRRTM1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrtm1 35
  • 92.19 (n)
  • 97.31 (a)
Lrrtm1 16
Lrrtm1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRRTM1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRTM1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LRRTM1 35
  • 91.76 (n)
  • 96.55 (a)
chicken
(Gallus gallus)
Aves LRRTM1 35
  • 79.21 (n)
  • 83.11 (a)
LRRTM1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRTM1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrtm1 35
  • 74.97 (n)
  • 79.73 (a)
zebrafish
(Danio rerio)
Actinopterygii lrrtm1 35
  • 66.41 (n)
  • 66.67 (a)
lrrtm1 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta haf 36
  • 9 (a)
OneToMany
Species with no ortholog for LRRTM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRTM1 Gene

ENSEMBL:
Gene Tree for LRRTM1 (if available)
TreeFam:
Gene Tree for LRRTM1 (if available)

Paralogs for LRRTM1 Gene

Paralogs for LRRTM1 Gene

Selected SIMAP similar genes for LRRTM1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for LRRTM1 Gene

genes like me logo Genes that share paralogs with LRRTM1: view

Variants for LRRTM1 Gene

Sequence variations from dbSNP and Humsavar for LRRTM1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_022681 -

Structural Variations from Database of Genomic Variants (DGV) for LRRTM1 Gene

Variant ID Type Subtype PubMed ID
dgv1208e1 CNV Complex 17122850
dgv1209e1 CNV Complex 17122850

Relevant External Links for LRRTM1 Gene

HapMap Linkage Disequilibrium report
LRRTM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRTM1 Gene

Disorders for LRRTM1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for LRRTM1 Gene including...

Search for LRRTM1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for LRRTM1 Gene

Relevant External Links for LRRTM1

Genetic Association Database (GAD)
LRRTM1
Human Genome Epidemiology (HuGE) Navigator
LRRTM1
genes like me logo Genes that share disorders with LRRTM1: view

No data available for UniProtKB/Swiss-Prot for LRRTM1 Gene

Publications for LRRTM1 Gene

  1. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. (PMID: 12676565) Lauren J. … Timmusk T.T. (Genomics 2003) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. (PMID: 17667961) Francks C. … Monaco A.P. (Mol. Psychiatry 2007) 3 4

Products for LRRTM1 Gene

Sources for LRRTM1 Gene

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