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Aliases for APOC4 Gene

Aliases for APOC4 Gene

  • Apolipoprotein C4 2 3 4 5
  • Apolipoprotein C-IV 2 3
  • APO-CIV 3 4
  • APOC-IV 3 4

External Ids for APOC4 Gene

Previous GeneCards Identifiers for APOC4 Gene

  • GC19P046090
  • GC19P045836
  • GC19P050115
  • GC19P050137
  • GC19P045445
  • GC19P041875

Summaries for APOC4 Gene

Entrez Gene Summary for APOC4 Gene

  • This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for APOC4 Gene

APOC4 (Apolipoprotein C4) is a Protein Coding gene. Diseases associated with APOC4 include Artery Disease. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include lipid transporter activity. An important paralog of this gene is APOC4-APOC2.

UniProtKB/Swiss-Prot for APOC4 Gene

  • May participate in lipoprotein metabolism.

Gene Wiki entry for APOC4 Gene

Additional gene information for APOC4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOC4 Gene

Genomics for APOC4 Gene

Regulatory Elements for APOC4 Gene

Enhancers for APOC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H044923 1.6 FANTOM5 Ensembl ENCODE 9.2 -16.2 -16227 4.3 HDGF FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 FOS APOC1P1 APOC2 APOC4 IGSF23 BCAM APOE APOC1 GC19P044915
GH19H044721 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.6 -218.0 -218007 4.9 ARID4B SIN3A DMAP1 YY1 GATA2 ZNF143 ZNF207 FOS RUNX3 SP5 ENSG00000266903 APOE RELB APOC2 BCL3 CLASRP IGSF23 APOC4 ENSG00000252200 GC19M044726
GH19H044945 1.2 Ensembl ENCODE 0.7 +3.7 3712 1.8 ELF3 TBP FOXA2 ATF1 ARID4B DMAP1 THRB ZSCAN9 RAD21 RARA APOC2 APOC4 APOC4-APOC2
GH19H044943 1.2 Ensembl ENCODE 0.7 +1.7 1732 0.6 HDGF PKNOX1 ATF1 ARNT YY1 ELK1 ATF7 REST ZNF592 SMARCA4 APOC2 APOC4 APOC4-APOC2
GH19H044934 1 ENCODE 0.4 -6.5 -6463 2.9 FOXA2 MLX ARID4B DMAP1 YY1 ZNF121 SLC30A9 SP5 ZHX2 MXD4 APOC2 APOC1 APOC4 APOC4-APOC2 GC19P044927
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around APOC4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for APOC4 Gene

Genomic Locations for APOC4 Gene
3,259 bases
Plus strand

Genomic View for APOC4 Gene

Genes around APOC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOC4 Gene

Proteins for APOC4 Gene

  • Protein details for APOC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apolipoprotein C-IV
    Protein Accession:
    Secondary Accessions:
    • B3KWY6
    • Q53YY8

    Protein attributes for APOC4 Gene

    127 amino acids
    Molecular mass:
    14553 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOC4 Gene

Post-translational modifications for APOC4 Gene

  • Glycosylation at posLast=6363
  • Modification sites at PhosphoSitePlus

Other Protein References for APOC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APOC4 Gene

Domains & Families for APOC4 Gene

Gene Families for APOC4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for APOC4 Gene


Suggested Antigen Peptide Sequences for APOC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the apolipoprotein C4 family.
  • Belongs to the apolipoprotein C4 family.
genes like me logo Genes that share domains with APOC4: view

Function for APOC4 Gene

Molecular function for APOC4 Gene

GENATLAS Biochemistry:
apolipoprotein C-IV
UniProtKB/Swiss-Prot Function:
May participate in lipoprotein metabolism.

Phenotypes From GWAS Catalog for APOC4 Gene

Gene Ontology (GO) - Molecular Function for APOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity TAS 8530039
genes like me logo Genes that share ontologies with APOC4: view
genes like me logo Genes that share phenotypes with APOC4: view

Animal Models for APOC4 Gene

MGI Knock Outs for APOC4:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for APOC4 Gene

Localization for APOC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOC4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOC4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for APOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0034361 very-low-density lipoprotein particle IMP 8827523
GO:0034364 high-density lipoprotein particle IDA 12700345
genes like me logo Genes that share ontologies with APOC4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for APOC4 Gene

Pathways & Interactions for APOC4 Gene

genes like me logo Genes that share pathways with APOC4: view

Interacting Proteins for APOC4 Gene

Selected Interacting proteins: P55056-APOC4_HUMAN for APOC4 Gene via IID

Gene Ontology (GO) - Biological Process for APOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 8530039
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
GO:0010890 positive regulation of sequestering of triglyceride IMP 18809223
GO:0034379 very-low-density lipoprotein particle assembly TAS --
genes like me logo Genes that share ontologies with APOC4: view

No data available for SIGNOR curated interactions for APOC4 Gene

Drugs & Compounds for APOC4 Gene

No Compound Related Data Available

Transcripts for APOC4 Gene

mRNA/cDNA for APOC4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(305) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOC4 Gene

Apolipoprotein C-IV:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOC4 Gene

No ASD Table

Relevant External Links for APOC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APOC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOC4 Gene

Protein differential expression in normal tissues from HIPED for APOC4 Gene

This gene is overexpressed in Serum (38.5), Synovial fluid (22.1), and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOC4 Gene

Protein tissue co-expression partners for APOC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of APOC4 Gene:


SOURCE GeneReport for Unigene cluster for APOC4 Gene:


mRNA Expression by UniProt/SwissProt for APOC4 Gene:

Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for APOC4 Gene

  • Liver(4.2)
  • Bone marrow(4)
  • Lung(4)
genes like me logo Genes that share expression patterns with APOC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOC4 Gene

Orthologs for APOC4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia APOC4 33
  • 97.9 (n)
-- 34
  • 95 (a)
(Canis familiaris)
Mammalia APOC4 33
  • 76.81 (n)
-- 34
  • 60 (a)
(Bos Taurus)
Mammalia APOC4 33 34
  • 74.02 (n)
(Rattus norvegicus)
Mammalia Apoc4 33
  • 73.39 (n)
(Mus musculus)
Mammalia Apoc4 33 16 34
  • 70.7 (n)
Species where no ortholog for APOC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOC4 Gene

Gene Tree for APOC4 (if available)
Gene Tree for APOC4 (if available)

Paralogs for APOC4 Gene

Paralogs for APOC4 Gene

(1) SIMAP similar genes for APOC4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with APOC4: view

Variants for APOC4 Gene

Sequence variations from dbSNP and Humsavar for APOC4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_036540 A breast cancer sample
rs1000679121 -- 44,940,346(+) ACCCC(A/G)TCTCT upstream-variant-2KB
rs1001298444 -- 44,943,164(+) GATCC(A/G)CCTGC intron-variant
rs1001772246 -- 44,942,988(+) GTGAT(A/C)TTGGC intron-variant
rs1001925585 -- 44,940,301(+) ATCAC(A/G)AGGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for APOC4 Gene

Variant ID Type Subtype PubMed ID
nsv509747 CNV insertion 20534489

Variation tolerance for APOC4 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.27; 81.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOC4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOC4 Gene

Disorders for APOC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for APOC4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
artery disease
  • arteriopathic disease
- elite association - COSMIC cancer census association via MalaCards
Search APOC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for APOC4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with APOC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APOC4 Gene

Publications for APOC4 Gene

  1. Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus. (PMID: 8530039) Allan CM … Taylor JM (Genomics 1995) 2 3 4 22 60
  2. DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile. (PMID: 10996355) Kamboh MI … Hamman RF (Atherosclerosis 2000) 3 4 22 60
  3. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 45 60
  4. APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men. (PMID: 20498921) Ken-Dror G … Drenos F (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B … Franks PW (Diabetologia 2010) 3 45 60

Products for APOC4 Gene

Sources for APOC4 Gene

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