Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IFNAR2 Gene

Aliases for IFNAR2 Gene

  • Interferon Alpha And Beta Receptor Subunit 2 2 3 5
  • Interferon (Alpha, Beta And Omega) Receptor 2 2 3
  • Interferon Alpha Binding Protein 3 4
  • Type I Interferon Receptor 2 3 4
  • IFN-Alpha/Beta Receptor 2 3 4
  • IFN-R-2 3 4
  • IFNABR 3 4
  • IFNARB 3 4
  • Interferon-Alpha/Beta Receptor Beta Chain 3
  • Human Interferon Alpha/Beta Receptor 3
  • Interferon Alpha/Beta Receptor 2 3
  • IFN-Alpha Binding Protein 4
  • Interferon Receptor 3
  • IFN-Alpha-REC 3
  • IFN-R 3
  • IMD45 3

External Ids for IFNAR2 Gene

Previous HGNC Symbols for IFNAR2 Gene

  • IFNABR

Previous GeneCards Identifiers for IFNAR2 Gene

  • GC21P031179
  • GC21P033522
  • GC21P033524
  • GC21P034602
  • GC21P020067

Summaries for IFNAR2 Gene

Entrez Gene Summary for IFNAR2 Gene

  • The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNAR2 Gene

IFNAR2 (Interferon Alpha And Beta Receptor Subunit 2) is a Protein Coding gene. Diseases associated with IFNAR2 include Measles and Hepatitis C. Among its related pathways are Type I Interferon Signaling Pathways and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include protein kinase binding and type I interferon binding.

UniProtKB/Swiss-Prot for IFNAR2 Gene

  • Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).

Gene Wiki entry for IFNAR2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNAR2 Gene

Genomics for IFNAR2 Gene

Regulatory Elements for IFNAR2 Gene

Enhancers for IFNAR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G033298 1.9 FANTOM5 Ensembl ENCODE dbSUPER 26.3 +71.1 71072 4.7 PKNOX1 FOXA2 ATF1 TCF12 ZNF766 GATA2 ZNF143 KLF13 CAVIN1 TBX21 IFNAR1 IFNAR2 IL10RB IFNGR2 ENSG00000249624 GART TMEM50B URB1 SON OLIG1
GH21G033304 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.7 +75.0 75006 1.8 PKNOX1 ATF1 YY1 TCF12 ZNF766 GATA2 ELK1 NCOA1 PPARG ZNF592 IFNAR2 IFNAR1 IL10RB ENSG00000249624 IFNGR2 GART SON OLIG1 OLIG2
GH21G033201 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.3 -25.9 -25934 4.5 HDGF PKNOX1 SIN3A DMAP1 ZNF48 YY1 FOS ZNF548 MCM3 ZNF662 EVA1C IFNAR2 IFNGR2 MIS18A OLIG2 ENSG00000249624 LINC01548 ENSG00000226433 OLIG1 C21orf62-AS1
GH21G033400 1.7 FANTOM5 ENCODE dbSUPER 19.6 +174.1 174055 6.7 FOXA2 MLX CREB3L1 AGO1 WRNIP1 ARID4B SIN3A ZNF2 YY1 FOS IFNGR2 TMEM50B IFNAR2 RPS5P3 ENSG00000231355 ENSG00000249624 DNAJC28 IL10RB GART IFNAR1
GH21G033359 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.2 +131.6 131583 3.1 HDGF PKNOX1 ARID4B ZNF48 ZNF2 YY1 GATA2 ZNF143 ZNF207 FOS IFNGR2 IFNAR2 IFNAR1 IL10RB GART SON OLIG1 GC21P033366 USF1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IFNAR2 on UCSC Golden Path with GeneCards custom track

Promoters for IFNAR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000141519 605 2201 HDGF PKNOX1 WRNIP1 SIN3A ZNF2 ZNF143 ZNF207 ZNF263 SP3 JUNB

Transcription factor binding sites by QIAGEN in the IFNAR2 gene promoter:

Genomic Location for IFNAR2 Gene

Chromosome:
21
Start:
33,229,895 bp from pter
End:
33,265,675 bp from pter
Size:
35,781 bases
Orientation:
Plus strand

Genomic View for IFNAR2 Gene

Genes around IFNAR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNAR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNAR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNAR2 Gene

Proteins for IFNAR2 Gene

  • Protein details for IFNAR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48551-INAR2_HUMAN
    Recommended name:
    Interferon alpha/beta receptor 2
    Protein Accession:
    P48551
    Secondary Accessions:
    • A8KAJ4
    • D3DSE8
    • D3DSE9
    • Q15467
    • Q6FHD7

    Protein attributes for IFNAR2 Gene

    Size:
    515 amino acids
    Molecular mass:
    57759 Da
    Quaternary structure:
    • Heterodimer with IFNAR1 (PubMed:8181059, PubMed:7665574, PubMed:10049744, PubMed:24075985, PubMed:21854986). Isoform 1 interacts with the transcriptional factors STAT1 and STAT2 (PubMed:9121453). Interacts with JAK1 (PubMed:8181059, PubMed:7759950).

    Three dimensional structures from OCA and Proteopedia for IFNAR2 Gene

    Alternative splice isoforms for IFNAR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFNAR2 Gene

Post-translational modifications for IFNAR2 Gene

  • Glycosylated.
  • Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
  • Glycosylation at isoforms=2, 358, posLast=8787, isoforms=2, 3116, isoforms=2, 3188, and posLast=192192
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for IFNAR2 (IFN-alpha/beta R2)
  • Abcam antibodies for IFNAR2
  • Cloud-Clone Corp. Antibodies for IFNAR2

No data available for DME Specific Peptides for IFNAR2 Gene

Domains & Families for IFNAR2 Gene

Gene Families for IFNAR2 Gene

Protein Domains for IFNAR2 Gene

Suggested Antigen Peptide Sequences for IFNAR2 Gene

Graphical View of Domain Structure for InterPro Entry

P48551

UniProtKB/Swiss-Prot:

INAR2_HUMAN :
  • Belongs to the type II cytokine receptor family.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IFNAR2: view

Function for IFNAR2 Gene

Molecular function for IFNAR2 Gene

GENATLAS Biochemistry:
interferon alpha/beta (type I) receptor,beta subunit,identified by monoclonal antibody IFNAR beta 1,cytokin receptor family II,member
UniProtKB/Swiss-Prot Function:
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).

Gene Ontology (GO) - Molecular Function for IFNAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004905 type I interferon receptor activity IDA 7665574
GO:0005515 protein binding IPI 7665574
GO:0019901 protein kinase binding IPI 7759950
genes like me logo Genes that share ontologies with IFNAR2: view
genes like me logo Genes that share phenotypes with IFNAR2: view

Animal Models for IFNAR2 Gene

MGI Knock Outs for IFNAR2:

Animal Model Products

miRNA for IFNAR2 Gene

miRTarBase miRNAs that target IFNAR2

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for IFNAR2 (IFN-alpha/beta R2)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFNAR2 Gene

Localization for IFNAR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNAR2 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNAR2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IFNAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 7588638
GO:0005615 extracellular space IEA --
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 7759950
genes like me logo Genes that share ontologies with IFNAR2: view

Pathways & Interactions for IFNAR2 Gene

genes like me logo Genes that share pathways with IFNAR2: view

SIGNOR curated interactions for IFNAR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IFNAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0007166 cell surface receptor signaling pathway TAS 8798579
GO:0007259 JAK-STAT cascade TAS 7588638
GO:0008283 cell proliferation IEA --
GO:0009615 response to virus TAS 7588638
genes like me logo Genes that share ontologies with IFNAR2: view

Drugs & Compounds for IFNAR2 Gene

(14) Drugs for IFNAR2 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Interferon Alfa-2a, Recombinant Approved Pharma binder, Target 0
Interferon Alfa-2b, Recombinant Approved Pharma binder, Target 0
Interferon alfacon-1 Approved Pharma binder, Target 13
Interferon alfa-n1 Approved Pharma binder, Target, agonist 0
Interferon alfa-n3 Approved, Investigational Pharma binder, Target, agonist 0

(6) Additional Compounds for IFNAR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNAR2: view

Transcripts for IFNAR2 Gene

Unigene Clusters for IFNAR2 Gene

Interferon (alpha, beta and omega) receptor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for IFNAR2 (IFN-alpha/beta R2)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNAR2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: -
SP7: -
SP8: -
SP9: - -

Relevant External Links for IFNAR2 Gene

GeneLoc Exon Structure for
IFNAR2
ECgene alternative splicing isoforms for
IFNAR2

Expression for IFNAR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNAR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFNAR2 Gene

This gene is overexpressed in Whole Blood (x6.5).

Protein differential expression in normal tissues from HIPED for IFNAR2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IFNAR2 Gene



Protein tissue co-expression partners for IFNAR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IFNAR2 Gene:

IFNAR2

SOURCE GeneReport for Unigene cluster for IFNAR2 Gene:

Hs.708195

mRNA Expression by UniProt/SwissProt for IFNAR2 Gene:

P48551-INAR2_HUMAN
Tissue specificity: Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.

Evidence on tissue expression from TISSUES for IFNAR2 Gene

  • Blood(4.4)
  • Spleen(2.5)
genes like me logo Genes that share expression patterns with IFNAR2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNAR2 Gene

Orthologs for IFNAR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNAR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNAR2 34 35
  • 98.58 (n)
dog
(Canis familiaris)
Mammalia IFNAR2 34
  • 73.59 (n)
-- 35
  • 58 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
cow
(Bos Taurus)
Mammalia IFNAR2 34 35
  • 73.29 (n)
rat
(Rattus norvegicus)
Mammalia Ifnar2 34
  • 66.67 (n)
mouse
(Mus musculus)
Mammalia Ifnar2 34 16 35
  • 64.91 (n)
oppossum
(Monodelphis domestica)
Mammalia IFNAR2 35
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFNAR2 35
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves IFNAR2 34 35
  • 44.8 (n)
lizard
(Anolis carolinensis)
Reptilia IFNAR2 35
  • 22 (a)
OneToOne
Species where no ortholog for IFNAR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNAR2 Gene

ENSEMBL:
Gene Tree for IFNAR2 (if available)
TreeFam:
Gene Tree for IFNAR2 (if available)

Paralogs for IFNAR2 Gene

No data available for Paralogs for IFNAR2 Gene

Variants for IFNAR2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNAR2 Gene

INAR2_HUMAN-P48551
Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].

Sequence variations from dbSNP and Humsavar for IFNAR2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs775739391 Pathogenic 33,246,807(+) ACACG(-/A)GGCCT reference, frameshift-variant
rs2229207 other 33,241,945(+) TGCCT(C/T)CATCT reference, missense
rs1000001509 -- 33,247,760(+) TTTCA(A/G)TTTCC intron-variant
rs1000380275 -- 33,241,600(+) AAAAA(A/G)GTTTT intron-variant
rs1000403142 -- 33,251,526(+) TGGCC(A/G)CTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IFNAR2 Gene

Variant ID Type Subtype PubMed ID
dgv7814n54 CNV loss 21841781
esv2723349 CNV deletion 23290073
esv2723351 CNV deletion 23290073
esv990908 CNV deletion 20482838
nsv1136627 CNV deletion 24896259
nsv587367 CNV loss 21841781
nsv587368 CNV loss 21841781
nsv587369 CNV loss 21841781
nsv587370 CNV loss 21841781
nsv587371 CNV loss 21841781
nsv587372 CNV loss 21841781
nsv587373 CNV loss 21841781

Variation tolerance for IFNAR2 Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNAR2 Gene

Human Gene Mutation Database (HGMD)
IFNAR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNAR2

Disorders for IFNAR2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for IFNAR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
measles
  • morbilli
hepatitis c
  • chronic hepatitis c
coronary aneurysm
  • aneurysm of coronary vessels
heart aneurysm
  • cardiac aneurysm
hepatitis
  • hepatitis a
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

INAR2_HUMAN
  • Immunodeficiency 45 (IMD45) [MIM:616669]: An autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination. {ECO:0000269 PubMed:26424569}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IFNAR2

Genetic Association Database (GAD)
IFNAR2
Human Genome Epidemiology (HuGE) Navigator
IFNAR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNAR2
genes like me logo Genes that share disorders with IFNAR2: view

No data available for Genatlas for IFNAR2 Gene

Publications for IFNAR2 Gene

  1. The human interferon alpha/beta receptor: characterization and molecular cloning. (PMID: 8181059) Novick D. … Rubinstein M. (Cell 1994) 2 3 4 22 64
  2. IFNAR1 and IFNAR2 polymorphisms in patients with BehAset's disease. (PMID: 19796549) Pay S. … Dinc A. (Clin. Exp. Rheumatol. 2009) 3 22 46 64
  3. IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. (PMID: 15885318) Leyva L. … Matesanz F. (J. Neuroimmunol. 2005) 3 22 46 64
  4. The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. (PMID: 12842042) Chill J.H. … Anglister J. (Structure 2003) 3 4 22 64
  5. Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. (PMID: 7588638) Lutfalla G. … Uze G. (EMBO J. 1995) 3 4 22 64

Products for IFNAR2 Gene

Sources for IFNAR2 Gene

Content
Loading form....