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Aliases for APOC3 Gene

Aliases for APOC3 Gene

  • Apolipoprotein C-III 2 3
  • Apolipoprotein C3 3 4
  • Apo-CIII 3 4
  • ApoC-III 3 4
  • HALP2 3 6
  • APOCIII 3

External Ids for APOC3 Gene

Summaries for APOC3 Gene

Entrez Gene Summary for APOC3 Gene

  • Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOC3 Gene

APOC3 (Apolipoprotein C-III) is a Protein Coding gene. Diseases associated with APOC3 include apolipoprotein c-iii deficiency and hyperalphalipoproteinemia. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include phospholipid binding and enzyme regulator activity.

UniProtKB/Swiss-Prot for APOC3 Gene

  • Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.

Gene Wiki entry for APOC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOC3 Gene

Genomics for APOC3 Gene

Genomic Location for APOC3 Gene

Start:
116,829,706 bp from pter
End:
116,833,072 bp from pter
Size:
3,367 bases
Orientation:
Plus strand

Genomic View for APOC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOC3 Gene

Regulatory Elements for APOC3 Gene

Proteins for APOC3 Gene

  • Protein details for APOC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02656-APOC3_HUMAN
    Recommended name:
    Apolipoprotein C-III
    Protein Accession:
    P02656
    Secondary Accessions:
    • Q08E83
    • Q6Q786

    Protein attributes for APOC3 Gene

    Size:
    99 amino acids
    Molecular mass:
    10852 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for APOC3 Gene

neXtProt entry for APOC3 Gene

Proteomics data for APOC3 Gene at MOPED

Post-translational modifications for APOC3 Gene

  • The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr94

Other Protein References for APOC3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for APOC3 Gene

Domains for APOC3 Gene

Gene Families for APOC3 Gene

HGNC:

Protein Domains for APOC3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

APOC3_HUMAN
Family:
  • Belongs to the apolipoprotein C3 family.:
    • P02656
genes like me logo Genes that share domains with APOC3: view

Function for APOC3 Gene

Molecular function for APOC3 Gene

GENATLAS Biochemistry: apolipoprotein C-III,major component of VLDL,associated with isolated low high density lipoprotein cholesterol
UniProtKB/Swiss-Prot Function: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.

Gene Ontology (GO) - Molecular Function for APOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005543 phospholipid binding IDA 11060345
GO:0008289 lipid binding --
GO:0015485 cholesterol binding IC 11162594
GO:0030234 enzyme regulator activity IDA 11060345
GO:0055102 lipase inhibitor activity IDA 15576844
genes like me logo Genes that share ontologies with APOC3: view
genes like me logo Genes that share phenotypes with APOC3: view

Animal Models for APOC3 Gene

MGI Knock Outs for APOC3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for APOC3 Gene

Localization for APOC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOC3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOC3 Gene COMPARTMENTS Subcellular localization image for APOC3 gene
Compartment Confidence
extracellular 5
endosome 4
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for APOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 11060345
GO:0005769 early endosome TAS --
GO:0034361 very-low-density lipoprotein particle IDA 16935699
GO:0034363 intermediate-density lipoprotein particle IDA 17336988
genes like me logo Genes that share ontologies with APOC3: view

Pathways for APOC3 Gene

genes like me logo Genes that share pathways with APOC3: view

Pathways by source for APOC3 Gene

1 PharmGKB pathway for APOC3 Gene
1 KEGG pathway for APOC3 Gene

Gene Ontology (GO) - Biological Process for APOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006641 triglyceride metabolic process IMP 17142127
GO:0006642 triglyceride mobilization IEA --
GO:0006869 lipid transport --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with APOC3: view

Compounds for APOC3 Gene

(52) Novoseek inferred chemical compound relationships for APOC3 Gene

Compound -log(P) Hits PubMed IDs
sele 78.1 3
cholesterol 76.5 97
lipid 73.8 77
mspi 69.2 14
fenofibrate 62.4 7

(1) PharmGKB related drug/compound annotations for APOC3 Gene

Drug/compound Annotation
ritonavir CA
genes like me logo Genes that share compounds with APOC3: view

Transcripts for APOC3 Gene

mRNA/cDNA for APOC3 Gene

Unigene Clusters for APOC3 Gene

Apolipoprotein C-III:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOC3 Gene

No ASD Table

Relevant External Links for APOC3 Gene

GeneLoc Exon Structure for
APOC3
ECgene alternative splicing isoforms for
APOC3

Expression for APOC3 Gene

mRNA expression in normal human tissues for APOC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOC3 Gene

This gene is overexpressed in Liver (51.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for APOC3 Gene

SOURCE GeneReport for Unigene cluster for APOC3 Gene Hs.73849

mRNA Expression by UniProt/SwissProt for APOC3 Gene

P02656-APOC3_HUMAN
Tissue specificity: Liver.
genes like me logo Genes that share expressions with APOC3: view

Orthologs for APOC3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOC3 36
  • 97.98 (n)
  • 96.97 (a)
APOC3 37
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOC3 36
  • 82.17 (n)
  • 69.77 (a)
APOC3 37
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOC3 36
  • 83.84 (n)
  • 73.74 (a)
APOC3 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apoc3 16
Apoc3 37
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APOC3 37
  • 46 (a)
OneToOne
Species with no ortholog for APOC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOC3 Gene

ENSEMBL:
Gene Tree for APOC3 (if available)
TreeFam:
Gene Tree for APOC3 (if available)

Paralogs for APOC3 Gene

No data available for Paralogs for APOC3 Gene

Variants for APOC3 Gene

Sequence variations from dbSNP and Humsavar for APOC3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4225 -- 116,832,955(+) GGGCT(G/T)CCCCT utr-variant-3-prime
rs4520 -- 116,830,819(+) CAGGG(C/T)TACAT synonymous-codon, reference
rs5128 -- 116,832,924(-) GAGCT(C/G)GCAGG utr-variant-3-prime
rs5129 -- 116,832,748(-) CAGGG(A/G)AAGCA intron-variant
rs5130 -- 116,832,430(+) CCAGG(C/T)GGTGC intron-variant

Relevant External Links for APOC3 Gene

HapMap Linkage Disequilibrium report
APOC3
Human Gene Mutation Database (HGMD)
APOC3

No data available for Structural Variations from Database of Genomic Variants (DGV) for APOC3 Gene

Disorders for APOC3 Gene

(1) OMIM Diseases for APOC3 Gene (107720)

UniProtKB/Swiss-Prot

APOC3_HUMAN
  • Hyperalphalipoproteinemia 2 (HALP2) [MIM:614028]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. {ECO:0000269 PubMed:2022742}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(36) Novoseek inferred disease relationships for APOC3 Gene

Disease -log(P) Hits PubMed IDs
hypertriglyceridemia 86.5 65
hyperlipidemia familial combined 74.6 4
dyslipidemia 72.6 21
hypertriglyceridemias familial 64.3 2
coronary heart disease 60.3 14

Genatlas disease for APOC3 Gene

hyperalphalipoproteinemia with an APOC-III variant

Relevant External Links for APOC3

Genetic Association Database (GAD)
APOC3
Human Genome Epidemiology (HuGE) Navigator
APOC3
genes like me logo Genes that share disorders with APOC3: view

Publications for APOC3 Gene

  1. Apolipoprotein C-III(Lys-58-->Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia. (PMID: 2022742) von Eckardstein A. … Assmann G. (J. Clin. Invest. 1991) 3 4 23
  2. Contribution of apolipoprotein C-III gene variants to determination of triglyceride levels and interaction with smoking in middle-aged men. (PMID: 11116069) Waterworth D.M. … Humphries S.E. (Arterioscler. Thromb. Vasc. Biol. 2000) 3 23 49
  3. Severe hypertriglyceridaemia in Type II diabetes: involvement of apoC-III Sst-I polymorphism, LPL mutations and apo E3 deficiency. (PMID: 11126401) MarAsais C. … Moulin P. (Diabetologia 2000) 3 23 49
  4. Common genetic variants that relate to disorders of lipid transport in Spanish subjects with premature coronary artery disease. (PMID: 11171287) Masana L. … Galton D.J. (Clin. Sci. 2001) 3 23 49
  5. New genetic variants in the apoA-I and apoC-III genes and familial combined hyperlipidemia. (PMID: 11181747) Groenendijk M. … Dallinga-Thie G.M. (J. Lipid Res. 2001) 3 23 49

Products for APOC3 Gene

Sources for APOC3 Gene

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