Aliases for APOC3 Gene
External Ids for APOC3 Gene
Previous GeneCards Identifiers for APOC3 Gene
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
GeneCards Summary for APOC3 Gene
APOC3 (Apolipoprotein C3) is a Protein Coding gene. Diseases associated with APOC3 include apolipoprotein c-iii deficiency and hyperalphalipoproteinemia. Among its related pathways are Signaling by GPCR and Lipoprotein metabolism. GO annotations related to this gene include lipid binding and cholesterol binding.
UniProtKB/Swiss-Prot for APOC3 Gene
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.