Free for academic non-profit institutions. Other users need a Commercial license

Aliases for APOC3 Gene

Aliases for APOC3 Gene

  • Apolipoprotein C3 2 3 4
  • Apolipoprotein C-III 2 5
  • Apo-CIII 3 4
  • ApoC-III 3 4
  • APOCIII 3
  • HALP2 3

External Ids for APOC3 Gene

Previous GeneCards Identifiers for APOC3 Gene

  • GC11P119053
  • GC11P118212
  • GC11P116734
  • GC11P116238
  • GC11P116205
  • GC11P116700
  • GC11P112632

Summaries for APOC3 Gene

Entrez Gene Summary for APOC3 Gene

  • Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOC3 Gene

APOC3 (Apolipoprotein C3) is a Protein Coding gene. Diseases associated with APOC3 include Apolipoprotein C-Iii Deficiency and Hyperalphalipoproteinemia. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include lipid binding and cholesterol binding.

UniProtKB/Swiss-Prot for APOC3 Gene

  • Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.

Gene Wiki entry for APOC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOC3 Gene

Genomics for APOC3 Gene

Regulatory Elements for APOC3 Gene

Enhancers for APOC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around APOC3 on UCSC Golden Path with GeneCards custom track

Promoters for APOC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APOC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for APOC3 Gene

Chromosome:
11
Start:
116,829,706 bp from pter
End:
116,833,072 bp from pter
Size:
3,367 bases
Orientation:
Plus strand

Genomic View for APOC3 Gene

Genes around APOC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOC3 Gene

Proteins for APOC3 Gene

  • Protein details for APOC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02656-APOC3_HUMAN
    Recommended name:
    Apolipoprotein C-III
    Protein Accession:
    P02656
    Secondary Accessions:
    • Q08E83
    • Q6Q786

    Protein attributes for APOC3 Gene

    Size:
    99 amino acids
    Molecular mass:
    10852 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for APOC3 Gene

neXtProt entry for APOC3 Gene

Proteomics data for APOC3 Gene at MOPED

Post-translational modifications for APOC3 Gene

  • The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.
  • Glycosylation at Thr 94
  • Modification sites at PhosphoSitePlus

Other Protein References for APOC3 Gene

Antibody Products

No data available for DME Specific Peptides for APOC3 Gene

Domains & Families for APOC3 Gene

Gene Families for APOC3 Gene

Protein Domains for APOC3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOC3 Gene

Graphical View of Domain Structure for InterPro Entry

P02656

UniProtKB/Swiss-Prot:

APOC3_HUMAN :
  • Belongs to the apolipoprotein C3 family.
Family:
  • Belongs to the apolipoprotein C3 family.
genes like me logo Genes that share domains with APOC3: view

Function for APOC3 Gene

Molecular function for APOC3 Gene

GENATLAS Biochemistry:
apolipoprotein C-III,major component of VLDL,associated with isolated low high density lipoprotein cholesterol
UniProtKB/Swiss-Prot Function:
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.

Gene Ontology (GO) - Molecular Function for APOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070653 high-density lipoprotein particle receptor binding IPI 9254056
genes like me logo Genes that share ontologies with APOC3: view
genes like me logo Genes that share phenotypes with APOC3: view

Human Phenotype Ontology for APOC3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for APOC3 Gene

Localization for APOC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOC3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOC3 Gene COMPARTMENTS Subcellular localization image for APOC3 gene
Compartment Confidence
extracellular 5
endosome 4
nucleus 2
peroxisome 2
cytosol 1

Gene Ontology (GO) - Cellular Components for APOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome TAS --
GO:0034363 intermediate-density lipoprotein particle IDA 17336988
genes like me logo Genes that share ontologies with APOC3: view

Pathways & Interactions for APOC3 Gene

genes like me logo Genes that share pathways with APOC3: view

Pathways by source for APOC3 Gene

1 PharmGKB pathway for APOC3 Gene
1 KEGG pathway for APOC3 Gene

Gene Ontology (GO) - Biological Process for APOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006641 triglyceride metabolic process IMP 17142127
GO:0006869 lipid transport IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA 16443932
GO:0007584 response to nutrient IEA --
genes like me logo Genes that share ontologies with APOC3: view

No data available for SIGNOR curated interactions for APOC3 Gene

Drugs & Compounds for APOC3 Gene

(26) Drugs for APOC3 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ritonavir Approved, Investigational Pharma HIV protease inhibitor 853

(29) Additional Compounds for APOC3 Gene - From: Novoseek and HMDB