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Aliases for IFNA4 Gene

Aliases for IFNA4 Gene

  • Interferon, Alpha 4 2 3 5
  • Interferon Alpha-4B 3 4
  • Interferon Alpha-76 3 4
  • Interferon Alpha-M1 3 4
  • IFN-Alpha-4 3 4
  • IFN-Alpha4a 3
  • INFA4 3

External Ids for IFNA4 Gene

Previous GeneCards Identifiers for IFNA4 Gene

  • GC09M021514
  • GC09M021387
  • GC09M021176
  • GC09M021149

Summaries for IFNA4 Gene

GeneCards Summary for IFNA4 Gene

IFNA4 (Interferon, Alpha 4) is a Protein Coding gene. Diseases associated with IFNA4 include Rabies. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Allograft rejection. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA4 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA4 Gene

Genomics for IFNA4 Gene

Regulatory Elements for IFNA4 Gene


Genomic Location for IFNA4 Gene

Chromosome:
9
Start:
21,186,618 bp from pter
End:
21,228,173 bp from pter
Size:
41,556 bases
Orientation:
Minus strand

Genomic View for IFNA4 Gene

Genes around IFNA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA4 Gene

Proteins for IFNA4 Gene

  • Protein details for IFNA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05014-IFNA4_HUMAN
    Recommended name:
    Interferon alpha-4
    Protein Accession:
    P05014
    Secondary Accessions:
    • P13358
    • Q14CS4
    • Q5VV15

    Protein attributes for IFNA4 Gene

    Size:
    189 amino acids
    Molecular mass:
    21808 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA4 Gene

Proteomics data for IFNA4 Gene at MOPED

Post-translational modifications for IFNA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IFNA4

No data available for DME Specific Peptides for IFNA4 Gene

Domains & Families for IFNA4 Gene

Gene Families for IFNA4 Gene

Suggested Antigen Peptide Sequences for IFNA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05014

UniProtKB/Swiss-Prot:

IFNA4_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA4: view

Function for IFNA4 Gene

Molecular function for IFNA4 Gene

GENATLAS Biochemistry:
interferon type I,alpha 4,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
genes like me logo Genes that share phenotypes with IFNA4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA4 Gene

Localization for IFNA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA4 Gene COMPARTMENTS Subcellular localization image for IFNA4 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for IFNA4 Gene

Pathways & Interactions for IFNA4 Gene

genes like me logo Genes that share pathways with IFNA4: view

Gene Ontology (GO) - Biological Process for IFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0007596 blood coagulation TAS --
GO:0009615 response to virus TAS 3891272
GO:0019221 cytokine-mediated signaling pathway IBA,TAS --
genes like me logo Genes that share ontologies with IFNA4: view

No data available for SIGNOR curated interactions for IFNA4 Gene

Drugs & Compounds for IFNA4 Gene

No Compound Related Data Available

Transcripts for IFNA4 Gene

mRNA/cDNA for IFNA4 Gene

(1) REFSEQ mRNAs :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA4 Gene

No ASD Table

Relevant External Links for IFNA4 Gene

GeneLoc Exon Structure for
IFNA4
ECgene alternative splicing isoforms for
IFNA4

Expression for IFNA4 Gene

mRNA expression in normal human tissues for IFNA4 Gene

SOURCE GeneReport for Unigene cluster for IFNA4 Gene Hs.1510

genes like me logo Genes that share expression patterns with IFNA4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IFNA4 Gene

Orthologs for IFNA4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA4 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ifna6 35
  • 76.04 (n)
  • 63.78 (a)
Ifnab 16
Gm12597 36
  • 62 (a)
ManyToMany
Gm13280 36
  • 60 (a)
ManyToMany
Ifna1 36
  • 61 (a)
ManyToMany
Ifna11 36
  • 59 (a)
ManyToMany
Ifna12 36
  • 61 (a)
ManyToMany
Ifna13 36
  • 62 (a)
ManyToMany
Ifna14 36
  • 59 (a)
ManyToMany
Ifna2 36
  • 59 (a)
ManyToMany
Ifna4 36
  • 58 (a)
ManyToMany
Ifna5 36
  • 62 (a)
ManyToMany
Ifna6 36
  • 62 (a)
ManyToMany
Ifna7 36
  • 58 (a)
ManyToMany
Ifna9 36
  • 60 (a)
ManyToMany
Ifnab 36
  • 59 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia IFNA17 35
  • 98.94 (n)
  • 97.35 (a)
-- 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ifna2 35
  • 75.27 (n)
  • 62.37 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 63 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
IFNAA 36
  • 62 (a)
ManyToMany
IFNAG 36
  • 63 (a)
ManyToMany
IFNAG 36
  • 64 (a)
ManyToMany
IFNAH 36
  • 63 (a)
ManyToMany
INFAF 36
  • 62 (a)
ManyToMany
Species with no ortholog for IFNA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA4 Gene

ENSEMBL:
Gene Tree for IFNA4 (if available)
TreeFam:
Gene Tree for IFNA4 (if available)

Paralogs for IFNA4 Gene

(18) SIMAP similar genes for IFNA4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA4: view

Variants for IFNA4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA4 Gene

IFNA4_HUMAN-P05014
Two forms exist; alpha-4a (shown here) and alpha-4b (PubMed:9335434). They seem to be equally abundant (PubMed:9335434).

Sequence variations from dbSNP and Humsavar for IFNA4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1062571 - 21,187,312(-) AGAAG(A/G)CTCAA reference, missense
rs3750480 - 21,187,122(+) AGTCC(A/T)CATTC reference, missense
rs201964250 - 21,187,386(+) AGAAA(G/T)GAGAG reference, missense
rs1062562 -- 21,187,508(-) TTACT(G/T)ATGGC reference, synonymous-codon
rs1062574 -- 21,187,116(-) GGACT(C/T)CATCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IFNA4 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
nsv892734 CNV Gain 21882294
nsv892735 CNV Loss 21882294
esv2738274 CNV Deletion 23290073
esv2738275 CNV Deletion 23290073
dgv2297e1 CNV Complex 17122850

Variation tolerance for IFNA4 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNA4 Gene

Human Gene Mutation Database (HGMD)
IFNA4

Disorders for IFNA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFNA4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rabies
  • lyssa
- elite association - COSMIC cancer census association via MalaCards
Search IFNA4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFNA4

Genetic Association Database (GAD)
IFNA4
Human Genome Epidemiology (HuGE) Navigator
IFNA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNA4
genes like me logo Genes that share disorders with IFNA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA4 Gene

Publications for IFNA4 Gene

  1. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 48 67
  2. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 3
  3. HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms. (PMID: 25972534) Reszka-Blanco N.J. … Su L. (J. Virol. 2015) 3
  4. Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients. (PMID: 26000985) Xiao C.X. … Guleng B. (Sci Rep 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for IFNA4 Gene

Sources for IFNA4 Gene

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