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Aliases for APOC2 Gene

Aliases for APOC2 Gene

  • Apolipoprotein C2 2 3 4
  • Apolipoprotein C-II 2 5
  • APO-CII 3 4
  • APOC-II 3 4
  • APC2 4

External Ids for APOC2 Gene

Previous GeneCards Identifiers for APOC2 Gene

  • GC19P046094
  • GC19P045840
  • GC19P050125
  • GC19P050141
  • GC19P050138
  • GC19P045449
  • GC19P041879

Summaries for APOC2 Gene

Entrez Gene Summary for APOC2 Gene

  • This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for APOC2 Gene

APOC2 (Apolipoprotein C2) is a Protein Coding gene. Diseases associated with APOC2 include hyperlipoproteinemia, type ib and hypertriglyceridemia. Among its related pathways are Signaling by GPCR and Lipoprotein metabolism. GO annotations related to this gene include protein homodimerization activity and enzyme activator activity. An important paralog of this gene is APOC4-APOC2.

UniProtKB/Swiss-Prot for APOC2 Gene

  • Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.

Gene Wiki entry for APOC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOC2 Gene

Genomics for APOC2 Gene

Regulatory Elements for APOC2 Gene

Promoters for APOC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APOC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for APOC2 Gene

Chromosome:
19
Start:
44,945,982 bp from pter
End:
44,949,565 bp from pter
Size:
3,584 bases
Orientation:
Plus strand

Genomic View for APOC2 Gene

Genes around APOC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOC2 Gene

Proteins for APOC2 Gene

  • Protein details for APOC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02655-APOC2_HUMAN
    Recommended name:
    Apolipoprotein C-II
    Protein Accession:
    P02655
    Secondary Accessions:
    • C0JYY4
    • Q9BS39
    • Q9UDE3
    • Q9UNK3

    Protein attributes for APOC2 Gene

    Size:
    101 amino acids
    Molecular mass:
    11284 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for APOC2 Gene

neXtProt entry for APOC2 Gene

Proteomics data for APOC2 Gene at MOPED

Post-translational modifications for APOC2 Gene

  • Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
  • Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOC2 Gene

Antibody Products

  • R&D Systems Antibodies for APOC2 (Apolipoprotein C-II/ApoC2)

No data available for DME Specific Peptides for APOC2 Gene

Domains & Families for APOC2 Gene

Gene Families for APOC2 Gene

Protein Domains for APOC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02655

UniProtKB/Swiss-Prot:

APOC2_HUMAN :
  • Belongs to the apolipoprotein C2 family.
Family:
  • Belongs to the apolipoprotein C2 family.
genes like me logo Genes that share domains with APOC2: view

Function for APOC2 Gene

Molecular function for APOC2 Gene

GENATLAS Biochemistry:
apolipoprotein C-II,component of VLDL,activator of several tri-acylglycerollipases
UniProtKB/Swiss-Prot Function:
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.
genes like me logo Genes that share phenotypes with APOC2: view

Human Phenotype Ontology for APOC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for APOC2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for APOC2 Gene

Localization for APOC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOC2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOC2 Gene COMPARTMENTS Subcellular localization image for APOC2 gene
Compartment Confidence
extracellular 5
endosome 4
nucleus 1

Gene Ontology (GO) - Cellular Components for APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome TAS --
GO:0034363 intermediate-density lipoprotein particle IDA 17336988
genes like me logo Genes that share ontologies with APOC2: view

Pathways & Interactions for APOC2 Gene

genes like me logo Genes that share pathways with APOC2: view

Interacting Proteins for APOC2 Gene

Gene Ontology (GO) - Biological Process for APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006629 lipid metabolic process IEA --
GO:0006869 lipid transport IEA --
GO:0007603 phototransduction, visible light TAS --
GO:0010518 positive regulation of phospholipase activity IDA 10727238
genes like me logo Genes that share ontologies with APOC2: view

No data available for SIGNOR curated interactions for APOC2 Gene

Drugs & Compounds for APOC2 Gene

(10) Drugs for APOC2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(23) Additional Compounds for APOC2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Triglycerides Group B
  • 1-Palmitoyl-2-palmitoyl-3-arachidonyl-glycerol
  • TAG(16:0/16:0/20:0)
  • TAG(52:0)
  • TG(16:0/16:0/20:0)
  • TG(52:0)
Triglycerides Group C
  • 1,2, 3-Propanetriyl-Decanoate
  • 1,2, 3-Propanetriyl-Decanoic acid
  • 2,3-Bis(decanoyloxy)propyl decanoate
  • 2,3-Bis(decanoyloxy)propyl decanoate (ACD/Name 4.0)
  • 2,3-Bis(decanoyloxy)propyl decanoic acid
621-71-6, 555-44-2, 30773-83-2, 122-32-7
Triglycerides Group D
  • 1-Stearoyl-2-stearoyl-3-stearoyl-glycerol
  • TAG(18:0/18:0/18:0)
  • TAG(54:0)
  • TG(18:0/18:0/18:0)
  • TG(54:0)
genes like me logo Genes that share compounds with APOC2: view

Transcripts for APOC2 Gene

mRNA/cDNA for APOC2 Gene

Unigene Clusters for APOC2 Gene

Apolipoprotein C-II:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOC2 Gene

No ASD Table

Relevant External Links for APOC2 Gene

GeneLoc Exon Structure for
APOC2
ECgene alternative splicing isoforms for
APOC2

Expression for APOC2 Gene

mRNA expression in normal human tissues for APOC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOC2 Gene

This gene is overexpressed in Liver (x50.8).

Protein differential expression in normal tissues from HIPED for APOC2 Gene

This gene is overexpressed in Serum (41.2) and Plasma (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for APOC2 Gene



SOURCE GeneReport for Unigene cluster for APOC2 Gene Hs.75615

mRNA Expression by UniProt/SwissProt for APOC2 Gene

P02655-APOC2_HUMAN
Tissue specificity: Liver and intestine.
genes like me logo Genes that share expression patterns with APOC2: view

Protein tissue co-expression partners for APOC2 Gene

Primer Products

In Situ Assay Products

Orthologs for APOC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOC2 35
  • 99.01 (n)
  • 99.01 (a)
APOC2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOC2 36
  • 69 (a)
OneToOne
APOC2 35
  • 77.23 (n)
  • 69.31 (a)
dog
(Canis familiaris)
Mammalia APOC2 35
  • 80 (n)
  • 65 (a)
APOC2 36
  • 42 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apoc2 36
  • 62 (a)
OneToOne
Apoc2 16
Apoc2 35
  • 73.54 (n)
  • 61.86 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia APOC2 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apoc2 35
  • 71.13 (n)
  • 65.98 (a)
Species with no ortholog for APOC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOC2 Gene

ENSEMBL:
Gene Tree for APOC2 (if available)
TreeFam:
Gene Tree for APOC2 (if available)

Paralogs for APOC2 Gene

Paralogs for APOC2 Gene

(1) SIMAP similar genes for APOC2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with APOC2: view

Variants for APOC2 Gene

Sequence variations from dbSNP and Humsavar for APOC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_000639 -
VAR_000640 Hyperlipoproteinemia 1B (HLPP1B)
VAR_000641 -
VAR_000642 -

Structural Variations from Database of Genomic Variants (DGV) for APOC2 Gene

Variant ID Type Subtype PubMed ID
nsv912133 CNV Loss 21882294
nsv912134 CNV Loss 21882294
nsv912140 CNV Gain 21882294

Variation tolerance for APOC2 Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOC2 Gene

HapMap Linkage Disequilibrium report
APOC2
Human Gene Mutation Database (HGMD)
APOC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOC2 Gene

Disorders for APOC2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for APOC2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hyperlipoproteinemia, type ib
  • apolipoprotein c-ii deficiency
hypertriglyceridemia
  • familial hypertriglyceridemia
familial apolipoprotein c-ii deficiency
  • familial apoc-ii deficiency
atherosclerosis
  • arteriosclerosis
pancreatitis
- elite association - COSMIC cancer census association via MalaCards
Search APOC2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

APOC2_HUMAN
  • Hyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. {ECO:0000269 PubMed:8323539}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for APOC2 Gene

hyperlipoproteinemia,type IB (CII deficiency)

Relevant External Links for APOC2

Genetic Association Database (GAD)
APOC2
Human Genome Epidemiology (HuGE) Navigator
APOC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOC2
genes like me logo Genes that share disorders with APOC2: view

Publications for APOC2 Gene

  1. Expression of the apolipoprotein C-II gene during myelomonocytic differentiation of human leukemic cells. (PMID: 11310852) Chun E.M. … Kim Y.H. (J. Leukoc. Biol. 2001) 3 4 23 67
  2. Site-directed mutagenesis of apolipoprotein CII to probe the role of its secondary structure for activation of lipoprotein lipase. (PMID: 20042600) Shen Y. … Olivecrona G. (J. Biol. Chem. 2010) 3 23
  3. Lipoprotein lipase mutation S447X associated with pancreatic calcification and steatorrhea in hyperlipidemic pancreatitis. (PMID: 19034041) Chang Y.T. … Wong J.M. (J. Clin. Gastroenterol. 2009) 3 23
  4. Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis. (PMID: 19534808) Coca-Prieto I. … GonzA!lez-Santos P. (BMC Gastroenterol 2009) 3 23
  5. Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. (PMID: 19878569) Chen S.N. … Marian A.J. (BMC Med. Genet. 2009) 3 23

Products for APOC2 Gene

Sources for APOC2 Gene

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