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Aliases for APOC2 Gene

Aliases for APOC2 Gene

  • Apolipoprotein C-II 2 3
  • Apolipoprotein C2 3 4
  • APO-CII 3 4
  • APOC-II 3 4
  • APC2 4

External Ids for APOC2 Gene

Summaries for APOC2 Gene

Entrez Gene Summary for APOC2 Gene

  • This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for APOC2 Gene

APOC2 (Apolipoprotein C-II) is a Protein Coding gene. Diseases associated with APOC2 include hyperlipoproteinemia, type ib and familial apolipoprotein c-ii deficiency. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include protein homodimerization activity and phospholipase binding.

UniProtKB/Swiss-Prot for APOC2 Gene

  • Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.

Gene Wiki entry for APOC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOC2 Gene

Genomics for APOC2 Gene

Genomic Location for APOC2 Gene

Start:
44,945,982 bp from pter
End:
44,949,565 bp from pter
Size:
3,584 bases
Orientation:
Plus strand

Genomic View for APOC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOC2 Gene

Regulatory Elements for APOC2 Gene

Proteins for APOC2 Gene

  • Protein details for APOC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02655-APOC2_HUMAN
    Recommended name:
    Apolipoprotein C-II
    Protein Accession:
    P02655
    Secondary Accessions:
    • C0JYY4
    • Q9BS39
    • Q9UDE3
    • Q9UNK3

    Protein attributes for APOC2 Gene

    Size:
    101 amino acids
    Molecular mass:
    11284 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for APOC2 Gene

neXtProt entry for APOC2 Gene

Proteomics data for APOC2 Gene at MOPED

Post-translational modifications for APOC2 Gene

  • Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
  • Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for APOC2 Gene

Domains for APOC2 Gene

Gene Families for APOC2 Gene

HGNC:

Protein Domains for APOC2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

APOC2_HUMAN
Family:
  • Belongs to the apolipoprotein C2 family.:
    • P02655
genes like me logo Genes that share domains with APOC2: view

Function for APOC2 Gene

Molecular function for APOC2 Gene

GENATLAS Biochemistry: apolipoprotein C-II,component of VLDL,activator of several tri-acylglycerollipases
UniProtKB/Swiss-Prot Function: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.

Gene Ontology (GO) - Molecular Function for APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity --
GO:0008289 lipid binding IDA 10727238
GO:0016004 phospholipase activator activity IDA 10727238
GO:0042803 protein homodimerization activity IMP 8245722
GO:0043274 phospholipase binding IPI 10727238
genes like me logo Genes that share ontologies with APOC2: view

Phenotypes for APOC2 Gene

GenomeRNAi human phenotypes for APOC2:
genes like me logo Genes that share phenotypes with APOC2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for APOC2 Gene

Localization for APOC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOC2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOC2 Gene COMPARTMENTS Subcellular localization image for APOC2 gene
Compartment Confidence
extracellular 5
endosome 4
nucleus 1

Gene Ontology (GO) - Cellular Components for APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 10727238
GO:0005769 early endosome TAS --
GO:0034361 very-low-density lipoprotein particle IDA 8245722
GO:0034362 low-density lipoprotein particle IDA 8245722
genes like me logo Genes that share ontologies with APOC2: view

Pathways for APOC2 Gene

genes like me logo Genes that share pathways with APOC2: view

Pathways by source for APOC2 Gene

Interacting Proteins for APOC2 Gene

Gene Ontology (GO) - Biological Process for APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006629 lipid metabolic process --
GO:0006869 lipid transport --
GO:0007603 phototransduction, visible light TAS --
GO:0010518 positive regulation of phospholipase activity IDA 10727238
genes like me logo Genes that share ontologies with APOC2: view

Compounds for APOC2 Gene

(289) HMDB Compounds for APOC2 Gene

Compound Synonyms Cas Number PubMed IDs
TG(10:0/10:0/10:0)[iso]
  • Tri-n-caprin
621-71-6
TG(12:0/12:0/12:0)
  • Triacylglycerol
Not Available
TG(15:0/16:0/20:2(11Z,14Z))[iso6]
  • Tracylglycerol(15:0/16:0/20:2)
Not Available
TG(15:0/16:0/20:3(8Z,11Z,14Z))[iso6]
  • TAG(15:0/16:0/20:3n6)
Not Available
TG(15:0/16:0/20:4(5Z,8Z,11Z,14Z))[iso6]
  • TAG(15:0/16:0/20:4n6)
Not Available

(30) Novoseek inferred chemical compound relationships for APOC2 Gene

Compound -log(P) Hits PubMed IDs
thioflavin t 68.4 5
cholesterol 63.4 36
lipid 63.4 42
trioleoylglycerol 54 1
dodecylphosphocholine 41.7 4
genes like me logo Genes that share compounds with APOC2: view

Transcripts for APOC2 Gene

mRNA/cDNA for APOC2 Gene

Unigene Clusters for APOC2 Gene

Apolipoprotein C-II:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOC2 Gene

No ASD Table

Relevant External Links for APOC2 Gene

GeneLoc Exon Structure for
APOC2
ECgene alternative splicing isoforms for
APOC2

Expression for APOC2 Gene

mRNA expression in normal human tissues for APOC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOC2 Gene

This gene is overexpressed in Liver (50.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for APOC2 Gene

SOURCE GeneReport for Unigene cluster for APOC2 Gene Hs.75615

mRNA Expression by UniProt/SwissProt for APOC2 Gene

P02655-APOC2_HUMAN
Tissue specificity: Liver and intestine.
genes like me logo Genes that share expressions with APOC2: view

Orthologs for APOC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOC2 36
  • 99.01 (n)
  • 99.01 (a)
APOC2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOC2 36
  • 77.23 (n)
  • 69.31 (a)
APOC2 37
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOC2 36
  • 80 (n)
  • 65 (a)
APOC2 37
  • 42 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apoc2 36
  • 73.54 (n)
  • 61.86 (a)
Apoc2 16
Apoc2 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APOC2 37
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apoc2 36
  • 71.13 (n)
  • 65.98 (a)
Species with no ortholog for APOC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOC2 Gene

ENSEMBL:
Gene Tree for APOC2 (if available)
TreeFam:
Gene Tree for APOC2 (if available)

Paralogs for APOC2 Gene

Selected SIMAP similar genes for APOC2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with APOC2: view

No data available for Paralogs for APOC2 Gene

Variants for APOC2 Gene

Sequence variations from dbSNP and Humsavar for APOC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_000639 -
VAR_000640 Hyperlipoproteinemia 1B (HLPP1B)
VAR_000641 -
VAR_000642 -

Structural Variations from Database of Genomic Variants (DGV) for APOC2 Gene

Variant ID Type Subtype PubMed ID
nsv912133 CNV Loss 21882294
nsv912134 CNV Loss 21882294
nsv912140 CNV Gain 21882294

Relevant External Links for APOC2 Gene

HapMap Linkage Disequilibrium report
APOC2
Human Gene Mutation Database (HGMD)
APOC2

Disorders for APOC2 Gene

(1) OMIM Diseases for APOC2 Gene (608083)

UniProtKB/Swiss-Prot

APOC2_HUMAN
  • Hyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. {ECO:0000269 PubMed:8323539}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for APOC2 Gene

(27) Novoseek inferred disease relationships for APOC2 Gene

Disease -log(P) Hits PubMed IDs
hypertriglyceridemia 83 28
endogenous hypertriglyceridemia 79.8 2
hyperlipoproteinemia type v 73.9 2
hypertriglyceridemias familial 71.3 4
xanthoma 67.4 1

Genatlas disease for APOC2 Gene

hyperlipoproteinemia,type IB (CII deficiency)

Relevant External Links for APOC2

Genetic Association Database (GAD)
APOC2
Human Genome Epidemiology (HuGE) Navigator
APOC2
genes like me logo Genes that share disorders with APOC2: view

Publications for APOC2 Gene

  1. An apolipoprotein CII mutation, CII Lys-19-->Thr identified in patients with hyperlipidemia. (PMID: 1782747) Hegele R.A. … Little J.A. (Dis. Markers 1991) 3 4 23
  2. Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII. (PMID: 1555583) Lycksell P.-O. … Graeslund A. (Eur. J. Biochem. 1992) 3 4 23
  3. Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing. (PMID: 2209608) Bengtsson-Olivecrona G. … Sletten K. (Eur. J. Biochem. 1990) 3 4 23
  4. The apolipoprotein C-II variant apoC-II Lys-19-->Thr is not associated with dyslipidemia in an affected kindred. (PMID: 7923858) Zysow B.R. … Kane J.P. (Clin. Genet. 1994) 3 4 23
  5. Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia. (PMID: 8490626) Pullinger C.R. … Kanr J.P. (Hum. Mol. Genet. 1993) 3 4 23

Products for APOC2 Gene

Sources for APOC2 Gene

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