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Aliases for IFNA1 Gene

Aliases for IFNA1 Gene

  • Interferon, Alpha 1 2 3
  • Interferon Alpha 1b 2 3
  • Interferon Alpha-D 3 4
  • IFN-Alpha-1/13 3 4
  • IFN-Alpha 1b 2 3
  • LeIF D 3 4
  • Interferon-Alpha1 3
  • IFNA1 IFNA13 4
  • IFN-AlphaD 3
  • IFN-ALPHA 3
  • IFNA13 3
  • IFNA@ 3
  • IFL 3
  • IFN 3

External Ids for IFNA1 Gene

Previous GeneCards Identifiers for IFNA1 Gene

  • GC09P021768
  • GC09P021641
  • GC09P021430
  • GC09P021424

Summaries for IFNA1 Gene

Entrez Gene Summary for IFNA1 Gene

  • The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Sep 2011]

GeneCards Summary for IFNA1 Gene

IFNA1 (Interferon, Alpha 1) is a Protein Coding gene. Diseases associated with IFNA1 include lung mixed small cell and squamous cell carcinoma and oral erosive lichen. Among its related pathways are PI3K-Akt signaling pathway and Immune System. GO annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.

UniProtKB/Swiss-Prot for IFNA1 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA1 Gene

Genomics for IFNA1 Gene

Regulatory Elements for IFNA1 Gene

Genomic Location for IFNA1 Gene

Chromosome:
9
Start:
21,409,169 bp from pter
End:
21,441,316 bp from pter
Size:
32,148 bases
Orientation:
Plus strand

Genomic View for IFNA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA1 Gene

Proteins for IFNA1 Gene

  • Protein details for IFNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01562-IFNA1_HUMAN
    Recommended name:
    Interferon alpha-1/13
    Protein Accession:
    P01562
    Secondary Accessions:
    • D4Q9M8
    • Q14605
    • Q2M1L8
    • Q52LB8
    • Q5VYQ2
    • Q7M4Q1
    • Q8WZ68
    • Q9UMJ3

    Protein attributes for IFNA1 Gene

    Size:
    189 amino acids
    Molecular mass:
    21725 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Interferons alpha-1 and alpha-13 have identical protein sequences

    Three dimensional structures from OCA and Proteopedia for IFNA1 Gene

neXtProt entry for IFNA1 Gene

Proteomics data for IFNA1 Gene at MOPED

Post-translational modifications for IFNA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IFNA1 (IFNA1/13)

Protein Products

No data available for DME Specific Peptides for IFNA1 Gene

Domains & Families for IFNA1 Gene

Gene Families for IFNA1 Gene

Graphical View of Domain Structure for InterPro Entry

P01562

UniProtKB/Swiss-Prot:

IFNA1_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA1: view

No data available for Suggested Antigen Peptide Sequences for IFNA1 Gene

Function for IFNA1 Gene

Molecular function for IFNA1 Gene

GENATLAS Biochemistry:
interferon type I,alpha 1,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Ontology (GO) - Molecular Function for IFNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding --
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA1: view

Phenotypes for IFNA1 Gene

GenomeRNAi human phenotypes for IFNA1:
genes like me logo Genes that share phenotypes with IFNA1: view

Animal Model Products

miRNA for IFNA1 Gene

miRTarBase miRNAs that target IFNA1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for IFNA1 Gene

Localization for IFNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNA1 Gene COMPARTMENTS Subcellular localization image for IFNA1 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
endosome 2
mitochondrion 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IFNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA1: view

Pathways & Interactions for IFNA1 Gene

genes like me logo Genes that share pathways with IFNA1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Angiogenic Growth Factors in human,mouse,rat
    • Antibacterial Response in human,mouse,rat

SIGNOR curated interactions for IFNA1 Gene

Activates:

Gene Ontology (GO) - Biological Process for IFNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA1: view

Drugs & Compounds for IFNA1 Gene

(77) Drugs for IFNA1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acitretin Approved Pharma Metabolite of etretinate 29
Amantadine Approved Pharma 63
Anagrelide Approved Pharma 21
Bexarotene Approved, Investigational Pharma Agonist Others 43
Bleomycin Approved Pharma 142

(51) Additional Compounds for IFNA1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2,5-Oligoadenylate
2-Chlorodeoxyadenosine
5-Aza-2deoxycytidine
5-Deoxy-5-fluorouridine
5-FLUORO-2-DEOXYURIDINE-5-MONOPHOSPHATE
genes like me logo Genes that share compounds with IFNA1: view

Transcripts for IFNA1 Gene

mRNA/cDNA for IFNA1 Gene

(1) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA1 Gene

No ASD Table

Relevant External Links for IFNA1 Gene

GeneLoc Exon Structure for
IFNA1
ECgene alternative splicing isoforms for
IFNA1

Expression for IFNA1 Gene

mRNA expression in normal human tissues for IFNA1 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.9) and Brain - Cerebellum (x7.9).

SOURCE GeneReport for Unigene cluster for IFNA1 Gene Hs.37026

genes like me logo Genes that share expression patterns with IFNA1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IFNA1 Gene

Orthologs for IFNA1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNA13 35
  • 99.12 (n)
  • 98.41 (a)
-- 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm12597 16
Gm12597 36
  • 62 (a)
ManyToMany
Gm13280 36
  • 63 (a)
ManyToMany
Ifna1 36
  • 63 (a)
ManyToMany
Ifna11 36
  • 59 (a)
ManyToMany
Ifna12 36
  • 62 (a)
ManyToMany
Ifna13 36
  • 65 (a)
ManyToMany
Ifna14 36
  • 60 (a)
ManyToMany
Ifna2 36
  • 59 (a)
ManyToMany
Ifna4 36
  • 60 (a)
ManyToMany
Ifna5 36
  • 63 (a)
ManyToMany
Ifna6 36
  • 65 (a)
ManyToMany
Ifna7 36
  • 61 (a)
ManyToMany
Ifna9 36
  • 64 (a)
ManyToMany
Ifnab 36
  • 60 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
IFNAA 36
  • 61 (a)
ManyToMany
IFNAG 36
  • 62 (a)
ManyToMany
IFNAG 36
  • 63 (a)
ManyToMany
IFNAH 36
  • 61 (a)
ManyToMany
INFAF 36
  • 61 (a)
ManyToMany
Species with no ortholog for IFNA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA1 Gene

ENSEMBL:
Gene Tree for IFNA1 (if available)
TreeFam:
Gene Tree for IFNA1 (if available)

Paralogs for IFNA1 Gene

(18) SIMAP similar genes for IFNA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IFNA1: view

Variants for IFNA1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA1 Gene

P01562-IFNA1_HUMAN
Two forms exist; alpha-1a (shown here) and alpha-1b

Sequence variations from dbSNP and Humsavar for IFNA1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1065752 -- 21,440,506(+) ATCTA(C/T)GATGG utr-variant-5-prime
rs1065753 -- 21,441,080(+) TAACA(C/T)CTGGT utr-variant-3-prime
rs1332190 -- 21,438,685(-) TCCAT(C/T)GTCTA upstream-variant-2KB
rs1758565 -- 21,440,432(+) AGCAA(A/G)GCCTT upstream-variant-2KB
rs1758567 - 21,440,536(+) GATGG(C/T)CCTGG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for IFNA1 Gene

Variant ID Type Subtype PubMed ID
nsv892724 CNV Gain 21882294
esv2752289 CNV Gain 17911159
nsv466297 CNV Gain 19166990
nsv892739 CNV Gain 21882294

Variation tolerance for IFNA1 Gene

Residual Variation Intolerance Score: 64.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNA1 Gene

HapMap Linkage Disequilibrium report
IFNA1

Disorders for IFNA1 Gene

MalaCards: The human disease database

(62) MalaCards diseases for IFNA1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
lung mixed small cell and squamous cell carcinoma
  • combined small and large cell lung cancer
oral erosive lichen
pancreatic cancer 2
  • pnca2
plantar wart
  • verruca plantaris
hepatitis c
  • hepatitis c infection
- elite association
Search IFNA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFNA1

Genetic Association Database (GAD)
IFNA1
Human Genome Epidemiology (HuGE) Navigator
IFNA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFNA1
genes like me logo Genes that share disorders with IFNA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA1 Gene

Publications for IFNA1 Gene

  1. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade O.I. … Diaz M.O. (Genomics 1992) 2 23 67
  2. A survey of therapy for advanced renal cell carcinoma. (PMID: 19576800) Basso M. … Barone C. (Urol. Oncol. 2010) 23 67
  3. Resolution of chronic hepatitis Delta after 1 year of combined therapy with pegylated interferon, tenofovir and emtricitabine. (PMID: 19914127) Mansour W. … Lunel F. (J. Clin. Virol. 2010) 23 67
  4. Biochemical monitoring of the early endocytic traffic of the type I interferon receptor. (PMID: 20028207) Payelle-Brogard B. … Pellegrini S. (J. Interferon Cytokine Res. 2010) 23 67
  5. Bevacizumab, sorafenib tosylate, sunitinib and temsirolimus for renal cell carcinoma: a systematic review and economic evaluation. (PMID: 20028613) Thompson Coon J. … Stein K. (Health Technol Assess 2010) 23 67

Products for IFNA1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Angiogenesis in human,mouse,rat
    • Angiogenic Growth Factors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFNA1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNA1
  • Block miRNA regulation of IFNA1 using miScript Target Protectors

Sources for IFNA1 Gene

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