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Aliases for IFIT1 Gene

Aliases for IFIT1 Gene

  • Interferon-Induced Protein With Tetratricopeptide Repeats 1 2 3
  • IFNAI1 3 4 6
  • G10P1 3 4 6
  • IFI56 3 4 6
  • Interferon-Induced 56 KDa Protein 3 4
  • IFI-56K 3 4
  • IFIT-1 3 4
  • ISG56 3 4
  • P56 3 4
  • Interferon, Alpha-Inducible Protein (MW 56kD) 3
  • Interferon-Inducible MRNA 561 3
  • IFI-56 3
  • RNM561 3
  • C56 3

External Ids for IFIT1 Gene

Previous HGNC Symbols for IFIT1 Gene

  • G10P1
  • IFI56
  • IFNAI1

Previous GeneCards Identifiers for IFIT1 Gene

  • GC10P090033
  • GC10P090374
  • GC10P091283
  • GC10P090816
  • GC10P091142
  • GC10P084786

Summaries for IFIT1 Gene

Entrez Gene Summary for IFIT1 Gene

  • This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

GeneCards Summary for IFIT1 Gene

IFIT1 (Interferon-Induced Protein With Tetratricopeptide Repeats 1) is a Protein Coding gene. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include RNA binding. An important paralog of this gene is IFIT3.

UniProtKB/Swiss-Prot for IFIT1 Gene

  • Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2-O-methylation of the 5 cap and bear a 5-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2-O-methylase for their mRNAs or by stealing host cap containing the 2-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.

Gene Wiki entry for IFIT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFIT1 Gene

Genomics for IFIT1 Gene

Regulatory Elements for IFIT1 Gene

Genomic Location for IFIT1 Gene

Start:
89,392,546 bp from pter
End:
89,406,487 bp from pter
Size:
13,942 bases
Orientation:
Plus strand

Genomic View for IFIT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFIT1 Gene

Proteins for IFIT1 Gene

  • Protein details for IFIT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09914-IFIT1_HUMAN
    Recommended name:
    Interferon-induced protein with tetratricopeptide repeats 1
    Protein Accession:
    P09914
    Secondary Accessions:
    • B3KS50
    • D3DR31
    • Q5T7J1
    • Q96QM5

    Protein attributes for IFIT1 Gene

    Size:
    478 amino acids
    Molecular mass:
    55360 Da
    Quaternary structure:
    • Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts (via TPR repeats 4-7) with EEF1A1 (By similarity). Interacts with EIF3C (By similarity). Interacts with IFIT2 and IFIT3. Interacts (via TPR repeats 1-4) with RPL15. Interacts with TMEM173/MITA and disrupts its interaction with MAVS or TBK1. Interacts with EIF3E. Interacts (via TPR repeat 2) with E1 proteins of HPV types 11, 18 and 3 and this interaction blocks E1 helicase activity and viral replication.

    Three dimensional structures from OCA and Proteopedia for IFIT1 Gene

    Alternative splice isoforms for IFIT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFIT1 Gene

Proteomics data for IFIT1 Gene at MOPED

Post-translational modifications for IFIT1 Gene

Other Protein References for IFIT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IFIT1 (IFIT1)

No data available for DME Specific Peptides for IFIT1 Gene

Domains for IFIT1 Gene

Gene Families for IFIT1 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for IFIT1 Gene

Graphical View of Domain Structure for InterPro Entry

P09914

UniProtKB/Swiss-Prot:

IFIT1_HUMAN :
  • P09914
Domain:
  • RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft.
Family:
  • Belongs to the IFIT family.
Similarity:
  • Contains 10 TPR repeats.
genes like me logo Genes that share domains with IFIT1: view

Function for IFIT1 Gene

Molecular function for IFIT1 Gene

GENATLAS Biochemistry:
interferon alpha-inducible protein,56kDa (clone IFI-56K),also induced by interleukin 1,retinoic acid,viral infection...
UniProtKB/Swiss-Prot Function:
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2-O-methylation of the 5 cap and bear a 5-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2-O-methylase for their mRNAs or by stealing host cap containing the 2-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
UniProtKB/Swiss-Prot Induction:
By type I interferons, dsRNAs and viruses.

Gene Ontology (GO) - Molecular Function for IFIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 21642987
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with IFIT1: view

Phenotypes for IFIT1 Gene

genes like me logo Genes that share phenotypes with IFIT1: view

Animal Models for IFIT1 Gene

MGI Knock Outs for IFIT1:

Animal Model Products

miRNA for IFIT1 Gene

miRTarBase miRNAs that target IFIT1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFIT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IFIT1 Gene

Localization for IFIT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFIT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFIT1 Gene COMPARTMENTS Subcellular localization image for IFIT1 gene
Compartment Confidence
cytosol 4
golgi apparatus 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for IFIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IFIT1: view

Pathways for IFIT1 Gene

genes like me logo Genes that share pathways with IFIT1: view

Pathways by source for IFIT1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Interferons & Receptors in human,mouse,rat
    • Type I Interferon Response in human,mouse,rat

Gene Ontology (GO) - Biological Process for IFIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009615 response to virus IMP 21642987
GO:0019060 intracellular transport of viral protein in host cell IDA 19008854
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032091 negative regulation of protein binding IDA 19416887
GO:0045070 positive regulation of viral genome replication IDA 19416887
genes like me logo Genes that share ontologies with IFIT1: view

Transcripts for IFIT1 Gene

Unigene Clusters for IFIT1 Gene

Interferon-induced protein with tetratricopeptide repeats 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFIT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFIT1 Gene

No ASD Table

Relevant External Links for IFIT1 Gene

GeneLoc Exon Structure for
IFIT1
ECgene alternative splicing isoforms for
IFIT1

Expression for IFIT1 Gene

mRNA expression in normal human tissues for IFIT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFIT1 Gene

This gene is overexpressed in Brain - Substantia nigra (5.7).

Protein differential expression in normal tissues for IFIT1 Gene

This gene is overexpressed in Spleen (16.2), Bone (9.0), and Lymph node (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFIT1 Gene

SOURCE GeneReport for Unigene cluster for IFIT1 Gene Hs.20315

genes like me logo Genes that share expressions with IFIT1: view

Expression partners for IFIT1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IFIT1 Gene

Orthologs for IFIT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFIT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IFIT1 35
  • 80.76 (n)
  • 67.56 (a)
IFIT1 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFIT1 35
  • 80.75 (n)
  • 70.7 (a)
IFIT1 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm14446 35
  • 69.82 (n)
  • 57.8 (a)
Ifit1 16
chimpanzee
(Pan troglodytes)
Mammalia IFIT1 35
  • 99.09 (n)
  • 98.33 (a)
rat
(Rattus norvegicus)
Mammalia Ifit1lb 35
  • 70.59 (n)
  • 58.39 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ifit5 35
  • 50.71 (n)
  • 39.05 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-26g8.12 35
  • 47.07 (n)
  • 36.49 (a)
CR759879.1 36
  • 30 (a)
ManyToMany
ifit2 36
  • 24 (a)
ManyToMany
ifit5 36
  • 31 (a)
ManyToMany
si:ch211-240h7.2 36
  • 24 (a)
ManyToMany
si:dkey-116m16.3 36
  • 24 (a)
ManyToMany
si:dkey-26g8.10 36
  • 31 (a)
ManyToMany
si:dkey-26g8.11 36
  • 32 (a)
ManyToMany
zgc:123282 36
  • 28 (a)
ManyToMany
Species with no ortholog for IFIT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFIT1 Gene

ENSEMBL:
Gene Tree for IFIT1 (if available)
TreeFam:
Gene Tree for IFIT1 (if available)

Paralogs for IFIT1 Gene

Paralogs for IFIT1 Gene

Selected SIMAP similar genes for IFIT1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for IFIT1 Gene

genes like me logo Genes that share paralogs with IFIT1: view

Variants for IFIT1 Gene

Sequence variations from dbSNP and Humsavar for IFIT1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs215493 -- 89,404,413(+) tttga(C/T)ataga utr-variant-3-prime
rs303208 -- 89,406,076(+) ATTTT(C/T)GTTGG utr-variant-3-prime
rs303209 -- 89,405,059(+) TGTAA(A/T)AAACA utr-variant-3-prime
rs303210 -- 89,402,920(+) CCAGA(C/T)AATGG reference, synonymous-codon
rs303211 -- 89,402,740(+) GGAAA(A/G)AATTA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IFIT1 Gene

Variant ID Type Subtype PubMed ID
esv34085 CNV Loss 18971310

Relevant External Links for IFIT1 Gene

HapMap Linkage Disequilibrium report
IFIT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFIT1 Gene

Disorders for IFIT1 Gene

Relevant External Links for IFIT1

Genetic Association Database (GAD)
IFIT1
Human Genome Epidemiology (HuGE) Navigator
IFIT1

No disorders were found for IFIT1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for IFIT1 Gene

Publications for IFIT1 Gene

  1. The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24. (PMID: 1377167) Lafage M. … Huez G. (Genomics 1992) 2 3 23
  2. The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. (PMID: 3360121) Wathelet M.G. … Huez G.A. (FEBS Lett. 1988) 2 3 4
  3. New inducers revealed by the promoter sequence analysis of two interferon-activated human genes. (PMID: 3121313) Wathelet M.G. … Huez G.A. (Eur. J. Biochem. 1987) 3 4
  4. [Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus]. (PMID: 12708317) Gavrilov B.G. … Sverdlov E.D. (Bioorg. Khim. 2003) 3 23
  5. Molecular cloning, full-length sequence and preliminary characterization of a 56-kDa protein induced by human interferons. (PMID: 3753936) Wathelet M. … Content J. (Eur. J. Biochem. 1986) 3 4

Products for IFIT1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Interferons & Receptors in human,mouse,rat
    • Type I Interferon Response in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IFIT1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IFIT1
    • Block miRNA regulation of IFIT1 using miScript Target Protectors
    • Addgene plasmids for IFIT1

    Sources for IFIT1 Gene

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