Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SP110 Gene

Aliases for SP110 Gene

  • SP110 Nuclear Body Protein 2 3
  • Interferon-Induced Protein 41, 30kD 2 3
  • Transcriptional Coactivator Sp110 3 4
  • Interferon-Induced Protein 41/75 3 4
  • Speckled 110 KDa 3 4
  • Interferon-Induced Protein 75, 52kD 3
  • Sp110 Nuclear Body Protein 5
  • Phosphoprotein 41 3
  • Phosphoprotein 75 3
  • IFI41 3
  • IFI75 3
  • IPR1 3
  • VODI 3

External Ids for SP110 Gene

Previous HGNC Symbols for SP110 Gene

  • IFI41
  • IFI75

Previous GeneCards Identifiers for SP110 Gene

  • GC02M229093
  • GC02M229765
  • GC02M230997
  • GC02M231236
  • GC02M230859
  • GC02M230741
  • GC02M222874

Summaries for SP110 Gene

Entrez Gene Summary for SP110 Gene

  • The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SP110 Gene

SP110 (SP110 Nuclear Body Protein) is a Protein Coding gene. Diseases associated with SP110 include hepatic venoocclusive disease with immunodeficiency and hepatic veno-occlusive disease. GO annotations related to this gene include chromatin binding and signal transducer activity. An important paralog of this gene is SP140L.

UniProtKB/Swiss-Prot for SP110 Gene

  • Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).

Gene Wiki entry for SP110 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP110 Gene

Genomics for SP110 Gene

Regulatory Elements for SP110 Gene

Promoters for SP110 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SP110 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SP110 gene promoter:

Genomic Location for SP110 Gene

Chromosome:
2
Start:
230,167,293 bp from pter
End:
230,225,729 bp from pter
Size:
58,437 bases
Orientation:
Minus strand

Genomic View for SP110 Gene

Genes around SP110 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP110 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP110 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP110 Gene

Proteins for SP110 Gene

  • Protein details for SP110 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB58-SP110_HUMAN
    Recommended name:
    Sp110 nuclear body protein
    Protein Accession:
    Q9HB58
    Secondary Accessions:
    • B4DVI4
    • F5H1M1
    • Q14976
    • Q14977
    • Q53TG2
    • Q8WUZ6
    • Q9HCT8

    Protein attributes for SP110 Gene

    Size:
    689 amino acids
    Molecular mass:
    78396 Da
    Quaternary structure:
    • Isoform 3 interacts with HCV core protein.
    • Isoform 3 interacts with HCV core protein.
    SequenceCaution:
    • Sequence=AAF99318.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAG09826.1; Type=Frameshift; Positions=141, 143; Evidence={ECO:0000305}; Sequence=AK026488; Type=Frameshift; Positions=296, 542, 567; Evidence={ECO:0000305};

    Alternative splice isoforms for SP110 Gene

neXtProt entry for SP110 Gene

Proteomics data for SP110 Gene at MOPED

Post-translational modifications for SP110 Gene

Antibody Products

No data available for DME Specific Peptides for SP110 Gene

Domains & Families for SP110 Gene

Suggested Antigen Peptide Sequences for SP110 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HB58

UniProtKB/Swiss-Prot:

SP110_HUMAN :
  • Contains 1 bromo domain.
  • Contains 1 PHD-type zinc finger.
Domain:
  • Contains 1 bromo domain.
  • Contains 1 HSR domain.
  • Contains 1 SAND domain.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with SP110: view

Function for SP110 Gene

Molecular function for SP110 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma and all-trans retinoic acid (ATRA).
genes like me logo Genes that share phenotypes with SP110: view

Human Phenotype Ontology for SP110 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for SP110 Gene

Localization for SP110 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP110 Gene

Nucleus. Note=Found in the nuclear body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SP110 Gene COMPARTMENTS Subcellular localization image for SP110 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for SP110 Gene

Pathways & Interactions for SP110 Gene

SuperPathways for SP110 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SP110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7693701
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with SP110: view

No data available for Pathways by source and SIGNOR curated interactions for SP110 Gene

Drugs & Compounds for SP110 Gene

No Compound Related Data Available

Transcripts for SP110 Gene

Unigene Clusters for SP110 Gene

SP110 nuclear body protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SP110 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - - -
SP2: - - - -
SP3:
SP4: -
SP5: - -
SP6: - - -
SP7:

ExUns: 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for SP110 Gene

GeneLoc Exon Structure for
SP110
ECgene alternative splicing isoforms for
SP110

Expression for SP110 Gene

mRNA expression in normal human tissues for SP110 Gene

mRNA differential expression in normal tissues according to GTEx for SP110 Gene

This gene is overexpressed in Whole Blood (x10.7).

Protein differential expression in normal tissues from HIPED for SP110 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.5), Blymphocyte (14.0), and CD8 Tcells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SP110 Gene



SOURCE GeneReport for Unigene cluster for SP110 Gene Hs.145150

mRNA Expression by UniProt/SwissProt for SP110 Gene

Q9HB58-SP110_HUMAN
Tissue specificity: Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with SP110: view

Protein tissue co-expression partners for SP110 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SP110 Gene

Orthologs for SP110 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SP110 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SP110 35
  • 98.7 (n)
  • 97.97 (a)
cow
(Bos Taurus)
Mammalia SP110 35
  • 75.1 (n)
  • 61.47 (a)
SP110 36
  • 44 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SP110 36
  • 59 (a)
OneToOne
SP110 35
  • 76.84 (n)
  • 62.71 (a)
mouse
(Mus musculus)
Mammalia LOC677525 35
  • 71.7 (n)
  • 55.1 (a)
Sp110 16
AC125149.3 36
  • 62 (a)
OneToMany
AC125149.4 36
  • 61 (a)
OneToMany
AC132444.3 36
  • 61 (a)
OneToMany
AC133103.4 36
  • 61 (a)
OneToMany
AC133103.5 36
  • 62 (a)
OneToMany
AC168977.1 36
  • 48 (a)
OneToMany
Sp110 36
  • 45 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 18 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SP110 36
  • 25 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sp110 35
  • 64.16 (n)
  • 49.34 (a)
zebrafish
(Danio rerio)
Actinopterygii BX569789.2 36
  • 33 (a)
ManyToMany
BX569789.4 36
  • 21 (a)
ManyToMany
zgc:113411 36
  • 21 (a)
ManyToMany
Species with no ortholog for SP110:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SP110 Gene

ENSEMBL:
Gene Tree for SP110 (if available)
TreeFam:
Gene Tree for SP110 (if available)

Paralogs for SP110 Gene

Paralogs for SP110 Gene

genes like me logo Genes that share paralogs with SP110: view

Variants for SP110 Gene

Sequence variations from dbSNP and Humsavar for SP110 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_027170 -
VAR_027171 -
VAR_027172 -
VAR_027173 -
VAR_027174 -

Structural Variations from Database of Genomic Variants (DGV) for SP110 Gene

Variant ID Type Subtype PubMed ID
esv29172 CNV Loss 19812545

Variation tolerance for SP110 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.13; 80.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SP110 Gene

HapMap Linkage Disequilibrium report
SP110
Human Gene Mutation Database (HGMD)
SP110

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP110 Gene

Disorders for SP110 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SP110 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hepatic venoocclusive disease with immunodeficiency
  • hepatic veno-occlusive disease with immunodeficiency
hepatic veno-occlusive disease
  • sinusoidal obstruction syndrome
lymph node tuberculosis
  • king's evil
pulmonary tuberculosis
  • tuberculosis pulmonary
extrapulmonary tuberculosis
  • eptb
- elite association - COSMIC cancer census association via MalaCards
Search SP110 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SP110_HUMAN
  • Hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]: Autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B-cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells. {ECO:0000269 PubMed:16648851}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SP110

Genetic Association Database (GAD)
SP110
Human Genome Epidemiology (HuGE) Navigator
SP110
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SP110
genes like me logo Genes that share disorders with SP110: view

No data available for Genatlas for SP110 Gene

Publications for SP110 Gene

  1. No associations of human pulmonary tuberculosis with Sp110 variants. (PMID: 16816019) Thye T. … Meyer C.G. (J. Med. Genet. 2006) 3 4 48 67
  2. Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. (PMID: 10913195) Bloch D.B. … Bloch K.D. (Mol. Cell. Biol. 2000) 3 23
  3. Colocalization within the nucleolus of two highly related IFN-induced human nuclear phosphoproteins with nucleolin. (PMID: 10388521) Welsh G.I. … Meurs E.F. (Exp. Cell Res. 1999) 2 3
  4. Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins. (PMID: 7693701) Kadereit S. … Meurs E.F. (J. Biol. Chem. 1993) 2 3
  5. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. (PMID: 25925205) Bhattacharya S. … Ghosh M.K. (Cell Oncol (Dordr) 2015) 3

Products for SP110 Gene

Sources for SP110 Gene

Back to Top

Content